Andy J Chien

Summary

Affiliation: University of Washington
Country: USA

Publications

  1. ncbi request reprint Hereditary woolly hair and keratosis pilaris
    Andy J Chien
    Division of Dermatology, University of Washington, Seattle, Washington, USA
    J Am Acad Dermatol 54:S35-9. 2006
  2. ncbi request reprint Why do so many clinicians believe that recurrent zoster is common?
    Andy J Chien
    The University of Washington Department of Medicine, Division of Dermatology, Seattle, USA
    Dermatol Online J 13:2. 2007
  3. pmc A Wnt survival guide: from flies to human disease
    Andy J Chien
    The University of Washington School of Medicine, Department of Medicine and the Institute for Stem Cell and Regenerative Medicine, Seattle, Washington 98109, USA
    J Invest Dermatol 129:1614-27. 2009
  4. doi request reprint Subungual Bowen disease in a patient with epidermodysplasia verruciformis presenting clinically as longitudinal melanonychia
    Galina Y Stetsenko
    Department of Pathology, Division of Dermatology, University of Washington School of Medicine, Seattle, WA 98195 6100, USA
    Am J Dermatopathol 30:582-5. 2008
  5. doi request reprint Management of melanocytic lesions in the primary care setting
    Kim M O'Connor
    University of Washington General Internal Medicine Clinic, Box 354760, 4245 Roosevelt Way NE, Seattle, WA 98105, USA
    Mayo Clin Proc 83:208-13; quiz 213-4. 2008
  6. pmc Activation of Wnt/β-catenin signaling increases apoptosis in melanoma cells treated with trail
    Zachary F Zimmerman
    Department of Medicine, The University of Washington School of Medicine, Seattle, Washington, USA
    PLoS ONE 8:e69593. 2013
  7. pmc Targeted BRAF inhibition impacts survival in melanoma patients with high levels of Wnt/β-catenin signaling
    Andy J Chien
    Division of Dermatology, University of Washington Department of Medicine, Seattle, Washington, United States of America The Group Health Research Institute, Seattle, Washington, United States of America
    PLoS ONE 9:e94748. 2014
  8. pmc WLS inhibits melanoma cell proliferation through the β-catenin signalling pathway and induces spontaneous metastasis
    Pei Tzu Yang
    Department of Pharmacology, Howard Hughes Medical Institute, Institute for Stem Cell and Regenerative Medicine, University of Washington School of Medicine, Seattle, WA, USA
    EMBO Mol Med 4:1294-307. 2012
  9. pmc Regulating the response to targeted MEK inhibition in melanoma: enhancing apoptosis in NRAS- and BRAF-mutant melanoma cells with Wnt/β-catenin activation
    William H Conrad
    The Howard Hughes Medical Institute, University of Washington, Seattle, WA, USA
    Cell Cycle 11:3724-30. 2012
  10. pmc CTLA-4 is a direct target of Wnt/beta-catenin signaling and is expressed in human melanoma tumors
    Kavita V Shah
    Department of Pharmacology, University of Washington, Seattle, Washington 98195, USA
    J Invest Dermatol 128:2870-9. 2008

