Melpo Christofidou-Solomidou

Summary

Affiliation: University of Pennsylvania
Country: USA

Publications

  1. pmc Dietary flaxseed administered post thoracic radiation treatment improves survival and mitigates radiation-induced pneumonopathy in mice
    Melpo Christofidou-Solomidou
    Department of Medicine, Pulmonary Allergy and Critical Care Division, University of Pennsylvania Medical Center, Philadelphia, PA 19104, USA
    BMC Cancer 11:269. 2011
  2. pmc Targeted detoxification of selected reactive oxygen species in the vascular endothelium
    Vladimir V Shuvaev
    Institute for Environmental Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 6068, USA
    J Pharmacol Exp Ther 331:404-11. 2009
  3. pmc Factors modulating the delivery and effect of enzymatic cargo conjugated with antibodies targeted to the pulmonary endothelium
    Vladimir V Shuvaev
    Institute for Environmental Medicine, School of Medicine, University of Pennsylvania Medical Center, 36th Street and Hamilron Walk, Philadelphia, PA 19104, USA
    J Control Release 118:235-44. 2007
  4. pmc Radiation mitigating properties of the lignan component in flaxseed
    Ralph Pietrofesa
    Department of Medicine, Pulmonary, Allergy and Critical Care Division, University of Pennsylvania, 3615 Civic Center Boulevard, Abramson Research Building, Suite 1016C, Philadelphia, PA 19104, USA
    BMC Cancer 13:179. 2013
  5. pmc Radioprotective role in lung of the flaxseed lignan complex enriched in the phenolic secoisolariciresinol diglucoside (SDG)
    Melpo Christofidou-Solomidou
    Department of Medicine, Pulmonary Allergy and Critical Care Division, University of Pennsylvania Medical Center, Philadelphia, Pennsylvania, USA
    Radiat Res 178:568-80. 2012
  6. ncbi request reprint Dietary flaxseed enhances antioxidant defenses and is protective in a mouse model of lung ischemia-reperfusion injury
    James C Lee
    Department of Medicine, Pulmonary, Allergy and Critical Care Division, University of Pennsylvania, Abramson Research Center, 3615 Civic Center Boulevard, Philadelphia, PA 19104, USA
    Am J Physiol Lung Cell Mol Physiol 294:L255-65. 2008
  7. pmc Gene expression profiling of flaxseed in mouse lung tissues-modulation of toxicologically relevant genes
    Floyd Dukes
    Department of Medicine, Pulmonary, Allergy and Critical Care Division, University of Pennsylvania, Philadelphia, PA 19104, USA
    BMC Complement Altern Med 12:47. 2012
  8. ncbi request reprint Dissociation between alveolar transmigration of neutrophils and lung injury in hyperoxia
    Sandra Perkowski
    School of Veterinary Medicine, University of Pennsylvania, 421 Curie Blvd, BRB II III, Philadelphia, 19104, USA
    Am J Physiol Lung Cell Mol Physiol 291:L1050-8. 2006
  9. pmc Prophylactic thrombolysis by thrombin-activated latent prourokinase targeted to PECAM-1 in the pulmonary vasculature
    Bi Sen Ding
    Department of Pharmacology, Institute for Translational Medicine and Therapeutics, University of Pennsylvania, Philadelphia, USA
    Blood 111:1999-2006. 2008
  10. ncbi request reprint PECAM-directed delivery of catalase to endothelium protects against pulmonary vascular oxidative stress
    Melpo Christofidou-Solomidou
    Department of Medicine, University of Pennsylvania, Philadelphia, PA 19104 6068, USA
    Am J Physiol Lung Cell Mol Physiol 285:L283-92. 2003

Research Grants

  1. Use of Curcumin and Flaxsseed in Radiation Pneumonopathy
    Melpo Christofidou Solomidou; Fiscal Year: 2007
  2. Secoisolariciresinol Diglucoside (SDB) Protection in Radiation Pheumonopathy
    Melpo Christofidou Solomidou; Fiscal Year: 2010

