Yuh Min Chook

Summary

Affiliation: University of Texas Southwestern Medical Center
Country: USA

Publications

  1. pmc Nuclear import by karyopherin-βs: recognition and inhibition
    Yuh Min Chook
    Department of Pharmacology, University of Texas Southerwestern Medical Center, Dallas, TX 75206, USA
    Biochim Biophys Acta 1813:1593-606. 2011
  2. pmc Sequence and structural analyses of nuclear export signals in the NESdb database
    Darui Xu
    Department of Pharmacology, University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390, USA
    Mol Biol Cell 23:3677-93. 2012
  3. pmc Structural basis for assembly and disassembly of the CRM1 nuclear export complex
    Xiuhua Dong
    Department of Pharmacology, University of Texas Southwestern Medical Center at Dallas, USA
    Nat Struct Mol Biol 16:558-60. 2009
  4. pmc Structural basis for leucine-rich nuclear export signal recognition by CRM1
    Xiuhua Dong
    Department of Pharmacology, University of Texas Southwestern Medical Center at Dallas, 6001 Forest Park, Dallas, Texas 75390 9041, USA
    Nature 458:1136-41. 2009
  5. pmc Atomic resolution structures in nuclear transport
    Katherine E Süel
    Department of Pharmacology, University of Texas Southwestern Medical Center at Dallas, 6001 Forest Park, Dallas, TX 75390 9041, USA
    Methods 39:342-55. 2006
  6. pmc Structural and energetic basis of ALS-causing mutations in the atypical proline-tyrosine nuclear localization signal of the Fused in Sarcoma protein (FUS)
    Zi Chao Zhang
    Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Proc Natl Acad Sci U S A 109:12017-21. 2012
  7. pmc Kap104p imports the PY-NLS-containing transcription factor Tfg2p into the nucleus
    Katherine E Süel
    Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    J Biol Chem 284:15416-24. 2009
  8. pmc Modular organization and combinatorial energetics of proline-tyrosine nuclear localization signals
    Katherine E Süel
    Department of Pharmacology, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas, United States of America
    PLoS Biol 6:e137. 2008
  9. pmc Evolutionary development of redundant nuclear localization signals in the mRNA export factor NXF1
    Zi Chao Zhang
    Department of Pharmacology, University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390 9041, USA
    Mol Biol Cell 22:4657-68. 2011
  10. pmc Conformational heterogeneity of karyopherin beta2 is segmental
    Ahmet E Cansizoglu
    Department of Pharmacology, University of Texas Southwestern Medical Center at Dallas, 6001 Forest Park, Dallas, TX 75390 9041, USA
    Structure 15:1431-41. 2007

Collaborators

  • Andras Fiser
  • Kamil Khafizov
  • Hamid Mirzaei
  • Kosaku Uyeda
  • Tsutomu Nakagawa
  • Katherine E Süel
  • Darui Xu
  • Zi Chao Zhang
  • Ahmet E Cansizoglu
  • Xiuhua Dong
  • Brittany J Lee
  • Michael Soniat
  • Qingxiang Sun
  • Garen Collett
  • Nick V Grishin
  • Qiang Ge
  • Alicia Farmer
  • Anindita Biswas
  • Beatriz M A Fontoura
  • Hongmei Gu
  • Brandan Hillerich
  • P Rajesh Kumar
  • Yazmin P Carrasco
  • Jeffery B Bonanno
  • Anthony S Gizzi
  • James D Love
  • Youcai Hu
  • Sukanya Chowdhury
  • Bridget Matikainen
  • Rahul C Bhosle
  • Ronald D Seidel
  • Xiaofeng Guo
  • Radhika N Banu
  • Alan S Glenn
  • Swetha Chamala
  • John MacMillan
  • Steven C Almo
  • Parthasarathy Sampathkumar
  • James Hammonds
  • Rafael Toro
  • Bonnie C Miller
  • Neal Satterly
  • R Max Wynn
  • Rita Martinez
  • Laurie K Jackson
  • Zichao Zhang
  • Thomas H Louis

