Divaker Choubey

Summary

Affiliation: University of Cincinnati
Country: USA

Publications

  1. ncbi request reprint Interferon-inducible IFI16 protein in human cancers and autoimmune diseases
    Divaker Choubey
    Cincinnati VA Medical Center, OH, USA
    Front Biosci 13:598-608. 2008
  2. pmc IFI16 induction by glucose restriction in human fibroblasts contributes to autophagy through activation of the ATM/AMPK/p53 pathway
    Xin Duan
    Department of Environmental Health, University of Cincinnati, Cincinnati, Ohio, United States of America
    PLoS ONE 6:e19532. 2011
  3. pmc IFI16 protein mediates the anti-inflammatory actions of the type-I interferons through suppression of activation of caspase-1 by inflammasomes
    Sudhakar Veeranki
    Department of Environmental Health, University of Cincinnati, Cincinnati, Ohio, United States of America
    PLoS ONE 6:e27040. 2011
  4. pmc Interferon-inducible IFI16, a negative regulator of cell growth, down-regulates expression of human telomerase reverse transcriptase (hTERT) gene
    Lynda Li Song
    Department of Environmental Health, Cincinnati, Ohio, United States of America
    PLoS ONE 5:e8569. 2010
  5. ncbi request reprint AIM2, an IFN-inducible cytosolic DNA sensor, in the development of benign prostate hyperplasia and prostate cancer
    Larissa Ponomareva
    Department of Environmental Health, University of Cincinnati, 3223 Eden Avenue, PO Box 670056, Cincinnati, OH 45267
    Mol Cancer Res 11:1193-202. 2013
  6. pmc Emerging roles for the interferon-inducible p200-family proteins in sex bias in systemic lupus erythematosus
    Divaker Choubey
    Department of Environmental Health, University of Cincinnati, Cincinnati, Ohio 45267, USA
    J Interferon Cytokine Res 31:893-906. 2011
  7. pmc Interferons in autoimmune and inflammatory diseases: regulation and roles
    Divaker Choubey
    Department of Environmental Health, University of Cincinnati, Cincinnati, Ohio 45267, USA
    J Interferon Cytokine Res 31:857-65. 2011
  8. pmc Interferon-inducible Ifi200-family genes as modifiers of lupus susceptibility
    Divaker Choubey
    Department of Environmental Health, University of Cincinnati, 3223 Eden Avenue, P O Box 670056, Cincinnati, OH 45267, United States
    Immunol Lett 147:10-7. 2012
  9. pmc DNA-responsive inflammasomes and their regulators in autoimmunity
    Divaker Choubey
    Department of Environmental Health, University of Cincinnati, 3223 Eden Avenue, P O Box 670056, Cincinnati, OH 45267, USA
    Clin Immunol 142:223-31. 2012
  10. pmc Interferon-inducible p200-family proteins as novel sensors of cytoplasmic DNA: role in inflammation and autoimmunity
    Divaker Choubey
    Department of Environmental Health, University of Cincinnati, Cincinnati, Ohio 45267, USA
    J Interferon Cytokine Res 30:371-80. 2010

Research Grants

  1. Gender-Specific Role of p202 in Lupus Susceptibility
    Divaker Choubey; Fiscal Year: 2009
  2. Gender-Specific Role of p202 in Lupus Susceptibility
    Divaker Choubey; Fiscal Year: 2010
  3. Gender-Specific Role of p202 in Lupus Susceptibility
    Divaker Choubey; Fiscal Year: 2005
  4. Gender-Specific Role of p202 in Lupus Susceptibility
    Divaker Choubey; Fiscal Year: 2006
  5. Role of IFI16 in Cellular Senescence
    Divaker Choubey; Fiscal Year: 2006
  6. Gender-Specific Role of p202 in Lupus Susceptibility
    Divaker Choubey; Fiscal Year: 2007
  7. Role of IFI16 in Cellular Senescence
    Divaker Choubey; Fiscal Year: 2009

