ROBERT CHEVALIER

Summary

Affiliation: University of Virginia
Country: USA

Publications

  1. pmc Responses of proximal tubular cells to injury in congenital renal disease: fight or flight
    Robert L Chevalier
    Division of Pediatric Nephrology, Department of Pediatrics, University of Virginia, PO Box 800386, Charlottesville, VA, 22908, USA
    Pediatr Nephrol 29:537-41. 2014
  2. pmc Chronic unilateral ureteral obstruction in the neonatal mouse delays maturation of both kidneys and leads to late formation of atubular glomeruli
    Michael S Forbes
    Dept of Pediatrics, Univ of Virginia, Box 800386, Charlottesville, VA 22908
    Am J Physiol Renal Physiol 305:F1736-46. 2013
  3. pmc Transforming growth factor-β1 receptor inhibition preserves glomerulotubular integrity during ureteral obstruction in adults but worsens injury in neonatal mice
    Carolina I Galarreta
    Dept of Pediatrics, Univ of Virginia, Box 800386, Charlottesville, VA 22908, USA
    Am J Physiol Renal Physiol 304:F481-90. 2013
  4. ncbi request reprint Mechanisms of fetal and neonatal renal impairment by pharmacologic inhibition of angiotensin
    Robert L Chevalier
    Department of Pediatrics, University of Virginia, Box 800386, Charlottesville, VA 22908, USA
    Curr Med Chem 19:4572-80. 2012
  5. pmc Fight-or-flight: murine unilateral ureteral obstruction causes extensive proximal tubular degeneration, collecting duct dilatation, and minimal fibrosis
    Michael S Forbes
    Division of Pediatric Nephrology, Department of Pediatrics, University of Virginia School of Medicine, Charlottesville, Virginia 22908, USA
    Am J Physiol Renal Physiol 303:F120-9. 2012
  6. ncbi request reprint Obstructive nephropathy: towards biomarker discovery and gene therapy
    Robert L Chevalier
    Department of Pediatrics at the University of Virginia, Charlottesville, VA 22908, USA
    Nat Clin Pract Nephrol 2:157-68. 2006
  7. ncbi request reprint Pathogenesis of renal injury in obstructive uropathy
    Robert L Chevalier
    Department of Pediatrics, University of Virginia, Charlottesville, Virginia 22908, USA
    Curr Opin Pediatr 18:153-60. 2006
  8. doi request reprint Formation of atubular glomeruli in the developing kidney following chronic urinary tract obstruction
    Robert L Chevalier
    Department of Pediatrics, University of Virginia Health System, Box 800386, Charlottesville, VA 22908, USA
    Pediatr Nephrol 26:1381-5. 2011
  9. ncbi request reprint Biomarkers of congenital obstructive nephropathy: past, present and future
    Robert L Chevalier
    Department of Pediatrics, University of Virginia, Charlottesville, VA 22908, USA
    J Urol 172:852-7. 2004
  10. ncbi request reprint Specific molecular targeting of renal injury in obstructive nephropathy
    R L Chevalier
    Department of Pediatrics, University of Virginia, Charlottesville, Virginia 22908, USA
    Kidney Int 70:1200-1. 2006

