Marie Francoise Chesselet

Summary

Affiliation: University of California
Country: USA

Publications

  1. doi request reprint Modelling of Parkinson's disease in mice
    Marie Francoise Chesselet
    Department of Neurology, David Geffen School of Medicine, University of California Los Angeles, USA
    Lancet Neurol 10:1108-18. 2011
  2. pmc A progressive mouse model of Parkinson's disease: the Thy1-aSyn ("Line 61") mice
    Marie Francoise Chesselet
    Department of Neurology, David Geffen School of Medicine, UCLA, Los Angeles, California 90095, USA
    Neurotherapeutics 9:297-314. 2012
  3. pmc In vivo alpha-synuclein overexpression in rodents: a useful model of Parkinson's disease?
    Marie Francoise Chesselet
    Department of Neurology and Neurobiology, David Geffen School of Medicine, UCLA, Los Angeles, CA 90095, USA
    Exp Neurol 209:22-7. 2008
  4. ncbi request reprint Development of striatal fast-spiking GABAergic interneurons
    Marie Francoise Chesselet
    Departments of Neurology and Neurobiology, The David Geffen School of Medicine at UCLA, Los Angeles, CA 90095 1769, USA
    Prog Brain Res 160:261-72. 2007
  5. ncbi request reprint Mouse models of Huntington's disease
    Liliana B Menalled
    Dept of Neurology, Reed Neurological Research Center, UCLA School of Medicine, 710 Westwood Plaza, Los Angeles, CA 90095, USA
    Trends Pharmacol Sci 23:32-9. 2002
  6. ncbi request reprint Early motor dysfunction and striosomal distribution of huntingtin microaggregates in Huntington's disease knock-in mice
    Liliana B Menalled
    Department of Neurology, University of California Los Angeles School of Medicine, Los Angeles, California 90095, USA
    J Neurosci 22:8266-76. 2002
  7. ncbi request reprint Functional and molecular development of striatal fast-spiking GABAergic interneurons and their cortical inputs
    Joshua L Plotkin
    Department of Neurology, The David Geffen School of Medicine at UCLA, Los Angeles, CA 90095 1769, USA
    Eur J Neurosci 22:1097-108. 2005
  8. ncbi request reprint Neuronal differentiation of stem cells isolated from adult muscle
    Marina Romero-Ramos
    Department of Neurology, UCLA School of Medicine, Los Angeles, California 90095, USA
    J Neurosci Res 69:894-907. 2002
  9. ncbi request reprint Transplantation of multipotent cells extracted from adult skeletal muscles into the subventricular zone of adult rats
    Laurence Mignon
    Department of Neurology, David Geffen School of Medicine at University of California Los Angeles, Los Angeles, California 90095, USA
    J Comp Neurol 491:96-108. 2005
  10. ncbi request reprint Behavioral phenotypes and pharmacology in genetic mouse models of Parkinsonism
    Sheila M Fleming
    Department of Neurology, The David Geffen School of Medicine at UCLA, Los Angeles, California 90095 1769, USA
    Behav Pharmacol 17:383-91. 2006

Research Grants

  1. TRAINING PROGRAM IN NEURAL REPAIR
    Marie Francoise Chesselet; Fiscal Year: 2007
  2. PLASTICITY OF GAD GENE EXPRESSION IN THE BASAL GANGLIA
    Marie Francoise Chesselet; Fiscal Year: 2007
  3. Center for Gene-Environment Studies in Parkinson Disease
    Marie Francoise Chesselet; Fiscal Year: 2006
  4. MECHANISMS OF AXONAL SPROUTING IN THE ADULT STRIATUM
    Marie Francoise Chesselet; Fiscal Year: 2003

