Julio A Chirinos

Summary

Affiliation: University of Pennsylvania
Country: USA

Publications

  1. pmc Central pulse pressure and its hemodynamic determinants in middle-aged adults with impaired fasting glucose and diabetes: the Asklepios study
    Julio A Chirinos
    University of Pennsylvania School of Medicine Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania, USA
    Diabetes Care 36:2359-65. 2013
  2. doi request reprint Early and late systolic wall stress differentially relate to myocardial contraction and relaxation in middle-aged adults: the Asklepios study
    Julio A Chirinos
    Philadelphia VA Medical Center and University of Pennsylvania, Philadelphia, PA 19104, USA
    Hypertension 61:296-303. 2013
  3. doi request reprint Arterial wave reflections and incident cardiovascular events and heart failure: MESA (Multiethnic Study of Atherosclerosis)
    Julio A Chirinos
    Philadelphia VA Medical Center and University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    J Am Coll Cardiol 60:2170-7. 2012
  4. doi request reprint Arterial properties as determinants of time-varying myocardial stress in humans
    Julio A Chirinos
    Philadelphia Veterans Affairs Medical Center University of Pennsylvania, Philadelphia, PA, USA
    Hypertension 60:64-70. 2012
  5. doi request reprint Arterial stiffness: basic concepts and measurement techniques
    Julio A Chirinos
    Philadelphia VA Medical Center, University of Pennsylvania Perelman School of Medicine, Rm 8B111 University and Woodland Av, Philadelphia, PA, USA
    J Cardiovasc Transl Res 5:243-55. 2012
  6. doi request reprint Body mass index and hypertension hemodynamic subtypes in the adult US population
    Julio A Chirinos
    Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia Veterans Affairs Medical Center, 19104, USA
    Arch Intern Med 169:580-6. 2009
  7. doi request reprint Noninvasive evaluation of left ventricular afterload: part 2: arterial pressure-flow and pressure-volume relations in humans
    Julio A Chirinos
    Department of Medicine, Philadelphia Veterans Affairs Medical Center University of Pennsylvania, Philadelphia, PA, USA
    Hypertension 56:563-70. 2010
  8. doi request reprint Arterial pulsatile hemodynamic load induced by isometric exercise strongly predicts left ventricular mass in hypertension
    Julio A Chirinos
    University of Pennsylvania, Philadelphia Veterans Affairs Medical Center, Philadelphia, PA 19104, USA
    Am J Physiol Heart Circ Physiol 298:H320-30. 2010
  9. doi request reprint Noninvasive evaluation of left ventricular afterload: part 1: pressure and flow measurements and basic principles of wave conduction and reflection
    Julio A Chirinos
    Department of Medicine, Philadelphia Veterans Affairs Medical Center University of Pennsylvania, Philadelphia, PA, USA
    Hypertension 56:555-62. 2010
  10. doi request reprint Endogenous nitric oxide synthase inhibitors, arterial hemodynamics, and subclinical vascular disease: the PREVENCION Study
    Julio A Chirinos
    University of Pennsylvania, Philadelphia, USA
    Hypertension 52:1051-9. 2008

Research Grants

  1. Inflammatory response to sleep apnea in obese subjects
    JULIO ALONSO CHIRINOS MEDINA; Fiscal Year: 2010
  2. Inflammatory response to sleep apnea in obese subjects
    JULIO CHIRINOS MEDINA; Fiscal Year: 2009
  3. Inflammatory response to sleep apnea in obese subjects
    JULIO CHIRINOS MEDINA; Fiscal Year: 2009