Collaborators

Detail Information

Publications31

  1. pmc Dietary flaxseed administered post thoracic radiation treatment improves survival and mitigates radiation-induced pneumonopathy in mice
    Melpo Christofidou-Solomidou
    Department of Medicine, Pulmonary Allergy and Critical Care Division, University of Pennsylvania Medical Center, Philadelphia, PA 19104, USA
    BMC Cancer 11:269. 2011
    ..We previously reported that dietary FS prevents pneumonopathy in a rodent model of thoracic X-ray radiation therapy (XRT). However, flaxseed's therapeutic usefulness in mitigating radiation effects post-exposure has never been evaluated...
  2. pmc Targeted detoxification of selected reactive oxygen species in the vascular endothelium
    Vladimir V Shuvaev
    Institute for Environmental Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 6068, USA
    J Pharmacol Exp Ther 331:404-11. 2009
    ..Therefore, the use of endothelial cell-targeted antioxidants identifies the key specific species of ROS involved in various forms of vascular disease and holds promise for the mechanistically tailored treatment of these pathologies...
  3. pmc Factors modulating the delivery and effect of enzymatic cargo conjugated with antibodies targeted to the pulmonary endothelium
    Vladimir V Shuvaev
    Institute for Environmental Medicine, School of Medicine, University of Pennsylvania Medical Center, 36th Street and Hamilron Walk, Philadelphia, PA 19104, USA
    J Control Release 118:235-44. 2007
    ..Understanding the nature of such "modulating biological factors" will hopefully allow optimization and ultimately applications of drug targeting for "individualized" pharmacotherapy...
  4. pmc Radiation mitigating properties of the lignan component in flaxseed
    Ralph Pietrofesa
    Department of Medicine, Pulmonary, Allergy and Critical Care Division, University of Pennsylvania, 3615 Civic Center Boulevard, Abramson Research Building, Suite 1016C, Philadelphia, PA 19104, USA
    BMC Cancer 13:179. 2013
    ..This could potentially lead to pulmonary inflammation, oxidative tissue injury, and fibrosis. This study aimed to evaluate the radiation mitigating effects of FLC in a mouse model of radiation pneumonopathy...
  5. pmc Radioprotective role in lung of the flaxseed lignan complex enriched in the phenolic secoisolariciresinol diglucoside (SDG)
    Melpo Christofidou-Solomidou
    Department of Medicine, Pulmonary Allergy and Critical Care Division, University of Pennsylvania Medical Center, Philadelphia, Pennsylvania, USA
    Radiat Res 178:568-80. 2012
    ..The dietary lignan complex of FS, mainly consisting of the phenolic secoisolariciresinol, is protective against radiation pneumonopathy in vivo while not hindering the tumoricidal effects of radiotherapy...
  6. ncbi request reprint Dietary flaxseed enhances antioxidant defenses and is protective in a mouse model of lung ischemia-reperfusion injury
    James C Lee
    Department of Medicine, Pulmonary, Allergy and Critical Care Division, University of Pennsylvania, Abramson Research Center, 3615 Civic Center Boulevard, Philadelphia, PA 19104, USA
    Am J Physiol Lung Cell Mol Physiol 294:L255-65. 2008
    ..We conclude that dietary FS is protective against IRI in an experimental murine model and that FS affects ROS generation and ROS detoxification via pathways not limited to upregulation of antioxidant enzymes such as HO-1...
  7. pmc Gene expression profiling of flaxseed in mouse lung tissues-modulation of toxicologically relevant genes
    Floyd Dukes
    Department of Medicine, Pulmonary, Allergy and Critical Care Division, University of Pennsylvania, Philadelphia, PA 19104, USA
    BMC Complement Altern Med 12:47. 2012
    ..We therefore postulated that flaxseed might modulate gene expression of vital signaling pathways, thus interfering with the development of tissue injury...