Collaborators

Detail Information

Publications25

  1. ncbi request reprint Interferon-inducible IFI16 protein in human cancers and autoimmune diseases
    Divaker Choubey
    Cincinnati VA Medical Center, OH, USA
    Front Biosci 13:598-608. 2008
    ..In this review, we discuss how our understanding of the regulation of IFI16 expression and its role in cell growth regulation will help elucidate the molecular mechanisms that contribute to the development of various human diseases...
  2. pmc IFI16 induction by glucose restriction in human fibroblasts contributes to autophagy through activation of the ATM/AMPK/p53 pathway
    Xin Duan
    Department of Environmental Health, University of Cincinnati, Cincinnati, Ohio, United States of America
    PLoS ONE 6:e19532. 2011
    ..Given that the activated p53 induces the expression of IFI16 protein, we investigated the potential role of the IFI16 protein in glucose restriction-induced responses...
  3. pmc IFI16 protein mediates the anti-inflammatory actions of the type-I interferons through suppression of activation of caspase-1 by inflammasomes
    Sudhakar Veeranki
    Department of Environmental Health, University of Cincinnati, Cincinnati, Ohio, United States of America
    PLoS ONE 6:e27040. 2011
    ....
  4. pmc Interferon-inducible IFI16, a negative regulator of cell growth, down-regulates expression of human telomerase reverse transcriptase (hTERT) gene
    Lynda Li Song
    Department of Environmental Health, Cincinnati, Ohio, United States of America
    PLoS ONE 5:e8569. 2010
    ..Here, we report that increased levels of IFI16 protein in normal HDFs and in HeLa cells negatively regulate the expression of human telomerase reverse transcriptase (hTERT) gene...
  5. ncbi request reprint AIM2, an IFN-inducible cytosolic DNA sensor, in the development of benign prostate hyperplasia and prostate cancer
    Larissa Ponomareva
    Department of Environmental Health, University of Cincinnati, 3223 Eden Avenue, PO Box 670056, Cincinnati, OH 45267
    Mol Cancer Res 11:1193-202. 2013
    ..Further, the cytosolic DNA activated the AIM2 inflammasome in the androgen receptor-negative PC3 prostate cancer cell line, suggesting that AIM2-mediated events are independent of androgen receptor status...
  6. pmc Emerging roles for the interferon-inducible p200-family proteins in sex bias in systemic lupus erythematosus
    Divaker Choubey
    Department of Environmental Health, University of Cincinnati, Cincinnati, Ohio 45267, USA
    J Interferon Cytokine Res 31:893-906. 2011
    ..An improved understanding of the regulation and roles of the p200-family proteins in immune cells is critical to understand lupus pathogenesis as well as response (or the lack of it) to various therapies...
  7. pmc Interferons in autoimmune and inflammatory diseases: regulation and roles
    Divaker Choubey
    Department of Environmental Health, University of Cincinnati, Cincinnati, Ohio 45267, USA
    J Interferon Cytokine Res 31:857-65. 2011
    ....
  8. pmc Interferon-inducible Ifi200-family genes as modifiers of lupus susceptibility
    Divaker Choubey
    Department of Environmental Health, University of Cincinnati, 3223 Eden Avenue, P O Box 670056, Cincinnati, OH 45267, United States
    Immunol Lett 147:10-7. 2012
    ..An improved understanding of the role of p200-family proteins in the development of autoimmunity is likely to identify new approaches to treat SLE patients...
  9. pmc DNA-responsive inflammasomes and their regulators in autoimmunity
    Divaker Choubey
    Department of Environmental Health, University of Cincinnati, 3223 Eden Avenue, P O Box 670056, Cincinnati, OH 45267, USA
    Clin Immunol 142:223-31. 2012
    ....
  10. pmc Interferon-inducible p200-family proteins as novel sensors of cytoplasmic DNA: role in inflammation and autoimmunity
    Divaker Choubey
    Department of Environmental Health, University of Cincinnati, Cincinnati, Ohio 45267, USA
    J Interferon Cytokine Res 30:371-80. 2010
    ..In this review, we discuss how the ability of p200-family proteins to sense cytoplasmic DNA may contribute to the development of chronic inflammation and associated diseases...
  11. pmc Interferon-inducible Ifi200-family genes in systemic lupus erythematosus
    Divaker Choubey
    Department of Environmental Health, University of Cincinnati, 3223 Eden Avenue, P O Box 670056, Cincinnati, OH 45267, United States
    Immunol Lett 119:32-41. 2008
    ..This review summarizes recent findings concerning the regulation and role of p200-family proteins in the development of SLE...
  12. pmc Differential roles for the interferon-inducible IFI16 and AIM2 innate immune sensors for cytosolic DNA in cellular senescence of human fibroblasts
    Xin Duan
    Department of Environmental Health, University of Cincinnati, 3223 Eden Avenue, Cincinnati, OH 45267, USA
    Mol Cancer Res 9:589-602. 2011
    ..Collectively, our observations show differential roles for the IFI16 and AIM2 proteins in cellular senescence and associated secretory phenotype...
  13. pmc Murine BAFF expression is up-regulated by estrogen and interferons: implications for sex bias in the development of autoimmunity
    Ravichandran Panchanathan
    Department of Environmental Health, University of Cincinnati, 3223 Eden Avenue, P O Box 670056, Cincinnati, OH 45267, United States
    Mol Immunol 53:15-23. 2013
    ..Together, our observations demonstrated that estrogen and IFN-induced increased levels of the p202 protein in immune cells contribute to sex bias in part through up-regulation of BAFF expression...
