Research Topics
Genomes and Genes | Hack Sun ChoiSummaryAffiliation: University of Minnesota Country: USA Publications
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Publications
A novel flavin-containing monooxygenase from Methylophaga sp strain SK1 and its indigo synthesis in Escherichia coliHack Sun Choi
Research Center for Proteineous Materials, Chosun University, Gwangju 501-759, Republic of Korea
Biochem Biophys Res Commun 306:930-6. 2003..This suggests that the recombinant strain has a potential to be applied in microbial indigo production...- A proteomics approach for identification of single strand DNA-binding proteins involved in transcriptional regulation of mouse mu opioid receptor geneHack Sun Choi
Department of Pharmacology, University of Minnesota Medical School, Minneapolis, Minnesota 55455, USA
Mol Cell Proteomics 7:1517-29. 2008..We demonstrate novel roles as transcriptional regulators in Oprm1 regulation for hnRNP K and alphaCP binding to the single strand DNA element... - Novel function of the poly(C)-binding protein alpha CP3 as a transcriptional repressor of the mu opioid receptor geneHack Sun Choi
Department of Pharmacology, University of Minnesota Medical School, 6 120 Jackson Hall, 321 Church St SE, Minneapolis, MN 55455, USA
FASEB J 21:3963-73. 2007..Our data suggest that alphaCP3 can function as a repressor of MOR transcription dependent on the MOR poly(C) sequence. We demonstrate for the first time a role of alphaCP3 as a transcriptional repressor in MOR gene regulation... - The opioid ligand binding of human mu-opioid receptor is modulated by novel splice variants of the receptorHack Sun Choi
Department of Pharmacology, Medical School, University of Minnesota, Minneapolis, MN 55455, USA
Biochem Biophys Res Commun 343:1132-40. 2006..In NMB cells expressing human MOR gene, transfection of SV1 or SV2 reduced binding activity of the endogenous MOR. These data support a potential role of SV1 and SV2 proteins as possible biological modulator of human mu-opioid receptor... - Poly(C)-binding proteins as transcriptional regulators of gene expressionHack Sun Choi
Department of Pharmacology, University of Minnesota Medical School, 6 120 Jackson Hall, 321 Church Street SE, Minneapolis, MN 55455, USA
Biochem Biophys Res Commun 380:431-6. 2009..PCBPs can function as a signal-dependent and coordinated regulator of transcription in eukaryotic cells. We address the molecular mechanisms by which PCBPs binding to single- and double-stranded DNA mediates gene expression... - Transcriptional regulation of mouse mu opioid receptor gene: Sp3 isoforms (M1, M2) function as repressors in neuronal cells to regulate the mu opioid receptor geneHack Sun Choi
Department of Pharmacology, University of Minnesota Medical School, Minneapolis, 55455, USA
Mol Pharmacol 67:1674-83. 2005..These results suggest that the binding of the M1 and M2 isoforms of the Sp3 transcription factor to the Sp binding sequence may play a role in mouse MOR gene expression... - Transcriptional regulation of mouse mu opioid receptor gene in neuronal cells by poly(ADP-ribose) polymerase-1Hack Sun Choi
Department of Pharmacology, University of Minnesota Medical School, Minneapolis, Minnesota 55455, USA
J Cell Mol Med 12:2319-33. 2008..Our data suggest that PARP-1 can function as a repressor of MOR transcription dependent on the MOR poly(C) sequence. We demonstrate for the first time a role of PARP-1 as a transcriptional repressor in MOR gene regulation... - Neuron-restrictive silencer factor (NRSF) functions as a repressor in neuronal cells to regulate the mu opioid receptor geneChun Sung Kim
Department of Pharmacology, University of Minnesota Medical School, Minneapolis, Minnesota 55455, USA
J Biol Chem 279:46464-73. 2004..Our data suggested that NRSF can function as a repressor of MOR transcription in specific cells, via a mechanism dependent on the MOR NRSE... - Evidence of the neuron-restrictive silencer factor (NRSF) interaction with Sp3 and its synergic repression to the mu opioid receptor (MOR) geneChun Sung Kim
