P R Chess

Summary

Affiliation: University of Rochester
Country: USA

Publications

  1. ncbi Reactive oxidant and p42/44 MAP kinase signaling is necessary for mechanical strain-induced proliferation in pulmonary epithelial cells
    Patricia R Chess
    Department of Pediatrics, University of Rochester, New York, USA
    J Appl Physiol 99:1226-32. 2005
  2. ncbi Macroarray analysis reveals a strain-induced oxidant response in pulmonary epithelial cells
    Patricia R Chess
    Department of Pediatrics, University of Rochester, Rochester, New York, USA
    Exp Lung Res 30:739-53. 2004
  3. ncbi Pathogenesis of bronchopulmonary dysplasia
    Patricia R Chess
    Department of Pediatrics, University of Rochester, Rochester, NY 14642, USA
    Semin Perinatol 30:171-8. 2006
  4. ncbi Mechanical strain-induced proliferation and signaling in pulmonary epithelial H441 cells
    P R Chess
    Department of Pediatrics, University of Rochester, Rochester, New York 14642, USA
    Am J Physiol Lung Cell Mol Physiol 279:L43-51. 2000
  5. ncbi Cyclic strain induces proliferation of cultured embryonic heart cells
    C E Miller
    Department of Pediatrics, University of Rochester School of Medicine and Dentistry, New York 14642, USA
    In Vitro Cell Dev Biol Anim 36:633-9. 2000
  6. ncbi Rescue use of DNase in critical lung atelectasis and mucus retention in premature neonates
    N O El Hassan
    Department of Pediatrics, Division of Neonatology, University of Rochester Medical Center, Rochester, NY 14642, USA
    Pediatrics 108:468-70. 2001
  7. ncbi Pressure-regulated volume control ventilation vs synchronized intermittent mandatory ventilation for very low-birth-weight infants: a randomized controlled trial
    CARL T D'ANGIO
    Strong Children s Research Center, University of Rochester, Rochester, NY 14642, USA
    Arch Pediatr Adolesc Med 159:868-75. 2005
  8. ncbi TNF receptor signaling contributes to chemokine secretion, inflammation, and respiratory deficits during Pneumocystis pneumonia
    Terry W Wright
    Department of Pediatrics, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
    J Immunol 172:2511-21. 2004
  9. ncbi Survival in early- and late-term infants with congenital diaphragmatic hernia treated with extracorporeal membrane oxygenation
    Timothy P Stevens
    Division of Neonatology, Department of Pediatrics, Strong Children s Research Center, Golisano Children s Hospital at Strong, Rochester, New York 14642, USA
    Pediatrics 110:590-6. 2002
  10. ncbi Early dexamethasone-attempting to prevent chronic lung disease
    R A Sinkin
    Departments of Pediatrics Neonatology and Biostatistics, Rochester, NY 14642, USA
    Pediatrics 105:542-8. 2000

