Seok Ki Choi

Summary

Affiliation: University of Michigan
Country: USA

Publications

  1. pmc Design and in vitro validation of multivalent dendrimer methotrexates as a folate-targeting anticancer therapeutic
    Thommey P Thomas
    Department of Internal Medicine, Michigan Nanotechnology Institute for Medicine and Biological Sciences, USA
    Curr Pharm Des 19:6594-605. 2013
  2. doi request reprint Dendrimer-based multivalent vancomycin nanoplatform for targeting the drug-resistant bacterial surface
    Seok Ki Choi
    Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan 48109, USA
    ACS Nano 7:214-28. 2013
  3. doi request reprint Photochemical release of methotrexate from folate receptor-targeting PAMAM dendrimer nanoconjugate
    Seok Ki Choi
    Michigan Nanotechnology Institute for Medicine and Biological Sciences, University of Michigan, Ann Arbor, MI 48109, USA
    Photochem Photobiol Sci 11:653-60. 2012
  4. pmc A photochemical approach for controlled drug release in targeted drug delivery
    Seok Ki Choi
    Michigan Nanotechnology Institute for Medicine and Biological Sciences, University of Michigan, Ann Arbor, MI 48109, USA
    Bioorg Med Chem 20:1281-90. 2012
  5. pmc Light-controlled release of caged doxorubicin from folate receptor-targeting PAMAM dendrimer nanoconjugate
    Seok Ki Choi
    Michigan Nanotechnology Institute for Medicine and Biological Sciences, University of Michigan, Medical School, Ann Arbor, MI 48109, USA
    Chem Commun (Camb) 46:2632-4. 2010
  6. pmc Avidity modulation of folate-targeted multivalent dendrimers for evaluating biophysical models of cancer targeting nanoparticles
    Justin E Silpe
    Michigan Nanotechnology Institute for Medicine and Biological Sciences, Macromolecular Science and Engineering, Program in Biomedical Sciences, Department of Internal Medicine, Department of Chemistry, and Department of Physics, University of Michigan, Ann Arbor, Michigan 48109, United States
    ACS Chem Biol 8:2063-71. 2013
  7. ncbi request reprint Polyvalent dendrimer-methotrexate as a folate receptor-targeted cancer therapeutic
    Thommey P Thomas
    Michigan Nanotechnology Institute for Medicine and Biological Sciences, Ann Arbor, Michigan 48109, United States
    Mol Pharm 9:2669-76. 2012
  8. pmc Dendrimer-based multivalent methotrexates as dual acting nanoconjugates for cancer cell targeting
    Ming Hsin Li
    Michigan Nanotechnology Institute for Medicine and Biological Sciences, and Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48109, USA
    Eur J Med Chem 47:560-72. 2012
  9. pmc Paclitaxel-conjugated PAMAM dendrimers adversely affect microtubule structure through two independent modes of action
    Erika N Cline
    Cellular and Molecular Biology Graduate Program, University of Michigan, Ann Arbor, MI 48109, USA
    Biomacromolecules 14:654-64. 2013
  10. pmc Design of riboflavin-presenting PAMAM dendrimers as a new nanoplatform for cancer-targeted delivery
    Thommey P Thomas
    Michigan Nanotechnology Institute for Medicine and Biological Sciences, Department of Internal Medicine, Division of Allergy, University of Michigan, Ann Arbor, MI 48109, USA
    Bioorg Med Chem Lett 20:5191-4. 2010

Collaborators

  • Mark M Banaszak Holl
  • Andrzej Myc
  • Thommey P Thomas
  • Ming Hsin Li
  • James R Baker
  • Justin E Silpe
  • Alina Kotlyar
  • Mallory A van Dongen
  • Mark M Banaszak Holl
  • Bradford G Orr
  • Ronald G Larson
  • Erika N Cline
  • Madhuresh Sumit
  • Shi Yu
  • Melvin Joice
  • Baohua Huang
  • Ananda Kumar Kanduluru
  • Philip S Low
  • Casey A Dougherty
  • Pascale R Leroueil
  • Nils G Walter
  • Sophia Bharathi
  • Jeffrey F Herbstman
  • Edgar Meyhofer
  • Jolanta Kukowska-Latallo
  • Georgios Skiniotis
  • Neha Kaul
  • Ankur M Desai
  • Hong Zong
  • Jeremy Gam
  • Kyung Hoon Lee
  • Ankur Desai

