Gwen Childs

Summary

Affiliation: University of Arkansas for Medical Sciences
Country: USA

Publications

  1. pmc Ghrelin restoration of function in vitro in somatotropes from male mice lacking the Janus kinase (JAK)-binding site of the leptin receptor
    Mohsin Syed
    Department of Neurobiology and Developmental Sciences, University of Arkansas for Medical Sciences, College of Medicine, 4301 West Markham, Slot 510, Little Rock, Arkansas 72205, USA
    Endocrinology 154:1565-76. 2013
  2. pmc Ablation of leptin signaling to somatotropes: changes in metabolic factors that cause obesity
    Noor Akhter
    Department of Neurobiology and Developmental Sciences, College of Medicine, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72205, USA
    Endocrinology 153:4705-15. 2012
  3. pmc The somatotrope as a metabolic sensor: deletion of leptin receptors causes obesity
    Gwen V Childs
    Professor and Chair, Department of Neurobiology and Developmental Sciences, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72205, USA
    Endocrinology 152:69-81. 2011
  4. ncbi request reprint Epidermal growth factor and gonadotropin-releasing hormone stimulate proliferation of enriched population of gonadotropes
    G V Childs
    Department of Anatomy G V C, University of Arkansas for Medical Science, Little Rock, Arkansas 72205 7199, USA
    Endocrinology 142:847-53. 2001
  5. pmc Estrogen mediated cross talk between the ovary and pituitary somatotrope. Pre-ovulatory support for reproductive activity
    Gwen V Childs
    Department of Neurobiology and Developmental Sciences, College of Medicine, 4301 W Markham, Slot 510, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA
    Mol Cell Endocrinol 247:60-3. 2006
  6. pmc Bipotential effects of estrogen on growth hormone synthesis and storage in vitro
    Gwen V Childs
    Department of Neurobiology and Developmental Sciences, College of Medicine, 4301 West Markham, University of Arkansas for Medical Science, Little Rock, Arkansas 72205, USA
    Endocrinology 146:1780-8. 2005
  7. ncbi request reprint Development of gonadotropes may involve cyclic transdifferentiation of growth hormone cells
    G V Childs
    Department of Anatomy and Neurobiology, University of Arkansas for Medical Sciences, Little Rock 72205, USA
    Arch Physiol Biochem 110:42-9. 2002
  8. ncbi request reprint Regulation of leptin mRNA and protein expression in pituitary somatotropes
    Iris A McDuffie
    Department of Nutrition, College of Medicine, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA
    J Histochem Cytochem 52:263-73. 2004
  9. pmc Dehydroepiandrosterone restoration of growth hormone gene expression in aging female rats, in vivo and in vitro: evidence for actions via estrogen receptors
    Mary Iruthayanathan
    Department of Neurobiology and Developmental Sciences, College of Medicine, University of Arkansas for Medical Sciences, Little Rock, 72212, USA
    Endocrinology 146:5176-87. 2005
  10. ncbi request reprint A study of student performance on self-scheduled, computer-based examinations in a medical histology course: is later better?
    E Robert Burns
    University of Arkansas for Medical Sciences, Little Rock 72223, USA
    Med Teach 29:990-2. 2007

Collaborators

  • Larry J Suva
  • Streamson Chua
  • Dana Gaddy
  • RHONDA KINEMAN
  • E Robert Burns
  • Noor Akhter
  • Christopher Crane
  • Mary Iruthayanathan
  • Yi Hong Zhou
  • Mohsin Syed
  • Angela K Odle
  • Anessa C Haney
  • Brandy W Johnson
  • Akihiko Kudo
  • Iris A McDuffie
  • Farhan M Syed
  • Melody Allensworth-James
  • Michael Cozart
  • Melody L Allensworth-James
  • Mohsin M Syed
  • Michael A Cozart
  • Farhan Syed

