Affiliation: University of California
Myers R, Timofeyev V, Li N, Kim C, Ledford H, Sirish P, et al
. Feedback mechanisms for cardiac-specific microRNAs and cAMP signaling in electrical remodeling. Circ Arrhythm Electrophysiol. 2015;8:942-50 pubmed publisher
..Taken together, our results illuminate the mechanistic links between miRs, adrenergic signaling, and electrical remodeling. They also serve as a proof-of-concept for the therapeutic potential of miR delivery post myocardial infarction. ..
Lu L, Sirish P, Zhang Z, Woltz R, Li N, Timofeyev V, et al
. Regulation of gene transcription by voltage-gated L-type calcium channel, Cav1.3. J Biol Chem. 2015;290:4663-76 pubmed publisher
..Utilizing a Cav1.3 null mutant mouse model, we demonstrate that ablation of Cav1.3 results in a decrease in the protein expression of myosin light chain 2, which interacts and increases the membrane localization of SK2 channels. ..
Zhang X, Lieu D, Chiamvimonvat N. Small-conductance Ca2+ -activated K+ channels and cardiac arrhythmias. Heart Rhythm. 2015;12:1845-51 pubmed publisher
..At the translational level, development of SK channel blockers as a new therapeutic strategy in the treatment of atrial fibrillation and the possible proarrhythmic effects merit further considerations and investigations. ..
Zhang X, Coulibaly Z, Chen W, Ledford H, Lee J, Sirish P, et al
. Coupling of SK channels, L-type Ca2+ channels, and ryanodine receptors in cardiomyocytes. Sci Rep. 2018;8:4670 pubmed publisher
Sirish P, Li N, Timofeyev V, Zhang X, Wang L, Yang J, et al
. Molecular Mechanisms and New Treatment Paradigm for Atrial Fibrillation. Circ Arrhythm Electrophysiol. 2016;9: pubmed publisher
Rafizadeh S, Zhang Z, Woltz R, Kim H, Myers R, Lu L, et al
. Functional interaction with filamin A and intracellular Ca2+ enhance the surface membrane expression of a small-conductance Ca2+-activated K+ (SK2) channel. Proc Natl Acad Sci U S A. 2014;111:9989-94 pubmed publisher
..The findings here may transcend the area of SK2 channel studies and may have implications not only in cardiac myocytes but in other types of excitable cells. ..
Frederich B, Timofeyev V, Thai P, Haddad M, Poe A, Lau V, et al
. Electrotaxis of cardiac progenitor cells, cardiac fibroblasts, and induced pluripotent stem cell-derived cardiac progenitor cells requires serum and is directed via PI3'K pathways. Heart Rhythm. 2017;14:1685-1692 pubmed publisher
..The electrotactic behaviors of these therapeutic cardiac cells may be used to improve cell-based therapy for recovering function in damaged myocardium. ..