B T Christian

Summary

Affiliation: University of Wisconsin
Country: USA

Publications

  1. pmc Serotonin transporter genotype affects serotonin 5-HT1A binding in primates
    Bradley T Christian
    Department of Medical Physics, University of Wisconsin Madison, Madison, Wisconsin 53705, USA
    J Neurosci 33:2512-6. 2013
  2. pmc Dynamic PET denoising with HYPR processing
    Bradley T Christian
    Department of Medical Physics, University of Wisconsin Madison, Madison, Wisconsin 53705, USA
    J Nucl Med 51:1147-54. 2010
  3. pmc Serotonin transporter binding and genotype in the nonhuman primate brain using [C-11]DASB PET
    B T Christian
    Department of Psychiatry, Harlow Primate Center, University of Wisconsin Madison, USA
    Neuroimage 47:1230-6. 2009
  4. pmc The distribution of D2/D3 receptor binding in the adolescent rhesus monkey using small animal PET imaging
    Bradley T Christian
    Department of Psychiatry, University of Wisconsin Madison, USA Department of Medical Physics, University of Wisconsin Madison, USA
    Neuroimage 44:1334-44. 2009
  5. ncbi request reprint Measuring dopamine neuromodulation in the thalamus: using [F-18]fallypride PET to study dopamine release during a spatial attention task
    Bradley T Christian
    Boonshoft Schizophrenia Center, Kettering Medical Center, Kettering, OH 45429, USA
    Neuroimage 31:139-52. 2006
  6. pmc Specific α4β2 nicotinic acetylcholine receptor binding of [F-18]nifene in the rhesus monkey
    A T Hillmer
    Department of Medical Physics, University of Wisconsin Madison, Madison, WI 53593, USA ahillmer wisc edu
    Synapse 65:1309-18. 2011
  7. ncbi request reprint In vitro and in vivo evaluation of the binding of the dopamine D2 receptor agonist (11)C-(R,S)-5-hydroxy-2-(di-n-propylamino)tetralin in rodents and nonhuman primate
    J Mukherjee
    Department of Internal Medicine Nuclear Medicine, Kettering Medical Center, Wright State University, Dayton, OH 45429, USA
    Synapse 37:64-70. 2000
  8. ncbi request reprint Quantitation of striatal and extrastriatal D-2 dopamine receptors using PET imaging of [(18)F]fallypride in nonhuman primates
    B T Christian
    Department of Internal Medicine Nuclear Medicine, Kettering Medical Center, Wright State University, Dayton, Ohio 45429, USA
    Synapse 38:71-9. 2000
  9. pmc An efficient synthesis of dopamine transporter tracer [¹⁸F]FECNT
    D Murali
    Department of Medical Physics, University of Wisconsin Madison, Madison, 1111 Highland Ave, 1005 WIMR, Madison, WI 53705, United States
    Appl Radiat Isot 72:128-32. 2013
  10. pmc In vivo kinetics of [F-18]MEFWAY: a comparison with [C-11]WAY100635 and [F-18]MPPF in the nonhuman primate
    D W Wooten
    Department of Medical Physics, Harlow Primate Center, Waisman Laboratory for Brain Imaging and Behavior, University of Wisconsin Madison, Madison, Wisconsin 53593, USA
    Synapse 65:592-600. 2011

