Research Topics
| Baocheng ChuSummaryAffiliation: University of Washington Country: USA Publications
| Collaborators
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Detail Information
Publications
A visible, targeted high-efficiency gene delivery and transfection strategyQiao Ying Yuan
Department of Geriatrics, Southwest Hospital, The Third Military Medical University, Chongqing 400038, China
BMC Biotechnol 11:56. 2011....
Images in cardiovascular medicine. Serial high-spatial-resolution, multisequence magnetic resonance imaging studies identify fibrous cap rupture and penetrating ulcer into carotid atherosclerotic plaqueBaocheng Chu
Department of Radiology, University of Washington, Seattle, WA 98195, USA
Circulation 113:e660-1. 2006- Determination of carotid artery atherosclerotic lesion type and distribution in hypercholesterolemic patients with moderate carotid stenosis using noninvasive magnetic resonance imagingBaocheng Chu
Department of Radiology, Box 357115, University of Washington, 1959 NE Pacific Street, Seattle, WA 98195, USA
Stroke 35:2444-8. 2004.... - Feasibility of in vivo, multicontrast-weighted MR imaging of carotid atherosclerosis for multicenter studiesBaocheng Chu
Department of Radiology, University of Washington, Seattle, Washington 98195, USA
J Magn Reson Imaging 21:809-17. 2005..To test the image quality (ImQ) and interscan coverage of MRI for measuring carotid atherosclerosis across multiple centers... - Images in cardiovascular medicine. Detection of carotid atherosclerotic plaque ulceration, calcification, and thrombosis by multicontrast weighted magnetic resonance imagingBaocheng Chu
Department of Radiology, University of Washington, 1959 NE Pacific St, Seattle, WA 98195, USA
Circulation 112:e3-4. 2005 - Reproducibility of carotid atherosclerotic lesion type characterization using high resolution multicontrast weighted cardiovascular magnetic resonanceBaocheng Chu
Department of Radiology, University of Washington Medical Center, Seattle, Washington 98195, USA
J Cardiovasc Magn Reson 8:793-9. 2006..Cardiovascular magnetic resonance (CMR) can characterize carotid atherosclerosis. The purpose of this study is to evaluate reader agreement of carotid atherosclerotic lesion types by CMR... - Magnetic [corrected] resonance imaging [corrected] features of the disruption-prone and the disrupted carotid plaqueBaocheng Chu
Vascular Imaging Laboratory, University of Washington, Seattle, Washington 98109, USA
JACC Cardiovasc Imaging 2:883-96. 2009..This pictorial essay illustrates the capability of CMR for identifying features of disruption-prone and disrupted atherosclerotic carotid plaques... - Intra- and interreader reproducibility of magnetic resonance imaging for quantifying the lipid-rich necrotic core is improved with gadolinium contrast enhancementNorihide Takaya
Department of Radiology, University of Washington, Seattle, Washington, USA
J Magn Reson Imaging 24:203-10. 2006..CONCLUSION: Reader reproducibility for in vivo MRI quantification of LR-NC size is significantly improved by the addition of Gd contrast in individuals with >50% carotid stenosis... 