Detail Information

Publications42

  1. pmc Central pulse pressure and its hemodynamic determinants in middle-aged adults with impaired fasting glucose and diabetes: the Asklepios study
    Julio A Chirinos
    University of Pennsylvania School of Medicine Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania, USA
    Diabetes Care 36:2359-65. 2013
    ..In a population-based study, we aimed to compare central PP and its hemodynamic determinants among adults with normal fasting glucose (n = 1654), IFG (n = 240), and type 2 diabetes (n = 33)...
  2. doi request reprint Early and late systolic wall stress differentially relate to myocardial contraction and relaxation in middle-aged adults: the Asklepios study
    Julio A Chirinos
    Philadelphia VA Medical Center and University of Pennsylvania, Philadelphia, PA 19104, USA
    Hypertension 61:296-303. 2013
    ..A loading sequence characterized by prominent late systolic wall stress was associated with lower longitudinal systolic function and diastolic relaxation...
  3. doi request reprint Arterial wave reflections and incident cardiovascular events and heart failure: MESA (Multiethnic Study of Atherosclerosis)
    Julio A Chirinos
    Philadelphia VA Medical Center and University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    J Am Coll Cardiol 60:2170-7. 2012
    ..This study sought to assess the relationship between central pressure profiles and cardiovascular events (CVEs) in a large community-based sample...
  4. doi request reprint Arterial properties as determinants of time-varying myocardial stress in humans
    Julio A Chirinos
    Philadelphia Veterans Affairs Medical Center University of Pennsylvania, Philadelphia, PA, USA
    Hypertension 60:64-70. 2012
    ..These observations may relate to the differential susceptibility of women to heart failure...
  5. doi request reprint Arterial stiffness: basic concepts and measurement techniques
    Julio A Chirinos
    Philadelphia VA Medical Center, University of Pennsylvania Perelman School of Medicine, Rm 8B111 University and Woodland Av, Philadelphia, PA, USA
    J Cardiovasc Transl Res 5:243-55. 2012
    ..This introductory paper reviews basic physical principles and definitions regarding arterial stiffness and the most important non-invasive methods for its quantification in vivo...
  6. doi request reprint Body mass index and hypertension hemodynamic subtypes in the adult US population
    Julio A Chirinos
    Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia Veterans Affairs Medical Center, 19104, USA
    Arch Intern Med 169:580-6. 2009
    ..Similarly, the study of hypertension subtypes provides important information regarding the relative importance of hemodynamic abnormalities contributing to obesity-related hypertension...
  7. doi request reprint Noninvasive evaluation of left ventricular afterload: part 2: arterial pressure-flow and pressure-volume relations in humans
    Julio A Chirinos
    Department of Medicine, Philadelphia Veterans Affairs Medical Center University of Pennsylvania, Philadelphia, PA, USA
    Hypertension 56:563-70. 2010
    ..Our review is aimed at helping researchers and clinicians obtain and interpret results from analyses of left ventricular afterload in clinical and epidemiological settings...
  8. doi request reprint Arterial pulsatile hemodynamic load induced by isometric exercise strongly predicts left ventricular mass in hypertension
    Julio A Chirinos
    University of Pennsylvania, Philadelphia Veterans Affairs Medical Center, Philadelphia, PA 19104, USA
    Am J Physiol Heart Circ Physiol 298:H320-30. 2010
    ....
  9. doi request reprint Noninvasive evaluation of left ventricular afterload: part 1: pressure and flow measurements and basic principles of wave conduction and reflection
    Julio A Chirinos
    Department of Medicine, Philadelphia Veterans Affairs Medical Center University of Pennsylvania, Philadelphia, PA, USA
    Hypertension 56:555-62. 2010
    ..Our review is aimed at helping researchers and clinicians apply and interpret results obtained from analyses of left ventricular afterload in clinical and epidemiological settings...
  10. doi request reprint Endogenous nitric oxide synthase inhibitors, arterial hemodynamics, and subclinical vascular disease: the PREVENCION Study
    Julio A Chirinos
    University of Pennsylvania, Philadelphia, USA
    Hypertension 52:1051-9. 2008
    ..L-arginine is independently associated with abnormal pulsatile (but not resistive) arterial hemodynamic indices, which may reflect abnormal L-arginine transport, leading to decreased intracellular bioavailability for NO synthesis...
  11. pmc Left ventricular mass: allometric scaling, normative values, effect of obesity, and prognostic performance
    Julio A Chirinos
    University of Pennsylvania Philadelphia Veterans Affairs Medical Center, Philadelphia, PA, USA
    Hypertension 56:91-8. 2010
    ..We provide more appropriate normalization methods, normative data by 2D echocardiography and gradient-echo cardiac MRI, and cutoffs for defining LVH, along with prognostic validation data...
