William D Chey

Summary

Affiliation: University of Michigan
Country: USA

Publications

  1. doi request reprint Safety and patient outcomes with lubiprostone for up to 52 weeks in patients with irritable bowel syndrome with constipation
    W D Chey
    GI Physiology Laboratory, University of Michigan Health System, Ann Arbor, 48109 0362, USA
    Aliment Pharmacol Ther 35:587-99. 2012
  2. ncbi request reprint Primary care physician perceptions of non-steroidal anti-inflammatory drug and aspirin-associated toxicity: results of a national survey
    W D Chey
    Division of Gastroenterology, University of Michigan, Ann Arbor, MI, USA
    Aliment Pharmacol Ther 23:655-68. 2006
  3. ncbi request reprint Irritable bowel syndrome: update on colonic neuromuscular dysfunction and treatment
    William D Chey
    Division of Gastroenterology, University of Michigan Medical Center, Ann Arbor, MI 48109 0362, USA
    Curr Gastroenterol Rep 8:273-81. 2006
  4. ncbi request reprint Review article: tegaserod -- the global experience
    W D Chey
    Division of Gastroenterology, University of Michigan Medical Center, Ann Arbor, MI 48109 0362, USA
    Aliment Pharmacol Ther 20:15-9. 2004
  5. ncbi request reprint Review article: uninvestigated dyspepsia and non-ulcer dyspepsia-the use of endoscopy and the roles of Helicobacter pylori eradication and antisecretory therapy
    W D Chey
    Department of Gastroenterology, University of Michigan Medical Center, Ann Arbor, MI 48109 0362, USA
    Aliment Pharmacol Ther 19:1-8. 2004
  6. doi request reprint Patient and physician satisfaction with proton pump inhibitors (PPIs): are there opportunities for improvement?
    William D Chey
    Division of Gastroenterology, University of Michigan Health System, 3912 Taubman Center, Ann Arbor, MI 48109 0362, USA
    Dig Dis Sci 55:3415-22. 2010
  7. ncbi request reprint Noninvasive Helicobacter pylori testing for the "test-and-treat" strategy: a decision analysis to assess the effect of past infection on test choice
    W D Chey
    Divisions of Gastroenterology, University of Michigan, Ann Arbor, MI, USA
    Arch Intern Med 161:2129-32. 2001
  8. ncbi request reprint Gastric emptying characteristics of a novel (13)C-octanoate-labeled muffin meal
    W D Chey
    Division of Gastroenterology, University of Michigan Medical Center, Ann Arbor, Michigan 48109 0362, USA
    J Clin Gastroenterol 32:394-9. 2001
  9. doi request reprint Treatment patterns and symptom control in patients with GERD: US community-based survey
    William D Chey
    University of Michigan Health System, Ann Arbor, MI 48109 0362, USA
    Curr Med Res Opin 25:1869-78. 2009
  10. ncbi request reprint Accurate diagnosis of Helicobacter pylori. 14C-urea breath test
    W D Chey
    University of Michigan Medical Center, Ann Arbor, Michigan, USA
    Gastroenterol Clin North Am 29:895-902. 2000

Detail Information

Publications81

  1. doi request reprint Safety and patient outcomes with lubiprostone for up to 52 weeks in patients with irritable bowel syndrome with constipation
    W D Chey
    GI Physiology Laboratory, University of Michigan Health System, Ann Arbor, 48109 0362, USA
    Aliment Pharmacol Ther 35:587-99. 2012
    ..Irritable bowel syndrome with constipation (IBS-C) significantly decreases quality of life and the ability to perform daily living activities...
  2. ncbi request reprint Primary care physician perceptions of non-steroidal anti-inflammatory drug and aspirin-associated toxicity: results of a national survey
    W D Chey
    Division of Gastroenterology, University of Michigan, Ann Arbor, MI, USA
    Aliment Pharmacol Ther 23:655-68. 2006
    ..To assess primary care physician perceptions of non-steroidal anti-inflammatory drug (NSAID) and aspirin-associated toxicity...
  3. ncbi request reprint Irritable bowel syndrome: update on colonic neuromuscular dysfunction and treatment
    William D Chey
    Division of Gastroenterology, University of Michigan Medical Center, Ann Arbor, MI 48109 0362, USA
    Curr Gastroenterol Rep 8:273-81. 2006
    ..This article reviews the accumulating body of evidence supporting the importance of neuromuscular dysfunction as a central cause of IBS symptoms and provides a rationale for the discussion of current and future drug development...
  4. ncbi request reprint Review article: tegaserod -- the global experience
    W D Chey
    Division of Gastroenterology, University of Michigan Medical Center, Ann Arbor, MI 48109 0362, USA
    Aliment Pharmacol Ther 20:15-9. 2004
    ....