Department of Pharmacology, University of Minnesota Medical School, 6 120 Jackson Hall, 321 Church Street SE, Minneapolis, MN 55455, USA
Nucleic Acids Res 34:6392-403. 2006.... - Novel function of neuron-restrictive silencer factor (NRSF) for posttranscriptional regulationChun Sung Kim
Department of Pharmacology, University of Minnesota Medical School, Minneapolis, Minnesota 55455, USA
Biochim Biophys Acta 1783:1835-46. 2008..We report here a novel function of NRSF that enhance the translation of the mu opioid receptor (MOR) gene through its RNA binding sequence, the neuron-restrictive silencer element (NRSE)... - uAUG-mediated translational initiations are responsible for human mu opioid receptor gene expressionKyu Young Song
Department of Pharmacology, University of Minnesota Medical School, Minneapolis, MN 55455, USA
J Cell Mol Med 14:1113-24. 2010..This re-initiation resulted in negative expression of OPRM1 under normal conditions. These results indicate that re-initiation in MOR gene expression could play an important role in OPRM1 regulation... - Evidence of endogenous mu opioid receptor regulation by epigenetic control of the promotersCheol Kyu Hwang
Department of Pharmacology, University of Minnesota, 6 120 Jackson Hall, 321 Church St S E, Minneapolis, MN 55455, USA
Mol Cell Biol 27:4720-36. 2007..Here, we propose that an epigenetic mechanism consisting of DNA methylation and chromatin modification underlies the cell stage-specific mechanism of MOR gene expression... - Epigenetic programming of mu-opioid receptor gene in mouse brain is regulated by MeCP2 and Brg1 chromatin remodelling factorCheol Kyu Hwang
Department of Pharmacology, University of Minnesota Medical School, Minneapolis, MN, USA
J Cell Mol Med 13:3591-615. 2009..We conclude that MOR gene expression is epigenetically programmed in various brain regions and that MeCP2 assists the epigenetic program during DNA methylation and chromatin remodelling of the MOR promoter... - Poly(C) binding protein family is a transcription factor in mu-opioid receptor gene expressionSung Su Kim
Department of Pharmacology, University of Minnesota Medical School, 6 120 Jackson Hall, 321 Church St SE, Minneapolis, MN 55455, USA
Mol Pharmacol 68:729-36. 2005..Chromatin immunoprecipitation assay confirmed the interaction of PCBPs with MOR promoter in vivo. In conclusion, we demonstrate that PCBPs act as a transcription factor and positively regulate MOR gene expression in NMB cells... - Differential use of an in-frame translation initiation codon regulates human mu opioid receptor (OPRM1)Kyu Young Song
Department of Pharmacology, University of Minnesota Medical School, Minneapolis, MN 55455, USA
Cell Mol Life Sci 66:2933-42. 2009..The data suggest that MOP expression is controlled in part by initiation of the long form of MOP at the alternate site... - Translational repression of mouse mu opioid receptor expression via leaky scanningKyu Young Song
Department of Pharmacology, University of Minnesota Medical School, Minneapolis, Minnesota 55455, USA
Nucleic Acids Res 35:1501-13. 2007..These results support the hypothesis that uORFs in mouse MOR mRNA act as negative regulators through a ribosome leaky scanning mechanism. Such leaky scanning resulted in the suppression of mouse MOR under normal conditions... - Transcriptional regulation of mouse mu opioid receptor gene by PU.1Cheol Kyu Hwang
Department of Pharmacology, University of Minnesota Medical School, 6 120 Jackson Hall, 321 Church Street SE, Minneapolis, MN 55455, USA
J Biol Chem 279:19764-74. 2004..1-mediated repression of MOR promoter activity after trichostatin A treatment in neuroblastoma NMB cells. Our results suggest that PU.1 may be an important regulator of the MOR gene, particularly in brain and immune cells... - Post-transcriptional regulation of mu-opioid receptor: role of the RNA-binding proteins heterogeneous nuclear ribonucleoprotein H1 and FKyu Young Song
Department of Pharmacology, University of Minnesota Medical School, Minneapolis, MN 55455, USA
Cell Mol Life Sci 69:599-610. 2012..We demonstrate for the first time a role of hnRNPs as post-transcriptional repressors in MOR gene regulation...