Changho Choi

Summary

Affiliation: University of Texas Southwestern Medical Center
Country: USA

Publications

  1. pmc 2-hydroxyglutarate detection by magnetic resonance spectroscopy in IDH-mutated patients with gliomas
    Changho Choi
    Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, Texas, USA
    Nat Med 18:624-9. 2012
  2. pmc Measurement of N-acetylaspartylglutamate in the human frontal brain by 1H-MRS at 7 T
    Changho Choi
    Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    Magn Reson Med 64:1247-51. 2010
  3. pmc Measurement of glycine in the human brain in vivo by 1H-MRS at 3 T: application in brain tumors
    Changho Choi
    Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, Texas, USA
    Magn Reson Med 66:609-18. 2011
  4. doi request reprint Improvement of resolution for brain coupled metabolites by optimized (1)H MRS at 7T
    Changho Choi
    Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, TX, USA
    NMR Biomed 23:1044-52. 2010
  5. doi request reprint Measurement of glycine in human prefrontal brain by point-resolved spectroscopy at 7.0 tesla in vivo
    Changho Choi
    Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    Magn Reson Med 62:1305-10. 2009
  6. ncbi request reprint Measurement of glycine in human brain by triple refocusing 1H-MRS in vivo at 3.0T
    Changho Choi
    Department of Biomedical Engineering, University of Alberta, Edmonton, Alberta, Canada
    Magn Reson Med 59:59-64. 2008
  7. pmc Measurement of glutathione in human brain at 3T using an improved double quantum filter in vivo
    Changho Choi
    Advanced Imaging Research Center, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390, USA
    J Magn Reson 198:160-6. 2009
  8. pmc In vivo detection of serine in the human brain by proton magnetic resonance spectroscopy (1H-MRS) at 7 Tesla
    Changho Choi
    Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    Magn Reson Med 62:1042-6. 2009
  9. pmc A comparative study of short- and long-TE ¹H MRS at 3 T for in vivo detection of 2-hydroxyglutarate in brain tumors
    Changho Choi
    Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, TX, USA Department of Radiology, University of Texas Southwestern Medical Center, Dallas, TX, USA Harold C Simmons Cancer Center, University of Texas Southwestern Medical Center, Dallas, TX, USA
    NMR Biomed 26:1242-50. 2013
  10. pmc Metabolism of [U-13 C]glucose in human brain tumors in vivo
    Elizabeth A Maher
    Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX, USA
    NMR Biomed 25:1234-44. 2012