Collaborators

Detail Information

Publications52

  1. doi request reprint Modelling of Parkinson's disease in mice
    Marie Francoise Chesselet
    Department of Neurology, David Geffen School of Medicine, University of California Los Angeles, USA
    Lancet Neurol 10:1108-18. 2011
    ..The hope is that this information could be used to advance the search for neuroprotective therapies for Parkinson's disease...
  2. pmc A progressive mouse model of Parkinson's disease: the Thy1-aSyn ("Line 61") mice
    Marie Francoise Chesselet
    Department of Neurology, David Geffen School of Medicine, UCLA, Los Angeles, California 90095, USA
    Neurotherapeutics 9:297-314. 2012
    ....
  3. pmc In vivo alpha-synuclein overexpression in rodents: a useful model of Parkinson's disease?
    Marie Francoise Chesselet
    Department of Neurology and Neurobiology, David Geffen School of Medicine, UCLA, Los Angeles, CA 90095, USA
    Exp Neurol 209:22-7. 2008
    ..The predictive value of all models of the disease, however, remains speculative in the absence of effective neuroprotective treatments for PD in humans...
  4. ncbi request reprint Development of striatal fast-spiking GABAergic interneurons
    Marie Francoise Chesselet
    Departments of Neurology and Neurobiology, The David Geffen School of Medicine at UCLA, Los Angeles, CA 90095 1769, USA
    Prog Brain Res 160:261-72. 2007
    ..These findings point to the need for future research to better understand the functional maturation of this critical population of striatal GABAergic neurons, and the consequences of abnormal maturation of these cells...
  5. ncbi request reprint Mouse models of Huntington's disease
    Liliana B Menalled
    Dept of Neurology, Reed Neurological Research Center, UCLA School of Medicine, 710 Westwood Plaza, Los Angeles, CA 90095, USA
    Trends Pharmacol Sci 23:32-9. 2002
    ..In this article, insights gained from mouse models towards the understanding of HD and the design of new therapeutic strategies are discussed...
  6. ncbi request reprint Early motor dysfunction and striosomal distribution of huntingtin microaggregates in Huntington's disease knock-in mice
    Liliana B Menalled
    Department of Neurology, University of California Los Angeles School of Medicine, Los Angeles, California 90095, USA
    J Neurosci 22:8266-76. 2002
    ....
  7. ncbi request reprint Functional and molecular development of striatal fast-spiking GABAergic interneurons and their cortical inputs
    Joshua L Plotkin
    Department of Neurology, The David Geffen School of Medicine at UCLA, Los Angeles, CA 90095 1769, USA
    Eur J Neurosci 22:1097-108. 2005
    ....
  8. ncbi request reprint Neuronal differentiation of stem cells isolated from adult muscle
    Marina Romero-Ramos
    Department of Neurology, UCLA School of Medicine, Los Angeles, California 90095, USA
    J Neurosci Res 69:894-907. 2002
    ..Therefore, PPSCs isolated from adult muscle could provide a novel source for autologous cell replacement in neurodegenerative and demyelinating diseases...
  9. ncbi request reprint Transplantation of multipotent cells extracted from adult skeletal muscles into the subventricular zone of adult rats
    Laurence Mignon
    Department of Neurology, David Geffen School of Medicine at University of California Los Angeles, Los Angeles, California 90095, USA
    J Comp Neurol 491:96-108. 2005
    ....
  10. ncbi request reprint Behavioral phenotypes and pharmacology in genetic mouse models of Parkinsonism
    Sheila M Fleming
    Department of Neurology, The David Geffen School of Medicine at UCLA, Los Angeles, California 90095 1769, USA
    Behav Pharmacol 17:383-91. 2006
    ..This review discusses the sensitivity of these tests in different genetic mice in addition to their behavioral response to dopamine agonists...
  11. ncbi request reprint Time course of early motor and neuropathological anomalies in a knock-in mouse model of Huntington's disease with 140 CAG repeats
    Liliana B Menalled
    Department of Neurology, University of California at Los Angeles, Los Angeles, California 90095, USA
    J Comp Neurol 465:11-26. 2003
    ..Because of their early behavioral anomalies and regionally specific pathology, these mice provide a powerful tool with which to evaluate the effectiveness of new therapies and to study the mechanisms involved in the neuropathology of HD...
  12. ncbi request reprint Early behavioral deficits in R6/2 mice suitable for use in preclinical drug testing
    M A Hickey