Effect of rosuvastatin therapy on carotid plaque morphology and composition in moderately hypercholesterolemic patients: a high-resolution magnetic resonance imaging trialHunter R Underhill
Department of Radiology, University of Washington, Seattle, WA 98109, USA
Am Heart J 155:584.e1-8. 2008..Magnetic resonance imaging (MRI) can noninvasively assess changes in atherosclerotic plaque morphology and composition. The ORION trial assessed the effects of rosuvastatin on carotid plaque volume and composition...- Predictors of carotid atherosclerotic plaque progression as measured by noninvasive magnetic resonance imagingTobias Saam
Department of Radiology, University of Washington, Seattle, WA, USA
Atherosclerosis 194:e34-42. 2007..Findings from this study suggest that increased normalized wall index and the use of statin therapy are associated with reduced rates of plaque progression amongst individuals with advanced, asymptomatic carotid atherosclerosis... - Carotid plaque morphology and composition: initial comparison between 1.5- and 3.0-T magnetic field strengthsHunter R Underhill
Department of Radiology, University of Washington, 815 Mercer St, Box 358050, Seattle, WA 98109, USA
Radiology 248:550-60. 2008..To prospectively compare the interpretation and quantification of carotid vessel wall morphology and plaque composition at 1.5-T with those at 3.0-T magnetic resonance (MR) imaging... - Scan-rescan reproducibility of carotid atherosclerotic plaque morphology and tissue composition measurements using multicontrast MRI at 3TFeiyu Li
Department of Radiology, University of Washington, Seattle, Washington 98109, USA
J Magn Reson Imaging 31:168-76. 2010..To evaluate interscan reproducibility of both vessel morphology and tissue composition measurements of carotid atherosclerosis using a fast, optimized, 3T multicontrast protocol... - The added value of longitudinal black-blood cardiovascular magnetic resonance angiography in the cross sectional identification of carotid atherosclerotic ulcerationWei Yu
Department of Radiology, University of Washington, Seattle, WA, USA
J Cardiovasc Magn Reson 11:31. 2009..This study evaluates the efficacy of adding longitudinal black-blood (BB) cardiovascular magnetic resonance (CMR) angiography to cross-sectional CMR images in the identification of carotid atherosclerotic ulceration... - MR imaging of carotid plaque composition during lipid-lowering therapy a prospective assessment of effect and time courseXue Qiao Zhao
Department of Medicine, Division of Cardiology, University of Washington, Seattle, Washington, USA
JACC Cardiovasc Imaging 4:977-86. 2011..The purpose of this study was to test the lipid depletion hypothesis and to establish the time course of change in carotid plaque morphology and composition during lipid therapy using high-resolution magnetic resonance imaging (MRI)... - Carotid artery atherosclerosis: effect of intensive lipid therapy on the vasa vasorum--evaluation by using dynamic contrast-enhanced MR imagingLi Dong
Department of Radiology, University of Washington School of Medicine, 815 Mercer St, Seattle, WA 98109, USA
Radiology 260:224-31. 2011..To investigate whether short-term, intensive lipid therapy leads to changes in microvascular characteristics, as measured by using dynamic contrast material-enhanced (DCE) magnetic resonance (MR) imaging... - The vulnerable, or high-risk, atherosclerotic plaque: noninvasive MR imaging for characterization and assessmentTobias Saam
Department of Radiology, University of Washington, Seattle, Washington, USA
Radiology 244:64-77. 2007..The use of MR imaging in animal models and in human disease in various vascular beds, particularly the carotid arteries, is presented... - Sample size calculation for clinical trials using magnetic resonance imaging for the quantitative assessment of carotid atherosclerosisTobias Saam
Department of Radiology, University of Washington, Seattle, Washington 98195, USA
J Cardiovasc Magn Reson 7:799-808. 2005..This study provides the basis for sample size calculation of future MRI trials... - In vivo quantitative measurement of intact fibrous cap and lipid-rich necrotic core size in atherosclerotic carotid plaque: comparison of high-resolution, contrast-enhanced magnetic resonance imaging and histologyJianming Cai
Department of Radiology, University of Washington, Seattle, WA, USA
Circulation 112:3437-44. 2005..These new parameters may be useful to evaluate plaque vulnerability and provide continuous variables for characterizing the intact FC and LR-NC in progression and regression studies... - Hemorrhage in the atherosclerotic carotid plaque: a high-resolution MRI studyBaocheng Chu
Department of Radiology, University of Washington, USA