Collaborators

Detail Information

Publications31

  1. pmc Serotonin transporter genotype affects serotonin 5-HT1A binding in primates
    Bradley T Christian
    Department of Medical Physics, University of Wisconsin Madison, Madison, Wisconsin 53705, USA
    J Neurosci 33:2512-6. 2013
    ....
  2. pmc Dynamic PET denoising with HYPR processing
    Bradley T Christian
    Department of Medical Physics, University of Wisconsin Madison, Madison, Wisconsin 53705, USA
    J Nucl Med 51:1147-54. 2010
    ....
  3. pmc Serotonin transporter binding and genotype in the nonhuman primate brain using [C-11]DASB PET
    B T Christian
    Department of Psychiatry, Harlow Primate Center, University of Wisconsin Madison, USA
    Neuroimage 47:1230-6. 2009
    ..Using the rhesus monkey, we examined the extent to which serotonin transporter genotype is associated with 5-HT transporter binding in brain regions implicated in emotion-related pathology...
  4. pmc The distribution of D2/D3 receptor binding in the adolescent rhesus monkey using small animal PET imaging
    Bradley T Christian
    Department of Psychiatry, University of Wisconsin Madison, USA Department of Medical Physics, University of Wisconsin Madison, USA
    Neuroimage 44:1334-44. 2009
    ..To facilitate comparison within and between primate models, we report in vivo D2/D3 binding in a large cohort of adolescent rhesus monkeys...
  5. ncbi request reprint Measuring dopamine neuromodulation in the thalamus: using [F-18]fallypride PET to study dopamine release during a spatial attention task
    Bradley T Christian
    Boonshoft Schizophrenia Center, Kettering Medical Center, Kettering, OH 45429, USA
    Neuroimage 31:139-52. 2006
    ..Measurements of extrastriatal dopamine neuromodulation hold great promise to further our understanding of extrastriatal dopamine involvement in normal cognition and neuropsychiatric pathology...
  6. pmc Specific α4β2 nicotinic acetylcholine receptor binding of [F-18]nifene in the rhesus monkey
    A T Hillmer
    Department of Medical Physics, University of Wisconsin Madison, Madison, WI 53593, USA ahillmer wisc edu
    Synapse 65:1309-18. 2011
    ..This work assesses the in vivo binding and imaging characteristics of [F-18]nifene in rhesus monkeys for the development of PET experiments examining nAChR binding...
  7. ncbi request reprint In vitro and in vivo evaluation of the binding of the dopamine D2 receptor agonist (11)C-(R,S)-5-hydroxy-2-(di-n-propylamino)tetralin in rodents and nonhuman primate
    J Mukherjee
    Department of Internal Medicine Nuclear Medicine, Kettering Medical Center, Wright State University, Dayton, OH 45429, USA
    Synapse 37:64-70. 2000
    ..A PET study in a rhesus monkey showed selective localization of (11)C-5-OH-DPAT in the striata and the ratio between striata and cerebellum approached approximately 2 at 40 min postinjection...
  8. ncbi request reprint Quantitation of striatal and extrastriatal D-2 dopamine receptors using PET imaging of [(18)F]fallypride in nonhuman primates
    B T Christian
    Department of Internal Medicine Nuclear Medicine, Kettering Medical Center, Wright State University, Dayton, Ohio 45429, USA
    Synapse 38:71-9. 2000
    ..For the extrastriatal regions, the effect of the k(2) term on DVR calculation is negligible. Repeatability measurements for all regions were found to be within 10% using the DVR parameter...
  9. pmc An efficient synthesis of dopamine transporter tracer [¹⁸F]FECNT
    D Murali
    Department of Medical Physics, University of Wisconsin Madison, Madison, 1111 Highland Ave, 1005 WIMR, Madison, WI 53705, United States
    Appl Radiat Isot 72:128-32. 2013
    ..The overall radiochemical yields of [(18)F]FECNT were 40% (n=29) and the total synthesis time was ca. 100 min. The average specific activity of [(18)F]FECNT was 377.4 GBq/μmol (10.2 Ci/μmol)...
  10. pmc In vivo kinetics of [F-18]MEFWAY: a comparison with [C-11]WAY100635 and [F-18]MPPF in the nonhuman primate
    D W Wooten
    Department of Medical Physics, Harlow Primate Center, Waisman Laboratory for Brain Imaging and Behavior, University of Wisconsin Madison, Madison, Wisconsin 53593, USA
    Synapse 65:592-600. 2011
    ..The goal of this work was to compare the in vivo kinetics of [F-18]mefway, [F-18]MPPF, and [C-11]WAY100635 in the rhesus monkey...
  11. ncbi request reprint Evaluation of dopamine D-2 receptor occupancy by clozapine, risperidone, and haloperidol in vivo in the rodent and nonhuman primate brain using 18F-fallypride
    J Mukherjee
    Department of Internal Medicine Nuclear Medicine, Kettering Medical Center, Wright State University, Dayton, OH, USA
    Neuropsychopharmacology 25:476-88. 2001
    ..The following extent of D-2 receptor occupancies were measured in the monkey brain using PET: clozapine approximately 70% (dose of 9.7 mg/kg), risperidone approximately 75% (0.05 mg/kg), and haloperidol approximately 90% (0.05 mg/kg)...
