K C Chiu

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi request reprint Fatty acid binding protein 2 and insulin resistance
    K C Chiu
    Department of Medicine, University of California, Los Angeles, School of Medicine, Los Angeles, California, USA
    Eur J Clin Invest 31:521-7. 2001
  2. ncbi request reprint Association of paraoxonase 1 polymorphism with beta-cell function: a case of molecular heterosis
    Ken C Chiu
    Division of Clinical Epidemiology and Preventive Medicine, Department of Medicine, University of California, Los Angeles, David Geffen School of Medicine, Los Angeles, California, USA
    Pancreas 28:e96-103. 2004
  3. ncbi request reprint New insulin sensitivity adjusted beta cell indices: validation according to a genetic study
    Ken C Chiu
    Division of Endocrinology, Diabetes, and Hypertension, University of California, Los Angeles, School of Medicine, Los Angeles, California, USA
    Pancreas 27:e23-8. 2003
  4. ncbi request reprint Comparison of the impact of the I27L polymorphism of the hepatocyte nuclear factor-1alpha on estimated and measured beta cell indices
    Ken C Chiu
    Division of Endocrinology, Diabetes and Hypertension, University of California Los Angeles School of Medicine, Los Angeles, CA, USA
    Eur J Endocrinol 148:641-7. 2003
  5. ncbi request reprint Transcription factor 1 and beta-cell function in glucose-tolerant subjects
    K C Chiu
    Division of Endocrinology, Diabetes, and Hypertension, Department of Medicine, University of California, Los Angeles School of Medicine, USA
    Diabet Med 20:225-30. 2003
  6. ncbi request reprint Association of leptin receptor polymorphism with insulin resistance
    Ken C Chiu
    Division of Clinical Epidemiology and Preventive Medicine, Department of Medicine, UCLA School of Medicine, University of California Los Angeles, 924 Westwood Boulevard 335, Los Angeles, CA 90024, USA
    Eur J Endocrinol 150:725-9. 2004
  7. ncbi request reprint Comparison of the relationship of age and beta cell function in three ethnic groups
    Ken C Chiu
    Division of Clinical Epidemiology and Preventive Medicine, Department of Medicine, University of California and David Geffen School of Medicine, Los Angeles, California, USA
    Clin Endocrinol (Oxf) 62:296-302. 2005
  8. pmc The A54T polymorphism at the intestinal fatty acid binding protein 2 is associated with insulin resistance in glucose tolerant Caucasians
    K C Chiu
    Division of Endocrinology, Diabetes and Hypertension, Department of Medicine, University of California, Los Angeles, School of Medicine, Los Angeles, California, USA
    BMC Genet 2:7. 2001
  9. ncbi request reprint Comparison of measured and estimated indices of insulin sensitivity and beta cell function: impact of ethnicity on insulin sensitivity and beta cell function in glucose-tolerant and normotensive subjects
    K C Chiu
    Division of Endocrinology, Diabetes, and Hypertension, Department of Medicine, University of California Los Angeles, School of Medicine, Los Angeles, California 90095 7097, USA
    J Clin Endocrinol Metab 86:1620-5. 2001
  10. pmc Hepatic glucokinase promoter polymorphism is associated with hepatic insulin resistance in Asian Indians
    K C Chiu
    Division of Endocrinology, Diabetes and Hypertension, Department of Medicine, University of California, Los Angeles, School of Medicine, Los Angeles, California, USA
    BMC Genet 1:2. 2000

