In Young Choi

Summary

Affiliation: University of Kansas Medical Center
Country: USA

Publications

  1. pmc Doubly selective multiple quantum chemical shift imaging and T(1) relaxation time measurement of glutathione (GSH) in the human brain in vivo
    In Young Choi
    Hoglund Brain Imaging Center, University of Kansas Medical Center, Kansas City, KS 66160, USA
    NMR Biomed 26:28-34. 2013
  2. ncbi request reprint In vivo detection of gray and white matter differences in GABA concentration in the human brain
    In Young Choi
    The Nathan Kline Institute, Medical Physics, Orangeburg, NY 10962, USA
    Neuroimage 33:85-93. 2006
  3. pmc Lower levels of glutathione in the brains of secondary progressive multiple sclerosis patients measured by 1H magnetic resonance chemical shift imaging at 3 T
    I Y Choi
    Hoglund Brain Imaging Center, Department of Neurology, University of Kansas Medical Center, Kansas City, KS 66160, USA
    Mult Scler 17:289-96. 2011
  4. pmc Effects of acute and chronic hyperglycemia on the neurochemical profiles in the rat brain with streptozotocin-induced diabetes detected using in vivo ¹H MR spectroscopy at 9.4 T
    Wen Tung Wang
    Hoglund Brain Imaging Center, University of Kansas Medical Center, Kansas City, Kansas, USA
    J Neurochem 121:407-17. 2012
  5. pmc Neuronal-glial alterations in non-primary motor areas in chronic subcortical stroke
    Carmen M Cirstea
    Hoglund Brain Imaging Center, University of Kansas Medical Center, Kansas City 66160, USA
    Brain Res 1463:75-84. 2012
  6. pmc Altered neurochemical profile after traumatic brain injury: (1)H-MRS biomarkers of pathological mechanisms
    Janna L Harris
    Hoglund Brain Imaging Center, University of Kansas Medical Center, Kansas City, Kansas 66160, USA
    J Cereb Blood Flow Metab 32:2122-34. 2012
  7. ncbi request reprint Single-shot two-echo technique for simultaneous measurement of GABA and creatine in the human brain in vivo
    In Young Choi
    Nathan Kline Institute, Medical Physics, Orangeburg, New York 10962, USA
    Magn Reson Med 51:1115-21. 2004
  8. ncbi request reprint In vivo single-shot three-dimensionally localized multiple quantum spectroscopy of GABA in the human brain with improved spectral selectivity
    In Young Choi
    The Nathan Kline Institute, Medical Physics, Orangeburg, NY 10962, USA
    J Magn Reson 172:9-16. 2005
  9. doi request reprint Motor and premotor cortices in subcortical stroke: proton magnetic resonance spectroscopy measures and arm motor impairment
    Sorin C Craciunas
    1University of Kansas Medical Center, Kansas City, KS, USA
    Neurorehabil Neural Repair 27:411-20. 2013
  10. ncbi request reprint Selective homonuclear Hartmann-Hahn transfer method for in vivo spectral editing in the human brain
    In Young Choi
    Medical Physics, Nathan Kline Institute, 140 Old Orangeburg Road, Orangeburg, NY 10962, USA
    Magn Reson Med 53:503-10. 2005

