SAMSON CHOW

Summary

Affiliation: University of California
Country: USA

Publications

  1. pmc A high-throughput method for cloning and sequencing human immunodeficiency virus type 1 integration sites
    Sanggu Kim
    Department of Molecular and Medical Pharmacology, Molecular Biology Institute, and UCLA AIDS Institute, UCLA School of Medicine, Los Angeles, CA 90095, USA
    J Virol 80:11313-21. 2006
  2. pmc Fidelity of target site duplication and sequence preference during integration of xenotropic murine leukemia virus-related virus
    Sanggu Kim
    Biomedical Engineering Interdepartmental Program, University of California Los Angeles, Los Angeles, California, United States of America
    PLoS ONE 5:e10255. 2010
  3. pmc Analysis of single-nucleotide polymorphisms in patient-derived retrovirus integration sites reveals contamination from cell lines acutely infected by xenotropic murine leukemia virus-related virus
    Alice Rusmevichientong
    Department of Molecular and Medical Pharmacology, UCLA AIDS Institute, UCLA School of Medicine, Los Angeles, CA 90095, USA
    J Virol 85:12830-4. 2011
  4. pmc Human immunodeficiency virus type 1 incorporated with fusion proteins consisting of integrase and the designed polydactyl zinc finger protein E2C can bias integration of viral DNA into a predetermined chromosomal region in human cells
    Wenjie Tan
    Department of Molecular and Medical Pharmacology, Molecular Biology Institute, and UCLA AIDS Institute, UCLA School of Medicine, Los Angeles, CA 90095, USA
    J Virol 80:1939-48. 2006
  5. pmc Human immunodeficiency virus integration efficiency and site selection in quiescent CD4+ T cells
    Dimitrios N Vatakis
    Department of Medicine, Division of Hematology Oncology, UCLA AIDS Institute, UCLA School of Medicine, Los Angeles, California 90095, USA
    J Virol 83:6222-33. 2009
  6. ncbi request reprint Correct integration mediated by integrase-LexA fusion proteins incorporated into HIV-1
    Michelle L Holmes-Son
    Department of Molecular and Medical Pharmacology, UCLA AIDS Institute, Los Angeles, California, 90095, USA
    Mol Ther 5:360-70. 2002
  7. pmc Fusion proteins consisting of human immunodeficiency virus type 1 integrase and the designed polydactyl zinc finger protein E2C direct integration of viral DNA into specific sites
    Wenjie Tan
    Department of Molecular and Medical Pharmacology, Molecular Biology Institute, and UCLA AIDS Institute, UCLA School of Medicine, Los Angeles, California 90095, USA
    J Virol 78:1301-13. 2004
  8. pmc Integration site preference of xenotropic murine leukemia virus-related virus, a new human retrovirus associated with prostate cancer
    Sanggu Kim
    Biomedical Engineering Interdepartmental Program, UCLA School of Medicine, Los Angeles, CA 90095, USA
    J Virol 82:9964-77. 2008
  9. pmc Molecular mechanisms by which human immunodeficiency virus type 1 integrase stimulates the early steps of reverse transcription
    Charles W Dobard
    Department of Molecular and Medical Pharmacology, School of Medicine, University of California Los Angeles, CA 90095, USA
    J Virol 81:10037-46. 2007
  10. pmc Requirement for integrase during reverse transcription of human immunodeficiency virus type 1 and the effect of cysteine mutations of integrase on its interactions with reverse transcriptase
    Kai Zhu
    Department of Molecular and Medical Pharmacology, UCLA School of Medicine, University of California Los Angeles, Los Angeles, CA 90095, USA
    J Virol 78:5045-55. 2004

Research Grants

  1. MOLECULAR MECHANISMS OF HIV1 DNA INTEGRATION
    SAMSON CHOW; Fiscal Year: 2002
  2. Molecular Mechanisms of HIV-1 DNA Integration
    SAMSON CHOW; Fiscal Year: 2007
  3. Molecular Mechanisms of HIV-1 DNA Integration
    SAMSON CHOW; Fiscal Year: 2006
  4. Molecular Mechanisms of HIV-1 DNA Integration
    SAMSON CHOW; Fiscal Year: 2004
  5. MOLECULAR MECHANISMS OF HIV1 DNA INTEGRATION
    SAMSON CHOW; Fiscal Year: 2001
  6. MOLECULAR MECHANISMS OF HIV1 DNA INTEGRATION
    SAMSON CHOW; Fiscal Year: 2003
  7. Molecular Mechanisms of HIV-1 DNA Integration
    SAMSON CHOW; Fiscal Year: 2005
  8. Molecular Mechanisms of HIV-1 DNA Integration
    SAMSON CHOW; Fiscal Year: 2005
  9. Molecular Mechanisms of HIV-1 DNA Integration
    SAMSON CHOW; Fiscal Year: 2004
  10. MOLECULAR MECHANISMS OF HIV1 DNA INTEGRATION
    SAMSON CHOW; Fiscal Year: 2003