  8. ncbi request reprint Dissociation between alveolar transmigration of neutrophils and lung injury in hyperoxia
    Sandra Perkowski
    School of Veterinary Medicine, University of Pennsylvania, 421 Curie Blvd, BRB II III, Philadelphia, 19104, USA
    Am J Physiol Lung Cell Mol Physiol 291:L1050-8. 2006
    ..Blocking PMN recruitment did not prevent lung injury, supporting dissociation between PMN infiltration and lung injury during hyperoxia in mice...
  9. pmc Prophylactic thrombolysis by thrombin-activated latent prourokinase targeted to PECAM-1 in the pulmonary vasculature
    Bi Sen Ding
    Department of Pharmacology, Institute for Translational Medicine and Therapeutics, University of Pennsylvania, Philadelphia, USA
    Blood 111:1999-2006. 2008
    ..Endothelium-targeted thromboprophylaxis triggered by a prothrombotic enzyme illustrates a novel approach to time- and site-specific regulation of proteolytic reactions that can be modulated for therapeutic benefit...
  10. ncbi request reprint PECAM-directed delivery of catalase to endothelium protects against pulmonary vascular oxidative stress
    Melpo Christofidou-Solomidou
    Department of Medicine, University of Pennsylvania, Philadelphia, PA 19104 6068, USA
    Am J Physiol Lung Cell Mol Physiol 285:L283-92. 2003
    ..g., for augmentation of antioxidant defense in the pulmonary endothelium and treatment of ALI...
  11. pmc Modulation of endothelial targeting by size of antibody-antioxidant enzyme conjugates
    Vladimir V Shuvaev
    Institute for Translational Medicine and Therapeutics, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    J Control Release 149:236-41. 2011
    ..These results show that: i) the size of an antibody/enzyme conjugate modulates efficacy and specificity of targeting, and ii) a size optimum should be defined in vivo to account for parameters that are difficult to model in cell culture...
  12. ncbi request reprint Dietary flaxseed supplementation ameliorates inflammation and oxidative tissue damage in experimental models of acute lung injury in mice
    Paul Kinniry
    Pulmonary, Allergy and Critical Care Division, University of Pennsylvania, USA
    J Nutr 136:1545-51. 2006
    ..0001), and decreased with FS treatment following acid aspiration (P = 0.011). Dietary FS decreased lung inflammation and lipid peroxidation, suggesting a protective role against pro-oxidant-induced tissue damage in vivo...
  13. pmc Dietary curcumin increases antioxidant defenses in lung, ameliorates radiation-induced pulmonary fibrosis, and improves survival in mice
    James C Lee
    Pulmonary, Allergy and Critical Care Division, Department of Medicine, University of Pennsylvania Medical Center, Philadelphia, Pennsylvania 19104, USA
    Radiat Res 173:590-601. 2010
    ..Thus dietary curcumin ameliorates radiation-induced pulmonary fibrosis and increases mouse survival while not impairing tumor cell killing by radiation...
  14. pmc Vascular immunotargeting of glucose oxidase to the endothelial antigens induces distinct forms of oxidant acute lung injury: targeting to thrombomodulin, but not to PECAM-1, causes pulmonary thrombosis and neutrophil transmigration
    Melpo Christofidou-Solomidou
    Department of Medicine, Pulmonary Critical Care Division, The Institute of Environmental Medicine, University of Pennsylvania Medical Center, Philadelphia, Pennsylvania 19104 6068, USA
    Am J Pathol 160:1155-69. 2002
    ..In particular, anti-TM/GOX causes lung injury combining oxidative, prothrombotic, and inflammatory components characteristic of the complex pathological picture seen in human ALI/ARDS...
  15. pmc Anchoring fusion thrombomodulin to the endothelial lumen protects against injury-induced lung thrombosis and inflammation
    Bi Sen Ding
    Department of Pharmacology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Am J Respir Crit Care Med 180:247-56. 2009