  5. ncbi request reprint Review article: uninvestigated dyspepsia and non-ulcer dyspepsia-the use of endoscopy and the roles of Helicobacter pylori eradication and antisecretory therapy
    W D Chey
    Department of Gastroenterology, University of Michigan Medical Center, Ann Arbor, MI 48109 0362, USA
    Aliment Pharmacol Ther 19:1-8. 2004
    ..The test-and-treat approach would receive increased enthusiasm if H. pylori cure is shown to prevent development of gastric cancer in non-ulcer dyspepsia patients in a large Western trial...
  6. doi request reprint Patient and physician satisfaction with proton pump inhibitors (PPIs): are there opportunities for improvement?
    William D Chey
    Division of Gastroenterology, University of Michigan Health System, 3912 Taubman Center, Ann Arbor, MI 48109 0362, USA
    Dig Dis Sci 55:3415-22. 2010
    ..Few studies have explored the satisfaction with proton pump inhibitors (PPIs) for gastroesophageal reflux disease (GERD)...
  7. ncbi request reprint Noninvasive Helicobacter pylori testing for the "test-and-treat" strategy: a decision analysis to assess the effect of past infection on test choice
    W D Chey
    Divisions of Gastroenterology, University of Michigan, Ann Arbor, MI, USA
    Arch Intern Med 161:2129-32. 2001
    ..Clinical guidelines support a noninvasive Helicobacter pylori "test-and-treat" strategy for individuals with uncomplicated dyspepsia. However, consensus is lacking regarding the preferred noninvasive testing method...
  8. ncbi request reprint Gastric emptying characteristics of a novel (13)C-octanoate-labeled muffin meal
    W D Chey
    Division of Gastroenterology, University of Michigan Medical Center, Ann Arbor, Michigan 48109 0362, USA
    J Clin Gastroenterol 32:394-9. 2001
    ..Determine the gastric emptying characteristics of a novel, 350-kcal test meal consisting of two muffins, using scintigraphy and the 13C-octanoate breath test (OBT)...
  9. doi request reprint Treatment patterns and symptom control in patients with GERD: US community-based survey
    William D Chey
    University of Michigan Health System, Ann Arbor, MI 48109 0362, USA
    Curr Med Res Opin 25:1869-78. 2009
    ..Proton pump inhibitors (PPIs) are the most commonly used pharmacological treatment for gastroesophageal reflux disease (GERD)...
  10. ncbi request reprint Accurate diagnosis of Helicobacter pylori. 14C-urea breath test
    W D Chey
    University of Michigan Medical Center, Ann Arbor, Michigan, USA
    Gastroenterol Clin North Am 29:895-902. 2000
    ..As such, the 14C-urea breath test provides an attractive, nonendoscopic means of identifying active H. pylori infection...
  11. ncbi request reprint Cilansetron: a new serotonergic agent for the irritable bowel syndrome with diarrhoea
    William D Chey
    University of Michigan, Division of Gastroenterology, Ann Arbor, MI, USA
    Expert Opin Investig Drugs 14:185-93. 2005
    ..A detailed risk management plan and post-marketing surveillance programme will be required should this drug become available for the treatment of patients with IBS-D...
  12. ncbi request reprint Tegaserod in the treatment of irritable bowel syndrome with constipation
    Richard Saad
    GI Physiology Laboratory, University of Michigan Medical Center, 3912 Taubman Center, Box 0362, Ann Arbor, MI 48109, USA
    Womens Health (Lond Engl) 2:29-42. 2006
    ....
  13. doi request reprint Heightened colon motor activity measured by a wireless capsule in patients with constipation: relation to colon transit and IBS
    William L Hasler
    University of Michigan Health System, Ann Arbor, Michigan, USA
    Am J Physiol Gastrointest Liver Physiol 297:G1107-14. 2009
    ..Constipated patients with normal or moderately delayed transit show increased motor activity that is partly explained by IBS. These findings emphasize differential effects on transit and motility in different constipation subtypes...
  14. doi request reprint Do stool form and frequency correlate with whole-gut and colonic transit? Results from a multicenter study in constipated individuals and healthy controls
    Richard J Saad
    Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan 48109, USA
    Am J Gastroenterol 105:403-11. 2010
    ..The aim of this study was to assess the correlation between stool characteristics (form and frequency) and gut transit in constipated and healthy adults...
