Herman Cheung

Summary

Affiliation: University of Miami
Country: USA

Publications

  1. ncbi request reprint Calcium crystal effects on the cells of the joint: implications for pathogenesis of disease
    H S Cheung
    Geriatric Research Education and Clinical Center, Miami Veterans Affairs Medical Center and Division of Rheumatology and Immunology, University of Miami School of Medicine, FL, USA
    Curr Opin Rheumatol 12:223-7. 2000
  2. ncbi request reprint Role of calcium-containing crystals in osteoarthritis
    Herman S Cheung
    Miami VA Medical Center and Dept of Biomedical Engineering, University of Miami, 1201 N W 16th St Miami, FL 33125, USA
    Front Biosci 10:1336-40. 2005
  3. ncbi request reprint Biologic effects of calcium-containing crystals
    Herman S Cheung
    Miami Veterans Administration Medical Center and Department of Biomedical Engineering, University of Miami, Miami, Florida, USA
    Curr Opin Rheumatol 17:336-40. 2005
  4. ncbi request reprint Phosphocitrate as a potential therapeutic strategy for crystal deposition disease
    H S Cheung
    Research Service, Miami VA Medical Center, FL 33125, USA
    Curr Rheumatol Rep 3:24-8. 2001
  5. ncbi request reprint Phosphocitrate blocks calcification-induced articular joint degeneration in a guinea pig model
    Herman S Cheung
    VA Medical Center, Miami, Florida 33125, USA
    Arthritis Rheum 54:2452-61. 2006
  6. ncbi request reprint Induction of early growth response gene Egr2 by basic calcium phosphate crystals through a calcium-dependent protein kinase C-independent p44/42 mitogen-activated protein kinase pathway
    Xiao R Zeng
    Department of Medicine, University of Miami School of Medicine, Miami, FL 33101, USA
    Cells Tissues Organs 174:63-72. 2003
  7. ncbi request reprint Inhibitors of articular calcium crystal formation
    John D Sallis
    Miami VA Medical Center Research Service and Geriatrics Research, Education and Clinical Center, Miami, Florida, USA
    Curr Opin Rheumatol 15:321-5. 2003
  8. ncbi request reprint Basic calcium phosphate crystal-induced Egr-1 expression stimulates mitogenesis in human fibroblasts
    Xiao R Zeng
    Department of Biomedical Engineering, University of Miami, Coral Gablek, FL 33146, USA
    Biochem Biophys Res Commun 330:658-64. 2005
  9. ncbi request reprint Inhibition of calcium phosphate-DNA coprecipitates induced cell death by phosphocitrates
    Yubo Sun
    Rheumatology and Immunology, University of Miami School of Medicine, Miami, Florida 33101, USA
    Front Biosci 10:803-8. 2005
  10. ncbi request reprint Telomerase-transduced osteoarthritic fibroblast-like synoviocyte cell line
    Yubo Sun
    Division of Rheumatology and Immunology, Department of Medicine, University of Miami School of Medicine, Miami, FL 33101, USA
    Biochem Biophys Res Commun 323:1287-92. 2004

