Research Topics
Genomes and Genes | Marie Francoise ChesseletSummaryAffiliation: University of California Country: USA Publications
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Publications
Modelling of Parkinson's disease in miceMarie Francoise Chesselet
Department of Neurology, David Geffen School of Medicine, University of California Los Angeles, USA
Lancet Neurol 10:1108-18. 2011..The hope is that this information could be used to advance the search for neuroprotective therapies for Parkinson's disease...
A progressive mouse model of Parkinson's disease: the Thy1-aSyn ("Line 61") miceMarie Francoise Chesselet
Department of Neurology, David Geffen School of Medicine, UCLA, Los Angeles, California 90095, USA
Neurotherapeutics 9:297-314. 2012....
Mouse models of Huntington's diseaseLiliana B Menalled
Dept of Neurology, Reed Neurological Research Center, UCLA School of Medicine, 710 Westwood Plaza, Los Angeles, CA 90095, USA
Trends Pharmacol Sci 23:32-9. 2002..In this article, insights gained from mouse models towards the understanding of HD and the design of new therapeutic strategies are discussed...- Development of striatal fast-spiking GABAergic interneuronsMarie Francoise Chesselet
Departments of Neurology and Neurobiology, The David Geffen School of Medicine at UCLA, Los Angeles, CA 90095 1769, USA
Prog Brain Res 160:261-72. 2007..These findings point to the need for future research to better understand the functional maturation of this critical population of striatal GABAergic neurons, and the consequences of abnormal maturation of these cells... - In vivo alpha-synuclein overexpression in rodents: a useful model of Parkinson's disease?Marie Francoise Chesselet
Department of Neurology and Neurobiology, David Geffen School of Medicine, UCLA, Los Angeles, CA 90095, USA
Exp Neurol 209:22-7. 2008..The predictive value of all models of the disease, however, remains speculative in the absence of effective neuroprotective treatments for PD in humans... - Early motor dysfunction and striosomal distribution of huntingtin microaggregates in Huntington's disease knock-in miceLiliana B Menalled
Department of Neurology, University of California Los Angeles School of Medicine, Los Angeles, California 90095, USA
J Neurosci 22:8266-76. 2002.... - Time course of early motor and neuropathological anomalies in a knock-in mouse model of Huntington's disease with 140 CAG repeatsLiliana B Menalled
Department of Neurology, University of California at Los Angeles, Los Angeles, California 90095, USA
J Comp Neurol 465:11-26. 2003..Because of their early behavioral anomalies and regionally specific pathology, these mice provide a powerful tool with which to evaluate the effectiveness of new therapies and to study the mechanisms involved in the neuropathology of HD... - Early and progressive sensorimotor anomalies in mice overexpressing wild-type human alpha-synucleinSheila M Fleming
Department of Neurology, The Mental Retardation Research Center, The David Geffen School of Medicine at University of California Los Angeles, Los Angeles, California 90095 1769, USA
J Neurosci 24:9434-40. 2004..These behavioral deficits provide a useful way to assess novel drug therapy in genetic models of synucleinopathies... - Analysis of striatal transcriptome in mice overexpressing human wild-type alpha-synuclein supports synaptic dysfunction and suggests mechanisms of neuroprotection for striatal neuronsYofre Cabeza-Arvelaiz
Department of Pathology and Environmental Health Sciences, The Geffen School of Medicine and School of Public Health, University of California, Los Angeles, 650 Charles E, Young Dr S, CHS 71 295, Los Angeles, CA 90095, USA
Mol Neurodegener 6:83. 2011..Therefore it is of interest to understand how overexpression of SNCA affects neuronal function in regions not directly targeted for neurodegeneration in PD... - Elevated tonic extracellular dopamine concentration and altered dopamine modulation of synaptic activity precede dopamine loss in the striatum of mice overexpressing human α-synucleinHoa A Lam
Hatos Center, University of California Los Angeles, Los Angeles, California, USA
J Neurosci Res 89:1091-102. 2011..Together, these data further validate this transgenic mouse line as a slowly progressing model of Parkinson's disease and provide evidence for early dopamine synaptic dysfunction prior to loss of striatal dopamine... - A pilot trial of the microtubule-interacting peptide (NAP) in mice overexpressing alpha-synuclein shows improvement in motor function and reduction of alpha-synuclein inclusionsSheila M Fleming
Departments of Neurology and Neurobiology, The David Geffen School of Medicine at UCLA, 710 Westwood Plaza, Los Angeles, CA 90095 1769, USA