Research Grants

Collaborators

Detail Information

Publications49

  1. pmc Responses of proximal tubular cells to injury in congenital renal disease: fight or flight
    Robert L Chevalier
    Division of Pediatric Nephrology, Department of Pediatrics, University of Virginia, PO Box 800386, Charlottesville, VA, 22908, USA
    Pediatr Nephrol 29:537-41. 2014
    ..Therapies should be directed at reducing proximal tubular mitochondrial oxidative injury to enhance repair and regeneration...
  2. pmc Chronic unilateral ureteral obstruction in the neonatal mouse delays maturation of both kidneys and leads to late formation of atubular glomeruli
    Michael S Forbes
    Dept of Pediatrics, Univ of Virginia, Box 800386, Charlottesville, VA 22908
    Am J Physiol Renal Physiol 305:F1736-46. 2013
    ..Antioxidant therapies directed at proximal tubular mitochondria during early renal maturation may slow progression of congenital obstructive nephropathy. ..
  3. pmc Transforming growth factor-β1 receptor inhibition preserves glomerulotubular integrity during ureteral obstruction in adults but worsens injury in neonatal mice
    Carolina I Galarreta
    Dept of Pediatrics, Univ of Virginia, Box 800386, Charlottesville, VA 22908, USA
    Am J Physiol Renal Physiol 304:F481-90. 2013
    ..These results indicate that while caution is necessary in treating congenital uropathies, ALK5 inhibitors may prevent nephron loss due to adult kidney disease...
  4. ncbi request reprint Mechanisms of fetal and neonatal renal impairment by pharmacologic inhibition of angiotensin
    Robert L Chevalier
    Department of Pediatrics, University of Virginia, Box 800386, Charlottesville, VA 22908, USA
    Curr Med Chem 19:4572-80. 2012
    ....
  5. pmc Fight-or-flight: murine unilateral ureteral obstruction causes extensive proximal tubular degeneration, collecting duct dilatation, and minimal fibrosis
    Michael S Forbes
    Division of Pediatric Nephrology, Department of Pediatrics, University of Virginia School of Medicine, Charlottesville, Virginia 22908, USA
    Am J Physiol Renal Physiol 303:F120-9. 2012
    ..Therapies to prevent or retard progression of renal disease should include targeting proximal tubule injury as well as interstitial fibrosis...
  6. ncbi request reprint Obstructive nephropathy: towards biomarker discovery and gene therapy
    Robert L Chevalier
    Department of Pediatrics at the University of Virginia, Charlottesville, VA 22908, USA
    Nat Clin Pract Nephrol 2:157-68. 2006
    ....
  7. ncbi request reprint Pathogenesis of renal injury in obstructive uropathy
    Robert L Chevalier
    Department of Pediatrics, University of Virginia, Charlottesville, Virginia 22908, USA
    Curr Opin Pediatr 18:153-60. 2006
    ..The major focus is on renal cellular and molecular events, with emphasis on those affecting the developing kidney...
  8. doi request reprint Formation of atubular glomeruli in the developing kidney following chronic urinary tract obstruction
    Robert L Chevalier
    Department of Pediatrics, University of Virginia Health System, Box 800386, Charlottesville, VA 22908, USA
    Pediatr Nephrol 26:1381-5. 2011
    ....
  9. ncbi request reprint Biomarkers of congenital obstructive nephropathy: past, present and future
    Robert L Chevalier
    Department of Pediatrics, University of Virginia, Charlottesville, VA 22908, USA
    J Urol 172:852-7. 2004
    ..This review addresses the need to define biomarkers that serve as surrogate end points for measuring the severity of obstruction, the evolution of renal maldevelopment and injury, and the response to medical or surgical intervention...
  10. ncbi request reprint Specific molecular targeting of renal injury in obstructive nephropathy
    R L Chevalier
    Department of Pediatrics, University of Virginia, Charlottesville, Virginia 22908, USA
    Kidney Int 70:1200-1. 2006
    ..Specific kinase inhibitors are promising therapeutic agents to slow or attenuate progressive renal fibrosis...
  11. ncbi request reprint Chronic partial ureteral obstruction and the developing kidney
    Robert L Chevalier
    Department of Pediatrics, University of Virginia, Box 800386, Charlottesville, VA 22908, USA
    Pediatr Radiol 38:S35-40. 2008
    ..Combined use of MRI and new urinary biomarkers should improve our understanding of human congenital obstructive nephropathy and should lead to new approaches to evaluation and management of this challenging group of patients...
  12. doi request reprint Generation and evolution of atubular glomeruli in the progression of renal disorders
    Robert L Chevalier
    Department of Pediatrics, University of Virginia, Box 800386, Charlottesville, VA 22908, USA
    J Am Soc Nephrol 19:197-206. 2008
    ..A better understanding of the vulnerability of the glomerulotubular junction and its protection from injury should lead to better strategies for preserving renal function in many nephropathies...
  13. doi request reprint Ureteral obstruction as a model of renal interstitial fibrosis and obstructive nephropathy