Research Grants

Collaborators

Detail Information

Publications21

  1. pmc Doubly selective multiple quantum chemical shift imaging and T(1) relaxation time measurement of glutathione (GSH) in the human brain in vivo
    In Young Choi
    Hoglund Brain Imaging Center, University of Kansas Medical Center, Kansas City, KS 66160, USA
    NMR Biomed 26:28-34. 2013
    ..This GSH-CSI method permits us to address regional differences of GSH in the human brain under conditions where oxidative stress has been implicated, including multiple sclerosis, aging and neurodegenerative diseases...
  2. ncbi request reprint In vivo detection of gray and white matter differences in GABA concentration in the human brain
    In Young Choi
    The Nathan Kline Institute, Medical Physics, Orangeburg, NY 10962, USA
    Neuroimage 33:85-93. 2006
    ..30+/-0.36 micromol/g and 0.16+/-0.16 micromol/g (mean+/-SD, n=13), respectively. It is expected that this method will become a useful tool for studying GABAergic function in the human brain in vivo...
  3. pmc Lower levels of glutathione in the brains of secondary progressive multiple sclerosis patients measured by 1H magnetic resonance chemical shift imaging at 3 T
    I Y Choi
    Hoglund Brain Imaging Center, Department of Neurology, University of Kansas Medical Center, Kansas City, KS 66160, USA
    Mult Scler 17:289-96. 2011
    ....
  4. pmc Effects of acute and chronic hyperglycemia on the neurochemical profiles in the rat brain with streptozotocin-induced diabetes detected using in vivo ¹H MR spectroscopy at 9.4 T
    Wen Tung Wang
    Hoglund Brain Imaging Center, University of Kansas Medical Center, Kansas City, Kansas, USA
    J Neurochem 121:407-17. 2012
    ....
  5. pmc Neuronal-glial alterations in non-primary motor areas in chronic subcortical stroke
    Carmen M Cirstea
    Hoglund Brain Imaging Center, University of Kansas Medical Center, Kansas City 66160, USA
    Brain Res 1463:75-84. 2012
    ..Ipsilesional alterations were related to proximal arm motor impairment. Our results suggest the involvement of these areas in post-stroke reorganization...
  6. pmc Altered neurochemical profile after traumatic brain injury: (1)H-MRS biomarkers of pathological mechanisms
    Janna L Harris
    Hoglund Brain Imaging Center, University of Kansas Medical Center, Kansas City, Kansas 66160, USA
    J Cereb Blood Flow Metab 32:2122-34. 2012
    ..Our results support the utility of (1)H-MRS for monitoring cellular mechanisms of TBI pathology in animal models, and the potential of this approach for preclinical evaluation of novel therapies...
  7. ncbi request reprint Single-shot two-echo technique for simultaneous measurement of GABA and creatine in the human brain in vivo
    In Young Choi
    Nathan Kline Institute, Medical Physics, Orangeburg, New York 10962, USA
    Magn Reson Med 51:1115-21. 2004
    ..69 +/- 0.18 micromol/g (mean +/- SD, N = 17) with the external reference method. The observed pattern of GABA doublet was consistent among all subjects, with a frequency separation of approximately 13 Hz...
  8. ncbi request reprint In vivo single-shot three-dimensionally localized multiple quantum spectroscopy of GABA in the human brain with improved spectral selectivity
    In Young Choi
    The Nathan Kline Institute, Medical Physics, Orangeburg, NY 10962, USA
    J Magn Reson 172:9-16. 2005
    ..The concentration of GABA was measured to be 0.7 +/- 0.2 micromol/g (means +/- SD, n = 15) in the fronto-parietal region of the human brain in vivo...
  9. doi request reprint Motor and premotor cortices in subcortical stroke: proton magnetic resonance spectroscopy measures and arm motor impairment
    Sorin C Craciunas
    1University of Kansas Medical Center, Kansas City, KS, USA
    Neurorehabil Neural Repair 27:411-20. 2013
    ..Although functional imaging and neurophysiological approaches reveal alterations in motor and premotor areas after stroke, insights into neurobiological events underlying these alterations are limited in human studies...
  10. ncbi request reprint Selective homonuclear Hartmann-Hahn transfer method for in vivo spectral editing in the human brain
    In Young Choi
    Medical Physics, Nathan Kline Institute, 140 Old Orangeburg Road, Orangeburg, NY 10962, USA
    Magn Reson Med 53:503-10. 2005
    ..The estimated concentration of GABA in the frontoparietal region of the human brain in vivo was 0.7 +/- 0.2 mumol/g (mean +/- SD, n = 12)...
  11. pmc Primary motor cortex in stroke: a functional MRI-guided proton MR spectroscopic study
    Carmen M Cirstea
    Hoglund Brain Imaging Center, University of Kansas Medical Center, 3901 Rainbow Boulevard, Mail Stop 1052, Kansas City, KS 66160, USA
    Stroke 42:1004-9. 2011
    ....
  12. pmc Iron deposition is independent of cellular inflammation in a cerebral model of multiple sclerosis
    Rachel Williams
    Department of Molecular and Integrative Physiology, University of Kansas Medical Center, Kansas City, KS 66160, USA
