SAMSON CHOWSummaryAffiliation: University of California Country: USA Publications
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Publications
A high-throughput method for cloning and sequencing human immunodeficiency virus type 1 integration sitesSanggu Kim
Department of Molecular and Medical Pharmacology, Molecular Biology Institute, and UCLA AIDS Institute, UCLA School of Medicine, Los Angeles, CA 90095, USA
J Virol 80:11313-21. 2006....- Analysis of single-nucleotide polymorphisms in patient-derived retrovirus integration sites reveals contamination from cell lines acutely infected by xenotropic murine leukemia virus-related virusAlice Rusmevichientong
Department of Molecular and Medical Pharmacology, UCLA AIDS Institute, UCLA School of Medicine, Los Angeles, CA 90095, USA
J Virol 85:12830-4. 2011..Our results provide direct evidence for contamination during analysis of XMRV integration sites... - Human immunodeficiency virus type 1 incorporated with fusion proteins consisting of integrase and the designed polydactyl zinc finger protein E2C can bias integration of viral DNA into a predetermined chromosomal region in human cellsWenjie Tan
Department of Molecular and Medical Pharmacology, Molecular Biology Institute, and UCLA AIDS Institute, UCLA School of Medicine, Los Angeles, CA 90095, USA
J Virol 80:1939-48. 2006..The results indicated that the IN-E2C fusion protein strategy is capable of directing integration of retroviral DNA into a predetermined chromosomal region in the human genome... - Human immunodeficiency virus integration efficiency and site selection in quiescent CD4+ T cellsDimitrios N Vatakis
Department of Medicine, Division of Hematology Oncology, UCLA AIDS Institute, UCLA School of Medicine, Los Angeles, California 90095, USA
J Virol 83:6222-33. 2009..While site selections are similar, the integration process in quiescent cells is plagued by the formation of high levels of incorrectly processed viral ends and abortive two-long-terminal-repeat circles... 
Correct integration mediated by integrase-LexA fusion proteins incorporated into HIV-1Michelle L Holmes-Son
Department of Molecular and Medical Pharmacology, UCLA AIDS Institute, Los Angeles, California, 90095, USA
Mol Ther 5:360-70. 2002....- Fusion proteins consisting of human immunodeficiency virus type 1 integrase and the designed polydactyl zinc finger protein E2C direct integration of viral DNA into specific sitesWenjie Tan
Department of Molecular and Medical Pharmacology, Molecular Biology Institute, and UCLA AIDS Institute, UCLA School of Medicine, Los Angeles, California 90095, USA
J Virol 78:1301-13. 2004..The results demonstrate that the integrase-E2C fusion proteins offer an efficient approach and a versatile framework for directing the integration of retroviral DNA into a predetermined DNA site... - Molecular mechanisms by which human immunodeficiency virus type 1 integrase stimulates the early steps of reverse transcriptionCharles W Dobard
Department of Molecular and Medical Pharmacology, School of Medicine, University of California Los Angeles, CA 90095, USA
J Virol 81:10037-46. 2007..Taken together, our results showed that IN acts at early steps of reverse transcription by increasing the processivity of RT and suppressing the formation of the pause products... - Requirement for integrase during reverse transcription of human immunodeficiency virus type 1 and the effect of cysteine mutations of integrase on its interactions with reverse transcriptaseKai Zhu
Department of Molecular and Medical Pharmacology, UCLA School of Medicine, University of California-Los Angeles, Los Angeles, CA 90095, USA
J Virol 78:5045-55. 2004..Our results indicate that integrase plays an important role during the reverse-transcription step of the viral life cycle, possibly through physical interactions with RT... - Integration site preference of xenotropic murine leukemia virus-related virus, a new human retrovirus associated with prostate cancerSanggu Kim
Biomedical Engineering Interdepartmental Program, UCLA School of Medicine, Los Angeles, CA 90095, USA
J Virol 82:9964-77. 2008..These results are consistent with a model in which XMRV may contribute to tumorigenicity via a paracrine mechanism... - High-throughput, sensitive quantification of repopulating hematopoietic stem cell clonesSanggu Kim
Department of Microbiology, University of California, David Geffen School of Medicine, Los Angeles, CA 90095, USA
J Virol 84:11771-80. 2010..This assay permits high-throughput and sensitive assessment of clonal populations and hence will be useful for a broad range of gene therapy, stem cell, and cancer research applications... - Efficient identification of human immunodeficiency virus type 1 mutants resistant to a protease inhibitor by using a random mutant librarySanggu Kim
UCLA School of Medicine, Los Angeles, CA 90095, USA
Antimicrob Agents Chemother 55:5090-8. 2011..Therefore, the new assay is efficient for identifying changes leading to drug resistance. The data also provide insights into the molecular mechanisms underlying the development of drug resistance... - Role of human immunodeficiency virus type 1 integrase in uncoating of the viral coreMarisa S Briones
Department of Molecular and Medical Pharmacology, Molecular Biology Institute and UCLA AIDS Institute, UCLA School of Medicine, Los Angeles, California 90095, USA
J Virol 84:5181-90. 2010..Taken together, our results indicate that IN is required during uncoating for maintaining CypA-CA interaction, which promotes optimal stability of the viral core... - Integrase interacts with nucleoporin NUP153 to mediate the nuclear import of human immunodeficiency virus type 1Cora L Woodward
Department of Molecular and Medical Pharmacology, UCLA School of Medicine, Los Angeles, California 90095, USA
J Virol 83:6522-33. 2009.... - Subcellular localization of feline immunodeficiency virus integrase and mapping of its karyophilic determinantCora L Woodward
Department of Molecular and Medical Pharmacology, Molecular Biology Institute and AIDS Institute, School of Medicine, University of California, Los Angeles, California 90095, USA
J Virol 77:4516-27. 2003..Alternatively, the HHCC motif may directly promote interaction between FIV integrase and cellular proteins involved in nuclear import... - Identifying and characterizing a functional HIV-1 reverse transcriptase-binding site on integraseThomas A Wilkinson
Department of Molecular and Medical Pharmacology, University of California, Los Angeles, California 90095, USA
J Biol Chem 284:7931-9. 2009..These results strengthen the notion that IN-RT interactions are biologically relevant during HIV-1 replication and also provide insights into this interaction at the molecular level... - Immediate activation fails to rescue efficient human immunodeficiency virus replication in quiescent CD4+ T cellsDimitrios N Vatakis
David Geffen School of Medicine at UCLA, 650 Charles Young Dr South, Box 951678, 11 934 Factor, Los Angeles, CA 90095 1678, USA
J Virol 81:3574-82. 2007..Together, these data demonstrate that the early stages of the HIV life cycle are inefficient in these poststimulated cells and that efficient replication cannot be induced by subsequent activation... - Rapid size dependent deletion of foreign gene sequences inserted into attenuated HIV-1 upon infection in vivo: implications for vaccine developmentDavid G Brooks
Department of Molecular and Medical Pharmacology, David Geffen School of Medicine and AIDS Institute, University of California, Los Angeles, 90095, USA
Curr HIV Res 3:377-92. 2005....
Research Grants
- MOLECULAR MECHANISMS OF HIV1 DNA INTEGRATIONSAMSON CHOW; Fiscal Year: 2003..Information obtained from studying integration site selection may lead to a new approach for inserting exogenous genes at specific sites. ..
- Molecular Mechanisms of HIV-1 DNA IntegrationSAMSON CHOW; Fiscal Year: 2004....
- Molecular Mechanisms of HIV-1 DNA IntegrationSAMSON CHOW; Fiscal Year: 2007..abstract_text> ..