  12. pmc High-affinity dopamine D2/D3 PET radioligands 18F-fallypride and 11C-FLB457: a comparison of kinetics in extrastriatal regions using a multiple-injection protocol
    Nicholas T Vandehey
    Department of Medical Physics, University of Wisconsin Madison, Madison, Wisconsin, USA
    J Cereb Blood Flow Metab 30:994-1007. 2010
    ..In the presence of specific D(2)/D(3) binding in the cerebellum, reference region analysis methods will give a greater bias in BP(ND) with (11)C-FLB457 than with (18)F-fallypride...
  13. ncbi request reprint Brain imaging of 18F-fallypride in normal volunteers: blood analysis, distribution, test-retest studies, and preliminary assessment of sensitivity to aging effects on dopamine D-2/D-3 receptors
    Jogeshwar Mukherjee
    Department of Nuclear Medicine PET, Kettering Medical Center, Dayton, Ohio 45429, USA
    Synapse 46:170-88. 2002
    ..PET studies with 18F-fallypride are thus suitable to study changes in D2/D3 receptors in striatal and extrastriatal brain regions...
  14. ncbi request reprint D2/D3 dopamine receptor binding with [F-18]fallypride in thalamus and cortex of patients with schizophrenia
    Monte S Buchsbaum
    Department of Psychiatry, Mt Sinai School of Medicine, New York, NY 10029, USA
    Schizophr Res 85:232-44. 2006
    ....
  15. pmc PET measurement of changes in D2/D3 dopamine receptor binding in a nonhuman primate during chronic deep brain stimulation of the bed nucleus of the stria terminalis
    Nicholas T Vandehey
    University of Wisconsin Madison, Department of Medical Physics, United States
    J Neurosci Methods 176:129-35. 2009
    ....
  16. pmc Fetal dopamine receptor characteristics assessed in utero
    Rachel M Bartlett
    Department of Medical Physics, School of Medicine and Public Health, University of Wisconsin Madison, Madison, Wisconsin 53705, USA
    J Cereb Blood Flow Metab 30:1437-40. 2010
    ..The agreement between fetal striatal DVRs using maternal arterial blood and maternal and fetal cerebellum as input functions strongly supports our hypothesis that the conditions necessary for graphical analysis have been met...
  17. ncbi request reprint Synthesis and biological evaluation of the binding of dopamine D2/D3 receptor agonist, (R,S)-5-hydroxy-2-(N-propyl-N-(5'-(18)F-fluoropentyl)aminotetralin ((18)F-5-OH-FPPAT) in rodents and nonhuman primates
    Bingzhi Shi
    Department of Internal Medicine Nuclear Medicine, Kettering Medical Center, Wright State University, Dayton, OH 45429, USA
    Nucl Med Biol 31:303-11. 2004
    ..A PET study in rhesus monkeys showed selective localization of (18)F-5-OH-FPPAT in the striata and the ratio between striata and cerebellum approached approximately 2 at 40 min post-injection...
  18. ncbi request reprint Measuring the in vivo binding parameters of [18F]-fallypride in monkeys using a PET multiple-injection protocol
    Bradley T Christian
    Department of PET Nuclear Medicine, Kettering Medical Center, Dayton, OH, USA
    J Cereb Blood Flow Metab 24:309-22. 2004
    ....
  19. ncbi request reprint Thalamic and prefrontal FDG uptake in never medicated patients with schizophrenia
    Douglas S Lehrer
    Wright State University Department of Psychiatry, c o The Wallace Kettering Neuroscience Institute, 3533 Southern Blvd, Suite 5200, Kettering, OH 45429, USA
    Am J Psychiatry 162:931-8. 2005
    ....
  20. pmc Reliability and precision of pseudo-continuous arterial spin labeling perfusion MRI on 3.0 T and comparison with 15O-water PET in elderly subjects at risk for Alzheimer's disease
    Guofan Xu
    GRECC, Madison VA Hospital, Madison, WI, USA
    NMR Biomed 23:286-93. 2010
    ..pcASL perfusion MRI offers an alternative method for non-invasive in vivo examination of early pathophysiological changes in AD...
  21. pmc Fetal dose estimates for (18)F-fluoro-L-thymidine using a pregnant monkey model
    Rachel M Bartlett
    Department of Medical Physics, School of Medicine and Public Health, University of Wisconsin Madison, Madison, Wisconsin 53705, USA
    J Nucl Med 51:288-92. 2010
    ..This study was undertaken to estimate-on the basis of biodistribution data obtained by PET/CT in pregnant rhesus monkeys-radiation absorbed dose to a human fetus administered (18)F-FLT...
  22. pmc Paraquat is excluded by the blood brain barrier in rhesus macaque: An in vivo pet study
    Rachel M Bartlett
    Department of Medical Physics, University of Wisconsin School of Medicine and Public Health, 1005 Wisconsin Institutes of Medical Research, 1111 Highland Avenue, Madison, WI 53705, USA
    Brain Res 1259:74-9. 2009
    ..This acute exposure study found that paraquat is excluded from the brain by the blood brain barrier and thus does not readily support the causative role of paraquat exposure in idiopathic Parkinson's disease...
