Konstantin T Christov

Summary

Affiliation: University of Illinois at Chicago
Country: USA

Publications

  1. ncbi Bexarotene Induces Cellular Senescence in MMTV-Neu Mouse Model of Mammary Carcinogenesis
    Anne Shilkaitis
    Department of Surgical Oncology, University of Illinois at Chicago, 840 South Wood Street M C 820, Chicago, IL 60612
    Cancer Prev Res (Phila) 6:299-308. 2013
  2. ncbi Dehydroepiandrosterone inhibits the progression phase of mammary carcinogenesis by inducing cellular senescence via a p16-dependent but p53-independent mechanism
    Anne Shilkaitis
    Department of Surgical Oncology, University of Illinois, 840 S, Wood Str, Chicago, IL 60612, USA
    Breast Cancer Res 7:R1132-40. 2005
  3. ncbi p27(Kip1) deficiency promotes prostate carcinogenesis but does not affect the efficacy of retinoids in suppressing the neoplastic process
    Winna Taylor
    University of Illinois at Chicago, Department of Surgery, Division of Surgical Oncology, 840 S Wood St, Chicago, IL 60612, USA
    BMC Cancer 10:541. 2010
  4. ncbi To kill tumor cells or permanently paralyze them in senescence?
    K Christov
    Department of Surgical Oncology and Cancer Center, University of Illinois at Chicago, Chicago, IL 60612, USA
    J BUON 14:189-96. 2009
  5. ncbi The novel RARbeta isoform (beta5) is a potential target of retinoids in breast cancer
    Konstantin Christov
    Department of Surgical Oncology and Cancer Center, University of Illinois at Chicago, 840 South Wood Street, Chicago, IL 60612, USA
    Curr Cancer Drug Targets 9:142-7. 2009
  6. ncbi Prostate intraepithelial neoplasia in Noble rats, a potential intermediate endpoint for chemoprevention studies
    K T Christov
    Department of Surgical Oncology Laboratories, University of Illinois, 840 South Wood Str, MC 820, Chicago, IL 60612, USA
    Eur J Cancer 40:1404-11. 2004
  7. ncbi Cell proliferation, apoptosis, and expression of cyclin D1 and cyclin E as potential biomarkers in tamoxifen-treated mammary tumors
    Konstantin Christov
    Department of Surgical Oncology, University of Illinois, Chicago, IL, USA
    Breast Cancer Res Treat 77:253-64. 2003
  8. ncbi Chemopreventive agents induce a senescence-like phenotype in rat mammary tumours
    K T Christov
    Department of Surgical Oncology, University of Illinois, 840 South Wood Street, Chicago, IL 60612, USA
    Eur J Cancer 39:230-9. 2003
  9. ncbi 9-cis-retinoic acid but not 4-(hydroxyphenyl)retinamide inhibits prostate intraepithelial neoplasia in Noble rats
    Konstantin T Christov
    Department of Surgical Oncology, College of Medicine, University of Illinois, 840 South Wood Street MC 820, Chicago, IL 60612, USA
    Cancer Res 62:5178-82. 2002
  10. ncbi Cellular responses of mammary carcinomas to aromatase inhibitors: effects of vorozole
    K Christov
    Department of Surgical Oncology, University of Illinois, Chicago 60612, USA
    Breast Cancer Res Treat 60:117-28. 2000

