Hack Sun Choi

Summary

Affiliation: University of Minnesota
Country: USA

Publications

  1. ncbi A novel flavin-containing monooxygenase from Methylophaga sp strain SK1 and its indigo synthesis in Escherichia coli
    Hack Sun Choi
    Research Center for Proteineous Materials, Chosun University, Gwangju 501 759, Republic of Korea
    Biochem Biophys Res Commun 306:930-6. 2003
  2. pmc A proteomics approach for identification of single strand DNA-binding proteins involved in transcriptional regulation of mouse mu opioid receptor gene
    Hack Sun Choi
    Department of Pharmacology, University of Minnesota Medical School, Minneapolis, Minnesota 55455, USA
    Mol Cell Proteomics 7:1517-29. 2008
  3. ncbi Novel function of the poly(C)-binding protein alpha CP3 as a transcriptional repressor of the mu opioid receptor gene
    Hack Sun Choi
    Department of Pharmacology, University of Minnesota Medical School, 6 120 Jackson Hall, 321 Church St SE, Minneapolis, MN 55455, USA
    FASEB J 21:3963-73. 2007
  4. doi Transcriptional regulation of mouse mu opioid receptor gene in neuronal cells by poly(ADP-ribose) polymerase-1
    Hack Sun Choi
    Department of Pharmacology, University of Minnesota Medical School, Minneapolis, Minnesota 55455, USA
    J Cell Mol Med 12:2319-33. 2008
  5. pmc Poly(C)-binding proteins as transcriptional regulators of gene expression
    Hack Sun Choi
    Department of Pharmacology, University of Minnesota Medical School, 6 120 Jackson Hall, 321 Church Street SE, Minneapolis, MN 55455, USA
    Biochem Biophys Res Commun 380:431-6. 2009
  6. ncbi The opioid ligand binding of human mu-opioid receptor is modulated by novel splice variants of the receptor
    Hack Sun Choi
    Department of Pharmacology, Medical School, University of Minnesota, Minneapolis, MN 55455, USA
    Biochem Biophys Res Commun 343:1132-40. 2006
  7. ncbi Transcriptional regulation of mouse mu opioid receptor gene: Sp3 isoforms (M1, M2) function as repressors in neuronal cells to regulate the mu opioid receptor gene
    Hack Sun Choi
    Department of Pharmacology, University of Minnesota Medical School, Minneapolis, 55455, USA
    Mol Pharmacol 67:1674-83. 2005
  8. ncbi Neuron-restrictive silencer factor (NRSF) functions as a repressor in neuronal cells to regulate the mu opioid receptor gene
    Chun Sung Kim
    Department of Pharmacology, University of Minnesota Medical School, Minneapolis, Minnesota 55455, USA
    J Biol Chem 279:46464-73. 2004
  9. pmc Evidence of the neuron-restrictive silencer factor (NRSF) interaction with Sp3 and its synergic repression to the mu opioid receptor (MOR) gene
    Chun Sung Kim
    Department of Pharmacology, University of Minnesota Medical School, 6 120 Jackson Hall, 321 Church Street SE, Minneapolis, MN 55455, USA
    Nucleic Acids Res 34:6392-403. 2006
  10. pmc uAUG-mediated translational initiations are responsible for human mu opioid receptor gene expression
    Kyu Young Song
    Department of Pharmacology, University of Minnesota Medical School, Minneapolis, MN 55455, USA
    J Cell Mol Med 14:1113-24. 2010

