Research Topics
Genomes and Genes | Alberto ChiarugiSummaryAffiliation: University of Massachusetts Medical School Country: USA Publications
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Publications
Cell biology. PARP-1--a perpetrator of apoptotic cell death?Alberto Chiarugi
Department of Preclinical and Clinical Pharmacology, University of Florence, 50139 Florence, Italy
Science 297:200-1. 2002
Inhibitors of poly(ADP-ribose) polymerase-1 suppress transcriptional activation in lymphocytes and ameliorate autoimmune encephalomyelitis in ratsAlberto Chiarugi
Department of Preclinical and Clinical Pharmacology, University of Florence, Florence, Italy
Br J Pharmacol 137:761-70. 2002..5. These findings indicate that PARP-1 promotes transcriptional activation in lymphocytes and inhibitors of its enzymatic activity are useful for the treatment of autoimmune disorders of the central nervous system...- Inhibition of nicotinamide phosphoribosyltransferase: cellular bioenergetics reveals a mitochondrial insensitive NAD poolMaria Pittelli
Department of Preclinical and Clinical Pharmacology, University of Florence, 50139 Florence, Italy
J Biol Chem 285:34106-14. 2010..For the first time, our data indicate that mitochondria lack the canonical NAD rescue pathway, broadening current understanding of cellular bioenergetics... 
Histone deacetylase (HDAC) inhibitors reduce the glial inflammatory response in vitro and in vivoGiuseppe Faraco
Department of Preclinical and Clinical Pharmacology, University of Florence, Florence, Italy
Neurobiol Dis 36:269-79. 2009..Data demonstrate that mouse glial cells have ongoing HDAC activity, and its inhibition suppresses the neuroinflammatory response because of a direct impairment of the transcriptional machinery...- Pharmacological effects of exogenous NAD on mitochondrial bioenergetics, DNA repair, and apoptosisMaria Pittelli
Department of Preclinical and Clinical Pharmacology, University of Florence, Florence, Italy
Mol Pharmacol 80:1136-46. 2011.... - PARP-1 inhibition prevents CNS migration of dendritic cells during EAE, suppressing the encephalitogenic response and relapse severityLeonardo Cavone
Department of Pharmacology, University of Florence, Florence, Italy
Mult Scler 17:794-807. 2011.... - Poly(ADP-ribose) catabolism triggers AMP-dependent mitochondrial energy failureLaura Formentini
Department of Preclinical and Clinical Pharmacology, University of Florence, 50139 Firenze, Italy
J Biol Chem 284:17668-76. 2009..Also, these data disclose unanticipated AMP-dependent impairment of mitochondrial exchange of adenine nucleotides, which can be of relevance to organelle functioning and disease pathogenesis... - Poly(ADP-ribose) accumulation and enhancement of postischemic brain damage in 110-kDa poly(ADP-ribose) glycohydrolase null miceAndrea Cozzi
Department of Pharmacology, University of Florence, Firenze, Italy
J Cereb Blood Flow Metab 26:684-95. 2006..Our findings show that PAR accumulation worsens ischemic brain injury, and highlight the therapeutic potential of strategies capable of maintaining PAR homeostasis... - Neither energy collapse nor transcription underlie in vitro neurotoxicity of poly(ADP-ribose) polymerase hyper-activationSilvia Fossati
Department of Pharmacology, University of Florence, Florence, Viale Pieraccini 6, 50139 Firenze, Italy
Neurochem Int 50:203-10. 2007.... - Mild activation of poly(ADP-ribose) polymerase (PARP) is neuroprotective in rat hippocampal slice models of ischemic toleranceElisabetta Gerace
Department of Preclinical and Clinical Pharmacology, University of Florence, Viale G Pieraccini 6, 50139 Florence, Italy