Collaborators

  • Janet S Sinsheimer
  • Christopher Lee
  • Prasad S Koka
  • Scott Kitchen
  • BETH DEIRDRE JAMIESON KARAVODIN
  • Sanggu Kim
  • Dimitrios N Vatakis
  • Thomas A Wilkinson
  • Cora L Woodward
  • Alice Rusmevichientong
  • Wenjie Tan
  • Robert H Silverman
  • Marisa S Briones
  • Namshin Kim
  • Charles W Dobard
  • Jerome A Zack
  • Kai Zhu
  • Jaydip Das Gupta
  • Beihua Dong
  • Irvin S Y Chen
  • Carlos F Barbas
  • David G Brooks
  • Michelle L Holmes-Son
  • Petra S Elias
  • Kunkai Su
  • Hangfei Qi
  • Yun Cheol Kim
  • Sherie L Morrison
  • Aylin C Bonifacino
  • Si Hua Mao
  • Dong Sung An
  • Robert E Donahue
  • Roland Remenyi
  • Angela P Presson
  • Shewit S Tekeste
  • Robert T Clubb
  • Sarin Prakobwanakit
  • Jennifer T Miller
  • Sherly Mosessian
  • Stuart F J Le Grice
  • Martin L Phillips
  • Kurt Januszyk
  • Min Zhang
  • Serena A Lee
  • Christina Gaughan
  • Eric A Klein
  • David Boren
  • Gregory Bristol
  • Yein Kim
  • Zheng Dong
  • Teresa Liang
  • Beth D Jamieson
  • Betty Poon
  • Michael D Cohen
  • Charles Dobard
  • David J Segal
  • Yao Wang
  • Han Htun
  • Wendy J Dixon