    ..Diverse forms of pulmonary and vascular injury are accompanied by down-regulation of TM, which aggravates tissue injury. We postulated that anchoring TM to the endothelial surface would restore its protective functions...
  16. pmc Loading PEG-catalase into filamentous and spherical polymer nanocarriers
    ERIC A SIMONE
    Department of Bioengineering, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Pharm Res 26:250-60. 2009
    ..Based on a unique phase alignment that occurs during formulation, we postulated that PEG-ylation of the cargo enzyme would enhance its encapsulation within diblock copolymer nanocarriers and thus resistance to proteases...
  17. pmc Dietary flaxseed prevents radiation-induced oxidative lung damage, inflammation and fibrosis in a mouse model of thoracic radiation injury
    James C Lee
    Department of Medicine, University of Pennsylvania Medical Center, Philadelphia, 19104, USA
    Cancer Biol Ther 8:47-53. 2009
    ..Taken together, these data suggest that dietary flaxseed may be clinically useful as an agent to increase the therapeutic index of thoracic XRT by increasing the radiation tolerance of lung tissues...
  18. pmc Systemic polyethylene glycol-modified (PEGylated) superoxide dismutase and catalase mixture attenuates radiation pulmonary fibrosis in the C57/bl6 mouse
    Mitchell Machtay
    Department of Medicine, Pulmonary, Allergy, and Critical Care Division, Thomas Jefferson University Medical Center, Philadelphia, PA 19104, USA
    Radiother Oncol 81:196-205. 2006
    ..Since oxidative injury is implicated in radiation-induced tissue damage to the lung, we studied systemically administered polyethylene glycol (PEGylated) antioxidant enzymes (AOEs) as pulmonary radioprotectors in mice...
  19. ncbi request reprint Role for platelet-endothelial cell adhesion molecule-1 in macrophage Fcgamma receptor function
    Steven M Albelda
    Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Am J Respir Cell Mol Biol 31:246-55. 2004
    ..Although PECAM-1 may not be required for transmigration of leukocytes into the alveolar space in many forms of complex lung inflammation, it is important in the function of Fcgamma receptors on alveolar macrophages...
  20. ncbi request reprint KL4-surfactant prevents hyperoxic and LPS-induced lung injury in mice
    Paul Kinniry
    Department of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Pediatr Pulmonol 41:916-28. 2006
    ..Evidence suggests the anti-inflammatory mechanism of the KL(4)-peptide is through inhibition of PMN transmigration through the endothelium...
  21. ncbi request reprint ICAM-directed vascular immunotargeting of antithrombotic agents to the endothelial luminal surface
    Juan Carlos Murciano
    Institute of Environmental Medicine, Department of Pharmacology, University of Pennsylvania, Philadelphia, PA, USA
    Blood 101:3977-84. 2003
    ..Enhanced drug delivery to sites of inflammation and the potential anti-inflammatory effect of blocking ICAM-1 may enhance the benefit of this targeting strategy...
  22. pmc Erythrocytosis and pulmonary hypertension in a mouse model of human HIF2A gain of function mutation
    Qiulin Tan
    Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Biol Chem 288:17134-44. 2013
    ..These findings firmly establish missense mutations in HIF-2α as a cause of erythrocytosis, highlight the importance of this HIF-α isoform in erythropoiesis, and point to physiologic consequences of HIF-2α dysregulation...
  23. pmc Neutrophil alpha-defensins cause lung injury by disrupting the capillary-epithelial barrier
    Khalil Bdeir
    Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA l9l04, USA
    Am J Respir Crit Care Med 181:935-46. 2010
    ....
  24. pmc The von Hippel-Lindau Chuvash mutation promotes pulmonary hypertension and fibrosis in mice
    Michele M Hickey
    Abramson Family Cancer Research Institute, University of Pennsylvania School of Medicine, Philadelphia, 19104, USA