    Robert L Chevalier
    Department of Pediatrics, University of Virginia, Charlottesville, 22908, USA
    Kidney Int 75:1145-52. 2009
    ..The UUO model is likely to reveal useful biomarkers of progression of renal disease, as well as new therapies, which are desperately needed to allow intervention before the establishment of irreversible renal injury...
  14. doi request reprint When is one kidney not enough?
    Robert L Chevalier
    Department of Pediatrics, Box 800386, University of Virginia Health System, Charlottesville, Virginia 22908, USA
    Kidney Int 76:475-7. 2009
    ..This outcome differs markedly from that of renal-transplant donors, who have no increased risk for renal failure. Because morbidity from CAKUTs may not develop until adulthood, these patients should be closely followed throughout life...
  15. doi request reprint Mechanisms of renal injury and progression of renal disease in congenital obstructive nephropathy
    Robert L Chevalier
    Department of Pediatrics, University of Virginia, Charlottesville, VA, USA
    Pediatr Nephrol 25:687-97. 2010
    ..Advances will depend on new biomarkers to evaluate the severity of obstruction, to determine therapy, and to follow the evolution of lesions...
  16. ncbi request reprint Perinatal obstructive nephropathy
    Robert L Chevalier
    Department of Pediatrics, Children s Medical Center, University of Virginia, Charlottesville, VA 22908, USA
    Semin Perinatol 28:124-31. 2004
    ....
  17. ncbi request reprint Unilateral ureteral obstruction in neonatal rats leads to renal insufficiency in adulthood
    R L Chevalier
    Department of Pediatrics, University of Virginia, Charlottesville, Virginia 22908, USA
    Kidney Int 58:1987-95. 2000
    ....
  18. ncbi request reprint Renal tubulointerstitial injury from ureteral obstruction in the neonatal rat is attenuated by IGF-1
    R L Chevalier
    Department of Pediatrics, University of Virginia, Charlottesville, USA
    Kidney Int 57:882-90. 2000
    ..As there are a number of similarities between acute renal failure and obstructive nephropathy, we examined the effects of IGF-1 on the renal cellular response to unilateral ureteral obstruction (UUO) in the neonatal rat...
  19. ncbi request reprint Recovery from release of ureteral obstruction in the rat: relationship to nephrogenesis
    Robert L Chevalier
    Department of Pediatrics, University of Virginia, Charlottesville, Virginia 22908, USA
    Kidney Int 61:2033-43. 2002
    ....
  20. ncbi request reprint The moth and the aspen tree: sodium in early postnatal development
    R L Chevalier
    Department of Pediatrics, University of Virginia, Charlottesville, Virginia 22908, USA
    Kidney Int 59:1617-25. 2001
    ..This will be particularly important as the survival of ever smaller preterm infants improves steadily...
  21. ncbi request reprint Chronic ureteral obstruction in the rat suppresses renal tubular Bcl-2 and stimulates apoptosis
    R L Chevalier
    Department of Pediatrics, University of Virginia School of Medicine, Charlottesville, VA, USA
    Exp Nephrol 8:115-22. 2000
    ..Dysregulation of apoptosis may be a response to renal injury similar to that underlying the development of cystic kidney disease or renal dysplasia...
  22. ncbi request reprint Obstructive nephropathy: lessons from cystic kidney disease
    R L Chevalier
    Department of Pediatrics, University of Virginia, School of Medicine, Charlottesville, VA, USA
    Nephron 84:6-12. 2000
    ..It is therefore likely that elucidation of the effects of mechanical stretch on renal tubular epithelial cells will contribute to our understanding of both conditions...
  23. ncbi request reprint Recovery following relief of unilateral ureteral obstruction in the neonatal rat
    R L Chevalier
    Department of Pediatrics, University of Virginia, Charlottesville 22908, USA
    Kidney Int 55:793-807. 1999
    ..This study was designed to distinguish the reversible and irreversible cellular consequences of temporary unilateral ureteral obstruction (UUO) on the developing kidney...
  24. ncbi request reprint Molecular and cellular pathophysiology of obstructive nephropathy
    R L Chevalier
    Department of Pediatrics, Box 386, University of Virginia, Health Sciences Center, Charlottesville, VA 22908, USA
    Pediatr Nephrol 13:612-9. 1999
    ..Future efforts to prevent the consequences of congenital urinary tract obstruction must account for the dual effects of obstruction: interference with normal renal development and progression of irreversible tubulointerstitial injury...
  25. ncbi request reprint Congenital urinary tract obstruction: Proceedings of the State-Of-The-Art Strategic Planning Workshop-National Institutes of Health, Bethesda, Maryland, USA, 11-12 March 2002
    Robert L Chevalier
    Department of Pediatrics, University of Virginia, Health Sciences Center, P O Box 800386, Charlottesville, VA 22908, USA
    Pediatr Nephrol 18:576-606. 2003
  26. ncbi request reprint Renal cellular response to ureteral obstruction: role of maturation and angiotensin II
