Mamatha Chivukula

Summary

Affiliation: University of Pittsburgh
Country: USA

Publications

  1. doi request reprint Evaluation of morphologic features to identify "basal-like phenotype" on core needle biopsies of breast
    Mamatha Chivukula
    Department of Pathology, Magee Women s Hospital of UPMC, Pittsburgh, PA 15213, USA
    Appl Immunohistochem Mol Morphol 16:411-6. 2008
  2. pmc Carcinomas of Distal Fallopian Tube and Their Association with Tubal Intraepithelial Carcinoma: Do They Share a Common "Precursor" Lesion? Loss of Heterozygosity and Immunohistochemical Analysis Using PAX 2, WT-1, and P53 Markers
    Mamatha Chivukula
    Department of Pathology, Magee Womens Hospital of UPMC, 300 Halket Street, Pittsburgh, PA 15213, USA
    ISRN Obstet Gynecol 2011:858647. 2011
  3. doi request reprint Pleomorphic lobular carcinoma in situ (PLCIS) on breast core needle biopsies: clinical significance and immunoprofile
    Mamatha Chivukula
    Department of Pathology, Magee Women s Hospital, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
    Am J Surg Pathol 32:1721-6. 2008
  4. doi request reprint Clinical importance of HER2 immunohistologic heterogeneous expression in core-needle biopsies vs resection specimens for equivocal (immunohistochemical score 2+) cases
    Mamatha Chivukula
    Department of Pathology, Magee Women s Hospital of UPMC, Pittsburgh, PA 115213, USA
    Mod Pathol 21:363-8. 2008
  5. doi request reprint PAX 2: a novel Müllerian marker for serous papillary carcinomas to differentiate from micropapillary breast carcinoma
    Mamatha Chivukula
    Department of Pathology, Magee Women s Hospital of UPMC, 300 Halket Street, Pittsburgh, PA 15213, USA
    Int J Gynecol Pathol 28:570-8. 2009
  6. doi request reprint Characterization of high-grade ductal carcinoma in situ with and without regressive changes: diagnostic and biologic implications
    Mamatha Chivukula
    Department of Pathology, Division of Anatomic Pathology, Magee Women s Hospital of University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania 15213, USA
    Appl Immunohistochem Mol Morphol 17:495-9. 2009
  7. ncbi request reprint Recurrent gynandroblastoma of ovary-A case report: a molecular and immunohistochemical analysis
    Mamatha Chivukula
    Department of Pathology, Magee Womens Hospital of the UPMC Health System, Pittsburgh, PA, USA
    Int J Gynecol Pathol 26:30-3. 2007
  8. ncbi request reprint The ductal phenotypic expression of the E-cadherin/catenin complex in tubulolobular carcinoma of the breast: an immunohistochemical and clinicopathologic study
    Nicole N Esposito
    Department of Pathology, University of Pittsburgh Medical Center, Pittsburgh, PA 15261, USA
    Mod Pathol 20:130-8. 2007
  9. ncbi request reprint Basal phenotype of ductal carcinoma in situ: recognition and immunohistologic profile
    David J Dabbs
    Department of Pathology, Magee Women s Hospital of UPMC, Pittsburgh, PA 15213, USA
    Mod Pathol 19:1506-11. 2006
  10. ncbi request reprint Lobular versus ductal breast neoplasms: the diagnostic utility of p120 catenin
    David J Dabbs
    Department of Pathology, Magee Women s Hospital of the University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
    Am J Surg Pathol 31:427-37. 2007