Stroke 35:1079-84. 2004..6 for reviewer 2), with moderate agreement between the 2 MRI readers (kappa=0.4, 95% CI: 0.3 to 0.6). CONCLUSIONS: Multicontrast MRI can detect and classify carotid intraplaque hemorrhage with high sensitivity and moderate specificity... - Discriminating carotid atherosclerotic lesion severity by luminal stenosis and plaque burden: a comparison utilizing high-resolution magnetic resonance imaging at 3.0 TeslaXihai Zhao
Department of Radiology, University of Washington, Seattle, WA 98109, USA
Stroke 42:347-53. 2011..To determine associations between stenosis, measures of plaque burden, and compositional features of carotid atherosclerosis, including high-risk features of intraplaque hemorrhage (IPH) and surface disruption... - MRI of atherosclerosis in clinical trialsChun Yuan
Department of Radiology, University of Washington, Seattle, WA 98195, USA
NMR Biomed 19:636-54. 2006..Also, the results of validation studies for measuring lesion size, composition and inflammation will be summarized. Finally, the status of several clinical trials involving MRI of atherosclerosis will be reviewed... - Presence of intraplaque hemorrhage stimulates progression of carotid atherosclerotic plaques: a high-resolution magnetic resonance imaging studyNorihide Takaya
Department of Radiology, University of Washington, Seattle, USA
Circulation 111:2768-75. 2005..Repeated bleeding into the plaque may produce a stimulus for the progression of atherosclerosis by increasing lipid core and plaque volume and creating new destabilizing factors... - Carotid plaque assessment using fast 3D isotropic resolution black-blood MRINiranjan Balu
Department of Radiology, University of Washington, Seattle, Washington 98019, USA
Magn Reson Med 65:627-37. 2011..3D-MERGE is a promising new tool for fast and accurate plaque burden assessment in patients with atherosclerotic plaque... - Effect of contrast enhancement on the measurement of carotid arterial lumen and wall volume using MRIBinh An P Phan
Department of Medicine, University of Washington, Seattle, Washington 98103 8771, USA
J Magn Reson Imaging 23:481-5. 2006..To investigate whether gadolinium (Gd)-based contrast enhancement (CE) affects high-resolution magnetic resonance imaging (MRI) measurements of carotid arterial wall volume... - Magnetic resonance imaging of carotid atherosclerosis: plaque analysisWilliam Kerwin
Department of Radiology, University of Washington, Seattle, WA 98109, USA
Top Magn Reson Imaging 18:371-8. 2007..The purpose of this investigation was to assess the performance of CASCADE compared with manual outlining... - Testing the hypothesis of atherosclerotic plaque lipid depletion during lipid therapy by magnetic resonance imaging: study design of Carotid Plaque Composition StudyXue Qiao Zhao
Division of Cardiology, Department of Medicine, University of Washington, Seattle, WA 98103, USA
Am Heart J 154:239-46. 2007..In vivo testing of the lipid depletion hypothesis in human beings during lipid-modifying therapy has not been possible until recent developments in magnetic resonance imaging (MRI)... - Comparison between 2D and 3D high-resolution black-blood techniques for carotid artery wall imaging in clinically significant atherosclerosisNiranjan Balu
Department of Bioengineering, University of Washington, Seattle, Washington, USA
J Magn Reson Imaging 27:918-24. 2008..To compare two- (2D) and three-dimensional (3D) black-blood imaging methods for morphological measurements of the carotid artery wall and atherosclerotic plaque... - Improvements in carotid plaque imaging using a new eight-element phased array coil at 3TNiranjan Balu
Department of Radiology, University of Washington, Seattle, Washington, USA
J Magn Reson Imaging 30:1209-14. 2009..To design and compare an eight-channel phased array (PA) coil for carotid imaging to an established four-channel PA design at 3T... - Prevalence of compositional features in subclinical carotid atherosclerosis determined by high-resolution magnetic resonance imaging in chinese patients with coronary artery diseaseXihai Zhao
Department of Radiology, University of Washington, 815 Mercer Street, Box 358050, Seattle, WA 98109, USA
Stroke 41:1157-62. 2010..This study sought to determine the prevalence of compositional features in subclinical carotid atherosclerosis by MRI in CAD patients... - Serial MRI of carotid plaque burden: influence of subject repositioning on measurement precisionNiranjan Balu
Department of Bioengineering, Vascular Imaging Laboratory, University of Washington, Seattle, Washington 98109, USA
Magn Reson Med 57:592-9. 2007..Orientation variability was the single most important factor that affected reproducibility, which suggests that methods are needed to obtain consistent orientation of the artery relative to the image plane... - Automated in vivo segmentation of carotid plaque MRI with Morphology-Enhanced probability mapsFei Liu
Department of Radiology, University of Washington, Seattle, WA 98109, USA