Eur J Neurosci 36:1993-2005. 2012..Our results suggest that preconditioning with appropriate pharmacological stimuli may promote neuroprotective mechanisms triggered by the sublethal activation of two otherwise deleterious executioners such as PARP and caspase-3/7... - Neurological basis of AMP-dependent thermoregulation and its relevance to central and peripheral hyperthermiaMirko Muzzi
Department of Preclinical and Clinical Pharmacology, University of Florence, Florence, Italy
J Cereb Blood Flow Metab 33:183-90. 2013..Together, data disclose the role of AMP, 5'-nucleotidase, and A1R in hypothalamic thermoregulation, as well and their therapeutic relevance to treatment of febrile illness... - Pharmacological inhibition of histone deacetylases by suberoylanilide hydroxamic acid specifically alters gene expression and reduces ischemic injury in the mouse brainGiuseppe Faraco
Department of Preclinical and Pharmacology, University of Florence, Viale Pieraccini 6, 50139 Firenze, Italy
Mol Pharmacol 70:1876-84. 2006..Data demonstrate that pharmacological inhibition of HDACs promotes expression of neuroprotective proteins within the ischemic brain and underscores the therapeutic potential of molecules inhibiting HDACs for stroke therapy... - Detection and pharmacological modulation of nicotinamide mononucleotide (NMN) in vitro and in vivoLaura Formentini
Department of Preclinical and Clinical Pharmacology, University of Florence, Italy
Biochem Pharmacol 77:1612-20. 2009..Data provide new information on the biochemistry and pharmacology of NAD biosynthesis, allowing a better understanding of pyridine nucleotide metabolism... - Nuclear poly(ADP-ribose) polymerase-1 rapidly triggers mitochondrial dysfunctionGiulia Cipriani
Department of Pharmacology, University of Florence, 50139 Florence, Italy
J Biol Chem 280:17227-34. 2005..Together, our data provide evidence for rapid nucleus-mitochondria cross-talk during hyper-poly(ADP-ribosyl)ation-dependent cell death... - 18β-glycyrrhetic acid inhibits immune activation triggered by HMGB1, a pro-inflammatory protein found in the tear fluid during conjunctivitis and blepharitisLeonardo Cavone
Department of Preclinical and Clinical Pharmacology, University of Florence, Florence, Italy
Ocul Immunol Inflamm 19:180-5. 2011..Evidence indicates that extracellularly released high-mobility group box 1 protein (HMGB1) behaves as a cytokine, promoting inflammation and disease pathogenesis. HMGB1 release occurs during endophtalmitis or uveoretinitis... - Ischemic neuroprotection by TRPV1 receptor-induced hypothermiaMirko Muzzi
Department of Pharmacology, University of Florence, Viale Pieraccini 6, Florence, Italy
J Cereb Blood Flow Metab 32:978-82. 2012..Data indicate that TRPV1 receptor agonists are promising candidates for hypothermic treatment of stroke... - Brain ischemic preconditioning does not require PARP-1Giuseppe Faraco
Department of Pharmacology, University of Florence, Italy
Stroke 41:181-3. 2010..PARP-1 KO mice were similarly protected by the 5-minute BCCAO. CONCLUSIONS: Data demonstrate that, at variance with the heart, PARP-1 is dispensable for brain ischemic preconditioning... - Post-ischemic brain damage: targeting PARP-1 within the ischemic neurovascular units as a realistic avenue to stroke treatmentFlavio Moroni
Department of Preclinical and Clinical Pharmacology, University of Florence, Italy
FEBS J 276:36-45. 2009.... - Carboxymethyl beta-glucan binds to corneal epithelial cells and increases cell adhesion to laminin and resistance to oxidative stressMarco Porcu
Department of Pharmacology, University of Florence, Florence, Italy
Cornea 26:73-9. 2007..In this study, we investigated the effects of carboxymethyl beta-glucan (CMG), a water-soluble derivative of yeast beta-glucan, on cultured rabbit corneal epithelial cells... - AMP-dependent hypothermia affords protection from ischemic brain injuryMirko Muzzi