Detail Information

Publications12

  1. pmc Ghrelin restoration of function in vitro in somatotropes from male mice lacking the Janus kinase (JAK)-binding site of the leptin receptor
    Mohsin Syed
    Department of Neurobiology and Developmental Sciences, University of Arkansas for Medical Sciences, College of Medicine, 4301 West Markham, Slot 510, Little Rock, Arkansas 72205, USA
    Endocrinology 154:1565-76. 2013
    ..These discoveries suggest that leptin may optimize somatotrope function by facilitating expression of membrane GHRH receptors and the production or maintenance of GH stores...
  2. pmc Ablation of leptin signaling to somatotropes: changes in metabolic factors that cause obesity
    Noor Akhter
    Department of Neurobiology and Developmental Sciences, College of Medicine, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72205, USA
    Endocrinology 153:4705-15. 2012
    ..These findings signify that leptin signals to somatotropes are vital for the normal metabolic activity needed to optimize body composition...
  3. pmc The somatotrope as a metabolic sensor: deletion of leptin receptors causes obesity
    Gwen V Childs
    Professor and Chair, Department of Neurobiology and Developmental Sciences, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72205, USA
    Endocrinology 152:69-81. 2011
    ..The specific ablation of the Lepr exon 17 gene in somatotropes resulted in GH deficiency with a consequential reduction in lipolytic activity normally maintained by GH and increased adiposity...
  4. ncbi request reprint Epidermal growth factor and gonadotropin-releasing hormone stimulate proliferation of enriched population of gonadotropes
    G V Childs
    Department of Anatomy G V C, University of Arkansas for Medical Science, Little Rock, Arkansas 72205 7199, USA
    Endocrinology 142:847-53. 2001
    ..The effects of the two growth factors were not additive. Collectively, these data confirm previous studies showing mitogenic functions for activin and now add EGF and GnRH as mitogens for gonadotropes...
  5. pmc Estrogen mediated cross talk between the ovary and pituitary somatotrope. Pre-ovulatory support for reproductive activity
    Gwen V Childs
    Department of Neurobiology and Developmental Sciences, College of Medicine, 4301 W Markham, Slot 510, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA
    Mol Cell Endocrinol 247:60-3. 2006
  6. pmc Bipotential effects of estrogen on growth hormone synthesis and storage in vitro
    Gwen V Childs
    Department of Neurobiology and Developmental Sciences, College of Medicine, 4301 West Markham, University of Arkansas for Medical Science, Little Rock, Arkansas 72205, USA
    Endocrinology 146:1780-8. 2005
    ..These bipotential effects may help explain the different findings reported in the literature...
  7. ncbi request reprint Development of gonadotropes may involve cyclic transdifferentiation of growth hormone cells
    G V Childs
    Department of Anatomy and Neurobiology, University of Arkansas for Medical Sciences, Little Rock 72205, USA
    Arch Physiol Biochem 110:42-9. 2002
    ..Collectively these data suggest that the anterior pituitary contains a subset of GH cells that have the capacity to respond to multiple releasing hormones and support more than one system...
  8. ncbi request reprint Regulation of leptin mRNA and protein expression in pituitary somatotropes
    Iris A McDuffie
    Department of Nutrition, College of Medicine, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA
    J Histochem Cytochem 52:263-73. 2004
    ..Because GH cells also have leptin receptors, this AP leptin may be an autocrine or paracrine regulator of pituitary cell function...
  9. pmc Dehydroepiandrosterone restoration of growth hormone gene expression in aging female rats, in vivo and in vitro: evidence for actions via estrogen receptors
    Mary Iruthayanathan
    Department of Neurobiology and Developmental Sciences, College of Medicine, University of Arkansas for Medical Sciences, Little Rock, 72212, USA
    Endocrinology 146:5176-87. 2005
    ..Trilostane, aminogluthemide, or ICI 182,780 completely blocked the stimulatory effects of DHEA, suggesting that DHEA metabolites may stimulate aging somatotropes via estrogen receptors...
  10. ncbi request reprint A study of student performance on self-scheduled, computer-based examinations in a medical histology course: is later better?
    E Robert Burns
    University of Arkansas for Medical Sciences, Little Rock 72223, USA
    Med Teach 29:990-2. 2007
    ..Students scheduling late have more time to prepare, which may provide them with an unfair advantage...
  11. pmc Anterior pituitary leptin expression changes in different reproductive states: in vitro stimulation by gonadotropin-releasing hormone
    Noor Akhter
    Department of Neurobiology and Developmental Sciences, College of Medicine, University of Arkansas for Medical Sciences, 4301 W Markham St, Slot 510, Little Rock, AR 72205, USA
    J Histochem Cytochem 55:151-66. 2007
    ..These regulatory influences, and the high expression of AP leptin during proestrus and pregnancy, suggest a supportive role for leptin during key events involved with reproduction...
  12. pmc Fasting and glucose effects on pituitary leptin expression: is leptin a local signal for nutrient status?
    Christopher Crane
    Department of Neurobiology and Developmental Sciences, College of Medicine, University of Arkansas for Medical Sciences, 4301 W Markham 510, Little Rock, AR 72205, USA
    J Histochem Cytochem 55:1059-73. 2007
    ..Collectively, the findings suggest that pituitary leptin expression could be coupled to glucose sensors like glucokinase to facilitate rapid responses by the neuroendocrine system to nutritional cues...

Research Grants4

  1. Regulation of Leptin Production by Gonadotropes
    Gwen Childs; Fiscal Year: 2005
    ..These feasibility studies will thus provide information that will allow us to design future experiments for full funding. ..
  2. Cellular Basis for Non-Parallel Gonadotropin Release
    Gwen Childs; Fiscal Year: 2005
    ..An understanding of mechanisms that selectively regulate gene expression in these cells will provide important information about how fertility is regulated. ..
  3. The Significance of Leptin Signals to Neonatal Somatotropes and Gonadotropes
    Gwen Childs; Fiscal Year: 2009
    ..This proposal thus addresses important questions about how leptin can affect reproductive competence at the level of the pituitary. ..
  4. The Significance of Leptin Signals to Neonatal Somatotropes and Gonadotropes
    Gwen V Childs; Fiscal Year: 2010
    ..This proposal thus addresses important questions about how leptin can affect reproductive competence at the level of the pituitary. ..