Vivian Cheung

Summary

Affiliation: University of Pennsylvania
Country: USA

Publications

  1. pmc Monozygotic twins reveal germline contribution to allelic expression differences
    Vivian G Cheung
    Howard Hughes Medical Institute, University of Pennsylvania, Philadelphia, PA 19104, USA
    Am J Hum Genet 82:1357-60. 2008
  2. pmc Genetic analysis of radiation-induced changes in human gene expression
    Denis A Smirnov
    Howard Hughes Medical Institute, USA
    Nature 459:587-91. 2009
  3. pmc Polymorphic cis- and trans-regulation of human gene expression
    Vivian G Cheung
    Howard Hughes Medical Institute, Philadelphia, Pennsylvania, USA
    PLoS Biol 8:. 2010
  4. pmc Genetic heterogeneity and trans regulators of gene expression
    Laurel A Bastone
    Division of Biostatistics, Department of Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, 423 Guardian Drive, Philadelphia, Pennsylvania 19104, USA
    BMC Proc 1:S80. 2007
  5. pmc Genetics of human gene expression: mapping DNA variants that influence gene expression
    Vivian G Cheung
    Howard Hughes Medical Institute, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Nat Rev Genet 10:595-604. 2009
  6. pmc Data for Genetic Analysis Workshop (GAW) 15, Problem 1: genetics of gene expression variation in humans
    Vivian G Cheung
    The Children s Hospital of Philadelphia, 3615 Civic Center Boulevard, Philadelphia, Pennsylvania 19104, USA
    BMC Proc 1:S2. 2007
  7. pmc Polymorphic variation in human meiotic recombination
    Vivian G Cheung
    Department of Pediatrics, University of Pennsylvania, Philadelphia, PA 19104, USA
    Am J Hum Genet 80:526-30. 2007
  8. pmc Heterozygous carriers of Nijmegen Breakage Syndrome have a distinct gene expression phenotype
    Vivian G Cheung
    Department of Pediatrics and Department of Genetics, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Genome Res 16:973-9. 2006
  9. pmc Mapping determinants of human gene expression by regional and genome-wide association
    Vivian G Cheung
    Department of Pediatrics, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Nature 437:1365-9. 2005
  10. ncbi request reprint Linkage-disequilibrium mapping without genotyping
    V G Cheung
    Department of Pediatrics, The Children s Hospital of Philadelphia, Pennsylvania 19104, USA
    Nat Genet 18:225-30. 1998