Research Grants

  1. P27Kipl deficiency, potential promoter of carcinogenesis
    Konstantin Christov Tzelkov; Fiscal Year: 2003

Collaborators

Detail Information

Publications15

  1. ncbi Bexarotene Induces Cellular Senescence in MMTV-Neu Mouse Model of Mammary Carcinogenesis
    Anne Shilkaitis
    Department of Surgical Oncology, University of Illinois at Chicago, 840 South Wood Street M C 820, Chicago, IL 60612
    Cancer Prev Res (Phila) 6:299-308. 2013
    ..Cancer Prev Res; 6(4); 299-308. ©2013 AACR...
  2. ncbi Dehydroepiandrosterone inhibits the progression phase of mammary carcinogenesis by inducing cellular senescence via a p16-dependent but p53-independent mechanism
    Anne Shilkaitis
    Department of Surgical Oncology, University of Illinois, 840 S, Wood Str, Chicago, IL 60612, USA
    Breast Cancer Res 7:R1132-40. 2005
    ..Here we examine whether DHEA and its analog DHEA 8354 can suppress the progression of hyperplastic and premalignant (carcinoma in situ) lesions in mammary gland toward malignant tumors and the cellular mechanisms involved...
  3. ncbi p27(Kip1) deficiency promotes prostate carcinogenesis but does not affect the efficacy of retinoids in suppressing the neoplastic process
    Winna Taylor
    University of Illinois at Chicago, Department of Surgery, Division of Surgical Oncology, 840 S Wood St, Chicago, IL 60612, USA
    BMC Cancer 10:541. 2010
    ..To test this hypothesis, we examined the efficacy of 9-cis retinoic acid (9cRA) to suppress prostate cell proliferation (PECP) and carcinogenesis in p27(Kip1) deficient mice...
  4. ncbi To kill tumor cells or permanently paralyze them in senescence?
    K Christov
    Department of Surgical Oncology and Cancer Center, University of Illinois at Chicago, Chicago, IL 60612, USA
    J BUON 14:189-96. 2009
    ..Novel information is provided about the role of retinoic acid receptor beta 5 (RARbeta5) in mediating the retinoid-induced senescent program...
  5. ncbi The novel RARbeta isoform (beta5) is a potential target of retinoids in breast cancer
    Konstantin Christov
    Department of Surgical Oncology and Cancer Center, University of Illinois at Chicago, 840 South Wood Street, Chicago, IL 60612, USA
    Curr Cancer Drug Targets 9:142-7. 2009
    ..We found that RARbeta5 may serve as a potential biomarker of resistance of breast cancer cells to retinoids and thus may have clinical implication in selecting patients that may benefit the most from clinical trials with retinoids...
  6. ncbi Prostate intraepithelial neoplasia in Noble rats, a potential intermediate endpoint for chemoprevention studies
    K T Christov
    Department of Surgical Oncology Laboratories, University of Illinois, 840 South Wood Str, MC 820, Chicago, IL 60612, USA
    Eur J Cancer 40:1404-11. 2004
    ....
  7. ncbi Cell proliferation, apoptosis, and expression of cyclin D1 and cyclin E as potential biomarkers in tamoxifen-treated mammary tumors
    Konstantin Christov
    Department of Surgical Oncology, University of Illinois, Chicago, IL, USA
    Breast Cancer Res Treat 77:253-64. 2003
    ....
  8. ncbi Chemopreventive agents induce a senescence-like phenotype in rat mammary tumours
    K T Christov
    Department of Surgical Oncology, University of Illinois, 840 South Wood Street, Chicago, IL 60612, USA
    Eur J Cancer 39:230-9. 2003
    ....
  9. ncbi 9-cis-retinoic acid but not 4-(hydroxyphenyl)retinamide inhibits prostate intraepithelial neoplasia in Noble rats
    Konstantin T Christov
    Department of Surgical Oncology, College of Medicine, University of Illinois, 840 South Wood Street MC 820, Chicago, IL 60612, USA
    Cancer Res 62:5178-82. 2002
    ....
  10. ncbi Cellular responses of mammary carcinomas to aromatase inhibitors: effects of vorozole
    K Christov
    Department of Surgical Oncology, University of Illinois, Chicago 60612, USA
    Breast Cancer Res Treat 60:117-28. 2000
    ....
  11. ncbi Inhibition of estrogen-independent mammary carcinogenesis by disruption of growth hormone signaling
    Xiao Zhang
    Department of Medicinal Chemistry and Pharmacognosy, University of Illinois at Chicago, Chicago, IL 60612, USA
    Carcinogenesis 28:143-50. 2007
    ....
  12. ncbi Prevention of N-methyl-N-nitrosourea-induced mammary carcinogenesis in rats by 1alpha-hydroxyvitamin D(5)
    R Mehta
    Department of Surgical Oncology, College of Medicine, University of Illinois, Chicago 60612, USA
    J Natl Cancer Inst 92:1836-40. 2000
    ..Here, we evaluate its efficacy in an experimental rat mammary carcinogenesis model...
  13. ncbi Estrogenic and antiestrogenic properties of resveratrol in mammary tumor models
    K P Bhat
    Program for Collaborative Research in the Pharmaceutical Sciences, Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago, Chicago, Illinois 60612, USA
    Cancer Res 61:7456-63. 2001
    ..In rodent models, carcinogen-induced preneoplastic lesions and mammary tumors are inhibited. These data suggest that resveratrol may have beneficial effects if used as a chemopreventive agent for breast cancer...
  14. ncbi Disruption of growth hormone signaling retards early stages of prostate carcinogenesis in the C3(1)/T antigen mouse
    Zhuohua Wang
    Department of Medicinal Chemistry and Pharmacognosy, University of Illinois at Chicago, 60612 7231, USA
    Endocrinology 146:5188-96. 2005
    ..These results indicate that disruption of GH signaling significantly inhibits prostate carcinogenesis...
  15. ncbi Different impact of p53 and p21 on the radiation response of mouse tissues
    E A Komarova
    Department of Molecular Genetics, University of Illinois at Chicago, 60607, USA
    Oncogene 19:3791-8. 2000
    ..High p53 mRNA expression is inherited as a recessive trait in cell-cell hybrids suggesting the involvement of a negative control mechanism in the regulation of p53 gene expression...

Research Grants1

  1. P27Kipl deficiency, potential promoter of carcinogenesis
    Konstantin Christov Tzelkov; Fiscal Year: 2003
    ..abstract_text> ..