J Chodosh

Summary

Affiliation: University of Oklahoma Health Sciences Center
Country: USA

Publications

  1. pmc Human adenovirus type 19 infection of corneal cells induces p38 MAPK-dependent interleukin-8 expression
    Jaya Rajaiya
    Molecular Pathogenesis of Eye Infection Research Center, Dean A, McGee Eye Institute, Department of Ophthalmology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA
    Virol J 5:17. 2008
  2. pmc Genomic and bioinformatics analysis of human adenovirus type 37: new insights into corneal tropism
    Christopher M Robinson
    Molecular Pathogenesis of Eye Infection Research Center, Dean A McGee Eye Institute, 608 Stanton L, Young Blvd, Oklahoma City, OK 73104, USA
    BMC Genomics 9:213. 2008
  3. ncbi request reprint Adenovirus keratitis: a role for interleukin-8
    J Chodosh
    Molecular Pathogenesis of Eye Infection Research Center, Dean A McGee Eye Institute, Department of Ophthalmology, University of Oklahoma Health Sciences Center, Oklahoma City 73104, USA
    Invest Ophthalmol Vis Sci 41:783-9. 2000
  4. ncbi request reprint The conjunctival lymphoid follicle in mucosal immunology
    James Chodosh
    Molecular Pathogenesis of Eye Infection Research Center, Dean A McGee Eye Institute, Departments of Ophthalmology and Cell Biology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma 73104, USA
    DNA Cell Biol 21:421-33. 2002
  5. ncbi request reprint Corneal expression of the inflammatory mediator CAP37
    Xin Ruan
    Department of Pathology, University of Oklahoma Health Sciences Center, Dean A McGee Eye Institute, Oklahoma City, OK 73190, USA
    Invest Ophthalmol Vis Sci 43:1414-21. 2002
  6. pmc Human adenovirus type 19: genomic and bioinformatics analysis of a keratoconjunctivitis isolate
    Christopher M Robinson
    The Molecular Pathogenesis of Eye Infection Research Center, Dean A McGee Eye Institute, University of Oklahoma Health Sciences Center, Oklahoma City, OK, United States
    Virus Res 139:122-6. 2009
  7. ncbi request reprint Modulation of corneal epithelial cell functions by the neutrophil-derived inflammatory mediator CAP37
    H Anne Pereira
    Department of Pathology, BNSB 463, P O Box 26901, Oklahoma City, OK 73190, USA
    Invest Ophthalmol Vis Sci 45:4284-92. 2004
  8. ncbi request reprint Virulence factor profiles and antimicrobial susceptibilities of ocular bacillus isolates
    Michelle C Callegan
    Department of Ophthalmology, Microbiology and Immunology, Oklahoma Center for Neuroscience, University of Oklahoma Health Sciences Center, OK, USA
    Curr Eye Res 31:693-702. 2006
  9. pmc Effect of anti-CXCL10 monoclonal antibody on herpes simplex virus type 1 keratitis and retinal infection
    Daniel J J Carr
    Department of Ophthalmology, Dean A McGee Eye Institute, The University of Oklahoma Health Sciences Center, 608 Stanton L Young Boulevard, Oklahoma City, OK 73104, USA
    J Virol 77:10037-46. 2003
  10. ncbi request reprint Adenovirus type 37 keratitis in the C57BL/6J mouse
    Ashish V Chintakuntlawar
    Molecular Pathogenesis of Eye Infection Research Center, Dean A McGee Eye Institute OUHSC, Oklahoma City, OK 73104, USA
    Invest Ophthalmol Vis Sci 48:781-8. 2007

