Neil C Chi
Affiliation: University of California
Bloomekatz J, Gálvez Santisteban M, Chi N. Myocardial plasticity: cardiac development, regeneration and disease. Curr Opin Genet Dev. 2016;40:120-130 pubmed publisher
..Here, we review recent studies of cardiac development, regeneration and disease that highlight how changes in myocardial identity (plasticity) is regulated and impacts adaptive and maladaptive cardiac responses. ..
Chi N, Bussen M, Brand Arzamendi K, Ding C, Olgin J, Shaw R, et al
. Cardiac conduction is required to preserve cardiac chamber morphology. Proc Natl Acad Sci U S A. 2010;107:14662-7 pubmed publisher
..Overall, these in vivo studies indicate that cardiac electrical forces are required to preserve cardiac chamber morphology and may act as a key epigenetic factor in cardiac remodeling...
Dickover M, Hegarty J, Ly K, Lopez D, Yang H, Zhang R, et al
. The atypical Rho GTPase, RhoU, regulates cell-adhesion molecules during cardiac morphogenesis. Dev Biol. 2014;389:182-91 pubmed publisher
..Failure to properly form these cell adhesions during cardiac development may lead to structural heart defects and mechanistically account for the cellular events that occur in certain human congenital heart diseases. ..
Yang H, Fang L, Zhan R, Hegarty J, Ren J, Hsiai T, et al
. Polo-like kinase 2 regulates angiogenic sprouting and blood vessel development. Dev Biol. 2015;404:49-60 pubmed publisher
..Overall, these findings reveal a conserved PLK2-RAP1 pathway that is crucial to regulate endothelial tip cell behavior in order to ensure proper vascular development and patterning in vertebrates. ..