Detail Information

Publications14

  1. pmc Design and in vitro validation of multivalent dendrimer methotrexates as a folate-targeting anticancer therapeutic
    Thommey P Thomas
    Department of Internal Medicine, Michigan Nanotechnology Institute for Medicine and Biological Sciences, USA
    Curr Pharm Des 19:6594-605. 2013
    ..This study identifies the combination of an optimal linker framework and multivalency as the two key design elements that contribute to achieving potent dual activity. ..
  2. doi request reprint Dendrimer-based multivalent vancomycin nanoplatform for targeting the drug-resistant bacterial surface
    Seok Ki Choi
    Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan 48109, USA
    ACS Nano 7:214-28. 2013
    ....
  3. doi request reprint Photochemical release of methotrexate from folate receptor-targeting PAMAM dendrimer nanoconjugate
    Seok Ki Choi
    Michigan Nanotechnology Institute for Medicine and Biological Sciences, University of Michigan, Ann Arbor, MI 48109, USA
    Photochem Photobiol Sci 11:653-60. 2012
    ....
  4. pmc A photochemical approach for controlled drug release in targeted drug delivery
    Seok Ki Choi
    Michigan Nanotechnology Institute for Medicine and Biological Sciences, University of Michigan, Ann Arbor, MI 48109, USA
    Bioorg Med Chem 20:1281-90. 2012
    ..The rate of the drug release varies in response to multiple control parameters, including linker design, light wavelength, exposure time, and the pH of the medium where the drug release occurs...
  5. pmc Light-controlled release of caged doxorubicin from folate receptor-targeting PAMAM dendrimer nanoconjugate
    Seok Ki Choi
    Michigan Nanotechnology Institute for Medicine and Biological Sciences, University of Michigan, Medical School, Ann Arbor, MI 48109, USA
    Chem Commun (Camb) 46:2632-4. 2010
    ..We report the synthesis and in vitro evaluation of folate receptor-targeted nanoconjugate that releases its therapeutic payload via a photochemical mechanism...
  6. pmc Avidity modulation of folate-targeted multivalent dendrimers for evaluating biophysical models of cancer targeting nanoparticles
    Justin E Silpe
    Michigan Nanotechnology Institute for Medicine and Biological Sciences, Macromolecular Science and Engineering, Program in Biomedical Sciences, Department of Internal Medicine, Department of Chemistry, and Department of Physics, University of Michigan, Ann Arbor, Michigan 48109, United States
    ACS Chem Biol 8:2063-71. 2013
    ..We believe this study provides experimental evidence supportive of the mechanistic hypothesis of multivalent NP uptake to a cancer cell over a healthy cell where the diseased cell expresses the folate receptor at higher density. ..
  7. ncbi request reprint Polyvalent dendrimer-methotrexate as a folate receptor-targeted cancer therapeutic
    Thommey P Thomas
    Michigan Nanotechnology Institute for Medicine and Biological Sciences, Ann Arbor, Michigan 48109, United States
    Mol Pharm 9:2669-76. 2012
    ..The newly synthesized G5-MTX(n) conjugate may serve as a FR-targeted chemotherapeutic with potential for cancer therapy...
  8. pmc Dendrimer-based multivalent methotrexates as dual acting nanoconjugates for cancer cell targeting
    Ming Hsin Li
    Michigan Nanotechnology Institute for Medicine and Biological Sciences, and Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48109, USA
    Eur J Med Chem 47:560-72. 2012
    ....
  9. pmc Paclitaxel-conjugated PAMAM dendrimers adversely affect microtubule structure through two independent modes of action
    Erika N Cline
    Cellular and Molecular Biology Graduate Program, University of Michigan, Ann Arbor, MI 48109, USA
    Biomacromolecules 14:654-64. 2013
    ..Our results provide mechanistic insights into the cytotoxicity of paclitaxel-conjugated PAMAM dendrimers and uncover unexpected risks of using such conjugates therapeutically...
  10. pmc Design of riboflavin-presenting PAMAM dendrimers as a new nanoplatform for cancer-targeted delivery
    Thommey P Thomas
    Michigan Nanotechnology Institute for Medicine and Biological Sciences, Department of Internal Medicine, Division of Allergy, University of Michigan, Ann Arbor, MI 48109, USA
    Bioorg Med Chem Lett 20:5191-4. 2010
    ....
  11. pmc Avidity mechanism of dendrimer-folic Acid conjugates
    Mallory A van Dongen
    Department of Chemistry and Department of Physics, Program in Macromolecular Sciences and Engineering, and Michigan Nanotechnology Institute for Medicine and Biological Sciences, University of Michigan, Ann Arbor, Michigan 48019, United States
    Mol Pharm 11:1696-706. 2014
    ..The increased avidity is due to a folate-keyed interaction between the dendrimer and protein surfaces that fits into the general framework of slow-onset, tight-binding mechanisms of ligand/protein interactions. ..
  12. doi request reprint Specific and cooperative interactions between oximes and PAMAM dendrimers as demonstrated by (1)H NMR study
    Seok Ki Choi
    Department of Internal Medicine, Michigan Nanotechnology Institute for Medicine and Biological Sciences, Department of Biomedical Engineering, and Department of Anesthesiology, University of Michigan, Ann Arbor, Michigan 48109, United States
    J Phys Chem B 116:10387-97. 2012
    ..Third, individual binding events between oximes and a dendrimer have a negative cooperative effect on subsequent oxime binding. In summary, this report provides a novel perspective important for designing host systems for drug delivery. ..
  13. doi request reprint DNA condensation by partially acetylated poly(amido amine) dendrimers: effects of dendrimer charge density on complex formation
    Shi Yu
    Department of Chemical Engineering, University of Michigan, Ann Arbor, MI 48109, USA
    Molecules 18:10707-20. 2013
    ....
  14. ncbi request reprint Evaluating binding avidities of populations of heterogeneous multivalent ligand-functionalized nanoparticles
    Ming Hsin Li
    Department of Biomedical Engineering, University of Michigan, Ann Arbor, Michigan 48109, United States
    ACS Nano 8:5600-9. 2014
    ..These analyses allowed an assessment of how avidity distributions are modulated by the number of functionalized ligands and suggested that there are threshold valences that differentiated fast- and slow-dissociation nanoparticles. ..