Research Grants

  1. Genetics of Ocular Adenoviruses
    James Chodosh; Fiscal Year: 2006

Collaborators

Detail Information

Publications36

  1. pmc Human adenovirus type 19 infection of corneal cells induces p38 MAPK-dependent interleukin-8 expression
    Jaya Rajaiya
    Molecular Pathogenesis of Eye Infection Research Center, Dean A, McGee Eye Institute, Department of Ophthalmology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA
    Virol J 5:17. 2008
    ....
  2. pmc Genomic and bioinformatics analysis of human adenovirus type 37: new insights into corneal tropism
    Christopher M Robinson
    Molecular Pathogenesis of Eye Infection Research Center, Dean A McGee Eye Institute, 608 Stanton L, Young Blvd, Oklahoma City, OK 73104, USA
    BMC Genomics 9:213. 2008
    ..A detailed bioinformatics analysis of the genome sequence of HAdV-37 is extremely important to understanding its unique pathogenicity in the eye...
  3. ncbi request reprint Adenovirus keratitis: a role for interleukin-8
    J Chodosh
    Molecular Pathogenesis of Eye Infection Research Center, Dean A McGee Eye Institute, Department of Ophthalmology, University of Oklahoma Health Sciences Center, Oklahoma City 73104, USA
    Invest Ophthalmol Vis Sci 41:783-9. 2000
    ..In this study, the capacity of Ad19-infected human corneal stromal fibroblasts (HCFs) to produce neutrophil chemotactants (chemokines) was tested...
  4. ncbi request reprint The conjunctival lymphoid follicle in mucosal immunology
    James Chodosh
    Molecular Pathogenesis of Eye Infection Research Center, Dean A McGee Eye Institute, Departments of Ophthalmology and Cell Biology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma 73104, USA
    DNA Cell Biol 21:421-33. 2002
    ..In this review, we examine the evidence for classification of CLF as part of the common mucosal immune system, and explore the possible therapeutic implications...
  5. ncbi request reprint Corneal expression of the inflammatory mediator CAP37
    Xin Ruan
    Department of Pathology, University of Oklahoma Health Sciences Center, Dean A McGee Eye Institute, Oklahoma City, OK 73190, USA
    Invest Ophthalmol Vis Sci 43:1414-21. 2002
    ..To further investigate the biological significance of CAP37 in infection and inflammation, a well-characterized in vivo rabbit model of bacterial keratitis was selected to study its contribution to host defenses...
  6. pmc Human adenovirus type 19: genomic and bioinformatics analysis of a keratoconjunctivitis isolate
    Christopher M Robinson
    The Molecular Pathogenesis of Eye Infection Research Center, Dean A McGee Eye Institute, University of Oklahoma Health Sciences Center, Oklahoma City, OK, United States
    Virus Res 139:122-6. 2009
    ..Elucidation of the HAdV-19C genome will facilitate future studies into the pathogenesis of EKC, and may shed light on the genetic determinants of corneal tropism...
  7. ncbi request reprint Modulation of corneal epithelial cell functions by the neutrophil-derived inflammatory mediator CAP37
    H Anne Pereira
    Department of Pathology, BNSB 463, P O Box 26901, Oklahoma City, OK 73190, USA
    Invest Ophthalmol Vis Sci 45:4284-92. 2004
    ..To investigate the effect of CAP37, an inflammatory mediator in neutrophils, on three important events in corneal wound healing: proliferation, migration, and adhesion...
  8. ncbi request reprint Virulence factor profiles and antimicrobial susceptibilities of ocular bacillus isolates
    Michelle C Callegan
    Department of Ophthalmology, Microbiology and Immunology, Oklahoma Center for Neuroscience, University of Oklahoma Health Sciences Center, OK, USA
    Curr Eye Res 31:693-702. 2006
    ..thuringiensis as an important ocular pathogen, demonstrates the potential ocular toxicity of B. cereus and B. thuringiensis isolates, and identifies antibiotics whose efficacy against Bacillus were superior to those used clinically...
  9. pmc Effect of anti-CXCL10 monoclonal antibody on herpes simplex virus type 1 keratitis and retinal infection
    Daniel J J Carr
    Department of Ophthalmology, Dean A McGee Eye Institute, The University of Oklahoma Health Sciences Center, 608 Stanton L Young Boulevard, Oklahoma City, OK 73104, USA
    J Virol 77:10037-46. 2003