Collaborators

Detail Information

Publications30

  1. pmc Monozygotic twins reveal germline contribution to allelic expression differences
    Vivian G Cheung
    Howard Hughes Medical Institute, University of Pennsylvania, Philadelphia, PA 19104, USA
    Am J Hum Genet 82:1357-60. 2008
    ..We also show that even subtle departures from equal allelic expression are often genetically determined...
  2. pmc Genetic analysis of radiation-induced changes in human gene expression
    Denis A Smirnov
    Howard Hughes Medical Institute, USA
    Nature 459:587-91. 2009
    ..These results have implications for our basic and clinical understanding of how human cells respond to radiation...
  3. pmc Polymorphic cis- and trans-regulation of human gene expression
    Vivian G Cheung
    Howard Hughes Medical Institute, Philadelphia, Pennsylvania, USA
    PLoS Biol 8:. 2010
    ..The identification of these regulators enabled the characterization of polymorphic regulation of human gene expression at a resolution that was unattainable in the past...
  4. pmc Genetic heterogeneity and trans regulators of gene expression
    Laurel A Bastone
    Division of Biostatistics, Department of Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, 423 Guardian Drive, Philadelphia, Pennsylvania 19104, USA
    BMC Proc 1:S80. 2007
    ..We test for linkage, accounting for heterogeneity, and classify individual families as "linked" and "unlinked" on the basis of their contribution to the overall evidence of linkage...
  5. pmc Genetics of human gene expression: mapping DNA variants that influence gene expression
    Vivian G Cheung
    Howard Hughes Medical Institute, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Nat Rev Genet 10:595-604. 2009
    ..These findings are important for basic understanding of gene regulation and of diseases that result from disruption of normal gene regulation...
  6. pmc Data for Genetic Analysis Workshop (GAW) 15, Problem 1: genetics of gene expression variation in humans
    Vivian G Cheung
    The Children s Hospital of Philadelphia, 3615 Civic Center Boulevard, Philadelphia, Pennsylvania 19104, USA
    BMC Proc 1:S2. 2007
    ..For this purpose, 2882 single-nucleotide polymorphism genotypes were also provided for each family member...
  7. pmc Polymorphic variation in human meiotic recombination
    Vivian G Cheung
    Department of Pediatrics, University of Pennsylvania, Philadelphia, PA 19104, USA
    Am J Hum Genet 80:526-30. 2007
    ..These findings have important implications for understanding genetic disorders that result from improper chromosome segregation...
  8. pmc Heterozygous carriers of Nijmegen Breakage Syndrome have a distinct gene expression phenotype
    Vivian G Cheung
    Department of Pediatrics and Department of Genetics, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Genome Res 16:973-9. 2006
    ..This has implications for the role that heterozygosity for recessive diseases plays in the overall genetic architecture of complex human traits and diseases...
  9. pmc Mapping determinants of human gene expression by regional and genome-wide association
    Vivian G Cheung
    Department of Pediatrics, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Nature 437:1365-9. 2005
    ..Our findings suggest that association studies with dense SNP maps will identify susceptibility loci or other determinants for some complex traits or diseases...
  10. ncbi request reprint Linkage-disequilibrium mapping without genotyping
    V G Cheung
    Department of Pediatrics, The Children s Hospital of Philadelphia, Pennsylvania 19104, USA
    Nat Genet 18:225-30. 1998
    ..1. We show that the combination of GMS and hybridization of IBD products to a chromosome-11 microarray correctly maps the HI gene to a 2-Mb region, thereby demonstrating linkage-disequilibrium mapping without genotyping...
  11. ncbi request reprint Making and reading microarrays
    V G Cheung
    Department of Pediatrics, University of Pennsylvania, Philadelphia 19104, USA
    Nat Genet 21:15-9. 1999
    ..The fact that we are now making and using microarrays to answer biological questions demonstrates that the technology can be implemented in a university environment...
  12. pmc A resource of mapped human bacterial artificial chromosome clones
    V G Cheung
    Department of Pediatrics, The Children s Hospital of Philadelphia, University of Pennsylvania, Philadelphia, Pennsylvania 19104 USA
    Genome Res 9:989-93. 1999
    ..In addition to the clones themselves, we describe a database, GenMapDB (http://genomics.med.upenn.edu/genmapdb), that contains information about each clone in our collection...
  13. ncbi request reprint Bridging genetics and genomics in neurology
    Vivian G Cheung
    Department of Pediatrics, University of Pennsylvania, School of Medicine, 3516 Civic Center Blvd, RM 516, Abramson, Philadelphia, PA 19104, USA
    Neurol Clin 20:867-77, viii. 2002
    ..In this article, we review the emerging technologies and discuss results from studies that have used genomic approaches...
  14. ncbi request reprint The genetics of variation in gene expression
    Vivian G Cheung
    Department of Pediatrics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Nat Genet 32:522-5. 2002
    ..Further advances in the genetic analysis of variation in gene expression will contribute to our understanding of transcriptional regulation and will provide models for studying other quantitative and complex traits...
  15. ncbi request reprint Natural variation in human gene expression assessed in lymphoblastoid cells
    Vivian G Cheung
    Department of Pediatrics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Nat Genet 33:422-5. 2003
    ..These observations suggest that there is a genetic contribution to polymorphic variation in the level of gene expression...
  16. pmc Genetic analysis of genome-wide variation in human gene expression
    Michael Morley
