Jason D Christie

Summary

Affiliation: University of Pennsylvania
Country: USA

Publications

  1. ncbi Minute ventilation recovery time measured using a new, simplified methodology predicts extubation outcome
    Christopher W Seymour
    Department of Medicine, Hospital of the Universeity of Pennsylvania, Philadelphia 19104, USA
    J Intensive Care Med 23:52-60. 2008
  2. ncbi Soluble p-selectin and the risk of primary graft dysfunction after lung transplantation
    Steven M Kawut
    Department of Medicine, Cardiovascular Institute, Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Chest 136:237-44. 2009
  3. ncbi A simple clinical predictive index for objective estimates of mortality in acute lung injury
    Colin R Cooke
    Division of Pulmonary and Critical Care Medicine, University of Washington, Seattle, WA, USA
    Crit Care Med 37:1913-20. 2009
  4. ncbi Construct validity of the definition of primary graft dysfunction after lung transplantation
    Jason D Christie
    Division of Pulmonary, Allergy, and Critical Care Medicine, University of Pennsylvania School of Medicine, 423 Guardian Drive, Philadelphia, PA 19104, USA
    J Heart Lung Transplant 29:1231-9. 2010
  5. ncbi Plasma levels of receptor for advanced glycation end products, blood transfusion, and risk of primary graft dysfunction
    Jason D Christie
    Pulmonary, Allergy, and Critical Care Division, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Am J Respir Crit Care Med 180:1010-5. 2009
  6. ncbi Variation in PTX3 is associated with primary graft dysfunction after lung transplantation
    Joshua M Diamond
    Pulmonary, Allergy, and Critical Care Division, University of Pennsylvania School of Medicine, 3400 Spruce St, 8 West Gates, Philadelphia, PA 19104, USA
    Am J Respir Crit Care Med 186:546-52. 2012
  7. ncbi Novel variants in the PRDX6 Gene and the risk of Acute Lung Injury following major trauma
    Melanie Rushefski
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of Pennsylvania School of Medicine, 3600 Spruce Street, Philadelphia, USA
    BMC Med Genet 12:77. 2011
  8. ncbi Serum lactate is associated with mortality in severe sepsis independent of organ failure and shock
    Mark E Mikkelsen
    Pulmonary, Allergy, and Critical Care Division, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    Crit Care Med 37:1670-7. 2009
  9. ncbi The adult respiratory distress syndrome cognitive outcomes study: long-term neuropsychological function in survivors of acute lung injury
    Mark E Mikkelsen
    Pulmonary, Allergy, and Critical Care Division, Perelman School of Medicine, University of Pennsylvania, 836 W Gates Pavilion, 3400 Spruce Street, Philadelphia, PA 19104, USA
    Am J Respir Crit Care Med 185:1307-15. 2012
  10. ncbi Can we predict daily adherence to warfarin?: Results from the International Normalized Ratio Adherence and Genetics (IN-RANGE) Study
    Alec B Platt
    MSCE, University of Pennsylvania School of Medicine, 707 Blockley Hall, 423 Guardian Dr, Philadelphia, PA 19104 6021, USA
    Chest 137:883-9. 2010

Research Grants

  1. Genetics of primary graft dysfunction
    Jason Christie; Fiscal Year: 2009
  2. Clinical Risk Factors for Primary Graft Dysfunction
    Jason Christie; Fiscal Year: 2009
  3. Genetics of primary graft dysfunction
    Jason D Christie; Fiscal Year: 2010
  4. Role of anti-Col (V) immunity in primary graft dysfunction
    David S Wilkes; Fiscal Year: 2010
  5. Clinical Risk Factors for Primary Graft Dysfunction
    Jason D Christie; Fiscal Year: 2010

Collaborators

Detail Information

Publications81

  1. ncbi Minute ventilation recovery time measured using a new, simplified methodology predicts extubation outcome
    Christopher W Seymour
    Department of Medicine, Hospital of the Universeity of Pennsylvania, Philadelphia 19104, USA
    J Intensive Care Med 23:52-60. 2008
    ..45-16.2, P < .02). C statistic was 0.79 +/- 0.17. It was concluded that minute ventilation recovery time, measured using a feasible methodology, can predict extubation outcome in medical and surgical intensive care unit patients...