  15. ncbi request reprint Primary-care physicians' perceptions and practices on the management of GERD: results of a national survey
    William D Chey
    University of Michigan Health System, Ann Arbor, Michigan 49109 0362, USA
    Am J Gastroenterol 100:1237-42. 2005
    ..Gastroesophageal reflux disease (GERD) is frequently managed by primary-care physicians (PCPs) although little is known about their current practices and management patterns...
  16. doi request reprint Generalized transit delay on wireless motility capsule testing in patients with clinical suspicion of gastroparesis, small intestinal dysmotility, or slow transit constipation
    Braden Kuo
    Division of Gastroenterology, Massachusetts General Hospital, Boston, MA, USA
    Dig Dis Sci 56:2928-38. 2011
    ..The prevalence of generalized transit delay and relation to symptoms in suspected gastroparesis, intestinal dysmotility, or slow transit constipation are unknown...
  17. pmc The yield of colonoscopy in patients with non-constipated irritable bowel syndrome: results from a prospective, controlled US trial
    William D Chey
    Divison of Gastroenterology, University of Michigan Health System, Ann Arbor, Michigan, USA
    Am J Gastroenterol 105:859-65. 2010
    ..This study compared the prevalence of structural colonic lesions in patients with suspected non-constipation-predominant IBS and healthy volunteers. We also determined the yield of rectosigmoid biopsies in patients with suspected IBS...
  18. doi request reprint Empiric quadruple vs. triple therapy for primary treatment of Helicobacter pylori infection: Systematic review and meta-analysis of efficacy and tolerability
    Jay Luther
    University of Michigan Medical Center, Ann Arbor, USA
    Am J Gastroenterol 105:65-73. 2010
    ..We performed a systematic review and meta-analysis to compare the efficacy and tolerability of these regimens as first-line treatment of H. pylori...
  19. doi request reprint Fiber and functional gastrointestinal disorders
    Shanti Eswaran
    Division of Gastroenterology, University of Michigan Health System, Ann Arbor, MI 48109 5362, USA
    Am J Gastroenterol 108:718-27. 2013
    ..Even when used judiciously, fiber can exacerbate abdominal distension, flatulence, constipation, and diarrhea...
  20. pmc Risk of recurrent Helicobacter pylori infection 1 year after initial eradication therapy in 7 Latin American communities
    Douglas R Morgan
    Division of Gastroenterology, Hepatology, and Nutrition, Department of Medicine, Vanderbilt Medical Center, Nashville, TN 37232, USA
    JAMA 309:578-86. 2013
    ..The long-term effectiveness of Helicobacter pylori eradication programs for preventing gastric cancer will depend on recurrence risk and individual and community factors...
  21. doi request reprint A clinician's guide to salvage therapy for persistent Helicobacter pylori infection
    Jay Luther
    Department of Internal Medicine, Division of Gastroenterology, University of Michigan Health System, Ann Arbor, MI 48109 5682, USA
    Hosp Pract (1995) 39:133-40. 2011
    ....
  22. ncbi request reprint Levofloxacin-based triple therapy versus bismuth-based quadruple therapy for persistent Helicobacter pylori infection: a meta-analysis
    Richard J Saad
    Department of Medicine, Division of Gastroenterology, University of Michigan Medical Center, 3912 Taubman Center, Ann Arbor, MI 48109, USA
    Am J Gastroenterol 101:488-96. 2006
    ..Levofloxacin-based triple therapy has been suggested as an alternative salvage therapy to bismuth-based quadruple therapy for persistent Helicobacter pylori (H. pylori) infection...
  23. ncbi request reprint A clinician's guide to managing Helicobacter pylori infection
    Richard Saad
    University of Michigan Medical Center, Ann Arbor 48109, USA
    Cleve Clin J Med 72:109-10, 112-3, 117-8 passim. 2005
    ..Care must be used in deciding whom to test for H pylori infection, as a positive result mandates treatment, making broad-based screening impractical...
  24. ncbi request reprint Reappraisal of non-invasive management strategies for uninvestigated dyspepsia: a cost-minimization analysis
    U Ladabaum
    Division of Gastroenterology, Department of Medicine, University of California, San Francisco, CA 94143 0538, USA
    Aliment Pharmacol Ther 16:1491-501. 2002
    ..The benefits of the Helicobacter pylori test-and-treat strategy are attributable largely to the cure of peptic ulcer disease while limiting the use of endoscopy...
  25. doi request reprint Long-term tegaserod treatment for dysmotility-like functional dyspepsia: results of two identical 1-year cohort studies
    William D Chey
    Division of Gastroenterology, University of Michigan Health System, 3912 Taubman Center, SPC 0362, Ann Arbor, MI 48109 0362, USA
    Dig Dis Sci 55:684-97. 2010
    ..Functional dyspepsia (FD) is a chronic disorder that adversely affects health-related quality of life (HRQoL). Published information on its long-term management is minimal and treatment options are limited...
