Henry A Choy

Summary

Affiliation: University of California
Country: USA

Publications

  1. pmc Multiple activities of LigB potentiate virulence of Leptospira interrogans: inhibition of alternative and classical pathways of complement
    Henry A Choy
    Department of Medicine, David Geffen School of Medicine at University of California Los Angeles UCLA, Los Angeles, California, United States of America
    PLoS ONE 7:e41566. 2012
  2. pmc Heterologous expression of pathogen-specific genes ligA and ligB in the saprophyte Leptospira biflexa confers enhanced adhesion to cultured cells and fibronectin
    Claudio Pereira Figueira
    Institut Pasteur, Unité de Biologie des Spirochètes, Paris Cedex 15, France
    BMC Microbiol 11:129. 2011
  3. pmc Physiological osmotic induction of Leptospira interrogans adhesion: LigA and LigB bind extracellular matrix proteins and fibrinogen
    Henry A Choy
    Division of Infectious Diseases, 111F, Veterans Affairs Greater Los Angeles Healthcare System, Los Angeles, California 90073, USA
    Infect Immun 75:2441-50. 2007
  4. pmc The multifunctional LigB adhesin binds homeostatic proteins with potential roles in cutaneous infection by pathogenic Leptospira interrogans
    Henry A Choy
    Department of Medicine, David Geffen School of Medicine at University of California Los Angeles, Los Angeles, California, United States of America
    PLoS ONE 6:e16879. 2011
  5. pmc A LigA three-domain region protects hamsters from lethal infection by Leptospira interrogans
    Mariana L Coutinho
    Veterans Affairs Greater Los Angeles Healthcare System, Los Angeles, California, USA
    PLoS Negl Trop Dis 5:e1422. 2011
  6. pmc The OmpL37 surface-exposed protein is expressed by pathogenic Leptospira during infection and binds skin and vascular elastin
    Marija Pinne
    Research Service, 151, Veterans Affairs Greater Los Angeles Healthcare System, Los Angeles, California, USA
    PLoS Negl Trop Dis 4:e815. 2010
  7. pmc Leptospira interrogans endostatin-like outer membrane proteins bind host fibronectin, laminin and regulators of complement
    Brian Stevenson
    Department of Microbiology, Immunology, and Molecular Genetics, University of Kentucky College of Medicine, Lexington, Kentucky, United States of America
    PLoS ONE 2:e1188. 2007

Collaborators

Detail Information

Publications7

  1. pmc Multiple activities of LigB potentiate virulence of Leptospira interrogans: inhibition of alternative and classical pathways of complement
    Henry A Choy
    Department of Medicine, David Geffen School of Medicine at University of California Los Angeles UCLA, Los Angeles, California, United States of America
    PLoS ONE 7:e41566. 2012
    ..Thus, LigB is an adaptable interface for L. interrogans to efficiently counteract the multiple homeostatic processes of the host...
  2. pmc Heterologous expression of pathogen-specific genes ligA and ligB in the saprophyte Leptospira biflexa confers enhanced adhesion to cultured cells and fibronectin
    Claudio Pereira Figueira
    Institut Pasteur, Unité de Biologie des Spirochètes, Paris Cedex 15, France
    BMC Microbiol 11:129. 2011
    ..Here, we describe a system for heterologous expression of the Leptospira interrogans genes ligA and ligB in the saprophyte Leptospira biflexa serovar Patoc...
  3. pmc Physiological osmotic induction of Leptospira interrogans adhesion: LigA and LigB bind extracellular matrix proteins and fibrinogen
    Henry A Choy
    Division of Infectious Diseases, 111F, Veterans Affairs Greater Los Angeles Healthcare System, Los Angeles, California 90073, USA
    Infect Immun 75:2441-50. 2007
    ..The characterization of the Lig adhesin function should aid the design of Lig-based vaccines and serodiagnostic tests...
  4. pmc The multifunctional LigB adhesin binds homeostatic proteins with potential roles in cutaneous infection by pathogenic Leptospira interrogans
    Henry A Choy
    Department of Medicine, David Geffen School of Medicine at University of California Los Angeles, Los Angeles, California, United States of America
    PLoS ONE 6:e16879. 2011
    ..Leptospirosis patient antibodies react with the LigB domain, suggesting applications in diagnosis and vaccines that are currently limited by the strain-specific leptospiral lipopolysaccharide coats...
  5. pmc A LigA three-domain region protects hamsters from lethal infection by Leptospira interrogans
    Mariana L Coutinho
    Veterans Affairs Greater Los Angeles Healthcare System, Los Angeles, California, USA
    PLoS Negl Trop Dis 5:e1422. 2011
    ....
  6. pmc The OmpL37 surface-exposed protein is expressed by pathogenic Leptospira during infection and binds skin and vascular elastin
    Marija Pinne
    Research Service, 151, Veterans Affairs Greater Los Angeles Healthcare System, Los Angeles, California, USA
    PLoS Negl Trop Dis 4:e815. 2010
    ..Thus, OmpL37 is a novel elastin-binding protein of pathogenic Leptospira that may be promoting attachment of Leptospira to host tissues...
  7. pmc Leptospira interrogans endostatin-like outer membrane proteins bind host fibronectin, laminin and regulators of complement
    Brian Stevenson
    Department of Microbiology, Immunology, and Molecular Genetics, University of Kentucky College of Medicine, Lexington, Kentucky, United States of America
    PLoS ONE 2:e1188. 2007
    ..These characteristics suggest that Len proteins together facilitate invasion and colonization of host tissues, and protect against host immune responses during mammalian infection...