Collaborators

Detail Information

Publications30

  1. doi request reprint Evaluation of morphologic features to identify "basal-like phenotype" on core needle biopsies of breast
    Mamatha Chivukula
    Department of Pathology, Magee Women s Hospital of UPMC, Pittsburgh, PA 15213, USA
    Appl Immunohistochem Mol Morphol 16:411-6. 2008
    ....
  2. pmc Carcinomas of Distal Fallopian Tube and Their Association with Tubal Intraepithelial Carcinoma: Do They Share a Common "Precursor" Lesion? Loss of Heterozygosity and Immunohistochemical Analysis Using PAX 2, WT-1, and P53 Markers
    Mamatha Chivukula
    Department of Pathology, Magee Womens Hospital of UPMC, 300 Halket Street, Pittsburgh, PA 15213, USA
    ISRN Obstet Gynecol 2011:858647. 2011
    ..PAX 2 LOH patterns might represent a "hidden PAX 2 signature" analogous to p53 signatures. PAX 2 might be an emerging marker for detection of early serous carcinomas particularly in BRCA + women...
  3. doi request reprint Pleomorphic lobular carcinoma in situ (PLCIS) on breast core needle biopsies: clinical significance and immunoprofile
    Mamatha Chivukula
    Department of Pathology, Magee Women s Hospital, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
    Am J Surg Pathol 32:1721-6. 2008
    ..PLCIS has a significant association with other high-risk lesions and invasive lobular carcinoma...
  4. doi request reprint Clinical importance of HER2 immunohistologic heterogeneous expression in core-needle biopsies vs resection specimens for equivocal (immunohistochemical score 2+) cases
    Mamatha Chivukula
    Department of Pathology, Magee Women s Hospital of UPMC, Pittsburgh, PA 115213, USA
    Mod Pathol 21:363-8. 2008
    ..However, performing fluorescence in situ hybridization on core-needle biopsies almost completely resolves the issue of heterogeneous expression of HER2...
  5. doi request reprint PAX 2: a novel Müllerian marker for serous papillary carcinomas to differentiate from micropapillary breast carcinoma
    Mamatha Chivukula
    Department of Pathology, Magee Women s Hospital of UPMC, 300 Halket Street, Pittsburgh, PA 15213, USA
    Int J Gynecol Pathol 28:570-8. 2009
    ..We therefore conclude that PAX 2 is a promising new, sensitive, and specific müllerian immunomarker for ovarian serous carcinomas (primary and metastatic)...
  6. doi request reprint Characterization of high-grade ductal carcinoma in situ with and without regressive changes: diagnostic and biologic implications
    Mamatha Chivukula
    Department of Pathology, Division of Anatomic Pathology, Magee Women s Hospital of University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania 15213, USA
    Appl Immunohistochem Mol Morphol 17:495-9. 2009
    ..HGDCIS-RC may also be a sign of an aggressive phenotype than other HGDCIS subtypes. Further outcome studies are necessary to determine if it has a clinical impact akin to other tumors with RC...
  7. ncbi request reprint Recurrent gynandroblastoma of ovary-A case report: a molecular and immunohistochemical analysis
    Mamatha Chivukula
    Department of Pathology, Magee Womens Hospital of the UPMC Health System, Pittsburgh, PA, USA
    Int J Gynecol Pathol 26:30-3. 2007
    ..All the previously mentioned immunostainings support the diagnosis. We report the first case of a recurrent gynandroblastoma 10 years after initial presentation along with its molecular analysis and immunohistochemical studies...
  8. ncbi request reprint The ductal phenotypic expression of the E-cadherin/catenin complex in tubulolobular carcinoma of the breast: an immunohistochemical and clinicopathologic study
    Nicole N Esposito
    Department of Pathology, University of Pittsburgh Medical Center, Pittsburgh, PA 15261, USA
    Mod Pathol 20:130-8. 2007
    ..Tubulolobular carcinoma appears to be more aggressive than tubular carcinoma, as 16% of patients had lymph node metastases, although all were alive at a mean follow-up of 40 months...
  9. ncbi request reprint Basal phenotype of ductal carcinoma in situ: recognition and immunohistologic profile
    David J Dabbs
    Department of Pathology, Magee Women s Hospital of UPMC, Pittsburgh, PA 15213, USA
    Mod Pathol 19:1506-11. 2006
    ....
  10. ncbi request reprint Lobular versus ductal breast neoplasms: the diagnostic utility of p120 catenin
    David J Dabbs
    Department of Pathology, Magee Women s Hospital of the University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
