Genomes and Genes
Neil C Chi
Affiliation: University of California
- Genetic and physiologic dissection of the vertebrate cardiac conduction systemNeil C Chi
Department of Biochemistry and Biophysics and Programs in Developmental Biology, Genetics, and Human Genetics, University of California San Francisco, San Francisco, California, United States of America
PLoS Biol 6:e109. 2008....
- Foxn4 directly regulates tbx2b expression and atrioventricular canal formationNeil C Chi
Department of Biochemistry and Biophysics, Programs in Developmental Biology, Genetics and Human Genetics, University of California, San Francisco, San Francisco, California 94158, USA
Genes Dev 22:734-9. 2008..sli/foxn4 is expressed in the AV canal, and its encoded product binds to a highly conserved tbx2 enhancer domain that contains Foxn4- and T-box-binding sites, both necessary to regulate tbx2b expression in the AV canal...
- Limited forward trafficking of connexin 43 reduces cell-cell coupling in stressed human and mouse myocardiumJames W Smyth
Cardiovascular Research Institute, Department of Medicine, University of California San Francisco, 505 Parnassus Avenue, San Francisco, CA 94143, USA
J Clin Invest 120:266-79. 2010..We anticipate that protecting the microtubule-based forward delivery apparatus of connexons could improve cell-cell coupling and reduce ischemia-related cardiac arrhythmias...
- Combinatorial regulation of endothelial gene expression by ets and forkhead transcription factorsSarah De Val
Cardiovascular Research Institute, University of California, San Francisco, San Francisco, CA 94158 2517, USA
Cell 135:1053-64. 2008..Finally, we show that FOX:ETS motifs are present in many known endothelial-specific enhancers and that this motif is an efficient predictor of endothelial enhancers in the human genome...
- BIN1 is reduced and Cav1.2 trafficking is impaired in human failing cardiomyocytesTing Ting Hong
Cardiovascular Research Institute, University of California, San Francisco, CA, USA
Heart Rhythm 9:812-20. 2012..2 channels at cardiac T tubules. Bridging integrator 1 (BIN1) is a membrane scaffolding protein that causes Cav1.2 to traffic to T tubules in healthy hearts. The mechanisms of Cav1.2 trafficking in heart failure are not known...
- Zebrafish model for human long QT syndromeRima Arnaout
Department of Biochemistry and Biophysics, Programs in Developmental Biology, Genetics, and Human Genetics, Cardiovascular Research Institute, University of California, 1550 Fourth Street, San Francisco, CA 94158, USA
Proc Natl Acad Sci U S A 104:11316-21. 2007..Our findings provide insight into the pathogenesis of homozygous kcnh2 mutations and expand the use of zebrafish mutants as a model system to study human arrhythmias...
- Loss of Dnmt1 catalytic activity reveals multiple roles for DNA methylation during pancreas development and regenerationRyan M Anderson
Department of Biochemistry and Biophysics, Programs in Developmental Biology, Genetics, and Human Genetics, Diabetes Center, and Liver Center, University of California, San Francisco, San Francisco, CA 94158 2324, USA
Dev Biol 334:213-23. 2009..In addition, Dnmt1 may influence the differentiation of pancreatic beta cell progenitors or the reprogramming of cells toward the pancreatic beta cell fate...
- Targeting neural circuitry in zebrafish using GAL4 enhancer trappingEthan K Scott
Department of Physiology, University of California, San Francisco, California 94158, USA
Nat Methods 4:323-6. 2007..Through targeted photoconversion of UAS-driven Kaede and variegated expression of UAS-driven GFP in single cells, we begin to characterize the cellular components of labeled circuits...
- A transgene-assisted genetic screen identifies essential regulators of vascular development in vertebrate embryosSuk Won Jin
Department of Biochemistry and Biophysics, Genetics and Human Genetics, and Cardiovascular Research Institute, University of California San Francisco, CA 94158, USA
Dev Biol 307:29-42. 2007..The analysis of the newly defined loci should lead to a greater understanding of vascular development and possibly provide new drug targets to treat the numerous pathologies associated with dysregulated blood vessel growth...
- Molecular determinants of responses to myocardial ischemia/reperfusion injury: focus on hypoxia-inducible and heat shock factorsNeil C Chi
Cardiology Section, Medical Service, Veterans Affairs Medical Center, University of California, 4150 Clement St, San Francisco, CA 94121, USA
Cardiovasc Res 61:437-47. 2004..Emphasis is placed on new mechanisms of action that regulate HIF-1alpha, HSF, and heat shock proteins as key responses to hypoxia and ischemia, and possible approaches to therapy based on these data are discussed...
- Identification of minimal enhancer elements sufficient for Pax3 expression in neural crest and implication of Tead2 as a regulator of Pax3Rita C Milewski
Cardiovascular Division, Department of Medicine, University of Pennsylvania, Philadelphia, PA, USA
Development 131:829-37. 2004..In addition, a Tead2-Engrailed fusion protein is able to repress retinoic acid-induced Pax3 expression in P19 cells and in vivo. These results suggest that Tead2 is an endogenous activator of Pax3 in neural crest...
- Zebrafish Heart Mutants:Physiological & Genetic AnalysesNeil Chi; Fiscal Year: 2007..These zebrafish mutants ultimately may serve as a novel gateway to gain new insight into the cellular and molecular mechanisms of human cardiac arrhythmias and heart failure. ..