  2. ncbi Soluble p-selectin and the risk of primary graft dysfunction after lung transplantation
    Steven M Kawut
    Department of Medicine, Cardiovascular Institute, Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Chest 136:237-44. 2009
    ..We hypothesized that higher plasma P-selectin levels reflecting platelet activation would therefore be associated with primary graft dysfunction (PGD) after lung transplantation...
  3. ncbi A simple clinical predictive index for objective estimates of mortality in acute lung injury
    Colin R Cooke
    Division of Pulmonary and Critical Care Medicine, University of Washington, Seattle, WA, USA
    Crit Care Med 37:1913-20. 2009
    ..We sought to develop a simple point score that would accurately capture the risk of hospital death for patients with acute lung injury (ALI)...
  4. ncbi Construct validity of the definition of primary graft dysfunction after lung transplantation
    Jason D Christie
    Division of Pulmonary, Allergy, and Critical Care Medicine, University of Pennsylvania School of Medicine, 423 Guardian Drive, Philadelphia, PA 19104, USA
    J Heart Lung Transplant 29:1231-9. 2010
    ..This study tested the discriminant validity of International Society for Heart and Lung Transplantation (ISHLT) primary graft dysfunction (PGD) grades with lung injury biomarker profiles and survival...
  5. ncbi Plasma levels of receptor for advanced glycation end products, blood transfusion, and risk of primary graft dysfunction
    Jason D Christie
    Pulmonary, Allergy, and Critical Care Division, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Am J Respir Crit Care Med 180:1010-5. 2009
    ..We hypothesized that patients with primary graft dysfunction (PGD) after lung transplantation would have higher RAGE levels in plasma than patients without PGD...
  6. ncbi Variation in PTX3 is associated with primary graft dysfunction after lung transplantation
    Joshua M Diamond
    Pulmonary, Allergy, and Critical Care Division, University of Pennsylvania School of Medicine, 3400 Spruce St, 8 West Gates, Philadelphia, PA 19104, USA
    Am J Respir Crit Care Med 186:546-52. 2012
    ..Elevated long pentraxin-3 (PTX3) levels are associated with the development of primary graft dysfunction (PGD) after lung transplantation. Abnormalities in innate immunity, mediated by PTX3 release, may play a role in PGD pathogenesis...
  7. ncbi Novel variants in the PRDX6 Gene and the risk of Acute Lung Injury following major trauma
    Melanie Rushefski
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of Pennsylvania School of Medicine, 3600 Spruce Street, Philadelphia, USA
    BMC Med Genet 12:77. 2011
    ..Little is known about genetic variation within the PRDX6 gene and its association with acute lung injury (ALI). In this study we sequenced the PRDX6 gene to uncover common variants, and tested association with ALI following major trauma...
  8. ncbi Serum lactate is associated with mortality in severe sepsis independent of organ failure and shock
    Mark E Mikkelsen
    Pulmonary, Allergy, and Critical Care Division, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    Crit Care Med 37:1670-7. 2009
    ..e., refractory hypotension)...
  9. ncbi The adult respiratory distress syndrome cognitive outcomes study: long-term neuropsychological function in survivors of acute lung injury
    Mark E Mikkelsen
    Pulmonary, Allergy, and Critical Care Division, Perelman School of Medicine, University of Pennsylvania, 836 W Gates Pavilion, 3400 Spruce Street, Philadelphia, PA 19104, USA
    Am J Respir Crit Care Med 185:1307-15. 2012
    ..Cognitive and psychiatric morbidity is common and potentially modifiable after acute lung injury (ALI). However, practical measures of neuropsychological function for use in multicenter trials are lacking...
  10. ncbi Can we predict daily adherence to warfarin?: Results from the International Normalized Ratio Adherence and Genetics (IN-RANGE) Study
    Alec B Platt
    MSCE, University of Pennsylvania School of Medicine, 707 Blockley Hall, 423 Guardian Dr, Philadelphia, PA 19104 6021, USA
    Chest 137:883-9. 2010
    ..Currently, no comprehensive screening tool exists to help providers assess the risk of nonadherence at the time of initiation of warfarin therapy...
  11. ncbi Impact of pulmonary artery pressure on exercise function in severe COPD
    Michael W Sims
    Department of Pulmonary, Allergy, and Critical Care, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Chest 136:412-9. 2009
    ..Although pulmonary hypertension commonly complicates COPD, the functional consequences of increased pulmonary artery pressures in patients with this condition remain poorly defined...