    Am J Surg Pathol 31:427-37. 2007
    ..Caution should be exercised when examining tumors in metastatic sites with P120ctn, with the incorporation of an appropriate panel of immunostains...
  11. pmc Comparison of survival outcomes between patients with malignant mixed mullerian tumors and high-grade endometrioid, clear cell, and papillary serous endometrial cancers
    Ashley Sinclair Felix
    Division of Cancer Prevention and Population Science, University of Pittsburgh Cancer Institute, Department of Epidemiology, University of Pittsburgh Graduate School of Public Health, and Department of Obstetrics and Gynecologic Oncology, Magee Women s Hospital of UPMC Health System, Pittsburgh, PA 15232, USA
    Int J Gynecol Cancer 21:877-84. 2011
    ..The goal of this study was to compare recurrence-free survival (RFS), disease-specific survival (DSS), and overall survival (OS) among EC subtypes...
  12. pmc Columnar cell lesions and pseudoangiomatous hyperplasia like stroma: is there an epithelial-stromal interaction?
    Rosemary A Recavarren
    Department of Pathology at Magee Women s Hospital of University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
    Int J Clin Exp Pathol 3:87-97. 2009
    ..Our study suggests an intimate vascular and hormone dependent epithelial-stromal interaction exists in CCPLS lesions...
  13. ncbi request reprint The spectrum of morphomolecular abnormalities of the E-cadherin/catenin complex in pleomorphic lobular carcinoma of the breast
    David J Dabbs
    Department of Pathology, Magee Women s Hospital of University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
    Appl Immunohistochem Mol Morphol 15:260-6. 2007
    ..The diffuse cytoplasmic immunostaining of p120 in lobular neoplasia may be useful diagnostically as a positive marker for lobular neoplasia...
  14. doi request reprint Clinical importance of histologic grading of lobular carcinoma in situ in breast core needle biopsy specimens: current issues and controversies
    Faye Gao
    Department of Pathology, University of Pittsburgh Medical Center, 200 Lothrop St, Pittsburgh, PA 15261, USA
    Am J Clin Pathol 133:767-71. 2010
    ..Our study illustrates the importance of grading LCIS; we recommend follow-up excision in LCIS NG 2 cases owing to a high incidence of residual LCIS and the likelihood of identifying other high-risk lesions...
  15. pmc Biomarker profile in breast carcinomas presenting with bone metastasis
    Olga L Bohn
    Department of Pathology, Magee Women s Hospital of University of Pittsburgh Medical Center, Pittsburgh, PA 15213 3180, USA
    Int J Clin Exp Pathol 3:139-46. 2009
    ..The high morbidity associated to metastatic breast cancer prompts the identification of predictive biomarkers of relapse of breast tumors to categorize patients at high risk of bone metastasis and serve as targeted therapy...
  16. doi request reprint Clinicopathologic implications of "flat epithelial atypia" in core needle biopsy specimens of the breast
    Mamatha Chivukula
    Dept of Pathology, Magee Women s Hospital of UPMC, University of Pittsburgh, PA 15213, USA
    Am J Clin Pathol 131:802-8. 2009
    ..Our study concludes that there is an association of FEA with ADH on multiple levels of CNB specimens, and follow-up surgical excision findings for FEA are clinically significant...
  17. doi request reprint Interobserver agreement among pathologists for semiquantitative hormone receptor scoring in breast carcinoma
    David A Cohen
    Department of Pathology, Magee Womens Hospital of UPMC, Pittsburgh, PA, USA
    Am J Clin Pathol 138:796-802. 2012
    ..85 (95% confidence interval [CI] = 0.79-0.90) for ER and 0.87 (95% CI = 0.82-0.92) for PR. Because the H-score provides a continuous measure of tumor hormone receptor content, we suggest universal adoption of this method...
  18. doi request reprint The effect of 96-hour formalin fixation on the immunohistochemical evaluation of estrogen receptor, progesterone receptor, and HER2 expression in invasive breast carcinoma
    Isil Z Yildiz-Aktas
    Department of Pathology, Magee Womens Hospital, University of Pittsburgh Medical Center, PA 15213, USA
    Am J Clin Pathol 137:691-8. 2012
    ..ER, PR, and HER2 immunohistochemical results should be considered valid for cases fixed up to 96 hours...
  19. ncbi request reprint Immunohistochemical comparison of gastrointestinal stromal tumor and solitary fibrous tumor
