Research Topics
| Martin K ChildersSummaryAffiliation: University of Missouri Country: USA Publications
Research Grants
| Collaborators
|
Detail Information
Publications
Low-dose cyclobenzaprine versus combination therapy with ibuprofen for acute neck or back pain with muscle spasm: a randomized trialMartin K Childers
Physical Medicine and Rehabilitation, University of Missouri Columbia, Columbia, MO 65212, USA
Curr Med Res Opin 21:1485-93. 2005....- Eccentric contraction injury in dystrophic canine muscleMartin K Childers
Departments of Physical Medicine and Rehabilitation, College of Veterinary Medicine, University of Missouri Columbia, One Hospital Drive, Columbia, MO 65212, USA
Arch Phys Med Rehabil 83:1572-8. 2002..To test the hypothesis that eccentric contractions induce greater injury in dystrophic compared with normal canine muscle... - The importance of electromyographic guidance and electrical stimulation for injection of botulinum toxinMartin K Childers
Department of Physical Medicine, School of Medicine, University of Missouri Columbia, DCO 46 00, One Hospital Drive, Columbia, MO 65212, USA
Phys Med Rehabil Clin N Am 14:781-92. 2003..Questions remain about the preferred administration of botulinum toxin for these conditions. Future clinical research is necessary to show clearly functional benefit of any particular injection localization method... - Regulatory light chain phosphorylation increases eccentric contraction-induced injury in skinned fast-twitch fibersMartin K Childers
Department of Physical Medicine and Rehabilitation, DCO 46 00, One Hospital Drive, University of Missouri Columbia, Columbia, Missouri 65212, USA
Muscle Nerve 29:313-7. 2004..5) activation from 26 +/- 9.8 to 35 +/- 9.6%. We conclude that RLC phosphorylation increases force deficits following eccentric contractions, perhaps by increasing the number of force-generating cross-bridges... - Dose-dependent response to intramuscular botulinum toxin type A for upper-limb spasticity in patients after a strokeMartin K Childers
Dept of Physical Medicine and Rehabilitation, University of Missouri at Columbia, One Hospital Drive, DCO 46 00, Columbia, MO 65212, USA
Arch Phys Med Rehabil 85:1063-9. 2004..To test the hypothesis that intramuscular (IM) botulinum toxin type A (BTX) reduces excessive muscle tone in a dose-dependent manner in the elbow, wrist, and fingers of patients who experience spasticity after a stroke... - Skinned single fibers from normal and dystrophin-deficient dogs incur comparable stretch-induced force deficitsMartin K Childers
Department of Physical Medicine and Rehabilitation, School of Medicine, University of Missouri Columbia, DCO 46 00, One Hospital Drive, Columbia, Missouri 65212, USA
Muscle Nerve 31:768-71. 2005.... - Testosterone replacement therapy and motor function in men with spinal cord injury: a retrospective analysisMary J Clark
Department of Health Psychology, University of Missouri Columbia, Columbia, Missouri, USA
Am J Phys Med Rehabil 87:281-4. 2008..To evaluate motor function in men with spinal cord injury (SCI) given testosterone replacement therapy (TRT)... - Effects of prednisone in canine muscular dystrophyJocelyn M K Liu
Dalton Cardiovascular Research Center, University of Missouri-Columbia, Columbia, Missouri, USA
Muscle Nerve 30:767-73. 2004..Thus, functional data indicate benefit but histopathologic changes following prednisone treatment in GRMD suggest possible deleterious consequences... - Golden retriever muscular dystrophy (GRMD): Developing and maintaining a colony and physiological functional measurementsJoe N Kornegay
Department of Pathology and Laboratory Medicine and The Gene Therapy Center, School of Medicine, University of North Carolina Chapel Hill, Chapel Hill, NC, USA