  26. pmc A randomized placebo-controlled phase IIb trial of a3309, a bile acid transporter inhibitor, for chronic idiopathic constipation
    William D Chey
    Department of Medicine, University of Michigan Health System, Ann Arbor, 48109 5362, USA
    Am J Gastroenterol 106:1803-12. 2011
    ..We conducted an 8-week, multicenter, randomized, double-blind, placebo-controlled, parallel group, phase IIb study, which evaluated A3309 in patients with chronic idiopathic constipation (CIC)...
  27. doi request reprint Lubiprostone for chronic idiopathic constipation and irritable bowel syndrome with constipation
    Richard Saad
    Division of Gastroenterology, Department of Medicine, University of Michigan Medical Center, Ann Arbor, MI 48109, USA
    Expert Rev Gastroenterol Hepatol 2:497-508. 2008
    ..There is no evidence of a rebound in constipation or IBS symptoms following cessation of lubiprostone. In general, lubiprostone is well tolerated, with the most common side effects including nausea, headache and diarrhea...
  28. doi request reprint Tegaserod for female patients suffering from IBS with mixed bowel habits or constipation: a randomized controlled trial
    William D Chey
    University of Michigan Health System, Division of Internal Medicine, Ann Arbor, Michigan, USA
    Am J Gastroenterol 103:1217-25. 2008
    ..This study aimed to evaluate the efficacy and safety of the 5-HT(4) agonist tegaserod in women with IBS-Mixed and IBS with constipation (IBS-C)...
  29. ncbi request reprint Breath tests for gastrointestinal disease: the real deal or just a lot of hot air?
    Richard J Saad
    Division of Gastroenterology, University of Michigan Health System, Ann Arbor, Michigan, USA
    Gastroenterology 133:1763-6. 2007
  30. ncbi request reprint Long-term safety and efficacy of alosetron in women with severe diarrhea-predominant irritable bowel syndrome
    William D Chey
    University of Michigan Medical Center, Ann Arbor, Michigan, USA
    Am J Gastroenterol 99:2195-203. 2004
    ..To assess long-term safety and efficacy of alosetron in women with severe, chronic diarrhea-predominant IBS and in a subset having more frequent urgency (i.e., bowel urgency at least 10 of 14 days during screening)...
  31. ncbi request reprint Advances in the management of irritable bowel syndrome
    Brooks D Cash
    Division of Gastroenterology, University of Michigan Health System, 3912 Taubman Center, Box 0362, 1500 East Medical Center Drive, Ann Arbor, MI 48109 0352, USA
    Curr Gastroenterol Rep 5:468-75. 2003
    ..No single medication has proven to be universally effective, and multiple therapeutic approaches exist. Greater understanding of gastrointestinal neurophysiology has led to promising advances in medical and nonmedical approaches to IBS...
  32. doi request reprint Agents that act luminally to treat diarrhoea and constipation
    Stacy Menees
    University of Michigan Health System, 3912 Taubman Center, SPC 5362, Ann Arbor, MI 48109 5362, USA
    Nat Rev Gastroenterol Hepatol 9:661-74. 2012
    ..As the physiological effects of luminally acting drugs are largely confined to the gastrointestinal tract, these agents are unlikely to cause adverse effects outside of the gastrointestinal tract...
  33. doi request reprint Emerging pharmacological therapies for the irritable bowel syndrome
    Monthira Maneerattanaporn
    Division of Gastroenterology, University of Michigan Health System, 3912 Taubman Center, Ann Arbor, MI 48109 0362, USA
    Gastroenterol Clin North Am 40:223-43. 2011
    ..This fact has important implications for the choices and efficacy of IBS treatment. This article reviews the IBS drugs that have reached phase II or III clinical trials...
  34. ncbi request reprint Endoscopy-negative reflux disease: concepts and clinical practice
    William D Chey
    Division of Gastroenterology, Department of Internal Medicine, University of Michigan Medical Center, Ann Arbor, Michigan 48109 0362, USA
    Am J Med 117:36S-43S. 2004
    ..In those with persistent heartburn symptoms, other structural or nonacid reflux etiologies for their symptoms should be explored...
  35. ncbi request reprint Review article: current and emerging therapies for functional dyspepsia
    R J Saad
    University of Michigan Medical Center, Ann Arbor, MI 48109, USA
    Aliment Pharmacol Ther 24:475-92. 2006
    ..A variety of emerging therapies are being developed for functional dyspepsia. Most of these therapies are intended to normalize pain perception and gastrointestinal motor and reflex function in this group of patients...