Mol Cell Neurosci 46:597-606. 2011..The data indicate a significant behavioral benefit and a long lasting improvement of α-synuclein pathology following administration of a short term (2 months) NAP administration in a mouse model of synucleinopathy... - Improvement of neuropathology and transcriptional deficits in CAG 140 knock-in mice supports a beneficial effect of dietary curcumin in Huntington's diseaseMiriam A Hickey
Department of Neurology, David Geffen School of Medicine, UCLA, Los Angeles, CA 90095, USA
Mol Neurodegener 7:12. 2012..We have examined the ability of life-long dietary curcumin to improve the early pathological phenotype of CAG140 mice... - Striatal atrophy and dendritic alterations in a knock-in mouse model of Huntington's diseaseRenata P Lerner
Department of Neurology, RNRC B114, 710 Westwood Plaza, UCLA David Geffen School of Medicine, Los Angeles, CA 90095, USA
Brain Res Bull 87:571-8. 2012..These data further indicate that CAG140 homozygote KI mice exhibit HD-like pathological features and are a useful model to test the effects of early and/or sustained administration of novel neuroprotective treatments... - Direct regulation of adult brain function by the male-specific factor SRYPhoebe Dewing
Department of Human Genetics, University of California, Los Angeles, Los Angles, California 90095, USA
Curr Biol 16:415-20. 2006..These results demonstrate a direct male-specific effect on the brain by a gene encoded only in the male genome, without any mediation by gonadal hormones... - Abnormal colonic motility in mice overexpressing human wild-type alpha-synucleinLixin Wang
CURE Digestive Diseases Center and Center for Neurobiology of Stress, David Geffen School of Medicine, University of California at Los Angeles and VAGLAHS, Los Angeles, California, USA
Neuroreport 19:873-6. 2008..These results indicate that Thy1-alphaSyn mice display altered basal and stress-stimulated propulsive colonic motility and will be a useful model to study gut dysfunction associated with Parkinson's disease... - Genetic mouse models of Huntington's and Parkinson's diseases: illuminating but imperfectMichael S Levine
Mental Retardation Research Center, The David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA
Trends Neurosci 27:691-7. 2004.... - Evidence for behavioral benefits of early dietary supplementation with CoEnzymeQ10 in a slowly progressing mouse model of Huntington's diseaseMiriam A Hickey
Department of Neurology, UCLA David Geffen School of Medicine, Los Angeles, CA 90095, USA
Mol Cell Neurosci 49:149-57. 2012..These data confirm that CoQ10 may be beneficial in HD but suggest that maximum benefit may be observed when treatment is begun at early stages of the disease and that dosage may be critical... - Olfactory deficits in mice overexpressing human wildtype alpha-synucleinSheila M Fleming
Department of Neurology and Neurobiology, The David Geffen School of Medicine at UCLA, 710 Westwood Plaza, Los Angeles, CA 90095 1769, USA
Eur J Neurosci 28:247-56. 2008..Furthermore, the buried pellet and block tests provided sufficient power for the detection of a 50% drug effect, indicating their usefulness for testing novel neuroprotective therapies... - Ziram causes dopaminergic cell damage by inhibiting E1 ligase of the proteasomeArthur P Chou
Department of Neurology, University of California at Los Angeles, David Geffen School of Medicine, Los Angeles, CA 90095, USA
J Biol Chem 283:34696-703. 2008..Chronic exposure to widely used dithiocarbamate fungicides may contribute to the development of PD, and elucidation of its mechanism would identify a new potential therapeutic target... - Traumatic brain injury in adult rats causes progressive nigrostriatal dopaminergic cell loss and enhanced vulnerability to the pesticide paraquatChe Brown Hutson
Department of Neurology, The David Geffen School of Medicine at UCLA, Los Angeles, California, USA
J Neurotrauma 28:1783-801. 2011..Furthermore, TBI and pesticide exposure, when occurring within a defined time frame, could combine to increase the PD risk... - Regionally-specific microglial activation in young mice over-expressing human wildtype alpha-synucleinMelanie B Watson
Department of Neurology, The David Geffen School of Medicine at UCLA, 710 Westwood Plaza, Los Angeles, CA 90095 1769, USA
Exp Neurol 237:318-34. 2012.... - Synchronous neuronal activity is a signal for axonal sprouting after cortical lesions in the adultS Thomas Carmichael
Department of Neurology, University of California Los Angeles, Los Angeles, California 90095, USA
J Neurosci 22:6062-70. 2002.... - Adipose tissue dysfunction tracks disease progression in two Huntington's disease mouse modelsJack Phan
Department of Human Genetics, David Geffen School of Medicine at UCLA, University of California, Los Angeles, CA 90095, USA
Hum Mol Genet 18:1006-16. 2009.... - Cognitive deficits in a mouse model of pre-manifest Parkinson's diseaseIddo Magen