  12. doi request reprint Time-varying myocardial stress and systolic pressure-stress relationship: role in myocardial-arterial coupling in hypertension
    Julio A Chirinos
    University of Pennsylvania, Philadelphia, USA
    Circulation 119:2798-807. 2009
    ..We assessed the relationship between instantaneous ejection-phase pressure and myocardial stress and the effect of arterial wave reflections on myocardial stress in hypertensive and normotensive adults...
  13. doi request reprint Efficacy of cholesterol uptake inhibition added to statin therapy among subjects following a low-carbohydrate diet: a randomized controlled trial
    Julio A Chirinos
    Department of Medicine, University of Pennsylvania and Philadelphia Veterans Affairs Medical Center, USA
    Am Heart J 159:918.e1-6. 2010
    ..However, the efficacy of cholesterol absorption inhibition added to statin therapy has not been studied in this common clinical setting...
  14. pmc Ethnic differences in arterial wave reflections and normative equations for augmentation index
    Julio A Chirinos
    Division of Cardiology, University of Pennsylvania Philadelphia Veterans Affairs Medical Center, PA, USA
    Hypertension 57:1108-16. 2011
    ..Our study provides normative data that can be used to complement the interpretation of individual hemodynamic assessments among men and women of various ethnic populations, after removing the effect of various physiological determinants...
  15. pmc Central pulse pressure in chronic kidney disease: a chronic renal insufficiency cohort ancillary study
    Raymond R Townsend
    University of Pennsylvania, 122 Founders Building, 3400 Spruce St, Philadelphia, PA 19104, USA
    Hypertension 56:518-24. 2010
    ..The large size of this unique chronic kidney disease cohort provides an ideal situation to study the role of brachial and central pressure measurements in kidney disease progression and cardiovascular disease incidence...
  16. ncbi request reprint Endothelial microparticles and platelet and leukocyte activation in patients with the metabolic syndrome
    Roque B Arteaga
    Department of Medicine, Leonard Miller School of Medicine, University of Miami, Florida, USA
    Am J Cardiol 98:70-4. 2006
    ..In conclusion, our data demonstrate endothelial cell microparticle release, platelet and leukocyte activation, and increased binding of EMPs and platelets to leukocytes in patients with the MS...
  17. doi request reprint Left ventricular remodeling in human heart failure: quantitative echocardiographic assessment of 1,794 patients
    Bonnie Ky
    Division of Cardiovascular Medicine Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Echocardiography 29:758-65. 2012
    ..We sought to define the adaptive remodeling that occurs in chronic human HF through the detailed analyses of a large quantitative echocardiography database...
  18. ncbi request reprint Usefulness of arterial compliance in the thigh in predicting exercise capacity in individuals without coronary heart disease
    Howard J Willens
    Department of Medicine, University of Miami School of Medicine, Miami, FL, USA
    Am J Cardiol 96:306-10. 2005
    ..In conclusion, thigh compliance measured with a simple-to-use, fully automated device independently predicts aerobic fitness in patients with a wide range of cardiovascular risk but without CHD...
  19. ncbi request reprint Prevalence of mitral annulus calcification in African Americans: comparison with non-Hispanic whites and Hispanics
    Howard J Willens
    Department of Medicine, Division of Cardiology, University of Miami, Miller School of Medicine, Florida, USA
    Ethn Dis 18:48-52. 2008
    ..We sought to compare prevalence and clinical correlates of mitral annulus calcification in non-Hispanic Whites, Hispanics, and African Americans...
  20. ncbi request reprint Correlation between apoptotic endothelial microparticles and serum interleukin-6 and C-reactive protein in healthy men
    Julio A Chirinos
    Department of Medicine, Wallace H Coulter Platelet Laboratory, University of Miami, Miami, Florida 33136, USA
    Am J Cardiol 95:1258-60. 2005
    ..49, p = 0.02) but not with EMP31 or EMP62E. EC apoptosis is associated with IL-6 levels in men and might be partially responsible for the increased cardiovascular risk associated with subclinical inflammation...
  21. ncbi request reprint Prevalence and clinical correlates of mitral annulus calcification in Hispanics and non-Hispanic whites
    Howard J Willens
    Department of Medicine, Division of Cardiology, University of Miami Miller School of Medicine, Miami, Florida, USA
    J Am Soc Echocardiogr 20:191-6. 2007
    ..Data about mitral annulus calcification (MAC) are sparse in Hispanics. We compare prevalence and clinical correlates of MAC in Hispanics and non-Hispanic whites...
  22. ncbi request reprint The relation between mitral annular calcification and mortality in patients undergoing diagnostic coronary angiography
    Howard J Willens
    Department of Medicine, University of Miami Miller School of Medicine, Miami, Florida, USA