Collaborators

Detail Information

Publications20

  1. pmc 2-hydroxyglutarate detection by magnetic resonance spectroscopy in IDH-mutated patients with gliomas
    Changho Choi
    Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, Texas, USA
    Nat Med 18:624-9. 2012
    ..Detection of 2HG correlated with mutations in IDH1 or IDH2 and with increased levels of D-2HG by mass spectrometry of the resected tumors. Noninvasive detection of 2HG may prove to be a valuable diagnostic and prognostic biomarker...
  2. pmc Measurement of N-acetylaspartylglutamate in the human frontal brain by 1H-MRS at 7 T
    Changho Choi
    Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    Magn Reson Med 64:1247-51. 2010
    ..13 and 0.28 by difference editing (95% confidence intervals 0.07-0.19 and 0.22-0.34), respectively, assuming identical relaxation effects between the metabolites...
  3. pmc Measurement of glycine in the human brain in vivo by 1H-MRS at 3 T: application in brain tumors
    Changho Choi
    Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, Texas, USA
    Magn Reson Med 66:609-18. 2011
    ..Metabolite concentrations were obtained using the water signal from the tumor mass. The study revealed that a subset of human gliomas contains glycine levels elevated 1.5-8 fold relative to normal...
  4. doi request reprint Improvement of resolution for brain coupled metabolites by optimized (1)H MRS at 7T
    Changho Choi
    Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, TX, USA
    NMR Biomed 23:1044-52. 2010
    ..The CRLB of Glu was similar between PRESS and short-TE stimulated-echo acquisition mode (STEAM), but the CRLBs of Gln and GSH were lower in PRESS than in both STEAM acquisitions...
  5. doi request reprint Measurement of glycine in human prefrontal brain by point-resolved spectroscopy at 7.0 tesla in vivo
    Changho Choi
    Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    Magn Reson Med 62:1305-10. 2009
    ..8 +/- 0.1 mM, with reference to total creatine at 8 mM...
  6. ncbi request reprint Measurement of glycine in human brain by triple refocusing 1H-MRS in vivo at 3.0T
    Changho Choi
    Department of Biomedical Engineering, University of Alberta, Edmonton, Alberta, Canada
    Magn Reson Med 59:59-64. 2008
    ..5 +/- 0.1 mM (mean +/- SD, n = 6), with reference to creatine at 8 mM...
  7. pmc Measurement of glutathione in human brain at 3T using an improved double quantum filter in vivo
    Changho Choi
    Advanced Imaging Research Center, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390, USA
    J Magn Reson 198:160-6. 2009
    ..0-ppm peak areas, the concentration of GSH in the medial parietal cortex of the healthy human brain in vivo was estimated to be 1.0+/-0.3mM (mean+/-SD, n=7), with reference to NAA at 10mM...
  8. pmc In vivo detection of serine in the human brain by proton magnetic resonance spectroscopy (1H-MRS) at 7 Tesla
    Changho Choi
    Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    Magn Reson Med 62:1042-6. 2009
    ..03-ppm peaks, assuming identical T(1) and T(2) between Ser and Cr, the Ser-to-Cr concentration ratio for the frontal cortex of healthy adults was estimated to be 0.8 +/- 0.2 (mean +/- SD; N = 6)...
  9. pmc A comparative study of short- and long-TE ¹H MRS at 3 T for in vivo detection of 2-hydroxyglutarate in brain tumors
    Changho Choi
    Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, TX, USA Department of Radiology, University of Texas Southwestern Medical Center, Dallas, TX, USA Harold C Simmons Cancer Center, University of Texas Southwestern Medical Center, Dallas, TX, USA
    NMR Biomed 26:1242-50. 2013
    ....
  10. pmc Metabolism of [U-13 C]glucose in human brain tumors in vivo
    Elizabeth A Maher
    Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX, USA
    NMR Biomed 25:1234-44. 2012
    ..This study illustrates a convenient approach that capitalizes on the high information content of (13) C NMR spectroscopy and enables the analysis of intermediary metabolism in diverse cancers growing in their native microenvironment...
  11. ncbi request reprint Proton spectral editing for discrimination of lactate and threonine 1.31 ppm resonances in human brain in vivo
    Changho Choi
    Department of Biomedical Engineering, University of Alberta, Edmonton, Alberta, Canada
    Magn Reson Med 56:660-5. 2006
    ..Using the calculated yields, the concentrations of Lac and Thr in the human occipital cortex were estimated to be 0.47+/-0.07 and 0.56+/-0.06 mM (mean+/-SD, N=7), respectively, with reference to Cr at 8 mM...
  12. pmc Glucose metabolism via the pentose phosphate pathway, glycolysis and Krebs cycle in an orthotopic mouse model of human brain tumors
    Isaac Marin-Valencia
    Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, TX, USA
    NMR Biomed 25:1177-86. 2012
    ..Taken together, these data demonstrate that (13) C-labeled glucose can be used in orthotopic mouse models to study tumor metabolism in vivo and to ascertain new metabolic targets for cancer diagnosis and therapy...
  13. pmc Measurement of glycine in gray and white matter in the human brain in vivo by 1H MRS at 7.0 T
    Abhishek Banerjee
    Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, Texas, USA
    Magn Reson Med 68:325-31. 2012
    ..The Gly concentrations in pure GM and white matter were estimated to be 1.1 and 0.1 mM, with 95% confidence intervals 1.0-1.2 and 0.0-0.2, respectively...
  14. pmc T2 measurement of J-coupled metabolites in the human brain at 3T
    Sandeep K Ganji
    Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, Texas, USA
    NMR Biomed 25:523-9. 2012
    ..T(2)(†)s of glutamate and myo-inositol were measured as 181 ± 16 and 197 ± 14 ms (mean ± SD, N = 5) for medial occipital cortices, and 180 ± 12 and 196 ± 17 ms for left occipital cortices, respectively...
  15. pmc Compressive sensing could accelerate 1H MR metabolic imaging in the clinic
    Sairam Geethanath
    Joint Graduate Program in Biomedical Engineering, UT Arlington and UT Southwestern Medical Center, Dallas, Tex, USA
    Radiology 262:985-94. 2012
    ..To retrospectively evaluate the fidelity of magnetic resonance (MR) spectroscopic imaging data preservation at a range of accelerations by using compressed sensing...
  16. ncbi request reprint Measurement of GABA and contaminants in gray and white matter in human brain in vivo
    Changho Choi
    Department of Biomedical Engineering, University of Alberta, Edmonton, Alberta, Canada
    Magn Reson Med 58:27-33. 2007
    ..1 +/- 0.1 and 0.8 +/- 0.1 mM (mean +/- SD, N=3) for gray matter (GM) and 0.4 +/- 0.1 and 0.7+/-0.1 mM (N=3) for white matter (WM), respectively...
  17. ncbi request reprint Measurement of brain glutamate and glutamine by spectrally-selective refocusing at 3 Tesla
    Changho Choi
    Department of Biomedical Engineering, University of Alberta, Edmonton, Alberta, Canada
    Magn Reson Med 55:997-1005. 2006
    ..The concentrations of Glu and Gln in the prefrontal cortex were estimated to be 9.7+/-0.5 and 3.0+/-0.7 mM (mean+/-SD, N=7), with reference to Cr at 8 mM...
  18. ncbi request reprint Detection of the myo-inositol 4.06-ppm resonance by selective J rewinding: application to human prefrontal cortex in vivo
    Changho Choi
    Department of Biomedical Engineering, University of Alberta, Edmonton, Alberta, Canada
    Magn Reson Med 54:1536-40. 2005
    ..The myo-inositol concentration in human prefrontal cortex is estimated to be 5.7 +/- 0.9 mumol/g (mean +/- SD, n = 7), with reference to NAA at 10 micromol/g...
  19. ncbi request reprint T2 measurement and quantification of glutamate in human brain in vivo
    Changho Choi
    Department of Biomedical Engineering, University of Alberta, Edmonton, Alberta, Canada
    Magn Reson Med 56:971-7. 2006
    ..37 +/- 1.06 and 8.87 +/- 0.56 mM for gray matter (GM), and 5.06 +/- 0.57 and 5.16 +/- 0.45 mM (mean +/- SD, N = 5) for white matter (WM), respectively...
  20. ncbi request reprint Brain gamma-aminobutyric acid measurement by proton double-quantum filtering with selective J rewinding
    Changho Choi
    Department of Biomedical Engineering, University of Alberta, Edmonton, Alberta, Canada
    Magn Reson Med 54:272-9. 2005
    ..The GABA concentration in human prefrontal cortex is estimated to be 0.8 +/- 0.1 micromol/g (mean +/- SD, n = 6), with reference to the internal standard creatine at 9 micromol/g...