Shelly A Christman
Affiliation: University of Minnesota
- Contributions of differential p53 expression in the spontaneous immortalization of a chicken embryo fibroblast cell lineShelly A Christman
Department of Animal Science, University of Minnesota, St, Paul, MN 55108, USA
BMC Cell Biol 7:27. 2006..The present study was carried out to determine whether the p53 pathway played a role in the spontaneous immortalization of the SC-2 chicken embryo fibroblast (CEF) cell line that has been in continuous culture for over three years...
- Events in the immortalizing process of primary human mammary epithelial cells by the catalytic subunit of human telomeraseHyunggee Kim
Department of Animal Science, University of Minnesota, St Paul, MN 55108, U S A
Biochem J 365:765-72. 2002..Together, our results indicate that in vitro immortalization in HME cells may require the activation of the function of telomerase and other genetic alterations such as the spontaneous loss of p16(INK4a) expression...
- Expression profiles of p53-, p16(INK4a)-, and telomere-regulating genes in replicative senescent primary human, mouse, and chicken fibroblast cellsHyunggee Kim
Department of Animal Science, University of Minnesota, St Paul, Minnesota 55108, USA
Exp Cell Res 272:199-208. 2002..Taken together, the present study demonstrates that the p53, p16(INK4a), and telomere regulatory functions may be differentially regulated during replicative senescence in human, mouse, and chicken fibroblast cells...
- Modulation of p53 expression and its role in the conversion to a fully immortalized chicken embryo fibroblast lineShelly A Christman
Department of Animal Science, University of Minnesota, 495 AnSci VetMed, 1988 Fitch Ave, St Paul, MN 55108, USA
FEBS Lett 579:6705-15. 2005....