  14. pmc Aim2 deficiency in mice suppresses the expression of the inhibitory Fcgamma receptor (FcgammaRIIB) through the induction of the IFN-inducible p202, a lupus susceptibility protein
    Ravichandran Panchanathan
    Department of Environmental Health, University of Cincinnati, Cincinnati, OH 45267, USA
    J Immunol 186:6762-70. 2011
    ..These observations demonstrate that the expression of Aim2 protein is required to maintain the expression of the Fcgr2b gene and also predict epistatic interactions between the Ifi200 genes and the Fcgr2b gene within the Nba2 interval...
  15. doi request reprint Expression of an IFN-inducible cellular senescence gene, IFI16, is up-regulated by p53
    Lynda Li Song
    Department of Environmental Health, University of Cincinnati, Cincinnati, Ohio 45267, USA
    Mol Cancer Res 6:1732-41. 2008
    ..Together, our observations provide support for the idea that up-regulation of IFI16 expression by p53 and functional interactions between IFI16 protein and p53 contribute to cellular senescence...
  16. pmc Cell type and gender-dependent differential regulation of the p202 and Aim2 proteins: implications for the regulation of innate immune responses in SLE
    Ravichandran Panchanathan
    Department of Environmental Health, University of Cincinnati, Cincinnati, OH 45267, United States
    Mol Immunol 49:273-80. 2011
    ....
  17. pmc Distinct regulation of murine lupus susceptibility genes by the IRF5/Blimp-1 axis
    Ravichandran Panchanathan
    Department of Environmental Health, University of Cincinnati, Cincinnati, OH 45267, USA
    J Immunol 188:270-8. 2012
    ....
  18. pmc Female and male sex hormones differentially regulate expression of Ifi202, an interferon-inducible lupus susceptibility gene within the Nba2 interval
    Ravichandran Panchanathan
    Department of Environmental Health, University of Cincinnati, Cincinnati, OH 45267, USA
    J Immunol 183:7031-8. 2009
    ..Collectively, our observations demonstrate that the female and male sex hormones differentially regulate the expression of Ifi202, thus providing support for the role of Ifi202 in sex bias in SLE...
  19. pmc Mutually positive regulatory feedback loop between interferons and estrogen receptor-alpha in mice: implications for sex bias in autoimmunity
    Ravichandran Panchanathan
    Department of Environmental Health, University of Cincinnati, Cincinnati, Ohio, United States of America
    PLoS ONE 5:e10868. 2010
    ..Here we report that activation of IFN (alpha or gamma)-signaling in immune cells up-regulates expression of estrogen receptor-alpha (ERalpha; encoded by the Esr1 gene) and stimulates expression of target genes...
  20. pmc Expression of murine Unc93b1 is up-regulated by interferon and estrogen signaling: implications for sex bias in the development of autoimmunity
    Ravichandran Panchanathan
    Department of Environmental Health, University of Cincinnati, 3223 Eden Avenue, PO Box 670056, Cincinnati, OH 45267, USA
    Int Immunol 25:521-9. 2013
    ..To our knowledge, our observations demonstrate for the first time that activation of interferon and estrogen signaling in immune cells up-regulates the expression of murine Unc93b1. ..
  21. pmc Aim2 deficiency stimulates the expression of IFN-inducible Ifi202, a lupus susceptibility murine gene within the Nba2 autoimmune susceptibility locus
    Ravichandran Panchanathan
    Department of Environmental Health, University of Cincinnati, Cincinnati, OH 45267, USA
    J Immunol 185:7385-93. 2010
    ..Collectively, our observations demonstrate an inverse correlation between Aim2 and p202 expressions. We predict that defects in Aim2 expression within immune cells contribute to increased susceptibility to lupus...
  22. pmc Interferon-inducible p200-family protein IFI16, an innate immune sensor for cytosolic and nuclear double-stranded DNA: regulation of subcellular localization
    Sudhakar Veeranki
    Department of Environmental Health, University of Cincinnati, 3223 Eden Avenue, P O Box 670056, Cincinnati, OH 45267, USA
    Mol Immunol 49:567-71. 2012
    ..We conclude that further studies are needed to understand the molecular mechanisms that regulate the subcellular localization of IFI16 protein...
  23. pmc Gender-dependent expression of murine Irf5 gene: implications for sex bias in autoimmunity
    Hui Shen
    Department of Environmental Health, University of Cincinnati, Cincinnati, OH 45267, USA
    J Mol Cell Biol 2:284-90. 2010
    ..Collectively, our observations demonstrate a gender bias in the expression and sub-cellular localization of the murine IRF5...
  24. pmc Systemic lupus erythematosus and increased risk to develop B cell malignancies: role of the p200-family proteins
    Sudhakar Veeranki
    Department of Environmental Health, University of Cincinnati, 3223 Eden Avenue, PO Box 670056, Cincinnati, OH 45267, United States
    Immunol Lett 133:1-5. 2010
    ..A complete understanding of the molecular mechanisms that regulate B cell homeostasis is necessary to identify SLE patients with an increased risk to develop B cell malignancies...
  25. pmc Disruption of mutually negative regulatory feedback loop between interferon-inducible p202 protein and the E2F family of transcription factors in lupus-prone mice
    Ravichandran Panchanathan
    Department of Environmental Health, University of Cincinnati, 3223 Eden Avenue, Cincinnati, OH 45267, USA
    J Immunol 180:5927-34. 2008
    ..Our observations support the idea that increased Ifi202 expression in certain strains of mice contributes to lupus susceptibility in part by inhibiting E2F1-mediated functions...