    Department of Pediatrics, University of Pennsylvania, The Children s Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA
    Nature 430:743-7. 2004
    ..The combination of microarray techniques for phenotyping and linkage analysis for quantitative traits allows the genetic mapping of determinants that contribute to variation in human gene expression...
  17. pmc Coexpression network based on natural variation in human gene expression reveals gene interactions and functions
    Renuka R Nayak
    Medical Scientist Training Program, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Genome Res 19:1953-62. 2009
    ..Therefore, our analysis of gene coexpression networks offers information on the role of human genes in normal and disease processes...
  18. pmc Genetic analysis of variation in human meiotic recombination
    Reshmi Chowdhury
    Department of Pediatrics, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America
    PLoS Genet 5:e1000648. 2009
    ..Characterization of genetic variants that influence natural variation in meiotic recombination will lead to a better understanding of normal meiotic events as well as of non-disjunction, the primary cause of pregnancy loss...
  19. pmc Common genetic variants account for differences in gene expression among ethnic groups
    Richard S Spielman
    Department of Genetics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Nat Genet 39:226-31. 2007
    ..As some of these are probably influenced by the level of gene expression, our results suggest that allele frequency differences at regulatory polymorphisms also account for some population differences in prevalence of complex diseases...
  20. pmc Gene expression phenotype in heterozygous carriers of ataxia telangiectasia
    Jason A Watts
    Department of Pediatrics, University of Pennsylvania, Philadelphia 19104, USA
    Am J Hum Genet 71:791-800. 2002
    ..More generally, we demonstrate that genomic technologies offer the opportunity to identify and study unaffected carriers, who are hundreds of times more common than affected patients...
  21. pmc Transcriptional response of lymphoblastoid cells to ionizing radiation
    Kuang Yu Jen
    Departments of Pediatrics and Genetics, University of Pennsylvania, The Children s Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA
    Genome Res 13:2092-100. 2003
    ..These findings will allow a better understanding of complex processes such as radiation-induced carcinogenesis and the development of biomarkers for radiation exposure...
  22. pmc In silico method for inferring genotypes in pedigrees
    Joshua T Burdick
    Department of Pediatrics, University of Pennsylvania, 3516 Civic Center Blvd, Philadelphia, Pennsylvania 19104, USA
    Nat Genet 38:1002-4. 2006
    ..The method can be used to obtain high-density genotypes in different family structures, including nuclear families commonly used in complex disease gene mapping studies...
  23. pmc ATM gene mutations result in both recessive and dominant expression phenotypes of genes and microRNAs
    Denis A Smirnov
    Departments of Pediatrics and Genetics, Howard Hughes Medical Institute, University of Pennsylvania, Philadelphia, PA 19104, USA
    Am J Hum Genet 83:243-53. 2008
    ..By integrating molecular and computational analyses of gene and microRNA expression, we show the complex consequences of a human gene mutation...
  24. ncbi request reprint Direct IBD mapping: identical-by-descent mapping without genotyping
    Denis Smirnov
    Department of Genetics, University of Pennsylvania, Philadelphia, PA 19104, USA
    Genomics 83:335-45. 2004
    ..genomic microarrays for identifying the genomic locations of the GMS-selected IBD fragments. Here, we describe steps that optimized the procedure and resources that will facilitate the development of direct IBD mapping...
  25. ncbi request reprint Method for manufacturing whole-genome microarrays by rolling circle amplification
    Denis A Smirnov
    Department of Genetics, University of Pennsylvania, Philadelphia 19104 4318, USA
    Genes Chromosomes Cancer 40:72-7. 2004
    ..These genomic microarrays detected all major chromosomal aberrations in cancer cells lines and in cell lines with aneuploidy. In this article, we discuss the advantages of using RCA for the manufacturing of large genomic microarrays...
  26. pmc Genetic variation in radiation-induced expression phenotypes
    Candace R Correa
    School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    Am J Hum Genet 75:885-90. 2004
    ..Our approach, which uses expression phenotypes in cell lines, allows us to expose cells from family members to radiation. Similar study design can be applied to dissect the genetic basis of other complex human traits...
  27. ncbi request reprint Identification of novel p53 target genes in ionizing radiation response
    Kuang Yu Jen
    Department of Pediatrics, University of Pennsylvania, The Children s Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA
    Cancer Res 65:7666-73. 2005
    ..Identification and characterization of ionizing radiation-responsive p53 target genes extend our knowledge of the diverse role that p53 plays in the DNA damage response...
  28. pmc Gene expression and genetic variation in response to endoplasmic reticulum stress in human cells
    Beth A Dombroski
    Department of Genetics, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Am J Hum Genet 86:719-29. 2010
    ..These results have implications for basic understanding of ER function and its role in disease susceptibility...
  29. pmc Identification of polymorphic antioxidant response elements in the human genome
    Xuting Wang
    Environmental Genomics Section, Laboratory of Molecular Genetics, National Institute of Environmental Health Sciences, National Institute of Health, Research Triangle Park, NC 27709, USA
    Hum Mol Genet 16:1188-200. 2007
    ....
  30. ncbi request reprint Polymorphic landscape of the human genome
    Vivian G Cheung
    Eur J Hum Genet 13:133-5. 2005