Department of Preclinical and Clinical Pharmacology University of Florence, Florence, Italy
J Cereb Blood Flow Metab 33:171-4. 2013..Data disclose that AMP-dependent hypothermia is of therapeutic relevance to treatment of brain ischemia... - A key role for poly(ADP-ribose) polymerase-1 activity during human dendritic cell maturationAlessandra Aldinucci
Department of Pharmacology, University of Florence, Viale Pieraccini 6, 50139 Florence, Italy
J Immunol 179:305-12. 2007..Together, data provide evidence for a key role of PARP-1 and poly ADP-ribosylation in DC immunocompetence and underscore the relevance of PARP-1 inhibitors to treatment of immune disorders... - Poly(ADP-ribosyl)ation and strokeAlberto Chiarugi
Department of Pharmacology, University of Florence, Viale Pieraccini 6, 50139 Firenze, Italy
Pharmacol Res 52:15-24. 2005.... - Intrinsic mechanisms of poly(ADP-ribose) neurotoxicity: three hypothesesAlberto Chiarugi
Department of Pharmacology, University of Florence, Viale Pieraccini 6, 50139 Firenze, Italy
Neurotoxicology 26:847-55. 2005..This review provides an appraisal of the possible molecular mechanisms underlying PAR neurotoxicity, highlighting the pleiotypic effects of the polymer on neural cells exposed to different stressful conditions... - Poly(ADP-ribose) polymerase-1 is a nuclear epigenetic regulator of mitochondrial DNA repair and transcriptionAndrea Lapucci
Department of Preclinical and Clinical Pharmacology, University of Florence, Florence, Italy
Mol Pharmacol 79:932-40. 2011..These data might have important implications in pharmacology of PARP-1 inhibitors as well as clinical oncology and aging... - "Simple but not simpler": toward a unified picture of energy requirements in cell deathAlberto Chiarugi
Department of Pharmacology, University of Florence, Florence, Italy
FASEB J 19:1783-8. 2005.... - Induction of CD83+CD14+ nondendritic antigen-presenting cells by exposure of monocytes to IFN-alphaGianni Gerlini
Plastic Surgery Unit, Regional Melanoma Referral Center, Tuscan Tumor Institute ITT, Santa Maria Annunziata Hospital, Florence, Italy
J Immunol 181:2999-3008. 2008..The present findings suggest that IFN-alpha alone promptly generates nondendritic APCs able to stimulate memory immune responses. This may represent an additional mode of action of IFN-alpha in vivo... - Relevance of high-mobility group protein box 1 to neurodegenerationSilvia Fossati
Department of Preclinical and Clinical Pharmacology, University of Florence, Florence, Italy
Int Rev Neurobiol 82:137-48. 2007.... - Inhibition of poly(ADP-ribose) glycohydrolase by gallotannin selectively up-regulates expression of proinflammatory genesElena Rapizzi
Department of Biological Chemistry, University of Florence, Italy
Mol Pharmacol 66:890-8. 2004..Overall, our data provide the first evidence that pharmacological inhibition of PARG leads to PAR-dependent alteration of gene expression profiles in macrophages... - The NAD metabolome--a key determinant of cancer cell biologyAlberto Chiarugi
Department of Preclinical and Clinical Pharmacology, University of Firenze, 50139, Italy
Nat Rev Cancer 12:741-52. 2012..This necessity supports the targeting of NAD metabolism as a new therapeutic concept for cancer treatment... - Targeting poly(ADP-ribose) polymerase-1 as a promising approach for immunomodulation in multiple sclerosis?Leonardo Cavone
Department of Preclinical and Clinical Pharmacology, Viale Pieraccini 6, University of Florence, 50139 Florence, Italy
Trends Mol Med 18:92-100. 2012..PARP-1 inhibitors have already reached the clinical arena as cancer treatments, and observations made in treating these patients could help advance treatments for MS... - Tryptophan availability selectively limits NO-synthase induction in macrophagesAlberto Chiarugi