Research Grants

Collaborators

Detail Information

Publications28

  1. ncbi request reprint Calcium crystal effects on the cells of the joint: implications for pathogenesis of disease
    H S Cheung
    Geriatric Research Education and Clinical Center, Miami Veterans Affairs Medical Center and Division of Rheumatology and Immunology, University of Miami School of Medicine, FL, USA
    Curr Opin Rheumatol 12:223-7. 2000
    ..Phosphocitrate, a specific inhibitor of biologic effect of calcium crystals, reverses the degenerative effects of crystals...
  2. ncbi request reprint Role of calcium-containing crystals in osteoarthritis
    Herman S Cheung
    Miami VA Medical Center and Dept of Biomedical Engineering, University of Miami, 1201 N W 16th St Miami, FL 33125, USA
    Front Biosci 10:1336-40. 2005
    ....
  3. ncbi request reprint Biologic effects of calcium-containing crystals
    Herman S Cheung
    Miami Veterans Administration Medical Center and Department of Biomedical Engineering, University of Miami, Miami, Florida, USA
    Curr Opin Rheumatol 17:336-40. 2005
    ..The purpose of this review is to highlight the recent findings of the biologic effect of these crystals...
  4. ncbi request reprint Phosphocitrate as a potential therapeutic strategy for crystal deposition disease
    H S Cheung
    Research Service, Miami VA Medical Center, FL 33125, USA
    Curr Rheumatol Rep 3:24-8. 2001
    ..Approaches that may ameliorate the degenerative process may ensue from new information about how crystals form and how they exert their biologic effects...
  5. ncbi request reprint Phosphocitrate blocks calcification-induced articular joint degeneration in a guinea pig model
    Herman S Cheung
    VA Medical Center, Miami, Florida 33125, USA
    Arthritis Rheum 54:2452-61. 2006
    ..The present study was undertaken to examine the role of calcification in OA disease progression and to evaluate a formulation of phosphocitrate (PC) as a potential therapeutic agent...
  6. ncbi request reprint Induction of early growth response gene Egr2 by basic calcium phosphate crystals through a calcium-dependent protein kinase C-independent p44/42 mitogen-activated protein kinase pathway
    Xiao R Zeng
    Department of Medicine, University of Miami School of Medicine, Miami, FL 33101, USA
    Cells Tissues Organs 174:63-72. 2003
    ..USA) we further showed that induced Egr2 could stimulate the activities of several transcription factors that are associated with cell proliferation, such as c-fos, SRF and c-myc...
  7. ncbi request reprint Inhibitors of articular calcium crystal formation
    John D Sallis
    Miami VA Medical Center Research Service and Geriatrics Research, Education and Clinical Center, Miami, Florida, USA
    Curr Opin Rheumatol 15:321-5. 2003
    ..The recently described phosphocitrate in a mixed calcium and sodium salt, yet to be tested in a guinea pig osteoarthritis model, appears to be an even more powerful inhibitor...
  8. ncbi request reprint Basic calcium phosphate crystal-induced Egr-1 expression stimulates mitogenesis in human fibroblasts
    Xiao R Zeng
    Department of Biomedical Engineering, University of Miami, Coral Gablek, FL 33146, USA
    Biochem Biophys Res Commun 330:658-64. 2005
    ..The results demonstrate that Egr-1 may play a key role in mediating BCP crystal-induced synovial fibroblast mitogenesis...
  9. ncbi request reprint Inhibition of calcium phosphate-DNA coprecipitates induced cell death by phosphocitrates
    Yubo Sun
    Rheumatology and Immunology, University of Miami School of Medicine, Miami, Florida 33101, USA
    Front Biosci 10:803-8. 2005
    ....
  10. ncbi request reprint Telomerase-transduced osteoarthritic fibroblast-like synoviocyte cell line
    Yubo Sun
    Division of Rheumatology and Immunology, Department of Medicine, University of Miami School of Medicine, Miami, FL 33101, USA
    Biochem Biophys Res Commun 323:1287-92. 2004
    ....
  11. ncbi request reprint P53 down-regulates matrix metalloproteinase-1 by targeting the communications between AP-1 and the basal transcription complex
    Yubo Sun
    Department of Medicine, University of Miami School of Medicine, Miami, Florida 33101, USA
    J Cell Biochem 92:258-69. 2004
    ..Finally, by using p53 truncated mutant constructs, we demonstrate that both the N-terminal activation domain and the C-terminal oligomerization domains of p53 were required for the down-regulation of MMP1 transcription...
  12. ncbi request reprint Basic calcium phosphate crystals stimulate the endocytotic activity of cells--inhibition by anti-calcification agents
    Yubo Sun
    Division of Rheumatology and Immunology, University of Miami School of Medicine, Miami, FL 33101, USA
    Biochem Biophys Res Commun 312:1053-9. 2003
    ....
  13. ncbi request reprint Use of a permanent magnetic field to inhibit the development of canine osteoarthritis
    Richard A Rogachefsky
    Department of Orthopedics, University of Miami School of Medicine, Miami, Florida, USA
    Bioelectromagnetics 25:260-70. 2004
    ..Further studies are needed to delineate more precisely the effect of the magnetic field in reducing the severity of OA...
  14. ncbi request reprint Basic calcium phosphate crystals induce matrix metalloproteinase-1 through the Ras/mitogen-activated protein kinase/c-Fos/AP-1/metalloproteinase 1 pathway. Involvement of transcription factor binding sites AP-1 and PEA-3
    Yubo Sun
    Department of Medicine, University of Miami School of Medicine, Miami, Florida 33101, USA
    J Biol Chem 277:1544-52. 2002
    ....
  15. ncbi request reprint Temporal expression patterns and corresponding protein inductions of early responsive genes in rabbit bone marrow-derived mesenchymal stem cells under cyclic compressive loading
    C Y Charles Huang
    Research Service, Miami VA Medical Center, 1201 NW 16th Street, Miami, Florida 33125, USA
    Stem Cells 23:1113-21. 2005