  23. ncbi request reprint Sustainable production of orphan radionuclides at Wisconsin
    R J Nickles
    Medical Physics Department, University of Wisconsin, Madison, WI 53706, USA
    Q J Nucl Med Mol Imaging 52:134-9. 2008
    ..This review covers our recent advances to scale-up the production of the heavy halogens and transition metals as feed-stock for non-conventional PET tracers that are currently attracting increased attention in oncology...
  24. pmc Serotonin transporter availability in the amygdala and bed nucleus of the stria terminalis predicts anxious temperament and brain glucose metabolic activity
    Jonathan A Oler
    Departments of Psychiatry, HealthEmotions Research Institute, University of Wisconsin Madison, 53719, USA
    J Neurosci 29:9961-6. 2009
    ..Collectively, these findings suggest that serotonergic modulation of neuronal excitability in the neural circuitry associated with anxiety mediates the developmental risk for affect-related psychopathology...
  25. ncbi request reprint Binding characteristics of high-affinity dopamine D2/D3 receptor agonists, 11C-PPHT and 11C-ZYY-339 in rodents and imaging in non-human primates by PET
    Jogeshwar Mukherjee
    Brain Imaging Center, Department of Psychiatry and Human Behavior, University of California Irvine, Irvine, California 92697, USA
    Synapse 54:83-91. 2004
    ..These findings with 11C-PPHT and 11C-ZYY-339 indicate the possibility of in vivo imaging of high-affinity state of dopamine D2/D3 receptors in both the striata and the thalamus...
  26. ncbi request reprint 11C-Fallypride: radiosynthesis and preliminary evaluation of a novel dopamine D2/D3 receptor PET radiotracer in non-human primate brain
    Jogeshwar Mukherjee
    Brain Imaging Center, Department of Psychiatry and Human Behavior, University of California Irvine, Irvine, CA 92697, USA
    Bioorg Med Chem 12:95-102. 2004
    ..This regional localization of (11)C-fallypride is similar to that observed previously for (18)F-fallypride. The results suggest (11)C-fallypride is a useful PET radiotracer for imaging dopamine D2/D3 receptors...
  27. ncbi request reprint Measurement of d-amphetamine-induced effects on the binding of dopamine D-2/D-3 receptor radioligand, 18F-fallypride in extrastriatal brain regions in non-human primates using PET
    Jogeshwar Mukherjee
    Brain Imaging Center, Department of Psychiatry and Human Behavior, University of California Irvine, 162 Irvine Hall, Irvine, CA 92697, USA
    Brain Res 1032:77-84. 2005
    ..Furthermore, our findings support the use of (18)F-fallypride to measure extrastriatal dopamine release...
  28. ncbi request reprint Nicotinic alpha4beta2 receptor imaging agents: part II. Synthesis and biological evaluation of 2-[18F]fluoro-3-[2-((S)-3-pyrrolinyl)methoxy]pyridine (18F-nifene) in rodents and imaging by PET in nonhuman primate
    Rama Pichika
    Brain Imaging Center, Department of Psychiatry and Human Behavior, University of California, Irvine, CA 92697 3960, USA
    Nucl Med Biol 33:295-304. 2006
    ..Thalamus-to-cerebellum ratio peaked at 30-35 min postinjection to a value of 2.2 and subsequently reduced. The faster binding profile of 18F-nifene indicates promise as a PET imaging agent and thus needs further evaluation...
  29. ncbi request reprint Evaluation of objective functions for estimation of kinetic parameters
    Raymond F Muzic
    Department of Radiology, University Hospitals of Cleveland, Case Western Reserve University, Cleveland, Ohio 44106, USA
    Med Phys 33:342-53. 2006
    ..Methods that determine values of weights based on model output--IRLS, ELS0, ELS1 and ELS3--generally perform better than methods that determine values of weights based directly on the experimental data...
  30. ncbi request reprint Synthesis and evaluation of nicotine alpha4beta2 receptor radioligand, 5-(3'-18F-fluoropropyl)-3-(2-(S)-pyrrolidinylmethoxy)pyridine, in rodents and PET in nonhuman primate
    Sankha Chattopadhyay
    Department of Psychiatry and Human Behavior Brain Imaging Center, University of California, Irvine, CA 92697, USA
    J Nucl Med 46:130-40. 2005
    ..We report the development and evaluation of a putative antagonist, 5-(3'-fluoropropyl)-3-(2-(S)-pyrrolidinylmethoxy)pyridine (nifrolidine) as a PET agent for nicotine alpha(4)beta(2) receptors...
  31. ncbi request reprint Synthesis and biologic evaluation of a novel serotonin 5-HT1A receptor radioligand, 18F-labeled mefway, in rodents and imaging by PET in a nonhuman primate
    Neil Saigal
    Brain Imaging Center, Department of Psychiatry and Human Behavior, University of California, Irvine, Irvine, California 92697 3960, USA
    J Nucl Med 47:1697-706. 2006
    ..We have synthesized N-{2-[4-(2-methoxyphenyl)piperazinyl]ethyl}-N-(2-pyridyl)-N-(4-18F-fluoromethylcyclohexane)carboxamide (18F-mefway), which contains a 18F on a primary carbon to make the compound more stable to defluorination...