Detail Information

Publications18

  1. pmc A high-throughput method for cloning and sequencing human immunodeficiency virus type 1 integration sites
    Sanggu Kim
    Department of Molecular and Medical Pharmacology, Molecular Biology Institute, and UCLA AIDS Institute, UCLA School of Medicine, Los Angeles, CA 90095, USA
    J Virol 80:11313-21. 2006
    ....
  2. pmc Fidelity of target site duplication and sequence preference during integration of xenotropic murine leukemia virus-related virus
    Sanggu Kim
    Biomedical Engineering Interdepartmental Program, University of California Los Angeles, Los Angeles, California, United States of America
    PLoS ONE 5:e10255. 2010
    ..We conclude that integration of XMRV DNA involves a coordinated joining of two viral DNA ends that are spaced 4 bp apart on the target DNA and proceeds with high fidelity...
  3. pmc Analysis of single-nucleotide polymorphisms in patient-derived retrovirus integration sites reveals contamination from cell lines acutely infected by xenotropic murine leukemia virus-related virus
    Alice Rusmevichientong
    Department of Molecular and Medical Pharmacology, UCLA AIDS Institute, UCLA School of Medicine, Los Angeles, CA 90095, USA
    J Virol 85:12830-4. 2011
    ..Our results provide direct evidence for contamination during analysis of XMRV integration sites...
  4. pmc Human immunodeficiency virus type 1 incorporated with fusion proteins consisting of integrase and the designed polydactyl zinc finger protein E2C can bias integration of viral DNA into a predetermined chromosomal region in human cells
    Wenjie Tan
    Department of Molecular and Medical Pharmacology, Molecular Biology Institute, and UCLA AIDS Institute, UCLA School of Medicine, Los Angeles, CA 90095, USA
    J Virol 80:1939-48. 2006
    ..The results indicated that the IN-E2C fusion protein strategy is capable of directing integration of retroviral DNA into a predetermined chromosomal region in the human genome...
  5. pmc Human immunodeficiency virus integration efficiency and site selection in quiescent CD4+ T cells
    Dimitrios N Vatakis
    Department of Medicine, Division of Hematology Oncology, UCLA AIDS Institute, UCLA School of Medicine, Los Angeles, California 90095, USA
    J Virol 83:6222-33. 2009
    ..While site selections are similar, the integration process in quiescent cells is plagued by the formation of high levels of incorrectly processed viral ends and abortive two-long-terminal-repeat circles...
  6. ncbi request reprint Correct integration mediated by integrase-LexA fusion proteins incorporated into HIV-1
    Michelle L Holmes-Son
    Department of Molecular and Medical Pharmacology, UCLA AIDS Institute, Los Angeles, California, 90095, USA
    Mol Ther 5:360-70. 2002
    ....
  7. pmc Fusion proteins consisting of human immunodeficiency virus type 1 integrase and the designed polydactyl zinc finger protein E2C direct integration of viral DNA into specific sites
    Wenjie Tan
    Department of Molecular and Medical Pharmacology, Molecular Biology Institute, and UCLA AIDS Institute, UCLA School of Medicine, Los Angeles, California 90095, USA
    J Virol 78:1301-13. 2004
    ..The results demonstrate that the integrase-E2C fusion proteins offer an efficient approach and a versatile framework for directing the integration of retroviral DNA into a predetermined DNA site...
  8. pmc Integration site preference of xenotropic murine leukemia virus-related virus, a new human retrovirus associated with prostate cancer
    Sanggu Kim
    Biomedical Engineering Interdepartmental Program, UCLA School of Medicine, Los Angeles, CA 90095, USA
    J Virol 82:9964-77. 2008
    ..These results are consistent with a model in which XMRV may contribute to tumorigenicity via a paracrine mechanism...
  9. pmc Molecular mechanisms by which human immunodeficiency virus type 1 integrase stimulates the early steps of reverse transcription
    Charles W Dobard
    Department of Molecular and Medical Pharmacology, School of Medicine, University of California Los Angeles, CA 90095, USA
    J Virol 81:10037-46. 2007
    ..Taken together, our results showed that IN acts at early steps of reverse transcription by increasing the processivity of RT and suppressing the formation of the pause products...
  10. pmc Requirement for integrase during reverse transcription of human immunodeficiency virus type 1 and the effect of cysteine mutations of integrase on its interactions with reverse transcriptase
    Kai Zhu
    Department of Molecular and Medical Pharmacology, UCLA School of Medicine, University of California Los Angeles, Los Angeles, CA 90095, USA
    J Virol 78:5045-55. 2004
    ..Our results indicate that integrase plays an important role during the reverse-transcription step of the viral life cycle, possibly through physical interactions with RT...
  11. pmc High-throughput, sensitive quantification of repopulating hematopoietic stem cell clones
    Sanggu Kim
    Department of Microbiology, University of California, David Geffen School of Medicine, Los Angeles, CA 90095, USA
    J Virol 84:11771-80. 2010
    ..This assay permits high-throughput and sensitive assessment of clonal populations and hence will be useful for a broad range of gene therapy, stem cell, and cancer research applications...
  12. pmc Efficient identification of human immunodeficiency virus type 1 mutants resistant to a protease inhibitor by using a random mutant library
    Sanggu Kim
    UCLA School of Medicine, Los Angeles, CA 90095, USA
    Antimicrob Agents Chemother 55:5090-8. 2011
    ..Therefore, the new assay is efficient for identifying changes leading to drug resistance. The data also provide insights into the molecular mechanisms underlying the development of drug resistance...
  13. pmc Subcellular localization of feline immunodeficiency virus integrase and mapping of its karyophilic determinant
    Cora L Woodward
    Department of Molecular and Medical Pharmacology, Molecular Biology Institute and AIDS Institute, School of Medicine, University of California, Los Angeles, California 90095, USA
    J Virol 77:4516-27. 2003
    ..Alternatively, the HHCC motif may directly promote interaction between FIV integrase and cellular proteins involved in nuclear import...
  14. pmc Role of human immunodeficiency virus type 1 integrase in uncoating of the viral core
    Marisa S Briones
    Department of Molecular and Medical Pharmacology, Molecular Biology Institute and UCLA AIDS Institute, UCLA School of Medicine, Los Angeles, California 90095, USA
    J Virol 84:5181-90. 2010
    ..Taken together, our results indicate that IN is required during uncoating for maintaining CypA-CA interaction, which promotes optimal stability of the viral core...
  15. pmc Integrase interacts with nucleoporin NUP153 to mediate the nuclear import of human immunodeficiency virus type 1
    Cora L Woodward
    Department of Molecular and Medical Pharmacology, UCLA School of Medicine, Los Angeles, California 90095, USA
    J Virol 83:6522-33. 2009
    ....
  16. pmc Identifying and characterizing a functional HIV-1 reverse transcriptase-binding site on integrase
    Thomas A Wilkinson
    Department of Molecular and Medical Pharmacology, University of California, Los Angeles, California 90095, USA
    J Biol Chem 284:7931-9. 2009
    ..These results strengthen the notion that IN-RT interactions are biologically relevant during HIV-1 replication and also provide insights into this interaction at the molecular level...
  17. pmc Immediate activation fails to rescue efficient human immunodeficiency virus replication in quiescent CD4+ T cells
    Dimitrios N Vatakis
    David Geffen School of Medicine at UCLA, 650 Charles Young Dr South, Box 951678, 11 934 Factor, Los Angeles, CA 90095 1678, USA
    J Virol 81:3574-82. 2007
    ..Together, these data demonstrate that the early stages of the HIV life cycle are inefficient in these poststimulated cells and that efficient replication cannot be induced by subsequent activation...
  18. ncbi request reprint Rapid size dependent deletion of foreign gene sequences inserted into attenuated HIV-1 upon infection in vivo: implications for vaccine development
    David G Brooks
    Department of Molecular and Medical Pharmacology, David Geffen School of Medicine and AIDS Institute, University of California, Los Angeles, 90095, USA
    Curr HIV Res 3:377-92. 2005
    ....