    Echocardiography 23:717-22. 2006
    ..98, 95% CI = 1.68-9.40, P = 0.001). MAC detected by two-dimensional echocardiography independently predicts mortality and may provide an easy-to-perform and inexpensive way to improve risk stratification...
  23. pmc Aortic PWV in chronic kidney disease: a CRIC ancillary study
    Raymond R Townsend
    Department of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA
    Am J Hypertens 23:282-9. 2010
    ..Little data exist characterizing aortic stiffness in patients with chronic kidney disease (CKD) who are not receiving dialysis, and in particular the effect of reduced kidney function on aortic PWV...
  24. ncbi request reprint Elevation of endothelial microparticles, platelets, and leukocyte activation in patients with venous thromboembolism
    Julio A Chirinos
    Department of Medicine, University of Miami, Miami, Florida, USA
    J Am Coll Cardiol 45:1467-71. 2005
    ..The purpose of this research was to determine the levels of platelet, leukocyte, and endothelial activation and markers of cellular interactions in patients with venous thromboembolism (VTE)...
  25. doi request reprint The utility of prescreening transesophageal echocardiograms: a prospective study
    Jeffrey Ogbara
    Department of Medicine, Cardiovascular Division, Echocardiography Laboratory University of Pennsylvania, Philadelphia, Pennsylvania, USA
    Echocardiography 28:767-73. 2011
    ..However, the intersection of the AUC with the safety and clinical use of transesophageal echocardiography (TEE) is not well established...
  26. pmc Regional left ventricular systolic function and the right ventricle: the multi-ethnic study of atherosclerosis right ventricle study
    Christopher T Dibble
    University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Chest 140:310-6. 2011
    ..We hypothesized that better septal function would be associated with higher RV ejection fraction and lower RV mass and volume by cardiac MRI...
  27. ncbi request reprint Comparison of epicardial and pericardial fat thickness assessed by echocardiography in African American and non-Hispanic White men: a pilot study
    Howard J Willens
    Department of Medicine, Division of Cardiology University of Miami Miller School of Medicine, USA
    Ethn Dis 18:311-6. 2008
    ..This study explores whether this racial pattern of VAT distribution extends to the intrathoracic VAT...
  28. doi request reprint Strain improves risk prediction beyond ejection fraction in chronic systolic heart failure
    Kathleen W Zhang
    Penn Cardiovascular Institute, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA
    J Am Heart Assoc 3:e000550. 2014
    ..The utility of longitudinal, circumferential, and radial strain and strain rate in determining prognosis in chronic heart failure is not well established...
  29. ncbi request reprint Effects of weight loss after gastric bypass on right and left ventricular function assessed by tissue Doppler imaging
    Howard J Willens
    Department of Medicine, Division of Cardiology, University of Miami School of Medicine, Miami, Florida 33021 8437, USA
    Am J Cardiol 95:1521-4. 2005
    ..6 +/- 2.5 to 10.3 +/- 2.7 cm/s, p = 0.037). In patients with severe obesity, significant weight loss results in an increase in tricuspid annular systolic and early diastolic velocities and mitral annular early diastolic velocities...
  30. ncbi request reprint Effects of weight loss after bariatric surgery on epicardial fat measured using echocardiography
    Howard J Willens
    Department of Medicine, Division of Cardiology, University of Miami Miller School of Medicine, Miami, Florida, USA
    Am J Cardiol 99:1242-5. 2007
    ..Measuring epicardial fat thickness using echocardiography may be useful to monitor visceral fat loss with weight reduction therapies...
  31. doi request reprint Ventricular-arterial coupling, remodeling, and prognosis in chronic heart failure
    Bonnie Ky
    Penn Cardiovascular Institute, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania Electronic address
    J Am Coll Cardiol 62:1165-72. 2013
    ....
  32. doi request reprint Noninvasive differentiation of pulmonary arterial and venous hypertension using conventional and Doppler tissue imaging echocardiography
    Howard J Willens
    Department of Medicine, Division of Cardiology, University of Miami Miller School of Medicine, Miami, Florida, USA
    J Am Soc Echocardiogr 21:715-9. 2008
    ..Optimal cutoff for diagnosing PVH was 9.2 for E/E' (sensitivity 95%, specificity 96%) and 1.7 for E/A (sensitivity 75%, specificity 91%). PAH and PVH may be differentiated by readily obtainable conventional and tissue Doppler parameters...
  33. doi request reprint Transthoracic and transesophageal echocardiography for the indication of suspected infective endocarditis: vegetations, blood cultures and imaging
    Vinay Kini
    Hospital of the University of Pennsylvania, Department of Medicine, Cardiovascular Division, Philadelphia, Pennsylvania, USA
    J Am Soc Echocardiogr 23:396-402. 2010