  12. ncbi SNP-set analysis replicates acute lung injury genetic risk factors
    Nuala J Meyer
    Department of Medicine Pulmonary, Allergy, and Critical Care Division, Perelman School of Medicine University of Pennsylvania, 3600 Spruce Street, 874 Maloney, Philadelphia, PA 19104, USA
    BMC Med Genet 13:52. 2012
    ..We used a gene - based replication strategy to test the reproducibility of prior acute lung injury (ALI) candidate gene associations...
  13. ncbi Lung transplant outcomes in white and African American recipients: special focus on acute and chronic rejection
    Rajiv Lingaraju
    Division of Pulmonary Critical Care, Department of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Heart Lung Transplant 28:8-13. 2009
    ....
  14. ncbi Factors associated with nonadherence to early goal-directed therapy in the ED
    Mark E Mikkelsen
    Pulmonary, Allergy, and Critical Care Division, University of Pennsylvania, Philadelphia, PA 19104, USA
    Chest 138:551-8. 2010
    ..EGDT appears to be underused, even in centers with formalized protocols. The aim of our study was to identify factors associated with not initiating EGDT in the ED...
  15. ncbi Variation in the myosin light chain kinase gene is associated with development of acute lung injury after major trauma
    Jason D Christie
    Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    Crit Care Med 36:2794-800. 2008
    ..We tested the association of MYLK gene variation in the development of acute lung injury in major trauma patients...
  16. ncbi Obesity and primary graft dysfunction after lung transplantation: the Lung Transplant Outcomes Group Obesity Study
    David J Lederer
    Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA
    Am J Respir Crit Care Med 184:1055-61. 2011
    ..Obesity has been linked to acute lung injury and is a risk factor for early mortality after lung transplantation...
  17. ncbi Risk factors for early primary graft dysfunction after lung transplantation: a registry study
    Catherine L Kuntz
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Clin Transplant 23:819-30. 2009
    ..We sought to identify risk factors for PGD using the United Network for Organ Sharing/International Society for Heart and Lung Transplant (UNOS/ISHLT) Registry...
  18. ncbi Adherence to warfarin assessed by electronic pill caps, clinician assessment, and patient reports: results from the IN-RANGE study
    Catherine S Parker
    Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, 717 Blockley Hall, 423 Guardian Drive, Philadelphia, PA 19104 6021, USA
    J Gen Intern Med 22:1254-9. 2007
    ..Patient adherence to warfarin may influence anticoagulation control; yet, adherence among warfarin users has not been rigorously studied...
  19. ncbi African American race, obesity, and blood product transfusion are risk factors for acute kidney injury in critically ill trauma patients
    Michael G S Shashaty
    Division of Pulmonary, Allergy, and Critical Care, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    J Crit Care 27:496-504. 2012
    ..Acute kidney injury (AKI) is a common source of morbidity after trauma. We sought to determine novel risk factors for AKI, by Acute Kidney Injury Network (AKIN) criteria, in critically ill trauma patients...
  20. ncbi Risk factors for nonadherence to warfarin: results from the IN-RANGE study
    Alec B Platt
    Department of Medicine, University of Pennsylvania School of Medicine, PA, USA
    Pharmacoepidemiol Drug Saf 17:853-60. 2008
    ..Warfarin is widely used to prevent stroke and venous thromboembolism despite its narrow therapeutic window. Warfarin nonadherence is a substantial problem, but risk factors have not been well elucidated...
  21. ncbi Serum cytokine profiles associated with early allograft dysfunction in patients undergoing liver transplantation
    Benjamin H Friedman
    Penn Transplant Institute, Department of Surgery, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Liver Transpl 18:166-76. 2012
    ..Furthermore, if validated, our findings may contribute to perioperative prediction of the occurrence of EAD and ultimately lead to identification of potential interventional therapies...
  22. ncbi Lower serum endocan levels are associated with the development of acute lung injury after major trauma
    Mark E Mikkelsen
    Pulmonary, Allergy, and Critical Care Division, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    J Crit Care 27:522.e11-7. 2012
    ..We tested the association of serum endocan levels with subsequent development of ALI after major trauma...
  23. ncbi Association of protein C and type 1 plasminogen activator inhibitor with primary graft dysfunction
    Jason D Christie
    Division of Pulmonary, Allergy, and Critical Care Medicine, Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Am J Respir Crit Care Med 175:69-74. 2007
    ..Design: Prospective, multicenter cohort study...