Research Grants9

  1. Gender-Specific Role of p202 in Lupus Susceptibility
    Divaker Choubey; Fiscal Year: 2009
    ..Our studies will increase the understanding of the molecular basis of sex bias in lupus disease and could potentially lead to better diagnostic tools as well as disease monitoring, and effective treatments. 1 ..
  2. Gender-Specific Role of p202 in Lupus Susceptibility
    Divaker Choubey; Fiscal Year: 2010
    ..Our studies will increase the understanding of the molecular basis of sex bias in lupus disease and could potentially lead to better diagnostic tools as well as disease monitoring, and effective treatments. 1 ..
  3. Gender-Specific Role of p202 in Lupus Susceptibility
    Divaker Choubey; Fiscal Year: 2005
    ..Significance: Our studies will identify molecular mechanisms by which gender-specific increased expression of p202 in cells of the immune system contributes to lupus susceptibility in a mouse model of lupus. ..
  4. Gender-Specific Role of p202 in Lupus Susceptibility
    Divaker Choubey; Fiscal Year: 2006
    ..Significance: Our studies will identify molecular mechanisms by which gender-specific increased expression of p202 in cells of the immune system contributes to lupus susceptibility in a mouse model of lupus. ..
  5. Role of IFI16 in Cellular Senescence
    Divaker Choubey; Fiscal Year: 2006
    ..The significance of our proposed experiments is that they will identify molecular mechanisms by which IFI16 regulates the transcription of senescence-associated genes and contributes to the senescence-associated cell cycle arrest. ..
  6. Gender-Specific Role of p202 in Lupus Susceptibility
    Divaker Choubey; Fiscal Year: 2007
    ..Significance: Our studies will identify molecular mechanisms by which gender-specific increased expression of p202 in cells of the immune system contributes to lupus susceptibility in a mouse model of lupus. ..
  7. Role of IFI16 in Cellular Senescence
    Divaker Choubey; Fiscal Year: 2009
    ..abstract_text> ..