Collaborators

Detail Information

Publications19

  1. ncbi A novel flavin-containing monooxygenase from Methylophaga sp strain SK1 and its indigo synthesis in Escherichia coli
    Hack Sun Choi
    Research Center for Proteineous Materials, Chosun University, Gwangju 501 759, Republic of Korea
    Biochem Biophys Res Commun 306:930-6. 2003
    ..This suggests that the recombinant strain has a potential to be applied in microbial indigo production...
  2. pmc A proteomics approach for identification of single strand DNA-binding proteins involved in transcriptional regulation of mouse mu opioid receptor gene
    Hack Sun Choi
    Department of Pharmacology, University of Minnesota Medical School, Minneapolis, Minnesota 55455, USA
    Mol Cell Proteomics 7:1517-29. 2008
    ..We demonstrate novel roles as transcriptional regulators in Oprm1 regulation for hnRNP K and alphaCP binding to the single strand DNA element...
  3. ncbi Novel function of the poly(C)-binding protein alpha CP3 as a transcriptional repressor of the mu opioid receptor gene
    Hack Sun Choi
    Department of Pharmacology, University of Minnesota Medical School, 6 120 Jackson Hall, 321 Church St SE, Minneapolis, MN 55455, USA
    FASEB J 21:3963-73. 2007
    ..Our data suggest that alphaCP3 can function as a repressor of MOR transcription dependent on the MOR poly(C) sequence. We demonstrate for the first time a role of alphaCP3 as a transcriptional repressor in MOR gene regulation...
  4. doi Transcriptional regulation of mouse mu opioid receptor gene in neuronal cells by poly(ADP-ribose) polymerase-1
    Hack Sun Choi
    Department of Pharmacology, University of Minnesota Medical School, Minneapolis, Minnesota 55455, USA
    J Cell Mol Med 12:2319-33. 2008
    ..Our data suggest that PARP-1 can function as a repressor of MOR transcription dependent on the MOR poly(C) sequence. We demonstrate for the first time a role of PARP-1 as a transcriptional repressor in MOR gene regulation...
  5. pmc Poly(C)-binding proteins as transcriptional regulators of gene expression
    Hack Sun Choi
    Department of Pharmacology, University of Minnesota Medical School, 6 120 Jackson Hall, 321 Church Street SE, Minneapolis, MN 55455, USA
    Biochem Biophys Res Commun 380:431-6. 2009
    ..PCBPs can function as a signal-dependent and coordinated regulator of transcription in eukaryotic cells. We address the molecular mechanisms by which PCBPs binding to single- and double-stranded DNA mediates gene expression...
  6. ncbi The opioid ligand binding of human mu-opioid receptor is modulated by novel splice variants of the receptor
    Hack Sun Choi
    Department of Pharmacology, Medical School, University of Minnesota, Minneapolis, MN 55455, USA
    Biochem Biophys Res Commun 343:1132-40. 2006
    ..In NMB cells expressing human MOR gene, transfection of SV1 or SV2 reduced binding activity of the endogenous MOR. These data support a potential role of SV1 and SV2 proteins as possible biological modulator of human mu-opioid receptor...
  7. ncbi Transcriptional regulation of mouse mu opioid receptor gene: Sp3 isoforms (M1, M2) function as repressors in neuronal cells to regulate the mu opioid receptor gene
    Hack Sun Choi
    Department of Pharmacology, University of Minnesota Medical School, Minneapolis, 55455, USA
    Mol Pharmacol 67:1674-83. 2005
    ..These results suggest that the binding of the M1 and M2 isoforms of the Sp3 transcription factor to the Sp binding sequence may play a role in mouse MOR gene expression...
  8. ncbi Neuron-restrictive silencer factor (NRSF) functions as a repressor in neuronal cells to regulate the mu opioid receptor gene
    Chun Sung Kim
    Department of Pharmacology, University of Minnesota Medical School, Minneapolis, Minnesota 55455, USA
    J Biol Chem 279:46464-73. 2004
    ..Our data suggested that NRSF can function as a repressor of MOR transcription in specific cells, via a mechanism dependent on the MOR NRSE...
  9. pmc Evidence of the neuron-restrictive silencer factor (NRSF) interaction with Sp3 and its synergic repression to the mu opioid receptor (MOR) gene
    Chun Sung Kim
    Department of Pharmacology, University of Minnesota Medical School, 6 120 Jackson Hall, 321 Church Street SE, Minneapolis, MN 55455, USA
    Nucleic Acids Res 34:6392-403. 2006
    ....
  10. pmc uAUG-mediated translational initiations are responsible for human mu opioid receptor gene expression
    Kyu Young Song
