Genomes and Genes
Alvin J Chin
Affiliation: University of Pennsylvania
- How insights from cardiovascular developmental biology have impacted the care of infants and children with congenital heart diseaseAlvin J Chin
Department of Pediatrics, Perelman School of Medicine at the University of Pennsylvania, United States
Mech Dev 129:75-97. 2012..These three developmental biology stories illustrate how the remaining unexplained mortality and morbidity of congenital heart disease can be solved...
- Heart and gut chiralities are controlled independently from initial heart position in the developing zebrafishA J Chin
Department of Biology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
Dev Biol 227:403-21. 2000....
- Serum alkaline phosphatase reflects post-Fontan hemodynamics in childrenAlvin J Chin
Division of Cardiology, Abramson Research Center, The Children s Hospital of Philadelphia, and Department of Pediatrics, University of Pennsylvania, School of Medicine, Philadelphia, PA 19104, USA
Pediatr Cardiol 30:138-45. 2009..Serum TALP activity, an indicator of osteoblastic function particularly in pre-adolescence, may be a marker of low cardiac output after a Fontan operation...
- Cloning and characterization of zebrafish tbx1Lazaros K Kochilas
Department of Pediatrics, Division of Pediatric Cardiology, Brown University Medical School, Providence, RI, USA
Gene Expr Patterns 3:645-51. 2003..This newly identified tbx1 expression pattern in cardiac regions other than the cardiac outflow tract offers a new insight into the role of the tbx1 transcription factor in cardiac development...
- Maternally controlled (beta)-catenin-mediated signaling is required for organizer formation in the zebrafishC Kelly
Department of Biology, The University of Pennsylvania, Philadelphia, PA 19104, USA
Development 127:3899-911. 2000..This work demonstrates that a maternal gene controlling localization of (beta)-catenin in dorsal nuclei is necessary for dorsal yolk syncytial layer gene activity and formation of the organizer in the zebrafish...
- Zebrafish hhex regulates liver development and digestive organ chiralityK N Wallace
Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
Genesis 30:141-3. 2001
- Analysis of Cx43alpha1 promoter function in the developing zebrafish embryoB Chatterjee
Biology Dept, University of Pennsylvania, Philadelphia, USA
Cell Commun Adhes 8:289-92. 2001..Overall these studies suggest that the sequence motifs and transcriptional regulation involved in the targeting Cx43alpha1 expression to neural crest cells are evolutionarily conserved in zebrafish and mouse embryos...
- Using health-related quality of life measures to predict cardiac function in survivors exposed to anthracyclinesJill P Ginsberg
Department of Pediatrics, Center for Outcomes Research, The Children s Hospital of Philadelphia, 3535 Market St, Suite 1029, Philadelphia, PA 19104, USA
J Clin Oncol 22:3149-55. 2004..This study reports on the predictive ability of HRQL measures to detect patients with abnormalities on serial cardiac testing...
- T-box genes and cardiac developmentKenneth Ryan
Children s Hospital of Philadelphia, University of Pennsylvania School of Medicine, Joseph Stokes Jr Research Institute, Division of Cardiology, Abramson Research Center, Philadelphia, Pennsylvania, USA
Birth Defects Res C Embryo Today 69:25-37. 2003..Drosophila melanogaster has eight T-box genes, whereas Caenorhabditis elegans has 22. Mammals appear to have at least 18 T-box genes, comprising five subfamilies...
- Heart and neural tube defects in transgenic mice overexpressing the Cx43 gap junction geneJ L Ewart
Department of Biology, University of Pennsylvania, Philadelphia 19104, USA
Development 124:1281-92. 1997..As such, the CMV43 mouse may represent a powerful new model system for examining the role of extracardiac cell populations in cardiac morphogenesis and other developmental processes...