    ..The aim of this study was to investigate the ability of transthoracic echocardiography (TTE) to detect vegetations and the relationship between blood cultures and transesophageal echocardiography (TEE)...
  34. pmc FGF-23 and the progression of coronary arterial calcification in patients new to dialysis
    Abigail May Khan
    Cardiovascular Division, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania, USA
    Clin J Am Soc Nephrol 7:2017-22. 2012
    ..The aim of this study was to evaluate the association of FGF-23 with CAC progression in advanced CKD...
  35. pmc Application of appropriateness criteria in outpatient transthoracic echocardiography
    James N Kirkpatrick
    Department of Medicine, Cardiovascular Division, Echocardiography Laboratory, University of Pennsylvania, Philadelphia, PA 19104, USA
    J Am Soc Echocardiogr 22:53-9. 2009
    ..Appropriateness criteria were applied to outpatient transthoracic echocardiographic (TTE) studies...
  36. ncbi request reprint Endocarditis associated with antineutrophil cytoplasmic antibodies: a case report and review of the literature
    Julio A Chirinos
    Department of Medicine, University of Miami, School of Medicine and Veterans Affairs Medical Center, Miami, FL, USA
    Clin Rheumatol 26:590-5. 2007
    ..In this paper, we review reported cases of ANCA-positive bacterial endocarditis and compare them to the reported cases of ANCA-associated idiopathic vasculitis with endocardial compromise...
  37. ncbi request reprint Supraventricular tachycardia in Wolff-Parkinson-White syndrome: to and fro
    Julio A Chirinos
    Division of Cardiology, University of Miami School of Medicine, Florida, USA
    Clin Cardiol 29:324. 2006
  38. ncbi request reprint Expression of the chemokine receptor CCR7 in prostate cancer presenting with generalized lymphadenopathy: report of a case, review of the literature, and analysis of chemokine receptor expression
    Gustavo A Heresi
    Department of Medicine, University of Miami School of Medicine, Miami, FL 33101, USA
    Urol Oncol 23:261-7. 2005
    ..Because of the association of chemokine receptor expression with specific metastatic patterns, we tested for expression of chemokine receptors known to mediate migration to lymph nodes...
  39. ncbi request reprint Digoxin use is associated with increased platelet and endothelial cell activation in patients with nonvalvular atrial fibrillation
    Julio A Chirinos
    Department of Medicine, Division of Cardiology, University of Miami School of Medicine, Miami, Florida 33136, USA
    Heart Rhythm 2:525-9. 2005
    ..The purpose of this study was to determine whether digoxin use is associated with increased flow cytometric markers of endothelial cell and platelet activation in patients with nonvalvular atrial fibrillation (AF)...
  40. ncbi request reprint Usefulness of C-reactive protein as an independent predictor of death in patients with ischemic cardiomyopathy
    Julio A Chirinos
    Division of Cardiology, Department of Medicine, University of Miami School of Medicine and Veterans Affairs Medical Center, Miami, Florida 33125, USA
    Am J Cardiol 95:88-90. 2005
    ..This correlation was independent of other prognostic factors, such as age, ejection fraction, symptoms of severe congestive heart failure, use of angiotensin-converting enzyme inhibitors, and use of beta blockers...
  41. ncbi request reprint Septic thrombophlebitis: diagnosis and management
    Julio A Chirinos
    Division of Cardiology, Department of Medicine, University of Miami School of Medicine, Miami, Florida, USA
    Am J Cardiovasc Drugs 6:9-14. 2006
    ..In this article, we review the diagnosis and management of septic thrombophlebitis, focusing on Lemierre syndrome, pylephlebitis, and septic thrombophlebitis of the pelvic veins...
  42. ncbi request reprint The evolution of Lemierre syndrome: report of 2 cases and review of the literature
    Julio A Chirinos
    Department of Medicine, University of Miami School of Medicine, FL, USA
    Medicine (Baltimore) 81:458-65. 2002
    ..4%), but significant morbidity occurred, which was likely preventable by early diagnosis and treatment. The pathophysiology, natural history, diagnostic methods for internal jugular vein thrombosis, and management are discussed...

Research Grants4

  1. Inflammatory response to sleep apnea in obese subjects
    JULIO ALONSO CHIRINOS MEDINA; Fiscal Year: 2010
    ..We propose that this study design will provide the best way to separate the independent effects of obesity and OSA on cardiovascular risk. ..
  2. Inflammatory response to sleep apnea in obese subjects
    JULIO CHIRINOS MEDINA; Fiscal Year: 2009
    ..We propose that this study design will provide the best way to separate the independent effects of obesity and OSA on cardiovascular risk. ..
  3. Inflammatory response to sleep apnea in obese subjects
    JULIO CHIRINOS MEDINA; Fiscal Year: 2009
    ..We propose that this study design will provide the best way to separate the independent effects of obesity and OSA on cardiovascular risk. ..