    Department of Neurology, UCLA David Geffen School of Medicine, RNRC B114, 710 Westwood Plaza, Los Angeles, CA 90095, USA
    Neurobiol Dis 20:1-11. 2005
    ..Furthermore, the data extend the range of behavioral deficits observed in 1-month-old R6/2 mice, an age when synaptic dysfunction can already be detected in the striatum...
  13. ncbi request reprint Behavioral and immunohistochemical effects of chronic intravenous and subcutaneous infusions of varying doses of rotenone
    Sheila M Fleming
    Department of Neurology, The David Geffen School of Medicine at UCLA, Los Angeles, CA 90095 1769, USA
    Exp Neurol 187:418-29. 2004
    ....
  14. ncbi request reprint Early and progressive sensorimotor anomalies in mice overexpressing wild-type human alpha-synuclein
    Sheila M Fleming
    Department of Neurology, The Mental Retardation Research Center, The David Geffen School of Medicine at University of California Los Angeles, Los Angeles, California 90095 1769, USA
    J Neurosci 24:9434-40. 2004
    ..These behavioral deficits provide a useful way to assess novel drug therapy in genetic models of synucleinopathies...
  15. ncbi request reprint Variable effects of chronic subcutaneous administration of rotenone on striatal histology
    Chunni Zhu
    Departments of Neurology and Neurobiology, The David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California 90095 1769, USA
    J Comp Neurol 478:418-26. 2004
    ....
  16. pmc Analysis of striatal transcriptome in mice overexpressing human wild-type alpha-synuclein supports synaptic dysfunction and suggests mechanisms of neuroprotection for striatal neurons
    Yofre Cabeza-Arvelaiz
    Department of Pathology and Environmental Health Sciences, The Geffen School of Medicine and School of Public Health, University of California, Los Angeles, 650 Charles E, Young Dr S, CHS 71 295, Los Angeles, CA 90095, USA
    Mol Neurodegener 6:83. 2011
    ..Therefore it is of interest to understand how overexpression of SNCA affects neuronal function in regions not directly targeted for neurodegeneration in PD...
  17. doi request reprint Elevated tonic extracellular dopamine concentration and altered dopamine modulation of synaptic activity precede dopamine loss in the striatum of mice overexpressing human α-synuclein
    Hoa A Lam
    Hatos Center, University of California Los Angeles, Los Angeles, California, USA
    J Neurosci Res 89:1091-102. 2011
    ..Together, these data further validate this transgenic mouse line as a slowly progressing model of Parkinson's disease and provide evidence for early dopamine synaptic dysfunction prior to loss of striatal dopamine...
  18. pmc A pilot trial of the microtubule-interacting peptide (NAP) in mice overexpressing alpha-synuclein shows improvement in motor function and reduction of alpha-synuclein inclusions
    Sheila M Fleming
    Departments of Neurology and Neurobiology, The David Geffen School of Medicine at UCLA, 710 Westwood Plaza, Los Angeles, CA 90095 1769, USA
    Mol Cell Neurosci 46:597-606. 2011
    ..The data indicate a significant behavioral benefit and a long lasting improvement of α-synuclein pathology following administration of a short term (2 months) NAP administration in a mouse model of synucleinopathy...
  19. pmc Striatal atrophy and dendritic alterations in a knock-in mouse model of Huntington's disease
    Renata P Lerner
    Department of Neurology, RNRC B114, 710 Westwood Plaza, UCLA David Geffen School of Medicine, Los Angeles, CA 90095, USA
    Brain Res Bull 87:571-8. 2012
    ..These data further indicate that CAG140 homozygote KI mice exhibit HD-like pathological features and are a useful model to test the effects of early and/or sustained administration of novel neuroprotective treatments...
  20. pmc Improvement of neuropathology and transcriptional deficits in CAG 140 knock-in mice supports a beneficial effect of dietary curcumin in Huntington's disease
    Miriam A Hickey
    Department of Neurology, David Geffen School of Medicine, UCLA, Los Angeles, CA 90095, USA
    Mol Neurodegener 7:12. 2012
    ..We have examined the ability of life-long dietary curcumin to improve the early pathological phenotype of CAG140 mice...
  21. pmc Genetic mouse models of parkinsonism: strengths and limitations
    Sheila M Fleming
    Departments of Neurology and Neurobiology, The David Geffen School of Medicine, UCLA, Los Angeles, California 90095, USA
    NeuroRx 2:495-503. 2005
    ..The recent discovery of specific genes causing familial forms of PD has contributed to the development of novel genetic mouse models of PD. This review discusses the validity, benefits, and limitations of these new models...