    R L Chevalier
    Department of Pediatrics, University of Virginia, School of Medicine, Charlottesville, Virginia 22908, USA
    Am J Physiol 277:F41-7. 1999
    ..We speculate that the unique early responses of the developing kidney to urinary tract obstruction are mediated by a highly activated renin-angiotensin system and preponderance of AT(2) receptors...
  27. ncbi request reprint Selectins mediate macrophage infiltration in obstructive nephropathy in newborn mice
    Bärbel Lange-Sperandio
    Department of Pediatrics, University of Virginia, Charlottesville, Virginia 22908 0386, USA
    Kidney Int 61:516-24. 2002
    ..Selectins, a family of three adhesion molecules, are involved in leukocyte recruitment to sites of inflammation and immune activity. We investigated the role of selectins in obstructive nephropathy in newborn mice...
  28. ncbi request reprint Variable chronic partial ureteral obstruction in the neonatal rat: a new model of ureteropelvic junction obstruction
    Barbara A Thornhill
    Department of Pediatrics, UVa Children s Hospital, University of Virginia, Charlottesville, Virginia, USA
    Kidney Int 67:42-52. 2005
    ..To elucidate the mechanisms underlying the renal consequences of congenital UPJ obstruction, we have developed a new model of variable partial unilateral ureteral obstruction (UUO) in the neonatal rat...
  29. ncbi request reprint Ureteral obstruction in neonatal mice elicits segment-specific tubular cell responses leading to nephron loss
    Francois Cachat
    Department of Pediatrics, University of Virginia, Charlottesville, Virginia 22908, USA
    Kidney Int 63:564-75. 2003
    ....
  30. ncbi request reprint Epidermal growth factor potentiates renal cell death in hydronephrotic neonatal mice, but cell survival in rats
    Susan C Kiley
    Department of Pediatrics, University of Virginia, Charlottesville, Virginia 22908, USA
    Kidney Int 68:504-14. 2005
    ..Epidermal growth factor (EGF) markedly attenuates tubular apoptosis induced by unilateral ureteral obstruction (UUO) in the neonatal rat, and reduces apoptosis induced by mechanical stretch of cultured rat tubular cells...
  31. ncbi request reprint Angiotensin-converting enzyme inhibition aggravates renal interstitial injury resulting from partial unilateral ureteral obstruction in the neonatal rat
    Christina O Chen
    Department of Pediatrics, University of Virginia, Box 800386, Charlottesville, VA 22908, USA
    Am J Physiol Renal Physiol 292:F946-55. 2007
    ..Thus, in contrast to its salutary effects at later ages, ACE inhibition can worsen injury to the partially obstructed kidney during renal maturation even after the completion of nephrogenesis...
  32. ncbi request reprint Species differences in renal Src activity direct EGF receptor regulation in life or death response to EGF
    Susan C Kiley
    Department of Pediatrics, University of Virginia, Box 801334, 409 Lane Road, Charlottesville, VA 22908, USA
    Am J Physiol Renal Physiol 293:F895-903. 2007
    ..The unexpected finding that a therapeutic agent (EGF) in rats is detrimental in mice underscores the importance of determining which animal best represents the response of human kidneys to a given agent...
  33. ncbi request reprint Urinary biomarkers: the future looks promising
    Susan C Kiley
    Department of Pediatrics, University of Virginia, Charlottesville, Virginia 22908, USA
    Kidney Int 76:133-4. 2009
    ..These changes appear relatively early in disease progression and remain responsive to antiviral therapy. Will these trends be borne out in a multicenter study?..
  34. ncbi request reprint Growth factor-mediated phosphorylation of proapoptotic BAD reduces tubule cell death in vitro and in vivo
    Susan C Kiley
    Department of Pediatrics, University of Virginia School of Medicine, Charlottesville, Virginia 22908, USA
    Kidney Int 63:33-42. 2003
    ..Because the mechanism underlying these salutary effects is largely unknown, we investigated signaling pathways potentially activated by growth factors to determine their roles in therapeutic action...
  35. pmc Inducible nitric oxide synthase modulates hydronephrosis following partial or complete unilateral ureteral obstruction in the neonatal mouse
    Kee Hwan Yoo
    Department of Pediatrics, University of Virginia, Charlottesville, Virginia 22908, USA
    Am J Physiol Renal Physiol 298:F62-71. 2010
    ..In contrast, in mice with complete UUO, iNOS attenuates apoptosis and enhances renal parenchymal thickness. Alterations in the severity of ureteral obstruction may therefore influence the effect of iNOS on long-term renal injury...
  36. ncbi request reprint Angiotensin AT1-receptor inhibition exacerbates renal injury resulting from partial unilateral ureteral obstruction in the neonatal rat
    Christopher M Coleman
    Dept of Pediatrics, University of Virginia, Box 800386, Charlottesville VA 22908, USA
    Am J Physiol Renal Physiol 293:F262-8. 2007
    ..These results suggest that angiotensin II receptor blockers should be avoided in the developing hydronephrotic kidney...