Research Grants24

  1. IDENTITY BY DESCENT MAPPING USING MICROARRAYS
    Vivian Cheung; Fiscal Year: 1999
    ..We expect that it can be applied as a tool for genome wide linkage disequilibrium analysis and affected relative pair mapping. ..
  2. IBD MAPPING & PATTERN OF HUMAN MEIOTIC RECOMBINATION
    Vivian Cheung; Fiscal Year: 2007
    ..It will also give insights into the pattern of human meiotic recombination, a key process that contributes to genetic diversity and to risk of non-disjunction. ..
  3. Gene Expression Phenotype in Autosomal Recessive Disease
    Vivian Cheung; Fiscal Year: 2007
    ..The approach can also be broadened to study the contribution of heterozygosity of recessive diseases to the complex genetic architecture of human diseases and traits. ..
  4. Genetics of individual variation in response to radiation exposure
    Vivian Cheung; Fiscal Year: 2007
    ..5 Gy and 3 Gy IR exposures. The results will provide information on the molecular and genetic basis of individual response to radiation exposure and form a foundation for a personalized approach to risk prediction. ..
  5. Genetics of individual variation in response to radiation exposure
    Vivian Cheung; Fiscal Year: 2009
    ..5 Gy and 3 Gy IR exposures. The results will provide information on the molecular and genetic basis of individual response to radiation exposure and form a foundation for a personalized approach to risk prediction. ..
  6. Genome-wide analysis of genetic variation and expression.
    Vivian Cheung; Fiscal Year: 2009
    ..Therefore, the molecular and analytical approaches developed here can be generalized and applied to the study of other quantitative traits in humans, including complex genetic diseases. ..
  7. Genetics of individual variation in response to radiation exposure
    Vivian G Cheung; Fiscal Year: 2010
    ..5 Gy and 3 Gy IR exposures. The results will provide information on the molecular and genetic basis of individual response to radiation exposure and form a foundation for a personalized approach to risk prediction. ..
  8. Genome-wide analysis of genetic variation and expression.
    Vivian Cheung; Fiscal Year: 2009
    ..Therefore, the molecular and analytical approaches developed here can be generalized and applied to the study of other quantitative traits in humans, including complex genetic diseases. ..
  9. Gene Expression Phenotype in Autosomal Recessive Disease
    Vivian Cheung; Fiscal Year: 2006
    ..The approach can also be broadened to study the contribution of heterozygosity of recessive diseases to the complex genetic architecture of human diseases and traits. ..
  10. IBD MAPPING & PATTERN OF HUMAN MEIOTIC RECOMBINATION
    Vivian Cheung; Fiscal Year: 2006
    ..It will also give insights into the pattern of human meiotic recombination, a key process that contributes to genetic diversity and to risk of non-disjunction. ..
  11. IDENTITY BY DESCENT MAPPING USING MICROARRAYS
    Vivian Cheung; Fiscal Year: 2000
    ..We expect that it can be applied as a tool for genome wide linkage disequilibrium analysis and affected relative pair mapping. ..
  12. CHARACTERIZATION OF MAPPED HUMAN BAC CLONES
    Vivian Cheung; Fiscal Year: 2001
    ..In the process of characterizing the clones, we will also get information that gives us insight into the concordance rate between RH map, genome sequence map and cytogenetic map. ..
  13. IDENTITY BY DESCENT MAPPING USING MICROARRAYS
    Vivian Cheung; Fiscal Year: 2001
    ..We expect that it can be applied as a tool for genome wide linkage disequilibrium analysis and affected relative pair mapping. ..
  14. IDENTITY BY DESCENT MAPPING USING MICROARRAYS
    Vivian Cheung; Fiscal Year: 2002
    ..We expect that it can be applied as a tool for genome wide linkage disequilibrium analysis and affected relative pair mapping. ..
  15. CHARACTERIZATION OF MAPPED HUMAN BAC CLONES
    Vivian Cheung; Fiscal Year: 2002
    ..In the process of characterizing the clones, we will also get information that gives us insight into the concordance rate between RH map, genome sequence map and cytogenetic map. ..
  16. IDENTITY BY DESCENT MAPPING USING MICROARRAYS
    Vivian Cheung; Fiscal Year: 2003
    ..We expect that it can be applied as a tool for genome wide linkage disequilibrium analysis and affected relative pair mapping. ..
  17. IBD MAPPING & PATTERN OF HUMAN MEIOTIC RECOMBINATION
    Vivian Cheung; Fiscal Year: 2004
    ..It will also give insights into the pattern of human meiotic recombination, a key process that contributes to genetic diversity and to risk of non-disjunction. ..
  18. Gene Expression Phenotype in Autosomal Recessive Disease
    Vivian Cheung; Fiscal Year: 2004
    ..The approach can also be broadened to study the contribution of heterozygosity of recessive diseases to the complex genetic architecture of human diseases and traits. ..
  19. IBD MAPPING & PATTERN OF HUMAN MEIOTIC RECOMBINATION
    Vivian Cheung; Fiscal Year: 2005
    ..It will also give insights into the pattern of human meiotic recombination, a key process that contributes to genetic diversity and to risk of non-disjunction. ..
  20. Gene Expression Phenotype in Autosomal Recessive Disease
    Vivian Cheung; Fiscal Year: 2005
    ..The approach can also be broadened to study the contribution of heterozygosity of recessive diseases to the complex genetic architecture of human diseases and traits. ..
  21. Genome-wide analysis of genetic variation and expression.
    Vivian G Cheung; Fiscal Year: 2010
    ..Therefore, the molecular and analytical approaches developed here can be generalized and applied to the study of other quantitative traits in humans, including complex genetic diseases. ..