Department of Neurology, The David Geffen School of Medicine at UCLA, 710 Westwood Plaza, Los Angeles, CA 90095 1769, USA
Eur J Neurosci 35:870-82. 2012..With high power to detect drug effects, these anomalies provide a novel platform for testing improved treatments for these pervasive cognitive deficits... - Genetic mouse models of Parkinson's disease The state of the artIddo Magen
Department of Neurology, David Geffen School of Medicine, UCLA, Los Angeles, CA, USA
Prog Brain Res 184:53-87. 2010..This chapter examines their respective advantages and highlights some of the key findings that have already emerged from the analysis of these new models of PD... - Bacterial artificial chromosome transgenic mice expressing a truncated mutant parkin exhibit age-dependent hypokinetic motor deficits, dopaminergic neuron degeneration, and accumulation of proteinase K-resistant alpha-synucleinXiao hong Lu
Center for Neurobehavioral Genetics, Semel Institute for Neuroscience and Human Behavior, David Geffen School of Medicine at University of California, Los Angeles, Los Angeles, California 90095, USA
J Neurosci 29:1962-76. 2009..Our study underscores the need to further explore the putative link between parkin dominant toxicity and PD... - Animal models of the non-motor features of Parkinson's diseaseKimberly McDowell
Department of Neurology, The David Geffen School of Medicine at UCLA, Los Angeles, CA 90095 1769, USA
Neurobiol Dis 46:597-606. 2012..This review summarizes the current available literature on the ability of both toxin-induced and genetically-based animal models to reproduce the NMS of PD... - Neurons express hemoglobin alpha- and beta-chains in rat and human brainsFranziska Richter
Department of Neurology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California 90095, USA
J Comp Neurol 515:538-47. 2009..Thus, hemoglobin chains are expressed in neurons and are regulated by treatments that affect mitochondria, opening up the possibility that they may play a novel role in neuronal function and response to injury... - Strengths and limitations of genetic mouse models of Parkinson's diseaseMarie Francoise Chesselet
Department of Neurology, David Geffen School of Medicine at UCLA, University of California Los Angeles, 710 Westwood Plaza, Los Angeles, CA 90064, USA
Parkinsonism Relat Disord 14:S84-7. 2008.... - Effects of antioxidants on cancer prevention and neuromotor performance in Atm deficient miceRamune Reliene
Department of Pathology, David Geffen School of Medicine and School of Public Health, UCLA, Los Angeles, CA 90095, USA
Food Chem Toxicol 46:1371-7. 2008..Our short-term study showed that NAC suppressed genome rearrangements linked to cancer. The long-term study demonstrated that NAC reduced the incidence and multiplicity of lymphoma and improved some aspects of motor performance... - The biological sciences section program at the 60th Annual Meeting of the Gerontological Society of AmericaRita B Effros
Department of Pathology and Laboratory Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095 1732, USA
J Gerontol A Biol Sci Med Sci 63:331-7. 2008..Novel animal models, including those showing no evidence of aging, as well as ethical and political implications of embryonic stem cells and alternative medicine are also discussed... - Effect of neurturin on multipotent cells isolated from the adult skeletal musclePatrick Vourc'h
Department of Neurology, Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA
Biochem Biophys Res Commun 332:215-23. 2005..Neurturin may therefore be beneficial in the use of these multipotent cells isolated from adult muscles for autologous transplants in neurological applications... - Neuronal NOS and cyclooxygenase-2 contribute to DNA damage in a mouse model of Parkinson diseaseTuan Hoang
Department of Neurology and Department of Neurobiology, University of California at Los Angeles, Los Angeles, CA 90095, USA
Free Radic Biol Med 47:1049-56. 2009....
Research Grants
- TRAINING PROGRAM IN NEURAL REPAIRMarie Francoise Chesselet; Fiscal Year: 2007....
- PLASTICITY OF GAD GENE EXPRESSION IN THE BASAL GANGLIAMarie Francoise Chesselet; Fiscal Year: 2007..These studies will provide basic information on the mechanisms involved in the maturation of a crucial population of striatal GABAerglc neurons and provide new cues for striatal pathologies. ..
- Center for Gene-Environment Studies in Parkinson DiseaseMarie Francoise Chesselet; Fiscal Year: 2006..Cell lines, primary neuronal cultures from genetically altered mice, and human lymphoblasts will be examined. ..
- MECHANISMS OF AXONAL SPROUTING IN THE ADULT STRIATUMMarie Francoise Chesselet; Fiscal Year: 2003..This has relevance for the treatment of stroke and neurodegenerative diseases, two major health concern and leading causes of disability. ..