  24. ncbi An alternative method of acute lung injury classification for use in observational studies
    Chirag V Shah
    Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, University of Pennsylvania School of Medicine, Blockley Hall, 423 Guardian Dr, Philadelphia, PA, USA
    Chest 138:1054-61. 2010
    ..We assessed the impact of excluding patients with difficult-to-classify or equivocal ALI diagnosis on clinical and genetic risk factor associations for ALI after trauma...
  25. ncbi Plasma monocyte chemotactic protein-1 levels at 24 hours are a biomarker of primary graft dysfunction after lung transplantation
    Rupal J Shah
    Pulmonary, Allergy, and Critical Care Division, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Transl Res 160:435-42. 2012
    ..Persistent elevations in MCP-1 levels at 24 hours are a biomarker of grade 3 PGD post-transplantation. Monocyte chemotaxis may play a role in the pathogenesis of PGD...
  26. ncbi The association of early transfusion with acute lung injury in patients with severe injury
    Daniel N Holena
    Division of Traumatology, University of Pennsylvania, Philadelphia, Pennsylvania, USA
    J Trauma Acute Care Surg 73:825-31. 2012
    ..We hypothesized that the relationship between PRBC delivery and ALI risk varies through time after injury...
  27. ncbi Central airways obstruction due to Aspergillus fumigatus after lung transplantation
    Elizabeth Cerceo
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    J Heart Lung Transplant 28:515-9. 2009
    ..All 3 patients presented with atypical features of Aspergillus infection, but all responded to treatments with either steroids, anti-fungals or both...
  28. ncbi Factors associated with the use of corticosteroids in the initial management of idiopathic pulmonary fibrosis
    Jeffrey C Munson
    Division of Pulmonary, Allergy and Critical Care Medicine, Hospital of the University of Pennsylvania, Philadelphia, PA, USA
    Pharmacoepidemiol Drug Saf 19:756-62. 2010
    ..The factors that are associated with the decision to prescribe corticosteroids have not been examined...
  29. ncbi Elevated pulmonary artery pressure is a risk factor for primary graft dysfunction following lung transplantation for idiopathic pulmonary fibrosis
    Adam Fang
    Division of Pulmonary, Allergy and Critical Care Medicine, Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Chest 139:782-7. 2011
    ..The purpose of this study was to evaluate the relationship between mean pulmonary artery pressure (mPAP) and PGD among patients with IPF...
  30. ncbi Clinical risk factors for primary graft dysfunction after lung transplantation
    Joshua M Diamond
    Pulmonary, Allergy and Critical Care Division, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA
    Am J Respir Crit Care Med 187:527-34. 2013
    ..Clinical trial registered with www.clinicaltrials.gov (NCT 00552357)...
  31. ncbi Elevated plasma angiopoietin-2 levels and primary graft dysfunction after lung transplantation
    Joshua M Diamond
    Pulmonary, Allergy, and Critical Care Division, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA
    PLoS ONE 7:e51932. 2012
    ..Angiopoietin-2 serves as a partial antagonist to the Tie-2 receptor and induces increased endothelial permeability. We hypothesized that elevated Ang2 levels would be associated with development of PGD...
  32. ncbi Post-transplant lymphoproliferative disorder after lung transplantation: a review of 35 cases
    Brandon E Kremer
    Abramson Cancer Center, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    J Heart Lung Transplant 31:296-304. 2012
    ..Post-transplant lymphoproliferative disorder (PTLD) is a complication of organ transplantation. The risk of developing PTLD varies depending on a number of factors, including the organ transplanted and the degree of immunosuppression used...
  33. ncbi Uncharted paths: hospital networks in critical care
    Theodore J Iwashyna
    Division of Pulmonary and Critical Care, Department of Medicine, University of Michigan, Ann Arbor, MI 48109, USA
    Chest 135:827-33. 2009
    ....
  34. ncbi Association of RBC transfusion with mortality in patients with acute lung injury
    Giora Netzer
    Division of Pulmonary and Critical Care Medicine, University of Maryland School of Medicine, MSTF Bldg, Room 800, 685 W Baltimore St, Baltimore, MD 21201, USA
    Chest 132:1116-23. 2007
    ..RBC transfusion has been associated with increased morbidity and mortality in a variety of clinical settings. We assessed the effect of RBC transfusion on in-hospital mortality in patients with acute lung injury (ALI)...
  35. ncbi Primary graft dysfunction
    James C Lee
    Division of Pulmonary, Allergy, and Critical Care Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Proc Am Thorac Soc 6:39-46. 2009
    ..Finally, we will summarize efforts at finding genetic and molecular markers for PGD and discuss future directions for PGD research...