    Department of Pharmacology, University of Minnesota Medical School, Minneapolis, MN 55455, USA
    J Cell Mol Med 14:1113-24. 2010
    ..This re-initiation resulted in negative expression of OPRM1 under normal conditions. These results indicate that re-initiation in MOR gene expression could play an important role in OPRM1 regulation...
  11. doi Epigenetic programming of mu-opioid receptor gene in mouse brain is regulated by MeCP2 and Brg1 chromatin remodelling factor
    Cheol Kyu Hwang
    Department of Pharmacology, University of Minnesota Medical School, Minneapolis, MN, USA
    J Cell Mol Med 13:3591-615. 2009
    ..We conclude that MOR gene expression is epigenetically programmed in various brain regions and that MeCP2 assists the epigenetic program during DNA methylation and chromatin remodelling of the MOR promoter...
  12. pmc Evidence of endogenous mu opioid receptor regulation by epigenetic control of the promoters
    Cheol Kyu Hwang
    Department of Pharmacology, University of Minnesota, 6 120 Jackson Hall, 321 Church St S E, Minneapolis, MN 55455, USA
    Mol Cell Biol 27:4720-36. 2007
    ..Here, we propose that an epigenetic mechanism consisting of DNA methylation and chromatin modification underlies the cell stage-specific mechanism of MOR gene expression...
  13. doi Novel function of neuron-restrictive silencer factor (NRSF) for posttranscriptional regulation
    Chun Sung Kim
    Department of Pharmacology, University of Minnesota Medical School, Minneapolis, Minnesota 55455, USA
    Biochim Biophys Acta 1783:1835-46. 2008
    ..We report here a novel function of NRSF that enhance the translation of the mu opioid receptor (MOR) gene through its RNA binding sequence, the neuron-restrictive silencer element (NRSE)...
  14. ncbi Poly(C) binding protein family is a transcription factor in mu-opioid receptor gene expression
    Sung Su Kim
    Department of Pharmacology, University of Minnesota Medical School, 6 120 Jackson Hall, 321 Church St SE, Minneapolis, MN 55455, USA
    Mol Pharmacol 68:729-36. 2005
    ..Chromatin immunoprecipitation assay confirmed the interaction of PCBPs with MOR promoter in vivo. In conclusion, we demonstrate that PCBPs act as a transcription factor and positively regulate MOR gene expression in NMB cells...
  15. doi Differential use of an in-frame translation initiation codon regulates human mu opioid receptor (OPRM1)
    Kyu Young Song
    Department of Pharmacology, University of Minnesota Medical School, Minneapolis, MN 55455, USA
    Cell Mol Life Sci 66:2933-42. 2009
    ..The data suggest that MOP expression is controlled in part by initiation of the long form of MOP at the alternate site...
  16. pmc Vimentin interacts with the 5'-untranslated region of mouse mu opioid receptor (MOR) and is required for post-transcriptional regulation
    Kyu Young Song
    Department of Pharmacology, University of Minnesota Medical School, Minneapolis, MN, USA
    RNA Biol 10:256-66. 2013
    ..Our data suggest that vimentin functions as a repressor of MOR translation, dependent on 175-150 of the MOR 5'-UTR...
  17. ncbi Transcriptional regulation of mouse mu opioid receptor gene by PU.1
    Cheol Kyu Hwang
    Department of Pharmacology, University of Minnesota Medical School, 6 120 Jackson Hall, 321 Church Street SE, Minneapolis, MN 55455, USA
    J Biol Chem 279:19764-74. 2004
    ..1-mediated repression of MOR promoter activity after trichostatin A treatment in neuroblastoma NMB cells. Our results suggest that PU.1 may be an important regulator of the MOR gene, particularly in brain and immune cells...
  18. pmc Translational repression of mouse mu opioid receptor expression via leaky scanning
    Kyu Young Song
    Department of Pharmacology, University of Minnesota Medical School, Minneapolis, Minnesota 55455, USA
    Nucleic Acids Res 35:1501-13. 2007
    ..These results support the hypothesis that uORFs in mouse MOR mRNA act as negative regulators through a ribosome leaky scanning mechanism. Such leaky scanning resulted in the suppression of mouse MOR under normal conditions...
  19. pmc Post-transcriptional regulation of mu-opioid receptor: role of the RNA-binding proteins heterogeneous nuclear ribonucleoprotein H1 and F
    Kyu Young Song
    Department of Pharmacology, University of Minnesota Medical School, Minneapolis, MN 55455, USA
    Cell Mol Life Sci 69:599-610. 2012
    ..We demonstrate for the first time a role of hnRNPs as post-transcriptional repressors in MOR gene regulation...