KANCHAN A CHITALEY

Summary

Affiliation: University of Washington
Country: USA

Publications

  1. ncbi Vasodilator-stimulated phosphoprotein is a substrate for protein kinase C
    K Chitaley
    Department of Surgery, University of Washington, Seattle, WA 98195, USA
    FEBS Lett 556:211-5. 2004
  2. doi Strain differences in susceptibility to in vivo erectile dysfunction following 6 weeks of induced hyperglycemia in the mouse
    Kanchan Chitaley
    University of Washington Urology, Seattle, Washington, DC 98104, USA
    J Sex Med 5:1149-55. 2008
  3. doi Type 1 and Type 2 diabetic-erectile dysfunction: same diagnosis (ICD-9), different disease?
    Kanchan Chitaley
    University of Washington, Department of Urology, Seattle, WA 98109, USA
    J Sex Med 6:262-8. 2009
  4. ncbi Adeno-associated viral gene transfer of dominant negative RhoA enhances erectile function in rats
    Kanchan Chitaley
    Department of Physiology, Medical College of Georgia, Augusta, GA 30912, USA
    Biochem Biophys Res Commun 298:427-32. 2002
  5. doi Erectile dysfunction in the type II diabetic db/db mouse: impaired venoocclusion with altered cavernosal vasoreactivity and matrix
    Ian P Luttrell
    Department of Urology, University of Washington, 300 Ninth Avenue, Seattle, WA 98104, USA
    Am J Physiol Heart Circ Physiol 294:H2204-11. 2008
  6. doi Review type 2 diabetes mellitus and erectile dysfunction
    Josephine Hidalgo-Tamola
    University of Washington, Department of Urology, Seattle, Washington, WA, USA
    J Sex Med 6:916-26. 2009
  7. pmc Transcriptional profiling of human cavernosal endothelial cells reveals distinctive cell adhesion phenotype and role for claudin 11 in vascular barrier function
    Hunter Wessells
    Departments of Urology, Harborview Medical Center, 325 Ninth Ave, Seattle Washington 98104, USA
    Physiol Genomics 39:100-8. 2009
  8. pmc Vasodilator-stimulated phosphoprotein regulates proliferation and growth inhibition by nitric oxide in vascular smooth muscle cells
    Lihua Chen
    Department of Surgery, University of Washington, Seattle, WA 98195, USA
    Arterioscler Thromb Vasc Biol 24:1403-8. 2004
  9. ncbi Nitric oxide inhibits RhoA/Rho-kinase signaling to cause penile erection
    Thomas M Mills
    Department of Physiology, Medical College of Georgia, Augusta, GA, USA
    Eur J Pharmacol 439:173-4. 2002
  10. ncbi Fluid shear stress-induced nitric oxide production in human cavernosal endothelial cells: inhibition by hyperglycaemia
    Hunter Wessells
    Department of Urology, University of Washington School of Medicine and Harborview Medical Center, Seattle, WA 98104 2499, USA
    BJU Int 97:1047-52. 2006