    J Clin Invest 120:827-39. 2010
    ..These findings strongly support a dependency of the Chuvash phenotype on HIF-2alpha and suggest potential treatments for Chuvash patients...
  25. pmc Synthesis and antioxidant evaluation of (S,S)- and (R,R)-secoisolariciresinol diglucosides (SDGs)
    Om P Mishra
    Department of Medicine, Pulmonary Allergy and Critical Care Division, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA
    Bioorg Med Chem Lett 23:5325-8. 2013
    ..63±8.67 μM] radicals. These results confirm previous studies with naturally occurring (S,S)-SDG-1 and establish both (S,S)-SDG-1 and (R,R)-SDG-2 as potent antioxidants and free radical scavengers for potential in vivo use...
  26. pmc Inhibition of autophagy as a strategy to augment radiosensitization by the dual phosphatidylinositol 3-kinase/mammalian target of rapamycin inhibitor NVP-BEZ235
    George J Cerniglia
    Department of Radiation Oncology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    Mol Pharmacol 82:1230-40. 2012
    ..Our data offer a rationale for combining NVP-BEZ235 along with an autophagy inhibitor (i.e., chloroquine) and radiation in future clinical trials...
  27. ncbi request reprint Platelet-endothelial cell adhesion molecule-1-directed immunotargeting to cardiopulmonary vasculature
    Arnaud Scherpereel
    Division of Pulmonary, Allergy, and Critical Care, Department of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104 6068, USA
    J Pharmacol Exp Ther 300:777-86. 2002
    ..This paradigm may be useful for drug targeting to endothelium in lungs, heart, and possibly other organs...
  28. ncbi request reprint Recombinant plasma gelsolin diminishes the acute inflammatory response to hyperoxia in mice
    Melpo Christofidou-Solomidou
    Division of Pulmonary Medicine, Department of Medicine, University of Pennsylvania Medical School, Philadelphia, USA
    J Investig Med 50:54-60. 2002
    ..By scavenging extracellular actin and modulating the effects of lysophosphatidic acid, plasma gelsolin could serve a critical protective role against oxidant injury...
  29. ncbi request reprint Size-dependent intracellular immunotargeting of therapeutic cargoes into endothelial cells
    Rainer Wiewrodt
    Pulmonary Critical Care Division, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Blood 99:912-22. 2002
    ..Thus, engineering of affinity carriers of specific size permits intracellular delivery of active cargoes to endothelium in vitro and in vivo, a paradigm useful for the targeting of drugs, genes, and toxins...
  30. ncbi request reprint PECAM-1 functions as a specific and potent inhibitor of mitochondrial-dependent apoptosis
    Cunji Gao
    Laboratories of PECAM 1 Research and Cell Biology, Blood Research Institute, The Blood Center of Southeastern Wisconsin, PO Box 2178, 638 N 18th St, Milwaukee, WI 53201, USA
    Blood 102:169-79. 2003
    ....
  31. ncbi request reprint Immunotargeting of catalase to the pulmonary endothelium alleviates oxidative stress and reduces acute lung transplantation injury
    Benjamin D Kozower
    Division of Cardiothoracic Surgery, Washington University School of Medicine, St Louis, MO 63110, USA
    Nat Biotechnol 21:392-8. 2003
    ..Potential applications of this strategy include improving the outcome of clinical lung transplantation and treating a wide variety of endothelial disorders...

Research Grants4

  1. Use of Curcumin and Flaxsseed in Radiation Pneumonopathy
    Melpo Christofidou Solomidou; Fiscal Year: 2007
    ....
  2. Secoisolariciresinol Diglucoside (SDB) Protection in Radiation Pheumonopathy
    Melpo Christofidou Solomidou; Fiscal Year: 2010
    ..Successful completion of the proposed studies will elucidate the mechanism and determine the usefulness of FS lignan-mediated radioprotection enabling future clinical trials in the context of lung cancer radiotherapy. ..