  36. ncbi Effect of single vs bilateral lung transplantation on plasma surfactant protein D levels in idiopathic pulmonary fibrosis
    Michael W Sims
    Division of Pulmonary, Allergy, and Critical Care Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    Chest 140:489-96. 2011
    ..However, little is known about SP-D levels in the setting of lung transplantation...
  37. ncbi Clinical protocols and trainee knowledge about mechanical ventilation
    Meeta Prasad
    Department of Medicine, University of Pennsylvania School of Medicine, 3600 Spruce St, Eighth Floor, West Gates Bldg, Philadelphia, PA 19104, USA
    JAMA 306:935-41. 2011
    ..Clinical protocols are associated with improved patient outcomes; however, they may negatively affect medical education by removing trainees from clinical decision making...
  38. ncbi The effect of primary graft dysfunction on survival after lung transplantation
    Jason D Christie
    Division of Pulmonary, Allergy, and Critical Care Medicine, Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, 423 Guardian Drive, 719 Blockley Hall, Philadelphia, PA 19104, USA
    Am J Respir Crit Care Med 171:1312-6. 2005
    ..Primary graft dysfunction is a severe acute lung injury syndrome after lung transplantation. Long-term outcomes of subjects with primary graft dysfunction have not been studied...
  39. ncbi Critical illness outcomes in specialty versus general intensive care units
    Jason P Lott
    University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Am J Respir Crit Care Med 179:676-83. 2009
    ..General intensive care units (ICUs) provide care across a wide range of diagnoses, whereas specialty ICUs provide diagnosis-specific care. Risk-adjusted outcome differences across such units are unknown...
  40. ncbi ANGPT2 genetic variant is associated with trauma-associated acute lung injury and altered plasma angiopoietin-2 isoform ratio
    Nuala J Meyer
    Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Am J Respir Crit Care Med 183:1344-53. 2011
    ..Acute lung injury (ALI) acts as a complex genetic trait, yet its genetic risk factors remain incompletely understood. Large-scale genotyping has not previously been reported for ALI...
  41. ncbi The structure of critical care transfer networks
    Theodore J Iwashyna
    Division of Pulmonary and Critical Care, Department of Medicine, University of Michigan, Ann Arbor, MI 48109, USA
    Med Care 47:787-93. 2009
    ..These transfers may be particularly important in critical care, where small relative improvements can yield substantial absolute changes in survival...
  42. ncbi Evaluation of a new method for measurement of minute ventilation recovery time
    Christopher W Seymour
    Department of Medicine, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania 19104-4283, USA
    Respir Care 51:133-9. 2006
    ..These methodological modifications may increase the feasibility of measuring V (E)RT, while reproducing the results obtained by the original method...
  43. ncbi Cognitive, mood and quality of life impairments in a select population of ARDS survivors
    Mark E Mikkelsen
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Respirology 14:76-82. 2009
    ..This study investigated associations between cognitive impairment, mood disorders and quality of life in a select group of ARDS survivors...
  44. ncbi A panel of lung injury biomarkers enhances the definition of primary graft dysfunction (PGD) after lung transplantation
    Rupal J Shah
    Pulmonary, Allergy, and Critical Care Division, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    J Heart Lung Transplant 31:942-9. 2012
    ..We aimed to identify combinations of biomarkers to enhance the definition of primary graft dysfunction (PGD) for translational research...
  45. ncbi The impact of development of acute lung injury on hospital mortality in critically ill trauma patients
    Chirag V Shah
    Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, Hospital of the University of Pennsylvania, Philadelphia, PA, USA
    Crit Care Med 36:2309-15. 2008
    ..We assessed the contribution of acute lung injury to in-hospital mortality in critically ill trauma patients...
  46. ncbi Genome wide association identifies PPFIA1 as a candidate gene for acute lung injury risk following major trauma
    Jason D Christie
    Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America
    PLoS ONE 7:e28268. 2012
    ..This study supports the feasibility of future multi-center GWA investigations of ALI risk, and identifies PPFIA1 as a potential functional candidate ALI risk gene for future research...
  47. ncbi Impact of primary graft failure on outcomes following lung transplantation
    Jason D Christie
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Chest 127:161-5. 2005
    ..Primary graft failure (PGF) is a severe acute lung injury syndrome that occurs following lung transplantation. We compared the clinical outcomes of patients who developed PGF with those who did not...