  36. ncbi request reprint Evaluation of the Ez-HBT Helicobacter blood test to establish Helicobacter pylori eradication
    F Ahmed
    Division of Gastroenterology, Syracuse VA Medical Center, Syracuse, NY 10128, USA
    Aliment Pharmacol Ther 22:875-80. 2005
    ..The urea blood test (Ez-HBT) has been shown to compare favourably with the urea breath test in the diagnosis of active Helicobacter pylori infection...
  37. ncbi request reprint Intragastric acidification reduces the occurrence of false-negative urea breath test results in patients taking a proton pump inhibitor
    W D Chey
    University of Michigan Health System, Ann Arbor, USA
    Am J Gastroenterol 96:1028-32. 2001
    ..These observations suggest that it may be possible to design a UBT protocol that will remain accurate in the face of PPI therapy...
  38. doi request reprint The role of food in the functional gastrointestinal disorders: introduction to a manuscript series
    William D Chey
    Division of Gastroenterology, University of Michigan Health System, Ann Arbor, MI 48109, USA
    Am J Gastroenterol 108:694-7. 2013
    ..The series concludes with a manuscript that provides guidance on proper clinical trial design when considering the role of food in FGIDs...
  39. doi request reprint The utility of probiotics in the treatment of irritable bowel syndrome: a systematic review
    Darren M Brenner
    Division of Gastroenterology, Department of Internal Medicine, Northwestern University Feinberg School of Medicine, Ann Arbor, Michigan, USA
    Am J Gastroenterol 104:1033-49; quiz 1050. 2009
    ..The aim of this study was to perform a systematic review of randomized controlled trials (RCTs) evaluating the efficacy, safety, and tolerability of probiotics in the treatment of IBS...
  40. doi request reprint Food: the forgotten factor in the irritable bowel syndrome
    Shanti Eswaran
    Division of Gastroenterology, University of Michigan Health System, 3912 Taubman Center, SPC 5362, Ann Arbor, MI 48109 5362, USA
    Gastroenterol Clin North Am 40:141-62. 2011
    ..This article reviews the literature supporting a causal link between food and the symptoms of IBS as well as the evidence supporting dietary interventions as a means of managing IBS symptoms...
  41. ncbi request reprint Tegaserod and other serotonergic agents: what is the evidence?
    William D Chey
    University of Michigan Health System, Ann Arbor, Michigan, USA
    Rev Gastroenterol Disord 3:S35-40. 2003
    ..The safety profile and restricted-use program for alosetron is also reviewed. This discussion is followed by a comprehensive review of the efficacy and safety data in support of tegaserod for women with constipation-predominant IBS...
  42. ncbi request reprint Low- versus high-dose azithromycin triple therapy for Helicobacter pylori infection
    W D Chey
    Department of Internal Medicine, University of Michigan, Ann Arbor, USA
    Aliment Pharmacol Ther 12:1263-7. 1998
    ..We report a clinical trial which evaluated the effectiveness of triple therapy containing low- and high-dose azithromycin to treat Helicobacter pylori infection...
  43. ncbi request reprint Oesophageal hypersensitivity is associated with features of psychiatric disorders and the irritable bowel syndrome
    J H Rubenstein
    Division of Gastroenterology, University of Michigan Medical School, Ann Arbor, MI 48109 0362, USA
    Aliment Pharmacol Ther 26:443-52. 2007
    ..We hypothesized that such PPI non-responders have heightened oesophageal sensation, and that oesophageal hypersensitivity is associated with psychiatric features including somatization and anxiety...
  44. doi request reprint Changing perceptions and practices regarding aspirin, nonsteroidal anti-inflammatory drugs, and cyclooxygenase-2 selective nonsteroidal anti-inflammatory drugs among US primary care providers
    N Elnachef
    Division of Gastroenterology, University of Michigan, Ann Arbor, MI 48109, USA
    Aliment Pharmacol Ther 28:1249-58. 2008
    ..Our understanding of the benefits and risks of aspirin non steroidal anti-inflammatory drugs (NSAIDs), cyclooxygenase-2 (COX-2) selective NSAIDs and gastro-protective agents (GPAs) continues to expand...
  45. doi request reprint Successful physical therapy for constipation related to puborectalis dyssynergia improves symptom severity and quality of life
    Christina Lewicky-Gaupp
    Division of Gynecology, Department of Obstetrics and Gynecology, University of Michigan Medical School, Ann Arbor, Michigan 48109 0276, USA
    Dis Colon Rectum 51:1686-91. 2008
    ..This study evaluated symptom severity and quality of life in patients with puborectalis dyssynergia before and after physical therapy...
