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Genomes and Genes | M C CheungSummaryAffiliation: University of Washington Country: USA Publications
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Publications
Phospholipid transfer protein activity is associated with inflammatory markers in patients with cardiovascular diseaseMarian C Cheung
Division of Metabolism, Endocrinology, and Nutrition, University of Washington, Seattle, WA 98109 4517, USA
Biochim Biophys Acta 1762:131-7. 2006..These findings show for the first time that plasma PLTP activity is associated positively with CRP in CVD, a state of chronic inflammation...
Lipoprotein lipase and hepatic lipase: their relationship with HDL subspecies Lp(A-I) and Lp(A-I,A-II)Marian C Cheung
Department of Medicine, University of Washington, Seattle, WA 98103, USA
J Lipid Res 44:1552-8. 2003..Furthermore, select correlations of LPL and/or HL with the apoA-I, cholesterol, and triglyceride of Lp(A-I) but not Lp(A-I,A-II) imply that the apoA-I and lipid of Lp(A-I) and Lp(A-I,A-II) are not fully equilibrated...- Antioxidant supplements block the response of HDL to simvastatin-niacin therapy in patients with coronary artery disease and low HDLM C Cheung
Division of Metabolism, Endocrinology, and Nutrition, Department of Medicine, School of Medicine, University of Washington, Seattle 98103, USA
Arterioscler Thromb Vasc Biol 21:1320-6. 2001..This unexpected adverse interaction between antioxidants and lipid therapy may have important implications for the management of CAD... - Plasma phospholipid transfer protein activity in patients with low HDL and cardiovascular disease treated with simvastatin and niacinM C Cheung
Division of Metabolism, Endocrinology, and Nutrition, University of Washington, School of Medicine, Seattle 98103, USA
Biochim Biophys Acta 1537:117-24. 2001..It also confirms our previous observation that an interrelationship exists between PLTP and apo-specific HDL particle subclasses in CVD patients with low HDL, and that this relationship is altered by drug intervention... - Active plasma phospholipid transfer protein is associated with apoA-I- but not apoE-containing lipoproteinsMarian C Cheung
Division of Metabolism, Endocrinology, and Nutrition, Department of Medicine, School of Medicine, University of Washington, Seattle, WA, USA
J Lipid Res 47:1315-21. 2006.... - Simvastatin and niacin, antioxidant vitamins, or the combination for the prevention of coronary diseaseB G Brown
Department of Medicine, University of Washington School of Medicine, Seattle 98195, USA
N Engl J Med 345:1583-92. 2001..CONCLUSIONS: Simvastatin plus niacin provides marked clinical and angiographically measurable benefits in patients with coronary disease and low HDL levels. The use of antioxidant vitamins in this setting must be questioned... - Introduction of the human PLTP transgene suppresses the atherogenic diet-induced increase in plasma phospholipid transfer activity in C57BL/6 miceA Y Tu
Department of Medicine, University of Washington, Seattle 98103, USA
Int J Clin Lab Res 29:14-21. 1999..001). These findings suggest that PLTP activity can modulate the effects of an atherogenic diet on high-density lipoproteins... - Association of plasma phospholipid transfer protein activity with IDL and buoyant LDL: impact of gender and adiposityM C Cheung
Division of Metabolism, Endocrinology, and Nutrition, Northwest Lipid Research Laboratories, Seattle, WA 98103, USA
Biochim Biophys Acta 1587:53-9. 2002..43, P<0.01). These data provide evidence for a role of PLTP in LpB metabolism, particularly IDL and buoyant LDL. They also suggest that gender and obesity-related factors can modulate the impact of PLTP on LpB... - Functional expression of human and mouse plasma phospholipid transfer protein: effect of recombinant and plasma PLTP on HDL subspeciesJ J Albers
Department of Medicine, Northwest Lipid Research Laboratories, University of Washington, Seattle 98103, USA