  22. ncbi request reprint Direct regulation of adult brain function by the male-specific factor SRY
    Phoebe Dewing
    Department of Human Genetics, University of California, Los Angeles, Los Angles, California 90095, USA
    Curr Biol 16:415-20. 2006
    ..These results demonstrate a direct male-specific effect on the brain by a gene encoded only in the male genome, without any mediation by gonadal hormones...
  23. ncbi request reprint Mechanisms of subventricular zone expansion after focal cortical ischemic injury
    Jeffrey E Gotts
    Department of Neurology, Geffen School of Medicine at University of California, Los Angeles, Los Angeles, CA 90095, USA
    J Comp Neurol 488:201-14. 2005
    ..However, these two mechanisms became uncoupled when cell number increased, indicating that a distant brain injury expands the SVZ by disrupting the balance between cell death and proliferation in this adult neurogenic zone...
  24. ncbi request reprint Isolation and characterization of cells with neurogenic potential from adult skeletal muscle
    Patrick Vourc'h
    Department of Neurology, Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095, USA
    Biochem Biophys Res Commun 317:893-901. 2004
    ....
  25. ncbi request reprint Region-specific sprouting of crossed corticofugal fibers after unilateral cortical lesions in adult mice
    Veronique Riban
    Department of Neurology, David Geffen School of Medicine, B 114 RNRC, 710 Westwood Plaza, UCLA, Los Angeles, CA 900095 1769, USA
    Exp Neurol 197:451-7. 2006
    ..These results show that local factors are critical for axonal sprouting in adult brain. They also extend previous findings in rats to a species readily amenable to genetic analysis in order to elucidate the mechanisms of this effect...
  26. pmc Olfactory deficits in mice overexpressing human wildtype alpha-synuclein
    Sheila M Fleming
    Department of Neurology and Neurobiology, The David Geffen School of Medicine at UCLA, 710 Westwood Plaza, Los Angeles, CA 90095 1769, USA
    Eur J Neurosci 28:247-56. 2008
    ..Furthermore, the buried pellet and block tests provided sufficient power for the detection of a 50% drug effect, indicating their usefulness for testing novel neuroprotective therapies...
  27. ncbi request reprint Genetic mouse models of Huntington's and Parkinson's diseases: illuminating but imperfect
    Michael S Levine
    Mental Retardation Research Center, The David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA
    Trends Neurosci 27:691-7. 2004
    ....
  28. ncbi request reprint Apoptosis in Huntington's disease
    Miriam A Hickey
    Department of Neurology, Reed Neurological Research Center, B114, The David Geffen School of Medicine at UCLA, 710 Westwood Plaza, 90095, Los Angeles, CA, USA
    Prog Neuropsychopharmacol Biol Psychiatry 27:255-65. 2003
    ..Here we review the evidence supporting these mechanisms of pathogenesis in HD...
  29. pmc Bacterial artificial chromosome transgenic mice expressing a truncated mutant parkin exhibit age-dependent hypokinetic motor deficits, dopaminergic neuron degeneration, and accumulation of proteinase K-resistant alpha-synuclein
    Xiao hong Lu
    Center for Neurobehavioral Genetics, Semel Institute for Neuroscience and Human Behavior, David Geffen School of Medicine at University of California, Los Angeles, Los Angeles, California 90095, USA
    J Neurosci 29:1962-76. 2009
    ..Our study underscores the need to further explore the putative link between parkin dominant toxicity and PD...
  30. pmc Abnormal colonic motility in mice overexpressing human wild-type alpha-synuclein
    Lixin Wang
    CURE Digestive Diseases Center and Center for Neurobiology of Stress, David Geffen School of Medicine, University of California at Los Angeles and VAGLAHS, Los Angeles, California, USA
    Neuroreport 19:873-6. 2008
    ..These results indicate that Thy1-alphaSyn mice display altered basal and stress-stimulated propulsive colonic motility and will be a useful model to study gut dysfunction associated with Parkinson's disease...
  31. pmc Evidence for behavioral benefits of early dietary supplementation with CoEnzymeQ10 in a slowly progressing mouse model of Huntington's disease
    Miriam A Hickey
    Department of Neurology, UCLA David Geffen School of Medicine, Los Angeles, CA 90095, USA
    Mol Cell Neurosci 49:149-57. 2012
    ..These data confirm that CoQ10 may be beneficial in HD but suggest that maximum benefit may be observed when treatment is begun at early stages of the disease and that dosage may be critical...