  46. ncbi request reprint Diagnosis of irritable bowel syndrome
    Brooks D Cash
    Division of Gastroenterology, Uniformed Services University of the Health Sciences, 8901 Wisconsin Avenue, Building 9, Bethesda, MD 20889, USA
    Gastroenterol Clin North Am 34:205-20, vi. 2005
    ..This article evaluates the diagnostic characteristics of various symptom-based criteria in routine clinical practice and reviews the data regarding the yield of the multiple commonly used diagnostic tests in patients with suspected IBS...
  47. pmc The impact of rotating shift work on the prevalence of irritable bowel syndrome in nurses
    Borko Nojkov
    Division of Gastroenterology, University of Michigan, Ann Arbor, Michigan 48105, USA
    Am J Gastroenterol 105:842-7. 2010
    ....
  48. ncbi request reprint Gastroesophageal reflux disease
    Colin W Howden
    Division of Gastroenterology, Northwestern University, Feinberg School of Medicine, Chicago, IL, USA
    J Fam Pract 52:240-7. 2003
    ..Unfortunately, the same survey found that most physicians recommend antireflux surgery for patients in whom medical therapy has failed...
  49. ncbi request reprint An evidence-based approach to clinical practice guidelines: diagnosis and treatment of irritable bowel syndrome
    Philip Schoenfeld
    Division of Gastroenterology, University of Michigan School of Medicine, Ann Arbor, MI, USA
    Clin Gastroenterol Hepatol 1:322-7. 2003
  50. ncbi request reprint Testing for Helicobacter pylori in the clinical setting
    J M Lake
    Division of Gastroenterology, Department of Internal Medicine, University of Michigan Health System, Ann Arbor, MI, USA
    Front Biosci 6:E129-36. 2001
    ..pylori-related disease. The potential advantages and disadvantages of various tests and the role of testing to confirm eradication after treatment for H. pylori is also discussed...
  51. ncbi request reprint Implications for treatment: pH, Helicobacter pylori or alternative approaches?
    W D Chey
    University of Michigan Medical Center, Ann Arbor, MI, USA
    Aliment Pharmacol Ther 21:17-8, 21-4. 2005
  52. doi request reprint Protective role of gluteofemoral obesity in erosive oesophagitis and Barrett's oesophagus
    Joel H Rubenstein
    Center for Clinical Management Research, Veterans Affairs Medical Center, Ann Arbor, Michigan, USA
    Gut 63:230-5. 2014
    ..As gluteofemoral obesity protects against diabetes mellitus and cardiovascular disease, we hypothesised that gluteofemoral obesity would be inversely associated with EO and BO...
  53. ncbi request reprint Linaclotide for irritable bowel syndrome with constipation: a 26-week, randomized, double-blind, placebo-controlled trial to evaluate efficacy and safety
    William D Chey
    Division of Gastroenterology, Department of Medicine, University of Michigan Health System, Ann Arbor, Michigan, USA
    Am J Gastroenterol 107:1702-12. 2012
    ..The objective of this trial was to determine the effi cacy and safety of linaclotide treatment in patients with irritable bowel syndrome with constipation (IBS-C) over 26 weeks...
  54. doi request reprint The efficacy and safety of rifaximin for the irritable bowel syndrome: a systematic review and meta-analysis
    Stacy B Menees
    Division of Gastroenterology, University of Michigan Health System, Ann Arbor, 48109 5362, USA
    Am J Gastroenterol 107:28-35; quiz 36. 2012
    ..The objective of our study was to perform a meta-analysis and systematic review of available randomized, placebo controlled trials evaluating the efficacy and tolerability of rifaximin in patients with IBS...
  55. ncbi request reprint Successful treatment of common variable immunodeficiency disorder-associated diarrhea with budesonide: a case report
    Najwa Elnachef
    Division of Gastroenterology, University of Michigan Health System, Ann Arbor, Michigan 48109 0362, USA
    Am J Gastroenterol 102:1322-5. 2007
    ..We report a patient with CVID and chronic diarrhea who significantly improved with budesonide...
  56. ncbi request reprint The utility of diagnostic tests in irritable bowel syndrome patients: a systematic review
    Brooks D Cash
    Division of Gastroenterology, Uniformed Services University of the Health Sciences, Bethesda, Maryland, USA
    Am J Gastroenterol 97:2812-9. 2002
    ..The aim of this study was to determine the pretest probability of organic GI disease and the accuracy of diagnostic tests for organic GI disease in patients who meet symptom-based criteria for irritable bowel syndrome (IBS)...
  57. doi request reprint Recent developments in the therapy of irritable bowel syndrome
    Richard J Saad
    Division of Gastroenterology, Department of Medicine, University of Michigan Medical Center, Ann Arbor, MI, USA
    Expert Opin Investig Drugs 17:117-30. 2008
    ....
