Keith P Choe
Affiliation: University of Florida
Fontaine P, CHOE K. The transcription factor SKN-1 and detoxification gene ugt-22 alter albendazole efficacy in Caenorhabditis elegans. Int J Parasitol Drugs Drug Resist. 2018;8:312-319 pubmed publisher
..Mutation and overexpression of ugt-22 alter albendazole EC50 by 2.3-2.5-fold. The influence of a nematode UGT on albendazole efficacy is consistent with recent studies demonstrating glucose conjugation of benzimidazoles. ..
Tang L, Dodd W, CHOE K. Isolation of a Hypomorphic skn-1 Allele That Does Not Require a Balancer for Maintenance. G3 (Bethesda). 2015;6:551-8 pubmed publisher
Dodd W, Tang L, Lone J, Wimberly K, Wu C, Consalvo C, et al
. A Damage Sensor Associated with the Cuticle Coordinates Three Core Environmental Stress Responses in Caenorhabditis elegans. Genetics. 2018;208:1467-1482 pubmed publisher
..Our results are consistent with a cuticle-associated damage sensor that coordinates detoxification, hyperosmotic, and antimicrobial responses through overlapping, but distinct, downstream signaling. ..
Choe K, Leung C, Miyamoto M. Unique structure and regulation of the nematode detoxification gene regulator, SKN-1: implications to understanding and controlling drug resistance. Drug Metab Rev. 2012;44:209-23 pubmed publisher
..Protein alignment and phylogenetic analyses indicate that these differences are shared among many nematodes, making SKN-1 a candidate for specifically targeting nematode detoxification and antioxidation...
Tang L, Choe K. Characterization of skn-1/wdr-23 phenotypes in Caenorhabditis elegans; pleiotrophy, aging, glutathione, and interactions with other longevity pathways. Mech Ageing Dev. 2015;149:88-98 pubmed publisher
..Lastly, genetic interaction data revise our understanding of which skn-1 variants are required for longevity during dietary restriction. ..
Wu C, Wang Y, Choe K. F-Box Protein XREP-4 Is a New Regulator of the Oxidative Stress Response in Caenorhabditis elegans. Genetics. 2017;206:859-871 pubmed publisher
..These results are consistent with XREP-4 influencing the SKN-1 stress response by functioning as a bridge between WDR-23 and the ubiquitin ligase component SKR-1. ..