Collaborators

Detail Information

Publications14

  1. ncbi request reprint Hereditary woolly hair and keratosis pilaris
    Andy J Chien
    Division of Dermatology, University of Washington, Seattle, Washington, USA
    J Am Acad Dermatol 54:S35-9. 2006
    ..Woolly hair elicits a broad differential diagnosis, including woolly hair nevus and several genodermatoses. Our report reviews the evaluation of woolly hair and discusses the conditions associated with this physical finding...
  2. ncbi request reprint Why do so many clinicians believe that recurrent zoster is common?
    Andy J Chien
    The University of Washington Department of Medicine, Division of Dermatology, Seattle, USA
    Dermatol Online J 13:2. 2007
  3. pmc A Wnt survival guide: from flies to human disease
    Andy J Chien
    The University of Washington School of Medicine, Department of Medicine and the Institute for Stem Cell and Regenerative Medicine, Seattle, Washington 98109, USA
    J Invest Dermatol 129:1614-27. 2009
    ..The aim of this review is to provide a context on the Wnt field that will facilitate the interpretation and study of Wnt signaling in the context of human disease...
  4. doi request reprint Subungual Bowen disease in a patient with epidermodysplasia verruciformis presenting clinically as longitudinal melanonychia
    Galina Y Stetsenko
    Department of Pathology, Division of Dermatology, University of Washington School of Medicine, Seattle, WA 98195 6100, USA
    Am J Dermatopathol 30:582-5. 2008
    ..To the best of our knowledge, this is first report of a subungual presentation of this condition with associated melanonychia...
  5. doi request reprint Management of melanocytic lesions in the primary care setting
    Kim M O'Connor
    University of Washington General Internal Medicine Clinic, Box 354760, 4245 Roosevelt Way NE, Seattle, WA 98105, USA
    Mayo Clin Proc 83:208-13; quiz 213-4. 2008
    ..Finally, it addresses the potential difficulties in interpreting pathology reports and reviews the implications of pathology results for patient counseling, education, and follow-up...
  6. pmc Activation of Wnt/β-catenin signaling increases apoptosis in melanoma cells treated with trail
    Zachary F Zimmerman
    Department of Medicine, The University of Washington School of Medicine, Seattle, Washington, USA
    PLoS ONE 8:e69593. 2013
    ..These studies describe a novel regulation of TRAIL sensitivity in melanoma by Wnt/β-catenin signaling, and suggest that strategies to enhance Wnt/β-catenin signaling in combination with TRAIL agonists warrant further investigation. ..
  7. pmc Targeted BRAF inhibition impacts survival in melanoma patients with high levels of Wnt/β-catenin signaling
    Andy J Chien
    Division of Dermatology, University of Washington Department of Medicine, Seattle, Washington, United States of America The Group Health Research Institute, Seattle, Washington, United States of America
    PLoS ONE 9:e94748. 2014
    ..Understanding these pathway interactions will be necessary to facilitate efforts to individualize therapies for melanoma patients. ..
  8. pmc WLS inhibits melanoma cell proliferation through the β-catenin signalling pathway and induces spontaneous metastasis
    Pei Tzu Yang
    Department of Pharmacology, Howard Hughes Medical Institute, Institute for Stem Cell and Regenerative Medicine, University of Washington School of Medicine, Seattle, WA, USA
    EMBO Mol Med 4:1294-307. 2012
    ..These data suggest that WLS functions as a negative regulator of melanoma proliferation and spontaneous metastasis by activating WNT/β-catenin signalling...
  9. pmc Regulating the response to targeted MEK inhibition in melanoma: enhancing apoptosis in NRAS- and BRAF-mutant melanoma cells with Wnt/β-catenin activation
    William H Conrad
    The Howard Hughes Medical Institute, University of Washington, Seattle, WA, USA
    Cell Cycle 11:3724-30. 2012
    ..Understanding the cellular context that makes melanoma cells susceptible to this combination treatment will contribute to the study and development of novel therapeutic combinations that may lead to more durable responses...
  10. pmc CTLA-4 is a direct target of Wnt/beta-catenin signaling and is expressed in human melanoma tumors
    Kavita V Shah
    Department of Pharmacology, University of Washington, Seattle, Washington 98195, USA
    J Invest Dermatol 128:2870-9. 2008
    ....
  11. pmc Activated Wnt/beta-catenin signaling in melanoma is associated with decreased proliferation in patient tumors and a murine melanoma model
    Andy J Chien
    Institute for Stem Cell and Regenerative Medicine, Department of Medicine, Division of Dermatology, University of Washington School of Medicine, Seattle, WA 98195, USA
    Proc Natl Acad Sci U S A 106:1193-8. 2009
    ..Our results may explain the observed loss of nuclear beta-catenin with melanoma progression in human tumors, which could reflect a dysregulation of cellular differentiation through a loss of homeostatic Wnt/beta-catenin signaling...
  12. ncbi request reprint Winnie the Pooh and psoriasis too: an isomorphic response of guttate psoriasis in a tattoo
    Kyle L Horner
    Division of Dermatology, Department of Medicine, University of Washington School of Medicine, Seattle, Washington, USA
    Pediatr Dermatol 24:E70-2. 2007
    ..We report a strep-induced guttate psoriasis isomorphic response in a Winnie the Pooh tattoo in a 19-year-old...
  13. ncbi request reprint Acute lymphoblastic leukemia presenting with urticarial plaques and hypereosinophilia in a child
    Andy J Chien
    University of Washington Department of Medicine, Division of Dermatology, Seattle, Washington 98195, USA
    J Am Acad Dermatol 51:S151-5. 2004
    ..Our discussion summarizes the clinical aspects of this disease and reviews the reported dermatological manifestations of ALL/Eo...
  14. ncbi request reprint Pigmented lesions of the iris: common in patients, uncommon in dermatology textbooks
    Shannon Simon
    Arch Dermatol 142:1243-4. 2006