    ..These findings suggest that the TGF-beta signal transduction and activities of AP-1 and Sox9 are involved in the early stage of BM-MSC chondrogenesis promoted by dynamic compressive loading...
  16. ncbi request reprint Molecular mechanism of the induction of metalloproteinases 1 and 3 in human fibroblasts by basic calcium phosphate crystals. Role of calcium-dependent protein kinase C alpha
    Paul M Reuben
    Department of Medicine, University of Miami School of Medicine, Miami, Florida 33101, USA
    J Biol Chem 277:15190-8. 2002
    ....
  17. ncbi request reprint Basic calcium phosphate crystals activate p44/42 MAPK signal transduction pathway via protein kinase Cmicro in human fibroblasts
    Paul M Reuben
    Research Service and Geriatric Research, Education and Clinical Center, Veterans Administration Medical Center, Miami, Florida 33125, USA
    J Biol Chem 279:35719-25. 2004
    ....
  18. doi request reprint Plasticity of stem cells derived from adult periodontal ligament
    C Y Charles Huang
    Department of Biomedical Engineering, University of Miami, Coral Gables, FL, USA
    Regen Med 4:809-21. 2009
    ..Stem cells derived from the neural crest may still reside in neural crest derivatives including the periodontal ligament (PDL). However, the pluripotency of PDL-derived stem cells has not been investigated...
  19. doi request reprint Cyclic compression maintains viability and induces chondrogenesis of human mesenchymal stem cells in fibrin gel scaffolds
    Daniel Pelaez
    Research Service and Geriatrics Research, Education, and Clinical Center, Veterans Affairs Medical Center, Miami, Florida 33125, USA
    Stem Cells Dev 18:93-102. 2009
    ..This study demonstrates the suitability of fibrin gel for supporting the cyclic compression-induced chondrogenesis of mesenchymal stem cells...
  20. ncbi request reprint Effects of cyclic compressive loading on chondrogenesis of rabbit bone-marrow derived mesenchymal stem cells
    C Y Charles Huang
    Research Service and Geriatrics Research, Education, and Clinical Center, Veterans Affairs Medical Center, Miami, Florida 33125, USA
    Stem Cells 22:313-23. 2004
    ..These findings suggest that cyclic compressive loading can promote the chondrogenesis of rabbit BM-MSCs by inducing the synthesis of TGF-beta1, which can stimulate the BM-MSCs to differentiate into chondrocytes...
  21. ncbi request reprint Regulation of matrix metalloproteinase (MMP) gene expression by protein kinases
    Paul M Reuben
    Research Service and Geriatric Research, Education and Clinical Center, Veterans Administration Medical Center, Miami, Florida 33125, USA
    Front Biosci 11:1199-215. 2006
    ..This review focuses on the regulation of the MMPs by the protein kinases at the level of gene expression and their signaling pathways...
  22. pmc Oxidative phosphorylation dysfunction modulates expression of extracellular matrix--remodeling genes and invasion
    Corina Van Waveren
    Department of Cell Biology and Anatomy, University of Miami School of Medicine, Miami, FL 33136, USA
    Carcinogenesis 27:409-18. 2006
    ....
  23. ncbi request reprint Chondrogenesis of human bone marrow-derived mesenchymal stem cells in agarose culture
    C Y Charles Huang
    Research Service and Geriatrics Research, Education, and Clinical Center, Miami Veterans Affairs Medical Center, 1201 NW 16th Street, Miami, FL 33125, USA
    Anat Rec A Discov Mol Cell Evol Biol 278:428-36. 2004
    ..This study establishes a basic model for future studies on chondrogenesis of hBM-MSCs using the agarose cultures...
  24. ncbi request reprint p53, proto-oncogene and rheumatoid arthritis
    Yubo Sun
    Department of Medicine, University of Miami School of Medicine, FL, USA
    Semin Arthritis Rheum 31:299-310. 2002
    ..To review the literature published in the past 6 years concerning the role of p53 tumor-suppressor protein in rheumatoid arthritis (RA)...
  25. pmc Molecular dynamics simulation studies of the effect of phosphocitrate on crystal-induced membranolysis
    Pranav Dalal
    Department of Chemistry and Biochemistry Center for Computational Sciences, Duquesne University, Pittsburgh, PA 15282, USA
    Biophys J 89:2251-7. 2005
    ..The protective role of PC, which may also play an important and potentially therapeutic function against crystal-induced membranolysis is also discussed...
  26. pmc Basic calcium phosphate crystals activate c-fos expression through a Ras/ERK dependent signaling mechanism
    Michael L Major
    Department of Biochemistry, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    Biochem Biophys Res Commun 355:654-60. 2007
    ....
  27. pmc Balance between polyoma enhancing activator 3 and activator protein 1 regulates Helicobacter pylori-stimulated matrix metalloproteinase 1 expression
    Jeng Yih Wu
    Department of Medicine, Michael E DeBakey Veterans Affairs Medical Center and Baylor College of Medicine, Houston, Texas 77030, USA
    Cancer Res 66:5111-20. 2006
    ..Thus, cag PAI and OipA provide a possible link between bacterial virulence factors and important host factors related to disease pathogenesis...
  28. ncbi request reprint Altered swelling behavior of femoral cartilage following joint immobilization in a canine model
    Daria A Narmoneva
    Department of Biomedical Engineering, Duke University, Durham, NC 22708 0281, USA
    J Orthop Res 20:83-91. 2002
    ..Our results suggest that 4 weeks of joint immobilization had a significant effect on cartilage mechanical function that may be linked to collagen changes in the cartilage extracellular matrix...

Research Grants8

  1. BIOLOGICAL EFFECTS OF BASIC CALCIUM PHOSPHATE CRYSTALS
    Herman Cheung; Fiscal Year: 2004
    ..Hypothesis 5: There are specific cis elements in the promotor of Tissue Inhibitor of Metalloproteinase (TIMP)-2 that regulate crystal inhibition of TIMP- 2 expression. ..