Collaborators

Detail Information

Publications23

  1. ncbi request reprint Fatty acid binding protein 2 and insulin resistance
    K C Chiu
    Department of Medicine, University of California, Los Angeles, School of Medicine, Los Angeles, California, USA
    Eur J Clin Invest 31:521-7. 2001
    ..Their genotypes were determined using a polymerase chain reaction-restriction fragment length polymorphism assay. The relationship between genotypes and phenotypes was examined...
  2. ncbi request reprint Association of paraoxonase 1 polymorphism with beta-cell function: a case of molecular heterosis
    Ken C Chiu
    Division of Clinical Epidemiology and Preventive Medicine, Department of Medicine, University of California, Los Angeles, David Geffen School of Medicine, Los Angeles, California, USA
    Pancreas 28:e96-103. 2004
    ..We observed the L55M polymorphism of the PON1 gene as an independent determinant for beta-cell function in glucose-tolerant whites. Our observations suggest that this polymorphism could play a role in beta-cell dysfunction...
  3. ncbi request reprint New insulin sensitivity adjusted beta cell indices: validation according to a genetic study
    Ken C Chiu
    Division of Endocrinology, Diabetes, and Hypertension, University of California, Los Angeles, School of Medicine, Los Angeles, California, USA
    Pancreas 27:e23-8. 2003
    ..To facilitate the identification of subjects with a low beta cell reserve, we developed beta cell indices and validated according to a genetic study...
  4. ncbi request reprint Comparison of the impact of the I27L polymorphism of the hepatocyte nuclear factor-1alpha on estimated and measured beta cell indices
    Ken C Chiu
    Division of Endocrinology, Diabetes and Hypertension, University of California Los Angeles School of Medicine, Los Angeles, CA, USA
    Eur J Endocrinol 148:641-7. 2003
    ..We investigated the impact of the I27L polymorphism of the hepatocyte nuclear factor-1alpha gene on measured and estimated beta cell indices. We also examined the conservation of this amino acid among different species...
  5. ncbi request reprint Transcription factor 1 and beta-cell function in glucose-tolerant subjects
    K C Chiu
    Division of Endocrinology, Diabetes, and Hypertension, Department of Medicine, University of California, Los Angeles School of Medicine, USA
    Diabet Med 20:225-30. 2003
    ..Mutations of transcription factor 1 (TCF1, or hepatocyte nuclear factor-1alpha) affect beta-cell function. We examined the impact of amino acid polymorphisms of this gene on beta-cell function in 60 glucose-tolerant Caucasians...
  6. ncbi request reprint Association of leptin receptor polymorphism with insulin resistance
    Ken C Chiu
    Division of Clinical Epidemiology and Preventive Medicine, Department of Medicine, UCLA School of Medicine, University of California Los Angeles, 924 Westwood Boulevard 335, Los Angeles, CA 90024, USA
    Eur J Endocrinol 150:725-9. 2004
    ..Although the role of the leptin receptor (LEPR) in obesity is well recognized, its role in insulin sensitivity remains unknown...
  7. ncbi request reprint Comparison of the relationship of age and beta cell function in three ethnic groups
    Ken C Chiu
    Division of Clinical Epidemiology and Preventive Medicine, Department of Medicine, University of California and David Geffen School of Medicine, Los Angeles, California, USA
    Clin Endocrinol (Oxf) 62:296-302. 2005
    ..It has been demonstrated that beta cell function declines at about 1% per year in glucose tolerant Caucasians. However, this relationship is not known to exist in other ethnic groups...
  8. pmc The A54T polymorphism at the intestinal fatty acid binding protein 2 is associated with insulin resistance in glucose tolerant Caucasians
    K C Chiu
    Division of Endocrinology, Diabetes and Hypertension, Department of Medicine, University of California, Los Angeles, School of Medicine, Los Angeles, California, USA
    BMC Genet 2:7. 2001
    ..Their genotypes were determined using a polymerase chain reaction-restriction fragment length polymorphism assay. The relationship between the genotypes and the phenotypes was examined...
  9. ncbi request reprint Comparison of measured and estimated indices of insulin sensitivity and beta cell function: impact of ethnicity on insulin sensitivity and beta cell function in glucose-tolerant and normotensive subjects
    K C Chiu
    Division of Endocrinology, Diabetes, and Hypertension, Department of Medicine, University of California Los Angeles, School of Medicine, Los Angeles, California 90095 7097, USA
    J Clin Endocrinol Metab 86:1620-5. 2001
    ....
  10. pmc Hepatic glucokinase promoter polymorphism is associated with hepatic insulin resistance in Asian Indians
    K C Chiu
    Division of Endocrinology, Diabetes and Hypertension, Department of Medicine, University of California, Los Angeles, School of Medicine, Los Angeles, California, USA
    BMC Genet 1:2. 2000
    ..Beta cell function was estimated using %B from the Homeostasis Model Assessment and insulingenic index (dI/dG)...
  11. ncbi request reprint Impact of apolipoprotein A5 polymorphisms on insulin sensitivity and beta-cell function
    Ken C Chiu
    Division of Clinical Epidemiology and Preventive Medicine, Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA, USA
    Pancreas 30:328-32. 2005
    ..Apolipoprotein A5 (APOA5) is an important determinant of lipid metabolism. The impact of the APOA5 gene on insulin sensitivity and beta-cell function has not been examined...