Methods Mol Biol 709:105-23. 2011..Key challenges in colony development (breeding, neonatal death, and the risk of inbreeding) and representative functional measurements (tibiotarsal joint angle and torque force; and eccentric contraction decrement) are discussed... - Stretch-induced force deficits in murine extensor digitorum longus muscles after cardiotoxin injectionChad Markert
Department of Biomedical Sciences, College of Veterinary Medicine, University of Missouri, Columbia, Missouri, USA
Muscle Nerve 34:485-8. 2006..001) on day 7. We speculate that increased contraction-induced damage in 7-day CTX-injected muscles results from changes in myofilament overlap that occurs during early regeneration... - The paradox of muscle hypertrophy in muscular dystrophyJoe N Kornegay
Department of Pathology and Laboratory Medicine, School of Medicine, University of North Carolina Chapel Hill, Chapel Hill, NC 27599, USA
Phys Med Rehabil Clin N Am 23:149-72, xii. 2012..Muscle hypertrophy can exaggerate postural instability and joint contractures. Deleterious consequences of muscle hypertrophy should be considered when developing treatments for muscular dystrophy... - Effects of intra-articular botulinum toxin type A in an equine model of acute synovitis: a pilot studyTracy Depuy
From the Department of Veterinary Medicine and Surgery, College of Veterinary Medicine, University of Missouri Columbia, Columbia, Missouri, USA
Am J Phys Med Rehabil 86:777-83. 2007..To test the hypothesis that botulinum toxin type A (BoNT-A) can attenuate lameness associated with acute synovitis in an equine model... - Targeting the neuromuscular junction in skeletal musclesMartin K Childers
Department of Physical Medicine and Rehabilitation, School of Medicine, University of Missouri-Columbia, Columbia, Missouri 65212, USA
Am J Phys Med Rehabil 83:S38-44. 2004..In this article, a rationale is presented for motor endplate targeting within specific limb muscles with respect to botulinum neurotoxin therapy... - Botulinum toxin type A use in piriformis muscle syndrome: a pilot studyMartin K Childers
Department of Physical Medicine and Rehabilitation, University of Missouri-Columbia Hospital, 65212, USA
Am J Phys Med Rehabil 81:751-9. 2002..CONCLUSIONS: VAS data suggest that intramuscular piriformis injection with 100 units of botulinum toxin type A can reduce pain to a greater extent than similar injections with vehicle alone... 
Mesenchymal stem cells: emerging therapy for Duchenne muscular dystrophyChad D Markert
Department of Neurology, School of Medicine, and Wake Forest Institute for Regenerative Medicine, Wake Forest University Health Sciences, Winston Salem, NC, USA
PM R 1:547-59. 2009..In this review, the authors explore the potential for mesenchymal stem cell therapy in the emerging field of regenerative medicine with a focus on treatment for Duchenne muscular dystrophy...- Testosterone levels among men with spinal cord injury admitted to inpatient rehabilitationLaura H Schopp
Department of Health Psychology, University of Missouri-Columbia, Columbia, Missouri 65212, USA
Am J Phys Med Rehabil 85:678-84; quiz 685-7. 2006..Future research is needed to investigate the etiology, pathogenesis, and potential avenues for treatment of low testosterone among men with SCI... - Myostatin expression in muscular dystrophies and mitochondrial encephalomyopathiesChad Markert
Pediatr Neurol 35:300; author reply 300. 2006
Research Grants
- MUSCLE RESPONSE TO STRESS IN CANINE MUSCULAR DYSTROPHYMARTIN CHILDERS; Fiscal Year: 2002..It is anticipated that findings will improve the understanding of how dystrophic muscle responds to physical stress resulting in improved treatment for patients with Duchenne muscular dystrophy. ..
- Leupeptin in a Canine Model of Duchenne Muscular DystrophyMARTIN CHILDERS; Fiscal Year: 2006..Specific Aim #4b: Compare lean body muscle mass and calpain activity between leupeptin and placebo-treated GRMD dogs. ..