    ..Collectively, the results suggest that CXCL10 expression in the eye initially orchestrates the inflammatory response to acute HSV-1 infection, which facilitates the spread of the virus to other restricted sites within the eye...
  10. ncbi request reprint Adenovirus type 37 keratitis in the C57BL/6J mouse
    Ashish V Chintakuntlawar
    Molecular Pathogenesis of Eye Infection Research Center, Dean A McGee Eye Institute OUHSC, Oklahoma City, OK 73104, USA
    Invest Ophthalmol Vis Sci 48:781-8. 2007
    ..To develop a mouse model of adenoviral keratitis that will allow further study of viral and host pathogenic mechanisms...
  11. ncbi request reprint JNK regulates MCP-1 expression in adenovirus type 19-infected human corneal fibroblasts
    Jingnan Xiao
    Department of Ophthalmology, University of Oklahoma Health Sciences Center, 73104, USA
    Invest Ophthalmol Vis Sci 46:3777-82. 2005
    ..In this context, the authors sought to investigate the potential role of another mitogen-activated protein kinase, c-Jun N-terminal kinase (JNK), in adenoviral ocular pathogenesis...
  12. ncbi request reprint Activation of focal adhesion kinase in adenovirus-infected human corneal fibroblasts
    Kanchana Natarajan
    Molecular Pathogenesis of Eye Infection Research Center, Dean A McGee Eye Institute, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma 73104, USA
    Invest Ophthalmol Vis Sci 43:2685-90. 2002
    ..Hence, a possible relationship between adenovirus infection and tyrosine phosphorylation of FAK in human corneal cells was explored...
  13. pmc Human adenovirus type 37 and the BALB/c mouse: progress toward a restricted adenovirus keratitis model (an American Ophthalmological Society thesis)
    James Chodosh
    Molecular Pathogenesis of Eye Infection Research Center, Dean A McGee Eye Institute, Departments of Ophthalmology, Cell Biology, Microbiology, and Immunology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA
    Trans Am Ophthalmol Soc 104:346-65. 2006
    ..To establish a mouse model of adenovirus keratitis in order to study innate immune mechanisms in the adenovirus-infected cornea...
  14. ncbi request reprint Corneal IL-8 expression following adenovirus infection is mediated by c-Src activation in human corneal fibroblasts
    Kanchana Natarajan
    Department of Ophthalmology, The Molecular Pathogenesis of Eye Infection Research Center, Dean A McGee Eye Institute, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA
    J Immunol 170:6234-43. 2003
    ..c-Src may act as a global regulator of early proinflammatory host responses to Ad19 infection of the human cornea...
  15. ncbi request reprint Selective uptake of iron oxide by rabbit conjunctival lymphoid follicles
    Roger A Astley
    Department of Ophthalmology, Molecular Pathogenesis of Eye Infection Research Center, Dean A McGee Eye Institute, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA
    Cornea 24:334-6. 2005
    ..To determine whether conjunctival lymphoid follicles are preferential sites for uptake of foreign material in the preocular tear film...
  16. ncbi request reprint Vitronectin: a possible determinant of adenovirus type 19 tropism for human corneal epithelium
    Jingnan Xiao
    Molecular Pathogenesis of Eye Infection Research Center, Dean A McGee Eye Institute, Department of Ophthalmology, University of Oklahoma Health Sciences Center, 608 Stanton L Young Boulevard, Oklahoma City, OK 73104, USA
    Am J Ophthalmol 140:363-9. 2005
    ..Adenoviruses typically demonstrate specific tissue tropisms, as in the association of Ad19 with epidemic keratoconjunctivitis. We sought to determine factors that might influence the apparent tropism of Ad19 for the cornea...
  17. pmc Corneal cell survival in adenovirus type 19 infection requires phosphoinositide 3-kinase/Akt activation
    Maitreyi S Rajala
    Molecular Pathogenesis of Eye Infection Research Center, Dean McGee Eye Institute, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA
    J Virol 79:12332-41. 2005
    ..The results presented in this paper provide the first direct evidence that PI3K-mediated Akt activation in adenovirus-infected corneal cells may contribute to viral pathogenesis by the prolongation of cell viability...