  48. ncbi Multiple variables affecting blood usage in lung transplantation
    Yongping Wang
    Department of Pathology and Laboratory Medicine, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Heart Lung Transplant 25:533-8. 2006
    ..Additional selected variables differentially predicted usage. These data will help transplant surgeons and transfusion medicine specialists better anticipate and prepare blood products for use in lung transplantation...
  49. ncbi Report of the ISHLT Working Group on Primary Lung Graft Dysfunction part I: introduction and methods
    Jason D Christie
    Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania, Philadelphia, Pennsylvania, USA
    J Heart Lung Transplant 24:1451-3. 2005
  50. ncbi Outcomes using extracorporeal life support for adult respiratory failure due to status asthmaticus
    Mark E Mikkelsen
    Pulmonary, Allergy, and Critical Care Division, Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    ASAIO J 55:47-52. 2009
    ....
  51. ncbi Report of the ISHLT Working Group on Primary Lung Graft Dysfunction part II: definition. A consensus statement of the International Society for Heart and Lung Transplantation
    Jason D Christie
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania, Philadelphia, Pennsylvania, USA
    J Heart Lung Transplant 24:1454-9. 2005
  52. ncbi Validation study of an automated electronic acute lung injury screening tool
    Helen C Azzam
    University of Pennsylvania Medical Center Pulmonary Allergy and Critical Care Division, Philadelphia, PA, USA
    J Am Med Inform Assoc 16:503-8. 2009
    ..CONCLUSIONS An automated electronic system that screens intubated ICU trauma patients, excluding patients with CHF, for ALI based on CXR reports and results of ABGs is sufficiently accurate to identify many early cases of ALI...
  53. ncbi Inflammasome-regulated cytokines are critical mediators of acute lung injury
    Tamas Dolinay
    Division of Pulmonary and Critical Care Medicine, Brigham and Women s Hospital, Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA
    Am J Respir Crit Care Med 185:1225-34. 2012
    ..The inflammasome/caspase-1 pathway regulates the maturation and secretion of proinflammatory cytokines (e.g., IL-18). IL-18 is associated with injury in animal models of systemic inflammation...
  54. ncbi Effect of work-hours regulations on intensive care unit mortality in United States teaching hospitals
    Meeta Prasad
    Division of Pulmonary, Allergy, and Critical Care Medicine MP, JDC, JMK, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    Crit Care Med 37:2564-9. 2009
    ..The United States instituted restrictions on resident work-hours in July 2003. The clinical impact of this reform on critically ill patients is unknown...
  55. ncbi Association of human NAD(P)H:quinone oxidoreductase 1 (NQO1) polymorphism with development of acute lung injury
    Anita J Reddy
    Duke University Medical Center, Department of Medicine, Division of Pulmonary, Allergy and Critical Care Medicine, Durham, NC, USA
    J Cell Mol Med 13:1784-91. 2009
    ..These novel findings may have important implications in diseases with oxidant stress aetiologies...
  56. ncbi Primary graft dysfunction: definition, risk factors, short- and long-term outcomes
    James C Lee
    Division of Pulmonary, Allergy, and Critical Care Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Semin Respir Crit Care Med 31:161-71. 2010
    ..Studies examining the short- and long-term effects of PGD on lung transplant outcomes are reviewed. Lastly, we highlight the emerging concepts in lung transplantation that will potentially impact PGD incidence and outcomes...
  57. ncbi The contribution of airway and lung tissue ischemia to primary graft dysfunction
    Joshua M Diamond
    Pulmonary, Allergy, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Curr Opin Organ Transplant 15:552-7. 2010
    ..This article reviews the significant role of allograft ischemia in the phenotypic presentation of PGD and the evidence for activation and disruption of normal cellular pathways for the development and long-term sequelae...
  58. ncbi Variants of DENND1B associated with asthma in children
    Patrick M A Sleiman
    Center for Applied Genomics, Philadelphia, PA 19104 4318, USA
    N Engl J Med 362:36-44. 2010
    ..Asthma is a complex disease that has genetic and environmental causes. The genetic factors associated with susceptibility to asthma remain largely unknown...
  59. ncbi The availability of clinical protocols in US teaching intensive care units
    Meeta Prasad
    Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    J Crit Care 25:610-9. 2010
    ..Clinical protocols to standardize care may improve patient outcomes but worsen trainee education. Our objective was to determine the availability of clinical protocols in teaching medical intensive care units (ICUs)...