  37. ncbi request reprint Renal vascular endothelial growth factor in neonatal obstructive nephropathy. II. Exogenous VEGF
    Laura E Burt
    Dept of Pediatrics, Univ of Virginia, Box 800386, Charlottesville, VA 22908, USA
    Am J Physiol Renal Physiol 292:F168-74. 2007
    ..We conclude that VEGF does not have salutary effects on the renal lesions caused by chronic UUO in the neonatal rat and may actually worsen obstructive nephropathy by aggravating the interstitial lesions...
  38. ncbi request reprint Renal vascular endothelial growth factor in neonatal obstructive nephropathy. I. Endogenous VEGF
    Laura E Burt
    Dept of Pediatrics, Univ of Virginia, Box 800386, Charlottesville, VA 22908, USA
    Am J Physiol Renal Physiol 292:F158-67. 2007
    ..Following UUO in the adult, the VEGF receptor is upregulated. Endogenous VEGF may serve an adaptive role in responding to tubular injury caused by UUO and may modulate adaptation by the contralateral kidney...
  39. ncbi request reprint Altered expression of immune modulator and structural genes in neonatal unilateral ureteral obstruction
    Douglas M Silverstein
    Division of Nephrology, Department of Pediatrics, Gene Therapy Program, Louisiana State University Health Sciences Center, New Orleans, Louisiana 70124, USA
    Kidney Int 64:25-35. 2003
    ..The renal consequences of chronic unilateral ureteral obstruction (UUO) in the neonatal rat are similar to those of clinical congenital obstructive nephropathy...
  40. pmc Lack of endothelial nitric-oxide synthase leads to progressive focal renal injury
    Michael S Forbes
    Department of Pediatrics, University of Virginia, Box 800386, Charlottesville, VA 22908, USA
    Am J Pathol 170:87-99. 2007
    ..Endogenous renal eNOS production therefore seems critical for the maintenance of nephron maturation and integrity...
  41. ncbi request reprint Macrophages induce apoptosis in proximal tubule cells
    Bärbel Lange-Sperandio
    Department of Pediatrics, University of Virginia, VA 22908, Charlottesville, USA
    Pediatr Nephrol 18:335-41. 2003
    ..We conclude that inflammatory macrophages mediate proximal tubule cell death, directing apoptosis mainly via release of unidentified soluble factors...
  42. ncbi request reprint Expression of connexins in the normal and obstructed developing kidney
    Douglas M Silverstein
    Division of Nephrology, Department of Pediatrics, Louisiana State University Health Sciences Center, New Orleans, Louisiana, USA
    Pediatr Nephrol 18:216-24. 2003
    ..In contrast, there was no change in connexin renal mRNA levels in adult UUO. We conclude that multiple connexins are expressed in the rat kidney and several are aberrantly expressed in neonatal UUO...
  43. pmc Proximal tubular injury and rapid formation of atubular glomeruli in mice with unilateral ureteral obstruction: a new look at an old model
    Michael S Forbes
    Dept of Pediatrics, University of Virginia, Box 800386, Charlottesville, VA 22908, USA
    Am J Physiol Renal Physiol 301:F110-7. 2011
    ....
  44. ncbi request reprint A2A adenosine receptor agonist and PDE4 inhibition delays inflammation but fails to reduce injury in experimental obstructive nephropathy
    Bärbel Lange-Sperandio
    Department of Pediatrics, Ruprecht Karls University, Heidelberg, Germany
    Nephron Exp Nephrol 100:e113-23. 2005
    ..We therefore studied the effects of A2A adenosine receptor agonist (ATL146e), and PDE4 inhibitor (rolipram) in mice subjected to UUO...
  45. ncbi request reprint Compensatory renal growth due to neonatal ureteral obstruction: implications for clinical studies
    Kee Hwan Yoo
    Department of Pediatrics, Korea University Guro Hospital, Seoul
    Pediatr Nephrol 21:368-75. 2006
    ..Factoring kidney length (or volume) by intervertebral length (or body surface area) should improve the precision of tracking renal growth...
  46. ncbi request reprint Obstructive nephropathy and the developing kidney: too little or too much angiotensin?
    Robert L Chevalier
    Kidney Int 65:1517-8. 2004
  47. doi request reprint The kidney in congenital ureteropelvic junction obstruction: a spectrum from normal to nephrectomy
    Seymour Rosen
    Department of Pathology, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215, USA
    J Urol 179:1257-63. 2008
    ..Our recent studies of renal histology in congenital ureteropelvic obstruction cases prompted us to review the literature in this regard, focusing on issues of development, normal variation, clinicopathological correlations and pathogenesis...
  48. ncbi request reprint Proceedings of the Eighth International Workshop on Developmental Nephrology: genes, morphogenesis, and function. The sessions
    Lisa M Satlin
    Division of Pediatric Nephrology, Box 1664, Mount Sinai School of Medicine, One Gustave L Levy Place, New York, NY 10029 6575, USA
    Pediatr Nephrol 18:174-95. 2003
  49. ncbi request reprint Promise for gene therapy in obstructive nephropathy
    Robert L Chevalier
    Kidney Int 66:1709-10. 2004