  18. pmc Computational analysis of human adenovirus type 22 provides evidence for recombination among species D human adenoviruses in the penton base gene
    Christopher M Robinson
    Department of Ophthalmology, Howe Laboratory, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, Massachusetts 02114, USA
    J Virol 83:8980-5. 2009
    ..Further study of recombination among HAdVs is needed to better predict possible recombination events among wild-type viruses and adenoviral gene therapy vectors...
  19. pmc Chemokine CXCL1/KC and its receptor CXCR2 are responsible for neutrophil chemotaxis in adenoviral keratitis
    Ashish V Chintakuntlawar
    Molecular Pathogenesis of Eye Infection Research Center, Dean McGee Eye Institute, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA
    J Interferon Cytokine Res 29:657-66. 2009
    ..In conclusion, both CXCL1 and CXCR2 play an important role in chemokine expression and neutrophil infiltration following adenoviral corneal infection, but have a redundant role in the development of keratitis...
  20. ncbi request reprint Retinal ganglion cell protection by 17-beta-estradiol in a mouse model of inherited glaucoma
    Xiaohong Zhou
    Department of Ophthalmology, Dean A McGee Eye Institute, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma 73104, USA
    Dev Neurobiol 67:603-16. 2007
    ..These findings suggest the possible involvement of multiple biochemical events, including estrogen receptor/Akt/CREB/thioredoxin-1, and estrogen receptor/MAPK/NF-kappaB, in estrogen-mediated retinal ganglion cell protection...
  21. pmc Specific NFkappaB subunit activation and kinetics of cytokine induction in adenoviral keratitis
    Jaya Rajaiya
    Department of Ophthalmology, Howe Laboratory, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, MA 02114, USA
    Mol Vis 15:2879-89. 2009
    ..Therefore, we sought to better understand the differential regulation of chemokine expression by NFkappaB in adenoviral infection of the cornea...
  22. ncbi request reprint Conjunctival lymphoid follicles in new world rodents
    Roger A Astley
    Department of Ophthalmology, Molecular Pathogenesis of Eye Infection Research Center, Dean A McGee Eye Institute, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA
    Anat Rec (Hoboken) 290:1190-4. 2007
    ..Our findings also suggest the deer mouse, Peromyscus maniculatus, might serve as a useful model species for studying ocular infections and immunology of the eye...
  23. pmc Viral capsid is a pathogen-associated molecular pattern in adenovirus keratitis
    Ashish V Chintakuntlawar
    University of Oklahoma Health Sciences Center, Department of Ophthalmology, Oklahoma City, Oklahoma, United States of America
    PLoS Pathog 6:e1000841. 2010
    ....
  24. ncbi request reprint Adenoviral keratoconjunctivitis in a tertiary care eye clinic
    Amir Latif Butt
    Molecular Pathogenesis of Eye Infection Research Center, Dean A McGee Eye Institute, Department of Ophthalmology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma 73104, USA
    Cornea 25:199-202. 2006
    ..To elucidate the natural history and epidemiology of adenoviral keratoconjunctivitis as seen in a tertiary care eye clinic...
  25. ncbi request reprint Structural and cellular architecture of conjunctival lymphoid follicles in the baboon (Papio anubis)
    Roger A Astley
    The Molecular Pathogenesis of Eye Infection Research Center, Dean A McGee Eye Institute, Department of Ophthalmology, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA
    Exp Eye Res 76:685-94. 2003
    ..CD35-positive follicular dendritic cells were observed only in germinal centers. CLFs appear highly organized consistent with a role in the adaptive immune response to conjunctival pathogens...
  26. ncbi request reprint Photorefractive keratectomy for myopia in the setting of Thygeson's superficial punctate keratitis
    S W Fite
    Molecular Pathogenesis of Eye Infection Research Center, Dean A. McGee Eye Institute, Department of Ophthalmology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma 73104
    Cornea 20:425-6. 2001
    ..The recurrence of lesions only in the peripheral untreated cornea suggests that the inflammatory signal in Thygeson's keratitis may reside in the superficial corneal stroma...