    Vinod B Shidham
    Department of Pathology, Medical College of Wisconsin, Milwaukee 53226, USA
    Arch Pathol Lab Med 126:1189-92. 2002
    ..The immunoreactivity of SFT with the Dako CD117 antibody has not been reported. Conversely, CD99 is a marker for SFT, and its expression in GIST has not been evaluated...
  20. ncbi request reprint Immunostaining of cytology smears: a comparative study to identify the most suitable method of smear preparation and fixation with reference to commonly used immunomarkers
    Vinod B Shidham
    Department of Pathology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    Diagn Cytopathol 29:217-21. 2003
    ..Most importantly, method C, which is the desired choice for cytomorphological staining, was not suitable for immunostaining...
  21. doi request reprint Basal-like subtype breast cancers in women older than 40 years of age
    Cagatay Ersahin
    Department of Pathology, Loyola University Medical Center, Maywood, IL 60153, USA
    Int J Surg Pathol 18:42-7. 2010
    ..BL cancer patients from all age groups require further investigation for BRCA-1, as well as gene microarray analysis to compare the gene expressions with those observed in the younger population...
  22. pmc Prognostic utility of the breast cancer index and comparison to Adjuvant! Online in a clinical case series of early breast cancer
    Rachel C Jankowitz
    Department of Medicine, Division of Hematology Oncology, UPMC, University of Pittsburgh Cancer Institute, 300 Halket Street, Suite 4628, Pittsburgh, PA 15213, USA
    Breast Cancer Res 13:R98. 2011
    ..Objectives of the current study were to validate BCI in a clinical case series and to compare the prognostic utility of BCI and Adjuvant!Online (AO)...
  23. pmc CSPG4 protein as a new target for the antibody-based immunotherapy of triple-negative breast cancer
    Xinhui Wang
    University of Pittsburgh Cancer Institute, Pittsburgh, PA 15213, USA
    J Natl Cancer Inst 102:1496-512. 2010
    ..The lack of effective therapy for triple-negative breast cancer (TNBC) prompted us to examine whether CSPG4 is expressed in TNBC and can be targeted with CSPG4-specific mAb...
  24. doi request reprint An immunohistochemical panel to differentiate metastatic breast carcinoma to skin from primary sweat gland carcinomas with a review of the literature
    Marian Rollins-Raval
    Department of Pathology, University of Pittsburgh Medical Center, Pennsylvania 15261, USA
    Arch Pathol Lab Med 135:975-83. 2011
    ..Although a few studies attempt to differentiate these entities employing immunohistochemical (IHC) studies (some of which we review here), to date, no panel of IHC stains exists, to our knowledge, to distinguish these entities...
  25. doi request reprint Is PAX2 a reliable marker in differentiating diffuse malignant mesotheliomas of peritoneum from serous carcinomas of müllerian origin?
    Faye F Gao
    Department of Pathology, Magee Women s Hospital, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
    Appl Immunohistochem Mol Morphol 20:272-6. 2012
    ..All cases were stained with PAX2, Wilm tumor gene 1, calretinin and the results were compared. Our results demonstrate that PAX2 can be used reliably as a Müllerian marker in formulating an efficient panel to differentiate DPMM and SC...
  26. doi request reprint Risk of malignancy when microscopic radial scars and microscopic papillomas are found at percutaneous biopsy
    Karen A Lee
    Breast Imaging, Department of Radiology, Magee Women s Hospital of the University of Pittsburgh Medical Center, 300 Halket St, Pittsburgh, PA 15213, USA
    AJR Am J Roentgenol 198:W141-5. 2012
    ....
  27. pmc Factors associated with Type I and Type II endometrial cancer
    Ashley S Felix
    Division of Cancer Prevention and Population Science, University of Pittsburgh Cancer Institute, 5150 Centre Avenue, Suite 4 C, Pittsburgh, PA 15232, USA
    Cancer Causes Control 21:1851-6. 2010
    ..We investigated risk factors for Type II (n = 176) vs. Type I (n = 1,576) endometrial cancer (EC) in cases treated at Magee-Womens Hospital between 1996 and 2008...
  28. ncbi request reprint FNAB cytology of chordoma masquerading as adenocarcinoma: case report
    Mamatha Chivukula
    Department of Pathology, Medical College of Wisconsin, 9200 West Wisconsin Avenue, Milwaukee, WI 53226, USA
    Diagn Cytopathol 26:306-9. 2002
    ....