Biochim Biophys Acta 1258:27-34. 1995..These observations suggest that PLTP may play a key role in extracellular phospholipid transport and modulation of HDL particles... - GPI-specific phospholipase D associates with an apoA-I- and apoA-IV-containing complexM A Deeg
Department of Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA
J Lipid Res 42:442-51. 2001..Deeg, M. A., E. L. Bierman, and M. C. Cheung. GPI-specific phospholipase D associates with an apoA-I- and apoA-IV-containing complex. J. Lipid Res. 2001. 42: 442--451... - Structure, expression, and chromosomal localization of the type I human vasoactive intestinal peptide receptor geneS P Sreedharan
Department of Medicine, University of California Medical Center, San Francisco 94143 0711, USA
Proc Natl Acad Sci U S A 92:2939-43. 1995..Fluorescence in situ hybridization localized the HVR1 gene to the short arm of human chromosome 3 (3p22), in a region associated with small-cell lung cancer... - Gender differences in lipoprotein metabolism and dietary response: basis in hormonal differences and implications for cardiovascular diseaseRobert H Knopp
Northwest Lipid Research Clinic, University of Washington, Box 359720, Seattle, WA 98104, USA
Curr Atheroscler Rep 7:472-9. 2005..Dietary fat restriction in women appears to have a less beneficial lipoprotein effect than in men. Dietary fat restriction for heart disease prevention may be less ideal in women than in men... - Reduced CSF PLTP activity in Alzheimer's disease and other neurologic diseases; PLTP induces ApoE secretion in primary human astrocytes in vitroSimona Vuletic
Department of Medicine, Northwest Lipid Metabolism and Diabetes Research Laboratories, University of Washington, Seattle, Washington 98109 4517, USA
J Neurosci Res 80:406-13. 2005..The findings of reduced PLTP activity in AD CSF, and the observation that PLTP can influence apoE secretion in astrocytes suggest a potential link between alterations in the brain lipid metabolism and AD pathogenesis... - Low-density lipoprotein inhibits secretion of phospholipid transfer protein in human trophoblastic BeWo cellsAn Yue Tu
Department of Medicine, Northwest Lipid Research Laboratories, Northwest Lipid Research Clinic, Division of Metabolism, Endocrinology, and Nutrition, University of Washington, 2121 N 35th Street, Seattle, WA 98103, USA
Exp Biol Med (Maywood) 229:1046-52. 2004..These results support the conclusion that LDL-mediated suppression of PLTP secretion in BeWo cells is through a LDL receptor-independent MAPK signaling pathway... - Emerging roles for phospholipid transfer protein in lipid and lipoprotein metabolismJohn J Albers
Department of Medicine and Northwest Lipid Research Laboratories, University of Washington, 2121 North 35th Street, Seattle, WA 98103, USA
Curr Opin Lipidol 15:255-60. 2004..This review highlights the recent key advances in our understanding of the role of phospholipid transfer protein in lipid and lipoprotein metabolism... - Antioxidant vitamins and lipid therapy: end of a long romance?B Greg Brown
Department of Medicine, Division of Cardiology, University of Washington School of Medicine, Seattle, USA
Arterioscler Thromb Vasc Biol 22:1535-46. 2002..We conclude that they should rarely, if ever, be recommended for cardiovascular protection... - Quantitative trait locus mapping of genes that regulate HDL cholesterol in SM/J and NZB/B1NJ inbred miceWendy A Pitman
The Jackson Laboratory, 600 Main Street, Bar Harbor, Maine 04609, USA
Physiol Genomics 9:93-102. 2002..With these QTL, we have identified chromosomal regions that affect lipoprotein profiles in these strains... - Shotgun proteomics implicates protease inhibition and complement activation in the antiinflammatory properties of HDLTomas Vaisar
Department of Medicine, University of Washington School of Medicine, Seattle, Washington 98195, USA
J Clin Invest 117:746-56. 2007....