  27. ncbi request reprint Cat's tooth keratitis: human corneal infection with Capnocytophaga canimorsus
    J Chodosh
    Molecular Pathogenesis of Eye Infection Research Center, Dean A. McGee Eye Institute, Department of Ophthalmology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma 73104, USA
    Cornea 20:661-3. 2001
    ..CONCLUSION: C. canimorsus keratitis may follow penetrating corneal injury and wound contamination with cat saliva and may be recalcitrant to topical antibiotic therapy...
  28. ncbi request reprint Evidence-based treatment of herpes simplex virus keratitis: a systematic review
    Scott Guess
    Public Health in Ophthalmology Working Group, Dean A McGee Eye Institute, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA
    Ocul Surf 5:240-50. 2007
    ....
  29. doi request reprint Cost-effectiveness of the Boston keratoprosthesis
    Jared D Ament
    Massachusetts Eye and Ear Infirmary, Department of Ophthalmology, Harvard Medical School, 243 Charles Street, Boston, MA 02114 4724, USA
    Am J Ophthalmol 149:221-228.e2. 2010
    ..To conduct a cost-utility analysis and determine the cost-effectiveness of the Boston Keratoprosthesis (Boston Kpro)...
  30. ncbi request reprint Conjunctival sporotrichosis in the absence of antecedent trauma
    Diana E Hampton
    Molecular Pathogenesis of Eye Infection Research Center, Dean A McGee Eye Institute, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma 73104, USA
    Cornea 21:831-3. 2002
    ..To describe a patient with conjunctivitis...
  31. ncbi request reprint Innate immunity in th e cornea: a putative role for keratocytes in the chemokine response to viral infection of the human corneal stroma
    Kanchana Natarajan
    Department of Ophthalmology, Molecular Pathogenesis of Eye Infection Research Center, Dean A McGee Eye Institute, Oklahoma City, Oklahoma, USA
    Adv Exp Med Biol 506:745-51. 2002
    ..In the absence of classic immunologic cells in the corneal stroma, keratocytes may play a similar role in the corneal responses to viral infection...
  32. pmc Anti-inflammatory effect of pigment epithelium-derived factor in DBA/2J mice
    Xiaohong Zhou
    Dean McGee Eye Institute, Department of Ophthalmology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA
    Mol Vis 15:438-50. 2009
    ..In this study, we examined the potential role of PEDF in protection of RGC in the DBA/2J mouse, an animal model of inherited glaucoma...
  33. ncbi request reprint Ocular rosacea in childhood
    Sayeda Asad Nazir
    University of Oklahoma College of Medicine, Oklahoma City, Oklahoma, USA
    Am J Ophthalmol 137:138-44. 2004
    ..To describe the clinical characteristics and treatment response of ocular rosacea in the pediatric population...
  34. doi request reprint Histopathology of Salzmann nodular corneal degeneration
    Donald U Stone
    Dean A McGee Eye Institute, Department of Ophthalmology, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA
    Cornea 27:148-51. 2008
    ..To define the histopathology of Salzmann nodular degeneration and suggest potential mechanisms involved in its pathogenesis...
  35. doi request reprint Keratoprosthesis in autoimmune disease
    Jessica Ciralsky
    Department of Ophthalmology, Harvard Medical School, Massachusetts Eye and Ear Infirmary, Boston, MA 02114, USA
    Ocul Immunol Inflamm 18:275-80. 2010
    ..To describe the clinical features and course of 2 patients with autoimmune diseases and their experience with the Boston keratoprosthesis. To draw on general medical literature to try to better understand recurrent complications...
  36. ncbi request reprint A randomized, double-masked, placebo-controlled, multicenter comparison of loteprednol etabonate ophthalmic suspension, 0.5%, and placebo for treatment of keratoconjunctivitis sicca in patients with delayed tear clearance
    Stephen C Pflugfelder
    Baylor College of Medicine, Houston, Texas, USA
    Am J Ophthalmol 138:444-57. 2004
    ..To evaluate loteprednol etabonate ophthalmic 0.5% suspension, versus placebo for treatment of the inflammatory component of keratoconjunctivitis sicca in patients with delayed tear clearance...

Research Grants1

  1. Genetics of Ocular Adenoviruses
    James Chodosh; Fiscal Year: 2006
    ..abstract_text> ..