Research Topics
| Changho ChoiSummaryAffiliation: University of Texas Southwestern Medical Center Country: USA Publications
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Detail Information
Publications
2-hydroxyglutarate detection by magnetic resonance spectroscopy in IDH-mutated patients with gliomasChangho Choi
Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, Texas, USA
Nat Med 18:624-9. 2012..Detection of 2HG correlated with mutations in IDH1 or IDH2 and with increased levels of D-2HG by mass spectrometry of the resected tumors. Noninvasive detection of 2HG may prove to be a valuable diagnostic and prognostic biomarker...- Measurement of glycine in human prefrontal brain by point-resolved spectroscopy at 7.0 tesla in vivoChangho Choi
Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
Magn Reson Med 62:1305-10. 2009..8 +/- 0.1 mM, with reference to total creatine at 8 mM... 
Measurement of glycine in the human brain in vivo by 1H-MRS at 3 T: application in brain tumorsChangho Choi
Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, Texas, USA
Magn Reson Med 66:609-18. 2011..Metabolite concentrations were obtained using the water signal from the tumor mass. The study revealed that a subset of human gliomas contains glycine levels elevated 1.5-8 fold relative to normal...- Improvement of resolution for brain coupled metabolites by optimized (1)H MRS at 7TChangho Choi
Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, TX, USA
NMR Biomed 23:1044-52. 2010..The CRLB of Glu was similar between PRESS and short-TE stimulated-echo acquisition mode (STEAM), but the CRLBs of Gln and GSH were lower in PRESS than in both STEAM acquisitions... - Measurement of N-acetylaspartylglutamate in the human frontal brain by 1H-MRS at 7 TChangho Choi
Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
Magn Reson Med 64:1247-51. 2010..13 and 0.28 by difference editing (95% confidence intervals 0.07-0.19 and 0.22-0.34), respectively, assuming identical relaxation effects between the metabolites... 
Measurement of glycine in human brain by triple refocusing 1H-MRS in vivo at 3.0TChangho Choi
Department of Biomedical Engineering, University of Alberta, Edmonton, Alberta, Canada
Magn Reson Med 59:59-64. 2008..5 +/- 0.1 mM (mean +/- SD, n = 6), with reference to creatine at 8 mM...- Measurement of glutathione in human brain at 3T using an improved double quantum filter in vivoChangho Choi
Advanced Imaging Research Center, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390, USA
J Magn Reson 198:160-6. 2009..0-ppm peak areas, the concentration of GSH in the medial parietal cortex of the healthy human brain in vivo was estimated to be 1.0+/-0.3mM (mean+/-SD, n=7), with reference to NAA at 10mM... - In vivo detection of serine in the human brain by proton magnetic resonance spectroscopy (1H-MRS) at 7 TeslaChangho Choi
Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
Magn Reson Med 62:1042-6. 2009..03-ppm peaks, assuming identical T(1) and T(2) between Ser and Cr, the Ser-to-Cr concentration ratio for the frontal cortex of healthy adults was estimated to be 0.8 +/- 0.2 (mean +/- SD; N = 6)... - Proton spectral editing for discrimination of lactate and threonine 1.31 ppm resonances in human brain in vivoChangho Choi
Department of Biomedical Engineering, University of Alberta, Edmonton, Alberta, Canada
Magn Reson Med 56:660-5. 2006..Using the calculated yields, the concentrations of Lac and Thr in the human occipital cortex were estimated to be 0.47+/-0.07 and 0.56+/-0.06 mM (mean+/-SD, N=7), respectively, with reference to Cr at 8 mM... - Measurement of glycine in gray and white matter in the human brain in vivo by 1H MRS at 7.0 TAbhishek Banerjee
Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, Texas, USA