Detail Information

Publications17

  1. pmc Nuclear import by karyopherin-βs: recognition and inhibition
    Yuh Min Chook
    Department of Pharmacology, University of Texas Southerwestern Medical Center, Dallas, TX 75206, USA
    Biochim Biophys Acta 1813:1593-606. 2011
    ..This article is part of a Special Issue entitled: Regulation of Signaling and Cellular Fate through Modulation of Nuclear Protein Import...
  2. pmc Sequence and structural analyses of nuclear export signals in the NESdb database
    Darui Xu
    Department of Pharmacology, University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390, USA
    Mol Biol Cell 23:3677-93. 2012
    ..Finally, we also tested CRM1-binding of 40 NESs that were found in the 56 structures. We found that 16 of the NES peptides did not bind CRM1, hence illustrating how NESs are easily misidentified...
  3. pmc Structural basis for assembly and disassembly of the CRM1 nuclear export complex
    Xiuhua Dong
    Department of Pharmacology, University of Texas Southwestern Medical Center at Dallas, USA
    Nat Struct Mol Biol 16:558-60. 2009
    ..Here we provide a model for human CRM1 export complex assembly and disassembly through structural and biochemical analyses of CRM1 bound to the substrate snurportin 1 (SNUPN, also called snuportin 1)...
  4. pmc Structural basis for leucine-rich nuclear export signal recognition by CRM1
    Xiuhua Dong
    Department of Pharmacology, University of Texas Southwestern Medical Center at Dallas, 6001 Forest Park, Dallas, Texas 75390 9041, USA
    Nature 458:1136-41. 2009
    ..Similar energetic construction is also used in multipartite nuclear localization signals to provide broad substrate specificity and rapid evolution in nuclear transport...
  5. pmc Atomic resolution structures in nuclear transport
    Katherine E Süel
    Department of Pharmacology, University of Texas Southwestern Medical Center at Dallas, 6001 Forest Park, Dallas, TX 75390 9041, USA
    Methods 39:342-55. 2006
    ..This paper catalogs 53 crystal and NMR structures of nuclear transport proteins, with the emphasis on providing information useful for mutagenesis and overexpression of recombinant proteins...
  6. pmc Structural and energetic basis of ALS-causing mutations in the atypical proline-tyrosine nuclear localization signal of the Fused in Sarcoma protein (FUS)
    Zi Chao Zhang
    Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Proc Natl Acad Sci U S A 109:12017-21. 2012
    ..5 nM) up to ninefold. Thermodynamic analyses of ALS mutations in the FUS PY-NLS show that the weakening of FUS-Kapβ2 binding affinity, the degree of cytoplasmic mislocalization, and ALS disease severity are correlated...
  7. pmc Kap104p imports the PY-NLS-containing transcription factor Tfg2p into the nucleus
    Katherine E Süel
    Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    J Biol Chem 284:15416-24. 2009
    ..More generally, steady-state localization of a nuclear protein is dictated by its nuclear import and export activities as well as its interactions in the nucleus and the cytoplasm...
  8. pmc Modular organization and combinatorial energetics of proline-tyrosine nuclear localization signals
    Katherine E Süel
    Department of Pharmacology, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas, United States of America
    PLoS Biol 6:e137. 2008
    ..The modular organization of the PY-NLS coupled with its combinatorial energetics lays a path to decode this diverse and evolvable signal for future comprehensive genome-scale identification of nuclear import substrates...
  9. pmc Evolutionary development of redundant nuclear localization signals in the mRNA export factor NXF1
    Zi Chao Zhang
    Department of Pharmacology, University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390 9041, USA
    Mol Biol Cell 22:4657-68. 2011
    ....
  10. pmc Conformational heterogeneity of karyopherin beta2 is segmental
    Ahmet E Cansizoglu
    Department of Pharmacology, University of Texas Southwestern Medical Center at Dallas, 6001 Forest Park, Dallas, TX 75390 9041, USA
    Structure 15:1431-41. 2007
    ..An analogous segmental architecture is also observed in Importin beta, suggesting that it is functionally significant and may be conserved in other import karyopherins...
  11. pmc Structure-based design of a pathway-specific nuclear import inhibitor
    Ahmet E Cansizoglu
    Department of Pharmacology, University of Texas Southwestern Medical Center at Dallas, 6001 Forest Park, Dallas, Texas 75390 9041, USA
    Nat Struct Mol Biol 14:452-4. 2007
    ..On the basis of these data and complementary biochemical analyses, we designed a Kapbeta2-specific nuclear import inhibitor, M9M...
  12. pmc NESdb: a database of NES-containing CRM1 cargoes
    Darui Xu
    Department of Pharmacology, University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390, USA
    Mol Biol Cell 23:3673-6. 2012
    ..NESdb will be updated regularly and will serve as an important resource for nuclear export signals. NESdb is freely available to nonprofit organizations at http://prodata.swmed.edu/LRNes...
  13. pmc Importin-alpha protein binding to a nuclear localization signal of carbohydrate response element-binding protein (ChREBP)
    Qiang Ge
    Department of Biochemistry, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390, USA
    J Biol Chem 286:28119-27. 2011
    ....
  14. pmc Recognition of nuclear targeting signals by Karyopherin-β proteins
    Darui Xu
    Department of Pharmacology, University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390 9041, USA
    Curr Opin Struct Biol 20:782-90. 2010
    ..We review recent findings relating to how these three classes of nuclear targeting signals are recognized by their Karyopherin-β nuclear transport factors...
  15. pmc Nuclear export inhibition through covalent conjugation and hydrolysis of Leptomycin B by CRM1
    Qingxiang Sun
    Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, TX 75390 9041, USA
    Proc Natl Acad Sci U S A 110:1303-8. 2013
    ..The nuclear export signal (NES)-binding groove of CRM1 is able to drive a chemical reaction in addition to binding protein cargoes for transport through the nuclear pore complex...
  16. pmc Crystal structure of human Karyopherin β2 bound to the PY-NLS of Saccharomyces cerevisiae Nab2
    Michael Soniat
    Department of Pharmacology, University of Texas Southwestern, Dallas, TX 75390, USA
    J Struct Funct Genomics 14:31-5. 2013
    ..05-Å resolution. A seven-residue segment of the PY-NLS of Nab2 is observed to bind Kapβ2 in an extended conformation and occupies the same PY-NLS binding site observed in other Kapβ2·PY-NLS structures...
  17. pmc Rules for nuclear localization sequence recognition by karyopherin beta 2
    Brittany J Lee
    Department of Pharmacology, University of Texas Southwestern Medical Center at Dallas, 6001 Forest Park, Dallas, TX 75390, USA
    Cell 126:543-58. 2006
    ..These studies define and validate a new NLS that could not be predicted by primary sequence analysis alone...