Research Grants23

  1. MOLECULAR MECHANISMS OF HIV1 DNA INTEGRATION
    SAMSON CHOW; Fiscal Year: 2002
    ..Information obtained from studying integration site selection may lead to a new approach for inserting exogenous genes at specific sites. ..
  2. Molecular Mechanisms of HIV-1 DNA Integration
    SAMSON CHOW; Fiscal Year: 2007
    ..abstract_text> ..
  3. Molecular Mechanisms of HIV-1 DNA Integration
    SAMSON CHOW; Fiscal Year: 2006
    ..abstract_text> ..
  4. Molecular Mechanisms of HIV-1 DNA Integration
    SAMSON CHOW; Fiscal Year: 2004
    ....
  5. MOLECULAR MECHANISMS OF HIV1 DNA INTEGRATION
    SAMSON CHOW; Fiscal Year: 2001
    ..Information obtained from studying integration site selection may lead to a new approach for inserting exogenous genes at specific sites. ..
  6. MOLECULAR MECHANISMS OF HIV1 DNA INTEGRATION
    SAMSON CHOW; Fiscal Year: 2003
    ..Information obtained from studying integration site selection may lead to a new approach for inserting exogenous genes at specific sites. ..
  7. Molecular Mechanisms of HIV-1 DNA Integration
    SAMSON CHOW; Fiscal Year: 2005
    ..abstract_text> ..
  8. Molecular Mechanisms of HIV-1 DNA Integration
    SAMSON CHOW; Fiscal Year: 2005
    ..abstract_text> ..
  9. Molecular Mechanisms of HIV-1 DNA Integration
    SAMSON CHOW; Fiscal Year: 2004
    ..abstract_text> ..
  10. MOLECULAR MECHANISMS OF HIV1 DNA INTEGRATION
    SAMSON CHOW; Fiscal Year: 2003
    ..Information obtained from studying integration site selection may lead to a new approach for inserting exogenous genes at specific sites. ..
  11. MOLECULAR MECHANISMS OF HIV1 DNA INTEGRATION
    SAMSON CHOW; Fiscal Year: 2002
    ..Information obtained from studying integration site selection may lead to a new approach for inserting exogenous genes at specific sites. ..
  12. MOLECULAR MECHANISMS OF HIV1 DNA INTEGRATION
    SAMSON CHOW; Fiscal Year: 2001
    ..Information obtained from studying integration site selection may lead to a new approach for inserting exogenous genes at specific sites. ..
  13. MOLECULAR MECHANISMS OF HIV1 DNA INTEGRATION
    SAMSON CHOW; Fiscal Year: 2000
    ..Information obtained from studying integration site selection may lead to a new approach for inserting exogenous genes at specific sites. ..
  14. MOLECULAR MECHANISMS OF HIV1 DNA INTEGRATION
    SAMSON CHOW; Fiscal Year: 1999
    ..Information obtained from studying integration site selection may lead to a new approach for inserting exogenous genes at specific sites. ..