  60. ncbi Measurement of a baseline minute ventilation for the calculation of minute ventilation recovery time: is a subjective method reliable?
    Christopher W Seymour
    Department of Medicine, Hospital of the University of Pennsylvania, Philadelphia, PA 19104 4283, USA
    Respir Care 50:468-72. 2005
    ..The purpose of the current study is to evaluate the inter-rater reliability of this subjective method for determining baseline V(E)...
  61. ncbi Adherence to sleep apnea therapy and use of lipid-lowering drugs: a study of the healthy-user effect
    Alec B Platt
    Center for Health Equity Research and Promotion, Philadelphia Veterans Affairs Medical Center, Philadelphia, PA, USA
    Chest 137:102-8. 2010
    ..This association may be confounded if CPAP adherents are healthier in ways not measured by investigators. We assessed whether patients adhering to lipid-lowering medications were more adherent to CPAP...
  62. ncbi Renal and vestibular toxicity due to inhaled tobramycin in a lung transplant recipient
    Vivek N Ahya
    Pulmonary, Allergy, and Critical Care Division, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    J Heart Lung Transplant 24:932-5. 2005
    ..We review the literature regarding the safety of inhaled tobramycin and discuss potential mechanisms that may promote systemic toxicity in transplant recipients...
  63. ncbi Clinical risk factors for primary graft failure following lung transplantation
    Jason D Christie
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of Pennsylvania School of Medicine, Philadelhia, 19104, USA
    Chest 124:1232-41. 2003
    ..s: Primary graft failure (PGF) is a devastating acute lung injury syndrome following lung transplantation. We sought to identify donor, recipient, and operative risk factors for its development...
  64. ncbi Update in transplantation 2007
    Paul A Corris
    University of Pennsylvania, Pulmonary and Critical Care Medicine, Center for Clinical Epidemiology and Biostatistics, 719 Blockley Hall, 423 Guardian Drive, Philadelphia, PA 19104, USA
    Am J Respir Crit Care Med 177:1062-7. 2008
  65. ncbi Donor transmission of malignant melanoma in a lung transplant recipient 32 years after curative resection
    Navkaranbir S Bajaj
    University of Alabama, Ryals School of Public Health, Birmingham, AL, USA
    Transpl Int 23:e26-31. 2010
    ....
  66. ncbi Formation and validation of a telephone battery to assess cognitive function in acute respiratory distress syndrome survivors
    Jason D Christie
    Division of Pulmonary, Allergy and Critical Care Medicine, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    J Crit Care 21:125-32. 2006
    ..Describe initial development and validation of a test battery composed of established instruments designed to detect, via telephone interview, cognitive abnormalities in survivors of acute respiratory distress syndrome...
  67. ncbi Genetic epidemiology of acute lung injury: choosing the right candidate genes is the first step
    Jason D Christie
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    Crit Care 8:411-3. 2004
    ..The application of these findings to future human studies of the genetic influence on ALI risks and outcomes is discussed here...
  68. ncbi Primary graft dysfunction
    James C Lee
    Division of Pulmonary, Allergy and Critical Care Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Clin Chest Med 32:279-93. 2011
    ..This article aims to provide a state-of-the-art review of PGD epidemiology, outcomes, and risk factors, and to summarize current efforts at biomarker development and novel strategies for prevention and treatment...
  69. ncbi Effect of treatment guidelines on the initial management of idiopathic pulmonary fibrosis
    Jeffrey C Munson
    Division of Pulmonary, Allergy and Critical Care Medicine, Hospital of the University of Pennsylvania, Philadelphia, PA, USA
    Br J Clin Pharmacol 70:118-25. 2010
    ..It is not known how the use of corticosteroids and cytotoxic agents in the treatment of IPF has changed over time and whether published guidelines have altered prescribing practices...
  70. ncbi Validation of a current definition of early allograft dysfunction in liver transplant recipients and analysis of risk factors
    Kim M Olthoff
    Department of Surgery, University of Pennsylvania, Philadelphia, PA 19104, USA
    Liver Transpl 16:943-9. 2010
    ..This definition can be used as an endpoint in translational studies aiming to identify mechanistic pathways leading to a subgroup of liver grafts with clinical expression of suboptimal function...
  71. ncbi The outcome of extubation failure in a community hospital intensive care unit: a cohort study
    Christopher W Seymour
    Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania, USA
    Crit Care 8:R322-7. 2004
    ..Given the large proportion of critical care delivered in the community setting, our purpose was to determine the impact of extubation failure on patient outcomes in a community hospital ICU...