  32. pmc Traumatic brain injury in adult rats causes progressive nigrostriatal dopaminergic cell loss and enhanced vulnerability to the pesticide paraquat
    Che Brown Hutson
    Department of Neurology, The David Geffen School of Medicine at UCLA, Los Angeles, California, USA
    J Neurotrauma 28:1783-801. 2011
    ..Furthermore, TBI and pesticide exposure, when occurring within a defined time frame, could combine to increase the PD risk...
  33. pmc Ziram causes dopaminergic cell damage by inhibiting E1 ligase of the proteasome
    Arthur P Chou
    Department of Neurology, University of California at Los Angeles, David Geffen School of Medicine, Los Angeles, CA 90095, USA
    J Biol Chem 283:34696-703. 2008
    ..Chronic exposure to widely used dithiocarbamate fungicides may contribute to the development of PD, and elucidation of its mechanism would identify a new potential therapeutic target...
  34. doi request reprint Genetic mouse models of Parkinson's disease The state of the art
    Iddo Magen
    Department of Neurology, David Geffen School of Medicine, UCLA, Los Angeles, CA, USA
    Prog Brain Res 184:53-87. 2010
    ..This chapter examines their respective advantages and highlights some of the key findings that have already emerged from the analysis of these new models of PD...
  35. ncbi request reprint Alpha-synuclein and transgenic mouse models
    Pierre Olivier Fernagut
    Departments of Neurology and Neurobiology, The David Geffen School of Medicine at UCLA, Los Angeles, CA 90095 1769, USA
    Neurobiol Dis 17:123-30. 2004
    ..This review describes the different alpha-synuclein transgenic models, their clinical relevance to synucleinopathies, and their further utilization to understand the disease process...
  36. pmc Regionally-specific microglial activation in young mice over-expressing human wildtype alpha-synuclein
    Melanie B Watson
    Department of Neurology, The David Geffen School of Medicine at UCLA, 710 Westwood Plaza, Los Angeles, CA 90095 1769, USA
    Exp Neurol 237:318-34. 2012
    ....
  37. ncbi request reprint Synchronous neuronal activity is a signal for axonal sprouting after cortical lesions in the adult
    S Thomas Carmichael
    Department of Neurology, University of California Los Angeles, Los Angeles, California 90095, USA
    J Neurosci 22:6062-70. 2002
    ....
  38. ncbi request reprint Migration and fate of newly born cells after focal cortical ischemia in adult rats
    Jeffrey E Gotts
    Department of Neurology and Neurobiology, Geffen School of Medicine at UCLA, Los Angeles, California 90095, USA
    J Neurosci Res 80:160-71. 2005
    ....
  39. ncbi request reprint Vascular changes in the subventricular zone after distal cortical lesions
    Jeffrey E Gotts
    Department of Neurology, Geffen School of Medicine at UCLA, 710 Westwood Plaza, RNRC B114, Los Angeles, CA 90095, USA
    Exp Neurol 194:139-50. 2005
    ..The data demonstrate that thermocoagulatory cortical lesions induce distal vascular changes that could play a role in lesion-induced SVZ expansion...
  40. pmc Adipose tissue dysfunction tracks disease progression in two Huntington's disease mouse models
    Jack Phan
    Department of Human Genetics, David Geffen School of Medicine at UCLA, University of California, Los Angeles, CA 90095, USA
    Hum Mol Genet 18:1006-16. 2009
    ....
  41. doi request reprint Cognitive deficits in a mouse model of pre-manifest Parkinson's disease
    Iddo Magen
    Department of Neurology, The David Geffen School of Medicine at UCLA, 710 Westwood Plaza, Los Angeles, CA 90095 1769, USA
    Eur J Neurosci 35:870-82. 2012
    ..With high power to detect drug effects, these anomalies provide a novel platform for testing improved treatments for these pervasive cognitive deficits...
  42. ncbi request reprint Metabolic correlates of lesion-specific plasticity: an in vivo imaging study
    Halleh M Mir
    Department of Neurology, UCLA School of Medicine, Los Angeles, CA 90095, USA
    Brain Res 1002:28-34. 2004
    ....
  43. ncbi request reprint Effect of GABA(A) receptor stimulation in the subthalamic nucleus on motor deficits induced by nigrostriatal lesions in the rat
    Arpesh Mehta
    Department of Neurology and Neurobiology, David Geffen School of Medicine at UCLA, B114, Reed Neurological Research Center, 710 Westwood Plaza, Los Angeles, CA 90095, USA
    Exp Neurol 193:110-7. 2005
    ....
  44. pmc Animal models of the non-motor features of Parkinson's disease
    Kimberly McDowell