    BMC Neurosci 12:59. 2011
    ..This model was used to investigate the relationship of iron deposition to inflammation...
  13. pmc Dynamic or inert metabolism? Turnover of N-acetyl aspartate and glutathione from D-[1-13C]glucose in the rat brain in vivo
    In Young Choi
    The Nathan Kline Institute, Medical Physics, Orangeburg, New York 10962, USA
    J Neurochem 91:778-87. 2004
    ..8 micromol/g, comparable to the cortical glutathione concentration. We conclude that NAA and GSH are completely turned over and that the metabolism is extremely slow (< 0.05% of the glucose metabolic rate)...
  14. ncbi request reprint In vivo NMR studies of neurodegenerative diseases in transgenic and rodent models
    In Young Choi
    The Nathan S Kline Institute, Center for Advanced Brain Imaging, Orangeburg, New York 10962, USA
    Neurochem Res 28:987-1001. 2003
    ..Enhanced MR measurable neurochemical parameters in vivo are described in regard to their importance in neurodegenerative disorders and their investigation into the metabolic alterations accompanying the pathogenesis of neurodegeneration...
  15. pmc Alternate day fasting impacts the brain insulin-signaling pathway of young adult male C57BL/6 mice
    Jianghua Lu
    Department of Neurology, University of Kansas Medical Center, Kansas City, Kansas, USA
    J Neurochem 117:154-63. 2011
    ..Our data indicate in young adult male C57BL/6 mice, RFR primarily affects brain energy metabolism by reducing brain insulin signaling, which potentially results indirectly as a consequence of reduced peripheral insulin production...
  16. pmc Quantitative in vivo measurement of early axonal transport deficits in a triple transgenic mouse model of Alzheimer's disease using manganese-enhanced MRI
    Jieun Kim
    Hoglund Brain Imaging Center, University of Kansas Medical Center, Kansas City, KS 66160, USA
    Neuroimage 56:1286-92. 2011
    ..The data show that impairment in axonal transport is a very early event in AD pathology in these mice, preceding both deposition of Aβ plaques and formation of Tau fibrils...
  17. ncbi request reprint A new strategy for in vivo spectral editing. Application to GABA editing using selective homonuclear polarization transfer spectroscopy
    Jun Shen
    Molecular Imaging Branch, National Institute of Mental Health, Building 10, Room 2D51A, 9000 Rockville Pike, Bethesda, MD 20892 1527, USA
    J Magn Reson 170:290-8. 2004
    ..This new method has been demonstrated for robust in vivo GABA editing in the rat brain and for study of GABA synthesis after acute vigabatrin administration...
  18. pmc Localized in vivo 13C NMR spectroscopy of the brain
    Rolf Gruetter
    Department of Radiology, Center for MR Research, University of Minnesota, 2021 6th Street SE, Minneapolis, MN 55455, USA
    NMR Biomed 16:313-38. 2003
    ..We conclude that the unique and novel insights provided by (13)C NMR spectroscopy have opened many new research areas that are likely to improve the understanding of brain carbohydrate metabolism in health and disease...
  19. ncbi request reprint In vivo 13C NMR assessment of brain glycogen concentration and turnover in the awake rat
    In Young Choi
    Department of Radiology, Center for Magnetic Resonance Research, University of Minnesota Medical School, 2021 6th Street SE, Minneapolis, MN 55455, USA
    Neurochem Int 43:317-22. 2003
    ..Absolute quantification of the total concentration of brain glycogen in the awake, normoglycemic rat yielded 3.3+/-0.8 micromol/g (n=6, mean+/-S.D.)...
  20. pmc Effect of hypoglycemia on brain glycogen metabolism in vivo
    In Young Choi
    Department of Radiology, Center for Magnetic Resonance Research, University of Minnesota Medical School, Minneapolis, Minnesota 55455, USA
    J Neurosci Res 72:25-32. 2003
    ....
  21. ncbi request reprint Elucidation of the role of fructose 2,6-bisphosphate in the regulation of glucose fluxes in mice using in vivo (13)C NMR measurements of hepatic carbohydrate metabolism
    In Young Choi
    Departments of RadiologyBiochemistry, Molecular Biology and Biophysics Neuroscience University of Minnesota Medical School, Minneapolis, MN 55455, USA
    Eur J Biochem 269:4418-26. 2002
    ..These observations provide a key to understanding the mechanisms by which elevated hepatic Fru-2,6-P2 levels promote reduced hepatic glucose production and lower blood glucose in diabetes mellitus...

Research Grants3

  1. Quantitative measure of oxidative stress in human brain
    In Young Choi; Fiscal Year: 2003
    ..abstract_text> ..
  2. MULTIPLE QUANTUM CHEMICAL SHIFT IMAGING OF GABA IN BRAIN
    In Young Choi; Fiscal Year: 2003
    ..IT and 4T. The overall goal of this proposal is to develop SI of GABA concentration and synthesis rate into a robust method for clinical research into the role of GABA metabolism in normal brain function and in disease. ..