  72. ncbi Change in forced expiratory time and spirometric performance during a single pulmonary function testing session
    Adam G Tsai
    Division of General Internal Medicine, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania, USA
    Respir Care 51:246-51. 2006
    ..Longer FET is associated with better spirometric performance. Bronchodilator administration is associated with modest prolongation of FET, but change in FET did not help identify bronchodilator responders...
  73. ncbi Racial differences pertaining to a belief about lung cancer surgery: results of a multicenter survey
    Mitchell L Margolis
    University of Pennsylvania and Philadelphia Veterans Affairs Medical Center, Philadelphia, Pennsylvania 19104, USA
    Ann Intern Med 139:558-63. 2003
    ....
  74. ncbi Relationship of environmental exposures to the clinical phenotype of sarcoidosis
    Mary Elizabeth Kreider
    Division of Pulmonary and Critical Care, University of Pennsylvania School of Medicine, 826 Gates Building, 3400 Spruce St, Philadelphia, PA 19104, USA
    Chest 128:207-15. 2005
    ..We examined the relationship between environmental and occupational exposures, and the clinical phenotype of sarcoidosis...
  75. ncbi The influence of patient adherence on anticoagulation control with warfarin: results from the International Normalized Ratio Adherence and Genetics (IN-RANGE) Study
    Stephen E Kimmel
    Department of Medicine, Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, 423 Guardian Drive, Philadelphia, PA 19104, USA
    Arch Intern Med 167:229-35. 2007
    ..Warfarin sodium is a highly efficacious drug, but proper levels of anticoagulation are difficult to maintain. Conflicting data exist on the influence of patient adherence on anticoagulation control...
  76. ncbi Anti-type V collagen humoral immunity in lung transplant primary graft dysfunction
    Takekazu Iwata
    Department of Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    J Immunol 181:5738-47. 2008
    ..This study demonstrates a major role for anti-col(V) humoral immunity in PGD, and identifies the airway epithelium as a target in PGD...
  77. ncbi Low use of durable medical equipment by chronically disabled elderly
    Theodore J Iwashyna
    Department of Medicine, Leonard Davis Institute, and Center for Clinical Epidemiology and Biostatistics, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania 19130, USA
    J Pain Symptom Manage 33:324-30. 2007
    ..Fewer than half the chronically disabled, and less than one-quarter of the newly disabled, received any DME from Medicare. These data suggest underuse of the benefit by the disabled elderly...
  78. ncbi Microarrays
    Jason D Christie
    Division of Pulmonary, Allergy and Critical Care Medicine, Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    Crit Care Med 33:S449-52. 2005
  79. ncbi Echocardiographic assessment of pulmonary hypertension in patients with advanced lung disease
    Selim M Arcasoy
    Division of Pulmonary, Allergy and Critical Care, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA
    Am J Respir Crit Care Med 167:735-40. 2003
    ....
  80. ncbi Recombinant plasma gelsolin diminishes the acute inflammatory response to hyperoxia in mice
    Melpo Christofidou-Solomidou
    Division of Pulmonary Medicine, Department of Medicine, University of Pennsylvania Medical School, Philadelphia, USA
    J Investig Med 50:54-60. 2002
    ..03). CONCLUSIONS: These data imply that i) gelsolin depletion contributes to the pathogenesis of oxygen toxicity and ii) repletion of gelsolin can partially abrogate the resultant exudative response...
  81. ncbi Registry of the International Society for Heart and Lung Transplantation: twenty-fourth official adult lung and heart-lung transplantation report-2007
    Elbert P Trulock
    Division of Pulmonary and Critical Care Medicine, Washington University School of Medicine, St. Louis, Missouri 63110, USA
    J Heart Lung Transplant 26:782-95. 2007

Research Grants7

  1. Genetics of primary graft dysfunction
    Jason Christie; Fiscal Year: 2009
    ....
  2. Clinical Risk Factors for Primary Graft Dysfunction
    Jason Christie; Fiscal Year: 2009
    ....
  3. Genetics of primary graft dysfunction
    Jason D Christie; Fiscal Year: 2010
    ....
  4. Role of anti-Col (V) immunity in primary graft dysfunction
    David S Wilkes; Fiscal Year: 2010
    ....
  5. Clinical Risk Factors for Primary Graft Dysfunction
    Jason D Christie; Fiscal Year: 2010
    ....