Detail Information

Publications16

  1. ncbi Vasodilator-stimulated phosphoprotein is a substrate for protein kinase C
    K Chitaley
    Department of Surgery, University of Washington, Seattle, WA 98195, USA
    FEBS Lett 556:211-5. 2004
    ..Additionally, recombinant PKCalpha directly phosphorylated Ser157 on VASP. In summary, our data support the hypothesis that PKC phosphorylates VASP and mediates serum-induced VASP regulation...
  2. doi Strain differences in susceptibility to in vivo erectile dysfunction following 6 weeks of induced hyperglycemia in the mouse
    Kanchan Chitaley
    University of Washington Urology, Seattle, Washington, DC 98104, USA
    J Sex Med 5:1149-55. 2008
    ..Although in vitro studies of the mouse cavernosum show impairment of vasoreactivity, to date, no studies have demonstrated the in vivo impairment of erectile function in diabetic mice...
  3. doi Type 1 and Type 2 diabetic-erectile dysfunction: same diagnosis (ICD-9), different disease?
    Kanchan Chitaley
    University of Washington, Department of Urology, Seattle, WA 98109, USA
    J Sex Med 6:262-8. 2009
    ..In the laboratory, the presence of erectile dysfunction (ED) has been established in animal models of both type 1 and type 2 diabetes...
  4. ncbi Adeno-associated viral gene transfer of dominant negative RhoA enhances erectile function in rats
    Kanchan Chitaley
    Department of Physiology, Medical College of Georgia, Augusta, GA 30912, USA
    Biochem Biophys Res Commun 298:427-32. 2002
    ..The novel findings of this study demonstrate a functional role of RhoA in maintaining the flaccid penis and provide support for the inhibition of RhoA as a potential therapy for the enhancement of erectile function...
  5. doi Erectile dysfunction in the type II diabetic db/db mouse: impaired venoocclusion with altered cavernosal vasoreactivity and matrix
    Ian P Luttrell
    Department of Urology, University of Washington, 300 Ninth Avenue, Seattle, WA 98104, USA
    Am J Physiol Heart Circ Physiol 294:H2204-11. 2008
    ..These vasoreactive and sinusoidal matrix alterations may alter tissue compliance dispensability, preventing the normal expansion necessary for erection...
  6. doi Review type 2 diabetes mellitus and erectile dysfunction
    Josephine Hidalgo-Tamola
    University of Washington, Department of Urology, Seattle, Washington, WA, USA
    J Sex Med 6:916-26. 2009
    ..Although most diabetic ED cases are in patients with type 2 diabetes (T2DM), the majority of basic science studies examining mechanisms of diabetic ED have been conducted in animal models of type 1 diabetes...
  7. pmc Transcriptional profiling of human cavernosal endothelial cells reveals distinctive cell adhesion phenotype and role for claudin 11 in vascular barrier function
    Hunter Wessells
    Departments of Urology, Harborview Medical Center, 325 Ninth Ave, Seattle Washington 98104, USA
    Physiol Genomics 39:100-8. 2009
    ..Contribution of the tight junction protein CLDN11 to barrier function in endothelial cells is novel and may reflect hemodynamic requirements of the corpus cavernosum...
  8. pmc Vasodilator-stimulated phosphoprotein regulates proliferation and growth inhibition by nitric oxide in vascular smooth muscle cells
    Lihua Chen
    Department of Surgery, University of Washington, Seattle, WA 98195, USA
    Arterioscler Thromb Vasc Biol 24:1403-8. 2004
    ..We have investigated the effects of VASP and VASP phosphorylation at serine157 and serine239 on smooth muscle cell (SMC) proliferation and nitric oxide (NO)-mediated growth inhibition...
  9. ncbi Nitric oxide inhibits RhoA/Rho-kinase signaling to cause penile erection
    Thomas M Mills
    Department of Physiology, Medical College of Georgia, Augusta, GA, USA
    Eur J Pharmacol 439:173-4. 2002
    ..These results support the hypothesis that NO inhibits Rho-kinase-induced cavernosal vasoconstriction during erection...
  10. ncbi Fluid shear stress-induced nitric oxide production in human cavernosal endothelial cells: inhibition by hyperglycaemia
    Hunter Wessells
    Department of Urology, University of Washington School of Medicine and Harborview Medical Center, Seattle, WA 98104 2499, USA
    BJU Int 97:1047-52. 2006
    ....
  11. ncbi Nitric oxide induces dilation of rat aorta via inhibition of rho-kinase signaling
    Kanchan Chitaley
    Department of Physiology, Medical College of Georgia, Augusta 30912 3000, USA
    Hypertension 39:438-42. 2002
    ....
  12. pmc RhoA/Rho-kinase suppresses endothelial nitric oxide synthase in the penis: a mechanism for diabetes-associated erectile dysfunction
    Trinity J Bivalacqua
    Department of Urology, Tulane Health Sciences Center, New Orleans, LA 70112, USA
    Proc Natl Acad Sci U S A 101:9121-6. 2004
    ..Importantly, these data imply that inhibition of RhoA/Rho-kinase improves eNOS protein content and activity thus restoring erectile function in diabetes...
  13. ncbi Inhibition of tonic contraction--a novel way to approach erectile dysfunction
    Thomas M Mills
    Department of Physiology, Medical College of Georgia, Augusta, 30912 3000, USA
    J Androl 23:S5-9. 2002
  14. pmc Constriction of carotid arteries by urokinase-type plasminogen activator requires catalytic activity and is independent of NH(2)-terminal domains
    Philip G Massey
    University of Washington, Seattle, WA 98195 7710, USA
    Thromb Haemost 102:983-92. 2009
    ..uPA catalytic activity, generated by artery wall cells, may contribute to lumen loss in human arteries. Elimination of uPA vasoconstrictor activity requires concomitant loss of fibrinolytic activity...
  15. ncbi Microtubule depolymerization facilitates contraction of rat aorta via activation of Rho-kinase
    Kanchan Chitaley
    Department of Physiology, University of Michigan, Ann Arbor, MI 48019, USA
    Vascul Pharmacol 38:157-61. 2002
    ..These results support the hypothesis that MT depolymerization facilitates contraction of rat aorta via activation of Rho-kinase...
  16. pmc Diabetes, obesity and erectile dysfunction: field overview and research priorities
    Kanchan Chitaley
    Department of Urology, University of Washington School of Medicine, Seattle, Washington, USA
    J Urol 182:S45-50. 2009
    ....

Research Grants5

  1. Erectile Dysfunction in Type II Diabetes: Role of Adiponectin
    Kanchan Chitaley; Fiscal Year: 2007
    ....
  2. Ceruloplasmin Mediated Penile Endothelial Dysfunction in Type 1 Diabetes
    Kanchan Chitaley; Fiscal Year: 2007
    ..Relevance to Public Health: Treatment or prevention of ED in men with diabetes is necessary to improve life satisfaction and reduce the utilization of health care resources in this rapidly growing portion of the American population. ..
  3. Disorganization of Elastin Matrix Mediates Erectile Dysfunction
    KANCHAN A CHITALEY; Fiscal Year: 2010
    ..We hypothesize that disruptions in elastin content and elastic fiber organization contribute to erectile dysfunction associated with type II diabetes. ..