Alfred Cheung

..The goal was to determine whether ultrasound exposure of an ePTFE graft can generate temperatures sufficient to prevent cell growth on the graft without damaging nearby soft tissues and blood...

..Cardiovascular diseases are the most common causes of death among chronic hemodialysis patients, yet the risk factors for these events have not been well established...

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..Because of the chronic nature of the stimuli, strategies that allow for the ready replenishment of the drug depot are preferable and are currently under development...

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..The subgroup results that demonstrate that patients with different durations of dialysis are affected differently by high-flux dialysis are interesting and require further study for confirmation...

..05 to 1.19; P = 0.001), after adjustment for residual kidney urea clearance and number of prestudy years on dialysis. This association is supportive of the potential value of beta(2)M as a marker to guide chronic hemodialysis therapy...

..In addition, awareness of these variations might facilitate the interpretation of laboratory results and the clinical treatment of these patients...

..More research efforts should be directed toward these dyslipidemic states and the multitude of other putative cardiovascular risk factors in dialysis patients...

..CONCLUSION: These data suggest that as in the general population, in CKD patients, obesity, a traditional risk factor for atherosclerosis, is associated with inflammation, a novel risk factor for atherosclerosis...

..The pharmacokinetic parameters and resulting computational simulations are helpful in exploring perivascular drug delivery strategies...

..Metabolic syndrome and inflammation are interlinked in patients with moderate chronic kidney disease (CKD)...

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..The effect of lipid-lowering therapy on clinical outcomes in peritoneal dialysis patients has not been carefully addressed...

..Successful prevention of graft stenosis would provide a superior alternative to the native fistula as hemodialysis vascular access...

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..The nature of the proliferating cells in these lesions is not well understood. A better understanding of the cells contributing to NH is important to the development of preventive strategies...

..In addition, MRI is useful for the monitoring of the location of the drug depot...

..This is the first population-based analysis of the familial component of ESRD and non-ESRD CKD...

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..We identified sources of variability in three histological methods for assessing hyperplasia in a porcine AV graft model...

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..The present study evaluated the association of serum TC and triglycerides with clinical outcomes in chronic peritoneal dialysis (PD) patients...

..24, 95% CI 1.01-1.49). In conclusion, this study suggests that, in addition to many putative risk factors, the increased risk of CV death in ESRD patients may have a familial contribution...

..We demonstrate that once the underlying stochastic process is characterized, quantification of the introduced variability is quite straightforward and provides an important step in the validation and verification process...

..Protein-energy wasting and inflammation are common and associated with an increased risk of mortality in hemodialysis (HD) patients. We examined the extent to which they mediate the associations of each other with death in this population...

..These results may provide an explanation for the differential susceptibility to proliferative vascular diseases of arteries and veins...

..To determine whether coadministration of misoprostol with the nonsteroidal antiinflammatory drug diclofenac lessens the increase in blood pressure and improves the alterations in renal hemodynamics induced by diclofenac...

..The authors report the use of magnetic resonance (MR) imaging (MRI) without contrast agent to monitor tissue hyperplasia formation as well as luminal area in a porcine model of AV graft stenosis...

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..Specifically, the effect of interdialytic fluid accumulation (or intradialytic fluid removal) on BP is controversial...

..Quiescent cells were cultured in the presence of growth factors, fetal bovine serum and incremental concentrations of the test drug. Cell proliferation was assessed by the MTT reduction assay...

..The goal of the study was to characterize the relationship between the duration of dialysis vs allograft and patient survival...

..Furthermore, these data do not support earlier initiation of dialysis. Therefore, for patients without clinical indications for initiation of dialysis, the appropriate GFR level for initiation of dialysis is unknown...

..The fundamental assumption of the MDRD formula is invalid in patients with advanced renal failure, and the use of this formula in these patients might introduce biases...

..It is not clear if this is the consequence of uraemia or related to the dialysis type. The goal of this project was to identify the relationship between BP and mortality in patients on chronic peritoneal dialysis (PD)...

..The effect of the pre-emptive re-transplant, and of inter-transplant waiting time generally, on graft and recipient survival is not well established...

..More intensive hemodialysis (HD) regimens (short daily and long thrice-weekly HD) provide potential opportunities for improved patient outcome. An adequate dialysis dose for these regimens cannot be established from the existing literature...

..We examined whether renal failure independently increases the risk of myocardial infarction and death...

..Although metabolic syndrome is associated with inflammation in the general population, it is unknown whether similar associations exist in patients with chronic kidney disease...

..The effect of pretransplantation renal replacement therapy (RRT) modality on allograft and recipient survival outcome is not well understood...

..Because cardiovascular disease is the leading cause of death and hypoalbuminemia predicts mortality, hypoalbuminemia may be associated with atherosclerosis...

..Most of these previous studies however have not been performed with rigorous controls...

..Novel designs of dialyzers include the optimization of fluid flow path geometry and increasing the membrane pore selectivity for solutes by using nanotechnology...

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..solutes be dependent on gender? 4) Should the dialysis dose for middle molecules be used in clinical practice? 5) What should be the dialysis dose when using hemodialysis treatment strategies that are more frequent than thrice weekly?..

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..Disruption of personal time, however, is an important consideration. Success of DHD program would depend on arrangements for transportation to dialysis unit...

..In vivo release of dipyridamole from microspheres/ReGel exhibited a comparable release pattern to that seen in vitro. This injectable platform is a promising technique for sustained perivascular delivery of antiproliferative drugs...

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..In contrast, p38 MAPK is an important pro-survival regulator in VSMCs and p42/44 MAPK appears to play a minor role in responding to anti-proliferative drugs...

..These data highlight inherent pharmacodynamic differences between VSMC and ASMC in receptor and cell signaling functions and suggest that imatinib therapy may be useful for the prevention of venous stenosis in vascular grafts...

..The decrease in plasma levels of FF > 100 kDa following HD suggests that adsorption to the dialysis membrane contributes to their removal...

..Although the values of these markers often evolve over time, no study has examined the accumulated effects of these abnormalities on important clinical end points...

..CONCLUSIONS: Patients undergoing hemodialysis thrice weekly appear to have no major benefit from a higher dialysis dose than that recommended by current U.S. guidelines or from the use of a high-flux membrane...

..We conclude that the mass transfer characteristics of high flux dialyzers can be altered by the shape of the hollow fibers...

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..It is, however, unclear if the risk and risk factors of SCD in these patients is modulated by the coexistence of mild chronic renal insufficiency...

..If nephrologists are to take their appropriate place as leaders of the care delivery team, nephrology fellowships must be restructured with appropriate emphasis placed on the comprehensive care of ESRD and CKD patients...

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..CONCLUSION: Inasmuch as myointimal hyperplasia occurs at both arterial and venous anastomoses, future strategies using radiation to prevent hemodialysis vascular access stenosis should take these differences into consideration...

..Furthermore, the results will provide the basis for local delivery of drugs and proteins of interest to a variety of tissues. ..

..It is highly likely that, within this 5-year proposal, the results of this project can be applied to pilot clinical studies. ..

..It is highly likely that, within this 5-year proposal, the results of this project can be applied to pilot clinical studies. ..

..It is highly likely that, within this 5-year proposal, the results of this project can be applied to pilot clinical studies. ..