Research Grants6

  1. Intercellular Signaling in Obstructive Nephropathy
    ROBERT CHEVALIER; Fiscal Year: 2003
    ..This will lead to improved outcomes in adulthood. ..
  2. Intercellular Signaling in Obstructive Nephropathy
    ROBERT CHEVALIER; Fiscal Year: 2004
    ..This will lead to improved outcomes in adulthood. ..
  3. Intercellular Signaling in Obstructive Nephropathy
    ROBERT CHEVALIER; Fiscal Year: 2005
    ..This will lead to improved outcomes in adulthood. ..
  4. TGF-beta superfamily in neonatal obstructive nephropathy and recovery
    ROBERT CHEVALIER; Fiscal Year: 2009
    ..A new animal (mouse) model is proposed to study the major cellular mechanisms for injury to the newborn kidney, as well as to evaluate new therapies to enhance recovery. ..
  5. TGF-beta superfamily in neonatal obstructive nephropathy and recovery
    Robert L Chevalier; Fiscal Year: 2010
    ..A new animal (mouse) model is proposed to study the major cellular mechanisms for injury to the newborn kidney, as well as to evaluate new therapies to enhance recovery. ..
  6. Intercellular Signaling in Obstructive Nephropathy
    ROBERT CHEVALIER; Fiscal Year: 2002
    ..This will lead to improved outcomes in adulthood. ..