  58. ncbi request reprint Number of responses on a review of systems questionnaire predicts the diagnosis of functional gastrointestinal disorders
    William H Brown
    Division of Gastroenterology, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan 48109 0362, USA
    J Clin Gastroenterol 36:222-7. 2003
    ..We evaluated whether the number of positive responses on a review of systems questionnaire predicted the diagnosis of functional gastrointestinal (GI) disorders...
  59. ncbi request reprint American College of Gastroenterology guideline on the management of Helicobacter pylori infection
    William D Chey
    University of Michigan Medical Center, Ann Arbor, Michigan 48109, USA
    Am J Gastroenterol 102:1808-25. 2007
    ..Recent data suggest that a PPI, levofloxacin, and amoxicillin for 10 days is more effective and better tolerated than bismuth quadruple therapy for persistent H. pylori infection, though this needs to be validated in the United States...
  60. doi request reprint Differences in intragastric pH in diabetic vs. idiopathic gastroparesis: relation to degree of gastric retention
    William L Hasler
    Division of Gastroenterology, Univ of Michigan Health System, Ann Arbor, MI 48109, USA
    Am J Physiol Gastrointest Liver Physiol 294:G1384-91. 2008
    ..those with mild delays. Thus both etiology and degree of gastric stasis determine gastric acidity in gastroparesis...
  61. pmc Pharmacologic and complementary and alternative medicine therapies for irritable bowel syndrome
    William D Chey
    Division of Gastroenterology, University of Michigan Health System, Ann Arbor, MI, USA
    Gut Liver 5:253-66. 2011
    ....
  62. ncbi request reprint Increased transduction of human intestinal epithelial cells by adenoviral vectors in inflammatory bowel disease
    Phyllissa Schmiedlin-Ren
    University of Michigan Medical School, Ann Arbor, 48109, USA
    Inflamm Bowel Dis 11:464-72. 2005
    ..The goal of this study was to assess the ability of a standard adenoviral vector to transfect epithelial cells in intestinal explants from patients with IBD compared with controls...
  63. ncbi request reprint Bifidobacterium infantis 35624: a novel probiotic for the treatment of irritable bowel syndrome
    Darren M Brenner
    Division of Gastroenterology, Department of Internal Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA
    Rev Gastroenterol Disord 9:7-15. 2009
    ..B. infantis 35624 appears safe and effective for the treatment of IBS...
  64. ncbi request reprint Utility of the Rome I and Rome II criteria for irritable bowel syndrome in U.S. women
    William D Chey
    University of Michigan, Ann Arbor, USA
    Am J Gastroenterol 97:2803-11. 2002
    ....
  65. ncbi request reprint Irritable bowel syndrome - an evidence-based approach to diagnosis
    B D Cash
    Division of Gastroenterology, Uniformed Services University of the Health Sciences, Bethesda, MD, USA
    Aliment Pharmacol Ther 19:1235-45. 2004
    ..The presence of alarm features or persistent non-response to symptom-directed therapies should prompt a more detailed diagnostic evaluation dictated by the patient's predominant symptoms...
  66. ncbi request reprint Gastric distention correlates with activation of multiple cortical and subcortical regions
    U Ladabaum
    Division of Gastroenterology, Department of Medicine, University of Michigan, Ann Arbor, Michigan, USA
    Gastroenterology 120:369-76. 2001
    ..However, the cerebral loci that process sensory information from the stomach are unknown. The aim of this study was to localize the human brain regions that are activated by gastric distention...
  67. doi request reprint The influence of co-morbid IBS and psychological distress on outcomes and quality of life following PPI therapy in patients with gastro-oesophageal reflux disease
    B Nojkov
    Division of Gastroenterology, University of Michigan Medical School, Ann Arbor, MI, USA
    Aliment Pharmacol Ther 27:473-82. 2008
    ..A subset of patients with gastro-oesophageal reflux disease (GERD) does not achieve complete symptom resolution with proton pump inhibitor (PPI) therapy. The factors which affect response to PPI therapy in GERD patients remain unclear...
  68. ncbi request reprint Intrasphincteric botulinum toxin versus pneumatic balloon dilation for treatment of primary achalasia
    Rajiv Bansal
    University of Michigan Medical Center, Division of Gastroenterology, Ann Arbor, Michigan 48109, USA
    J Clin Gastroenterol 36:209-14. 2003
    ..Direct comparisons of the two techniques are needed to define their role in clinical management...