Magn Reson Med 68:325-31. 2012..The Gly concentrations in pure GM and white matter were estimated to be 1.1 and 0.1 mM, with 95% confidence intervals 1.0-1.2 and 0.0-0.2, respectively... - T2 measurement of J-coupled metabolites in the human brain at 3TSandeep K Ganji
Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, Texas, USA
NMR Biomed 25:523-9. 2012..T(2)(†)s of glutamate and myo-inositol were measured as 181 ± 16 and 197 ± 14 ms (mean ± SD, N = 5) for medial occipital cortices, and 180 ± 12 and 196 ± 17 ms for left occipital cortices, respectively... - Compressive sensing could accelerate 1H MR metabolic imaging in the clinicSairam Geethanath
Joint Graduate Program in Biomedical Engineering, UT Arlington and UT Southwestern Medical Center, Dallas, Tex, USA
Radiology 262:985-94. 2012..To retrospectively evaluate the fidelity of magnetic resonance (MR) spectroscopic imaging data preservation at a range of accelerations by using compressed sensing... - Measurement of GABA and contaminants in gray and white matter in human brain in vivoChangho Choi
Department of Biomedical Engineering, University of Alberta, Edmonton, Alberta, Canada
Magn Reson Med 58:27-33. 2007..1 +/- 0.1 and 0.8 +/- 0.1 mM (mean +/- SD, N=3) for gray matter (GM) and 0.4 +/- 0.1 and 0.7+/-0.1 mM (N=3) for white matter (WM), respectively... - Measurement of brain glutamate and glutamine by spectrally-selective refocusing at 3 TeslaChangho Choi
Department of Biomedical Engineering, University of Alberta, Edmonton, Alberta, Canada
Magn Reson Med 55:997-1005. 2006..The concentrations of Glu and Gln in the prefrontal cortex were estimated to be 9.7+/-0.5 and 3.0+/-0.7 mM (mean+/-SD, N=7), with reference to Cr at 8 mM... - Metabolism of [U-13 C]glucose in human brain tumors in vivoElizabeth A Maher
Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX, USA
NMR Biomed 25:1234-44. 2012..This study illustrates a convenient approach that capitalizes on the high information content of (13) C NMR spectroscopy and enables the analysis of intermediary metabolism in diverse cancers growing in their native microenvironment... - T2 measurement and quantification of glutamate in human brain in vivoChangho Choi
Department of Biomedical Engineering, University of Alberta, Edmonton, Alberta, Canada
Magn Reson Med 56:971-7. 2006..37 +/- 1.06 and 8.87 +/- 0.56 mM for gray matter (GM), and 5.06 +/- 0.57 and 5.16 +/- 0.45 mM (mean +/- SD, N = 5) for white matter (WM), respectively... - Detection of the myo-inositol 4.06-ppm resonance by selective J rewinding: application to human prefrontal cortex in vivoChangho Choi
Department of Biomedical Engineering, University of Alberta, Edmonton, Alberta, Canada
Magn Reson Med 54:1536-40. 2005..The myo-inositol concentration in human prefrontal cortex is estimated to be 5.7 +/- 0.9 mumol/g (mean +/- SD, n = 7), with reference to NAA at 10 micromol/g... - Glucose metabolism via the pentose phosphate pathway, glycolysis and Krebs cycle in an orthotopic mouse model of human brain tumorsIsaac Marin-Valencia
Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, TX, USA
NMR Biomed 25:1177-86. 2012..Taken together, these data demonstrate that (13) C-labeled glucose can be used in orthotopic mouse models to study tumor metabolism in vivo and to ascertain new metabolic targets for cancer diagnosis and therapy... - Brain gamma-aminobutyric acid measurement by proton double-quantum filtering with selective J rewindingChangho Choi
Department of Biomedical Engineering, University of Alberta, Edmonton, Alberta, Canada
Magn Reson Med 54:272-9. 2005..The GABA concentration in human prefrontal cortex is estimated to be 0.8 +/- 0.1 micromol/g (mean +/- SD, n = 6), with reference to the internal standard creatine at 9 micromol/g...