Magn Reson Med 55:659-68. 2006..71, 0.76, 0.33, and 0.78, respectively. These results show that in vivo automatic segmentation of carotid MRI is feasible and comparable to or possibly more accurate than manual review for quantifying plaque composition... - Association between carotid plaque characteristics and subsequent ischemic cerebrovascular events: a prospective assessment with MRI--initial resultsNorihide Takaya
Department of Radiology, University of Washington, Seattle, WA, USA
Stroke 37:818-23. 2006..Findings from this prospective study provide a basis for larger multicenter studies to assess the risk of plaque features for subsequent ischemic events... - Association of high-density lipoprotein levels and carotid atherosclerotic plaque characteristics by magnetic resonance imagingBinh An P Phan
Division of Cardiology, Department of Medicine, University of Washington, 1914 N 34th Street, Suite 105, Seattle, WA, 98103 8771, USA
Int J Cardiovasc Imaging 23:337-42. 2007..81 +/- 19 mm(3), P = 0.05) compared with patients with HDL levels > 35 mg/dL. Among CAD patients, low HDL-C levels were significantly associated with increased carotid atherosclerotic plaque burden and lipid content by MRI... - Time-efficient black blood RCA wall imaging at 3T using improved motion sensitized driven equilibrium (iMSDE): feasibility and reproducibilityJinnan Wang
Department of Radiology, University of Washington, Seattle, Washington, United States of America
PLoS ONE 6:e26567. 2011..The aim of this study was to explore the feasibility and reproducibility of a time-efficient coronary vessel wall measurement approach using an improved motion-sensitized driven equilibrium (iMSDE) pulse sequence... - The association of lesion eccentricity with plaque morphology and components in the superficial femoral artery: a high-spatial-resolution, multi-contrast weighted CMR studyFeiyu Li
Department of Radiology, University of Washington, Seattle, WA, USA
J Cardiovasc Magn Reson 12:37. 2010..This study investigated associations of plaque eccentricity with plaque components and morphology in the proximal superficial femoral artery using cardiovascular magnetic resonance (CMR)... - Differences in carotid arterial morphology and composition between individuals with and without obstructive coronary artery disease: a cardiovascular magnetic resonance studyHunter R Underhill
Department of Radiology University of Washington, Seattle, WA, USA
J Cardiovasc Magn Reson 10:31. 2008.... - Improved suppression of plaque-mimicking artifacts in black-blood carotid atherosclerosis imaging using a multislice motion-sensitized driven-equilibrium (MSDE) turbo spin-echo (TSE) sequenceJinnan Wang
Department of Bioengineering, University of Washington, Seattle, Washington, USA
Magn Reson Med 58:973-81. 2007.... - Imaging and cell targeting characteristics of magnetic nanoparticles modified by a functionalizable zwitterionic polymer with adhesive 3,4-dihydroxyphenyl-l-alanine linkagesLei Zhang
Department of Chemical Engineering, University of Washington, Box 351750, Seattle, WA 98195, United States
Biomaterials 31:6582-8. 2010.... - Changes in measured size of atherosclerotic plaque calcifications in dual-energy CT of ex vivo carotid endarterectomy specimens: effect of monochromatic keV image reconstructionsLorenzo Mannelli
Departments of Radiology, University of Washington, Seattle, WA, USA
Eur Radiol 23:367-74. 2013..The aim of this study was to compare the size of the calcifications measured on the different keV images to a histological standard... - Determination of nanoparticle vehicle unpackaging by MR imaging of a T(2) magnetic relaxation switchIn Kyu Park
Department of Bioengineering, University of Washington W H Foege Building, Room N530P, Box 355061, 1705 NE Pacific Street, Seattle, WA 98195, USA
Biomaterials 29:724-32. 2008..Thus, this material integrates capabilities of gene delivery with magnetic resonance (MR) contrast and also provides an MR-based read-out for vector unpackaging... - Immune responses to AAV in canine muscle monitored by cellular assays and noninvasive imagingZejing Wang
Program in Transplantation Biology, Division of Clinical Research, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
Mol Ther 18:617-24. 2010..These assays should be incorporated into future human clinical trials of AAV gene therapy to monitor immune responses... - Prevalence of American Heart Association type VI carotid atherosclerotic lesions identified by magnetic resonance imaging for different levels of stenosis as measured by duplex ultrasoundTobias Saam
Department of Clinical Radiology, University of Munich, Grosshadern Campus, Munich, Germany
J Am Coll Cardiol 51:1014-21. 2008.... - Reader and platform reproducibility for quantitative assessment of carotid atherosclerotic plaque using 1.5T Siemens, Philips, and General Electric scannersTobias Saam
Department of Clinical Radiology, University of Munich, Munich, Germany
J Magn Reson Imaging 26:344-52. 2007..To evaluate the platform and reader reproducibility of quantitative carotid plaque measurements...