Department of Preclinical and Clinical Pharmacology, University of Florence, Viale Pieraccini 6, 50139 Florence, Italy
J Leukoc Biol 73:172-7. 2003..Our results suggest that a reduced local TRP availability may modify macrophage function and possibly the outcome of immune responses... - Antidromic vasodilatation and the migraine mechanismPierangelo Geppetti
Headache Centre, Careggi University Hospital, Department of Preclinical and Clinical Pharmacology, University of Florence, Florence, Italy
J Headache Pain 13:103-11. 2012.... - Poly(ADP-ribose) polymerase as a key player in excitotoxicity and post-ischemic brain damageElena Meli
Department of Preclinical and Clinical Pharmacology, University of Florence, Viale Pieraccini 6, 50135 Florence, Italy
Toxicol Lett 139:153-62. 2003..Hence, it appears reasonable to propose PARP inhibitors as useful therapeutic agents in pathological brain conditions were necrosis predominates... - The emerging therapeutic potential of sirtuin-interacting drugs: from cell death to lifespan extensionMarco Porcu
Department of Preclinical and Clinical Pharmacology, University of Florence, 50139 Florence, Italy
Trends Pharmacol Sci 26:94-103. 2005..In this article, we focus on sirtuins and provide an appraisal of current compounds that either activate or inhibit sirtuin activity, highlighting their therapeutic potential for the treatment of human diseases... - Poly(ADP-ribose) polymerase-1 activity promotes NF-kappaB-driven transcription and microglial activation: implication for neurodegenerative disordersAlberto Chiarugi
Department of Neuroscience, Stroke and Neurovascular Regulation Laboratory, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachussets, USA
J Neurochem 85:306-17. 2003.... - Characterization of the molecular events following impairment of NF-kappaB-driven transcription in neuronsAlberto Chiarugi
Department of Cellular and Molecular Physiology, University of Massachusetts Medical School, Worcester, MA 01605, USA
Brain Res Mol Brain Res 109:179-88. 2002.... - Novel isoquinolinone-derived inhibitors of poly(ADP-ribose) polymerase-1: pharmacological characterization and neuroprotective effects in an in vitro model of cerebral ischemiaAlberto Chiarugi
Dipartimento di Farmacologia Preclinica e Clinica, , Viale Pieraccini, 6, 50139 Firenze, Italy
J Pharmacol Exp Ther 305:943-9. 2003..93, P < 0.01) was observed. Our results suggest that TIQ-A and its derivatives are a new class of neuroprotectants that may be helpful in studies aimed at understanding the involvement of PARP-1 in physiology and pathology... - Neuroprotective effects of propofol in models of cerebral ischemia: inhibition of mitochondrial swelling as a possible mechanismChiara Adembri
Dipartimento di Area Critica Medico Chirurgica, Sezione di Anestesiologia e Terapia Intensiva, Universita di Firenze, Italy
Anesthesiology 104:80-9. 2006..Moreover, the mechanisms involved in its neuroprotective effects are yet unclear... - STAT1 is activated in neurons after ischemia and contributes to ischemic brain injuryYasushi Takagi
Stroke and Neurovascular Regulation, Neuroscience Center, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston 02129, USA
J Cereb Blood Flow Metab 22:1311-8. 2002..These results indicate that STAT1 is activated and translocated within ischemic neurons and may contribute to brain injury by regulating transcription and phosphorylation of proteins related to apoptosis and cell death... - Poly(ADP-ribosyl)ation regulates heat shock factor-1 activity and the heat shock response in murine fibroblastsSilvia Fossati
International Agency for Research on Cancer, Lyon, France
Biochem Cell Biol 84:703-12. 2006..The data indicate that poly(ADP-ribosyl)ation finely regulates HSF-1 activity, and emphasize the complex role of PARP-1 in the heat-shock response of mammalian cells...