  12. ncbi request reprint The I27L amino acid polymorphism of hepatic nuclear factor-1alpha is associated with insulin resistance
    K C Chiu
    Department of Medicine, University of California School of Medicine, Los Angeles 90095, USA
    J Clin Endocrinol Metab 85:2178-83. 2000
    ..Therefore, we conclude that the I27L polymorphism is associated with insulin resistance, but not beta-cell function. The mechanism of this association is unclear, but HNF-1alpha may play a role in regulating hepatic glucose metabolism...
  13. ncbi request reprint Insulin sensitivity differs among ethnic groups with a compensatory response in beta-cell function
    K C Chiu
    Department of Medicine, University of California, Los Angeles, School of Medicine, USA
    Diabetes Care 23:1353-8. 2000
    ..A drastic difference is evident in the prevalence of type 2 diabetes among ethnic groups. We examined the role of beta-cell function and insulin sensitivity in this disparity among 4 ethnic groups...
  14. ncbi request reprint Beta cell function declines with age in glucose tolerant Caucasians
    K C Chiu
    Division of Endocrinology, Diabetes and Hypertension, University of California, Los Angeles, School of Medicine, Los Angeles, California, USA
    Clin Endocrinol (Oxf) 53:569-75. 2000
    ..However, existing data are controversial on the effect of ageing on both insulin sensitivity and beta cell function...
  15. ncbi request reprint Hypovitaminosis D is associated with insulin resistance and beta cell dysfunction
    Ken C Chiu
    Division of Clinical Epidemiology and Preventive Medicine, Department of Medicine, University of California Los Angeles School of Medicine, 924 Westwood Boulevard, Los Angeles, CA 90024, USA
    Am J Clin Nutr 79:820-5. 2004
    ..Although the role of vitamin D in type 2 diabetes is well recognized, its relation to glucose metabolism is not well studied...
  16. ncbi request reprint Fish oil decreases macrophage tumor necrosis factor gene transcription by altering the NF kappa B activity
    C J Lo
    Department of Surgery, University of California, Los Angeles, California, 90095, USA
    J Surg Res 82:216-21. 1999
    ..This study investigated the effects of eicosapentanenoic acid (EPA), a major component of fish oil, on transcriptional regulation of tumor necrosis factor (TNF) gene in lipopolysaccharide (LPS)-stimulated macrophages (MO)...
  17. ncbi request reprint The GENNID Study. A resource for mapping the genes that cause NIDDM
    L J Raffel
    Cedars Sinai Research Institute, Los Angeles, California 90048, USA
    Diabetes Care 19:864-72. 1996
    ..To develop a resource, consisting of comprehensive data and lymphoblastoid cell lines, of well-characterized NIDDM families that will be available to the scientific community for genetic studies of NIDDM...
  18. ncbi request reprint Fish oil augments macrophage cyclooxygenase II (COX-2) gene expression induced by endotoxin
    C J Lo
    Department of Surgery, University of California, Los Angeles, Los Angeles, California 90095 6904, USA
    J Surg Res 86:103-7. 1999
    ..This study was designed to investigate the effects of eicosapentaenoic acid (EPA), a major component of fish oil, on macrophage (Mphi) cyclooxygenase (COX) gene expression induced by LPS...
  19. ncbi request reprint Relative contribution of insulin sensitivity and beta-cell function to plasma glucose and insulin concentrations during the oral glucose tolerance test
    Ken C Chiu
    Division of Endocrinology, Diabetes and Hypertension, Department of Medicine, University of California, Los Angeles, School of Medicine, Los Angeles, CA, USA
    Metabolism 51:115-20. 2002
    ..Therefore, we conclude that it is essential to measure beta-cell function in vivo if one plans to study the genetic influence of beta-cell dysfunction...
  20. ncbi request reprint Glucokinase and NIDDM. A candidate gene that paid off
    M A Permutt
    Division of Endocrinology, Diabetes, and Metabolism, Washington University School of Medicine, St Louis, MO 63110
    Diabetes 41:1367-72. 1992
    ..This study considers the phenotypes that result from glucokinase defects and the relationship of MODY to NIDDM, and it estimates the role of glucokinase defects in NIDDM in general...
  21. ncbi request reprint Fish oil modulates macrophage P44/P42 mitogen-activated protein kinase activity induced by lipopolysaccharide
    C J Lo
    Department of Surgery, University of California, Los Angeles, USA
    JPEN J Parenter Enteral Nutr 24:159-63. 2000
    ..Overactivity of MAPK has been implicated in the development of many diseases, including cancer and sepsis. This study investigated the hypothesis that fish oil altered the membrane phospholipid composition and modulated MAPK activity...
  22. ncbi request reprint Association study of the genetic polymorphisms of the transcription factor 7-like 2 (TCF7L2) gene and type 2 diabetes in the Chinese population
    Yi Cheng Chang
    Department of Internal Medicine, National Taiwan University Hospital Yunlin Branch, Yunlin, Taiwan
    Diabetes 56:2631-7. 2007
    ..In this study, we aimed to explore the effect of the TCF7L2 polymorphisms in a Han Chinese population...
  23. ncbi request reprint The Arg16Gly polymorphism of human beta2-adrenoreceptor is associated with type 2 diabetes in Taiwanese people
    Tien Jyun Chang
    Department of Internal Medicine, En Chu Kung Hospital, San shia Town, Taipei Hsien, Taiwan
    Clin Endocrinol (Oxf) 57:685-90. 2002
    ..In this study, the association of ADRB2 with risk and age of onset of type 2 diabetes has been examined in a Taiwanese population...