    Department of Neurology, The David Geffen School of Medicine at UCLA, Los Angeles, CA 90095 1769, USA
    Neurobiol Dis 46:597-606. 2012
    ..This review summarizes the current available literature on the ability of both toxin-induced and genetically-based animal models to reproduce the NMS of PD...
  45. pmc Neurons express hemoglobin alpha- and beta-chains in rat and human brains
    Franziska Richter
    Department of Neurology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California 90095, USA
    J Comp Neurol 515:538-47. 2009
    ..Thus, hemoglobin chains are expressed in neurons and are regulated by treatments that affect mitochondria, opening up the possibility that they may play a novel role in neuronal function and response to injury...
  46. pmc Strengths and limitations of genetic mouse models of Parkinson's disease
    Marie Francoise Chesselet
    Department of Neurology, David Geffen School of Medicine at UCLA, University of California Los Angeles, 710 Westwood Plaza, Los Angeles, CA 90064, USA
    Parkinsonism Relat Disord 14:S84-7. 2008
    ....
  47. pmc Effects of antioxidants on cancer prevention and neuromotor performance in Atm deficient mice
    Ramune Reliene
    Department of Pathology, David Geffen School of Medicine and School of Public Health, UCLA, Los Angeles, CA 90095, USA
    Food Chem Toxicol 46:1371-7. 2008
    ..Our short-term study showed that NAC suppressed genome rearrangements linked to cancer. The long-term study demonstrated that NAC reduced the incidence and multiplicity of lymphoma and improved some aspects of motor performance...
  48. ncbi request reprint The biological sciences section program at the 60th Annual Meeting of the Gerontological Society of America
    Rita B Effros
    Department of Pathology and Laboratory Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095 1732, USA
    J Gerontol A Biol Sci Med Sci 63:331-7. 2008
    ..Novel animal models, including those showing no evidence of aging, as well as ethical and political implications of embryonic stem cells and alternative medicine are also discussed...
  49. ncbi request reprint Effect of neurturin on multipotent cells isolated from the adult skeletal muscle
    Patrick Vourc'h
    Department of Neurology, Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA
    Biochem Biophys Res Commun 332:215-23. 2005
    ..Neurturin may therefore be beneficial in the use of these multipotent cells isolated from adult muscles for autologous transplants in neurological applications...
  50. ncbi request reprint Development and anatomic localization of torsinA
    Shelley R Oberlin
    Department of Neurology, David Geffen School of Medicine, UCLA, Los Angeles, California, USA
    Adv Neurol 94:61-5. 2004
    ..Notably, large cholinergic interneurons of the striatum displayed intense torsin labeling between postnatal days 14 and 21, a period of intense synaptogenesis in this region...
  51. doi request reprint Mouse models of cognitive deficits due to alpha-synuclein pathology
    Iddo Magen
    Department of Neurology, The David Geffen School of Medicine at UCLA, Westwood Plaza, Los Angeles, CA, USA
    J Parkinsons Dis 1:217-27. 2011
    ..This chapter will review cognitive alterations observed in these models and discuss how they may help understand the various forms and stages of cognitive deficits observed in patients with synucleopathies. ..
  52. pmc Neuronal NOS and cyclooxygenase-2 contribute to DNA damage in a mouse model of Parkinson disease
    Tuan Hoang
    Department of Neurology and Department of Neurobiology, University of California at Los Angeles, Los Angeles, CA 90095, USA
    Free Radic Biol Med 47:1049-56. 2009
    ....

Research Grants14

  1. TRAINING PROGRAM IN NEURAL REPAIR
    Marie Francoise Chesselet; Fiscal Year: 2007
    ....
  2. PLASTICITY OF GAD GENE EXPRESSION IN THE BASAL GANGLIA
    Marie Francoise Chesselet; Fiscal Year: 2007
    ..These studies will provide basic information on the mechanisms involved in the maturation of a crucial population of striatal GABAerglc neurons and provide new cues for striatal pathologies. ..
  3. Center for Gene-Environment Studies in Parkinson Disease
    Marie Francoise Chesselet; Fiscal Year: 2006
    ..Cell lines, primary neuronal cultures from genetically altered mice, and human lymphoblasts will be examined. ..
  4. MECHANISMS OF AXONAL SPROUTING IN THE ADULT STRIATUM
    Marie Francoise Chesselet; Fiscal Year: 2003
    ..This has relevance for the treatment of stroke and neurodegenerative diseases, two major health concern and leading causes of disability. ..