  69. ncbi request reprint Nausea and vomiting
    William L Hasler
    Division of Gastroenterology, University of Michigan Medical Center, Ann Arbor, 48109, USA
    Gastroenterology 125:1860-7. 2003
  70. ncbi request reprint Can endoscopic ultrasound or magnetic resonance cholangiopancreatography replace ERCP in patients with suspected biliary disease? A prospective trial and cost analysis
    J M Scheiman
    Department of Internal Medicine, University of Michigan Medical Center, Ann Arbor 48109, USA
    Am J Gastroenterol 96:2900-4. 2001
    ..The economic outcomes of EUS-, MRCP-, and ERCP-based diagnostic strategies were evaluated...
  71. ncbi request reprint Review article: The role of serotonergic agents in the treatment of patients with primary chronic constipation
    B D Cash
    Department of Gastroenterology, Uniformed Services University of the Health Sciences, National Naval Medical Center, Bethesda, MD, USA
    Aliment Pharmacol Ther 22:1047-60. 2005
    ....
  72. ncbi request reprint Peptic ulcer disease in patients with chronic liver disease: looking beyond bugs and drugs
    Richard J Saad
    Gastrointest Endosc 62:357-9. 2005
  73. ncbi request reprint Functional bowel disorders
    George F Longstreth
    Kaiser Permanente Medical Care Program, San Diego, California 92120, USA
    Gastroenterology 130:1480-91. 2006
    ..Treatment of FBDs is based on an individualized evaluation, explanation, and reassurance. Alterations in diet, drug treatment aimed at predominant symptoms, and psychotherapy may be beneficial...
  74. doi request reprint Tegaserod treatment for dysmotility-like functional dyspepsia: results of two randomized, controlled trials
    Nimish Vakil
    University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin and Marquette University College of Health Sciences, Milwaukee, Wisconsin 53233, USA
    Am J Gastroenterol 103:1906-19. 2008
    ..Therapies for dysmotility-like functional dyspepsia (FD) are limited. We studied tegaserod, a selective serotonin type 4 receptor agonist, in patients with FD...
  75. ncbi request reprint Incidence of ischemic colitis and serious complications of constipation among patients using alosetron: systematic review of clinical trials and post-marketing surveillance data
    Lin Chang
    Center for Neurovisceral Sciences and Women s Health, Department of Medicine, UCLA and VA Greater Los Angeles Healthcare Center, California, USA
    Am J Gastroenterol 101:1069-79. 2006
    ..This systematic review calculated the incidence of these adverse events in alosetron-using patients in clinical trials and post-marketing surveillance...
  76. ncbi request reprint Tegaserod does not alter fasting or meal-induced biliary tract motility
    Robert S Fisher
    Temple University Hospital, Philadelphia, USA
    Am J Gastroenterol 99:1342-9. 2004
    ....
  77. ncbi request reprint Effect of tegaserod in chronic constipation: a randomized, double-blind, controlled trial
    John F Johanson
    University of Illinois College of Medicine, Rockford, IL, USA
    Clin Gastroenterol Hepatol 2:796-805. 2004
    ..Chronic constipation is a common gastrointestinal disorder. The aim of this study was to evaluate the efficacy, safety, and tolerability of tegaserod, a serotonin subtype 4 receptor partial agonist in patients with chronic constipation...
  78. ncbi request reprint Erosive esophagitis and NERD: Can we really classify patients with heartburn by endoscopic findings?
    William D Chey
    Clin Gastroenterol Hepatol 2:654-5. 2004
  79. ncbi request reprint Impaired gastrocolonic response and peristaltic reflex in slow-transit constipation: role of 5-HT(3) pathways
    Einar S Björnsson
    Division of Gastroenterology, Department of Internal Medicine, Sahlgrenska University Hospital, S 41345 Gothenburg, Sweden
    Am J Physiol Gastrointest Liver Physiol 283:G400-7. 2002
    ..Thus abnormalities of neural reflex modulation of colonic motor function may play pathophysiological roles in slow-transit constipation...
  80. ncbi request reprint Clinical predictors of Barrett's esophagus length
    Ram Dickman
    The Neuro Enteric Clinical Research Group, Southern Arizona VA Health Care System, Tucson, Arizona 85723 0001, USA
    Gastrointest Endosc 62:675-81. 2005
    ..The aim of this multicenter study was to determine which clinical factors are highly correlated with the length of BE...
  81. ncbi request reprint Design of treatment trials for functional gastrointestinal disorders
    E Jan Irvine
    Division of Gastroenterology, St Michael s Hospital and University of Toronto, Toronto, Ontario, Canada
    Gastroenterology 130:1538-51. 2006
    ..Trials should be registered in a public location, prior to initiation, and should be published even if the results are negative or inconclusive...