Research Grants

  1. SIGNALING OF MECHANICAL STRAIN IN LUNG EPITHELIAL CELLS
    Patricia Chess; Fiscal Year: 2003

Collaborators

Detail Information

Publications24

  1. ncbi Reactive oxidant and p42/44 MAP kinase signaling is necessary for mechanical strain-induced proliferation in pulmonary epithelial cells
    Patricia R Chess
    Department of Pediatrics, University of Rochester, New York, USA
    J Appl Physiol 99:1226-32. 2005
    ....
  2. ncbi Macroarray analysis reveals a strain-induced oxidant response in pulmonary epithelial cells
    Patricia R Chess
    Department of Pediatrics, University of Rochester, Rochester, New York, USA
    Exp Lung Res 30:739-53. 2004
    ..Strain-induced oxidative stress was verified with the oxidant-sensitive dye dichlorodihydrofluorescein diacetate...
  3. ncbi Pathogenesis of bronchopulmonary dysplasia
    Patricia R Chess
    Department of Pediatrics, University of Rochester, Rochester, NY 14642, USA
    Semin Perinatol 30:171-8. 2006
    ..The contribution of hyperoxia and hypoxia, mechanical forces, vascular maldevelopment, inflammation, fluid management, patent ductus arteriosus (PDA), nutrition, and genetics will be discussed...
  4. ncbi Mechanical strain-induced proliferation and signaling in pulmonary epithelial H441 cells
    P R Chess
    Department of Pediatrics, University of Rochester, Rochester, New York 14642, USA
    Am J Physiol Lung Cell Mol Physiol 279:L43-51. 2000
    ..We conclude that strain induces proliferation in pulmonary epithelial cells and that tyrosine kinase activity is necessary to signal the proliferative response to mechanical strain...
  5. ncbi Cyclic strain induces proliferation of cultured embryonic heart cells
    C E Miller
    Department of Pediatrics, University of Rochester School of Medicine and Dentistry, New York 14642, USA
    In Vitro Cell Dev Biol Anim 36:633-9. 2000
    ..The results of this study indicate that embryonic chick cardiocytes can be cultured in an active mechanical environment without significant detachment and damage and that increased proliferation may be a primary response to strain...
  6. ncbi Rescue use of DNase in critical lung atelectasis and mucus retention in premature neonates
    N O El Hassan
    Department of Pediatrics, Division of Neonatology, University of Rochester Medical Center, Rochester, NY 14642, USA
    Pediatrics 108:468-70. 2001
    ..The rescue use of DNase was effective in reestablishing airway patency. Thus, this drug could be a valuable tool in treating atelectasis and mucus-plugging in mechanically ventilated, premature neonates...
  7. ncbi Pressure-regulated volume control ventilation vs synchronized intermittent mandatory ventilation for very low-birth-weight infants: a randomized controlled trial
    CARL T D'ANGIO
    Strong Children s Research Center, University of Rochester, Rochester, NY 14642, USA
    Arch Pediatr Adolesc Med 159:868-75. 2005
    ....
  8. ncbi TNF receptor signaling contributes to chemokine secretion, inflammation, and respiratory deficits during Pneumocystis pneumonia
    Terry W Wright
    Department of Pediatrics, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
    J Immunol 172:2511-21. 2004
    ....
  9. ncbi Survival in early- and late-term infants with congenital diaphragmatic hernia treated with extracorporeal membrane oxygenation
    Timothy P Stevens
    Division of Neonatology, Department of Pediatrics, Strong Children s Research Center, Golisano Children s Hospital at Strong, Rochester, New York 14642, USA
    Pediatrics 110:590-6. 2002
    ..Changes in survival rates of term infants and the factors associated with these changes were assessed over the 25 years that ECMO has been available...
  10. ncbi Early dexamethasone-attempting to prevent chronic lung disease
    R A Sinkin
    Departments of Pediatrics Neonatology and Biostatistics, Rochester, NY 14642, USA
    Pediatrics 105:542-8. 2000
    ..1) A multicenter, randomized, double-blind trial was undertaken to confirm these results...
  11. ncbi Inhibition of surfactant activity by Pneumocystis carinii organisms and components in vitro
    Zhengdong Wang
    Dept. of Pediatrics, Box 850, Univ. of Rochester School of Medicine, 601 Elmwood Ave, Rochester, NY 14642, USA
    Am J Physiol Lung Cell Mol Physiol 288:L1124-31. 2005
    ....
  12. ncbi Neonatal oxygen adversely affects lung function in adult mice without altering surfactant composition or activity
    Min Yee
    Dept of Pediatrics, Univ of Rochester, Rochester, NY 14642, USA
    Am J Physiol Lung Cell Mol Physiol 297:L641-9. 2009
    ..Furthermore, the disruptive effects of oxygen on epithelial development and lung mechanics are not equivalently dose dependent...
  13. ncbi The effect of gentle ventilation on survival in congenital diaphragmatic hernia
    Patricia R Chess
    Departments of Pediatrics and Biomedical Engineering, University of Rochester, Rochester, NY 14642
    Pediatrics 113:917. 2004
  14. ncbi Growth arrest in G1 protects against oxygen-induced DNA damage and cell death
    Raymond C Rancourt
    Department of Environmental Medicine, The University of Rochester, Rochester, New York 14642, USA
    J Cell Physiol 193:26-36. 2002
    ..Our findings suggest that the protective effects of G1 is mediated not simply by a reduction in intracellular ROS, but rather through an enhanced ability to limit or rapidly recognize and repair damaged DNA...
  15. ncbi Expression of vascular endothelial growth factor and Flk-1 in developing and glucocorticoid-treated mouse lung
    A J Bhatt
    Strong Children s Research Center Division of Neonatology, Children s Hospital at Strong, University of Rochester School of Medicine, New York, USA
    Pediatr Res 47:606-13. 2000
    ..The relatively high levels of VEGF and Flk-1 mRNA in adult lung imply a role for pulmonary VEGF in endothelial cell maintenance or capillary permeability...
  16. ncbi CD40 is a functional activation antigen and B7-independent T cell costimulatory molecule on normal human lung fibroblasts
    G D Sempowski
    University of Rochester Cancer Center, and Department of Microbiology, NY 14642, USA
    J Immunol 158:4670-7. 1997
    ..Data reported herein support the hypothesis that cognate interactions between tissue fibroblasts and infiltrating T lymphocytes, via the CD40/CD40L pathway, augment inflammation and may promote fibrogenesis by activating both cell types...
  17. ncbi Growth factors in lung development
    Vasanth H Kumar
    Department of Pediatrics (Neonatology, State University of New York, The Women and Children's Hospital of Buffalo, Buffalo, New York, USA
    Adv Clin Chem 40:261-316. 2005
    ....
  18. ncbi Surfactant dysfunction in SP-A-/- and iNOS-/- mice with mycoplasma infection
    Judy M Hickman-Davis
    Department of Pediatrics, University of Rochester School of Medicine, Rochester, NY 14642, USA
    Am J Respir Cell Mol Biol 36:103-13. 2007
    ..In addition, SP-A deficiency modifies surfactant aggregate content and lowers the inhibition resistance of LA surfactant in vitro compared with congenic normal mice...
  19. ncbi Peripheral cell wall lipids of Mycobacterium tuberculosis are inhibitory to surfactant function
    Zhengdong Wang
    Department of Pediatrics, University of Rochester School of Medicine, Box 850, 601 Elmwood Avenue, Rochester, NY 14642, USA
    Tuberculosis (Edinb) 88:178-86. 2008
    ....
  20. ncbi Surfactant for pediatric acute lung injury
    Douglas F Willson
    Pediatric ICU and Division of Pediatric Critical Care, University of Virginia Children s Medical Center, UVA Health Sciences System, Box 800386, Charlottesville, VA 22908 0386, USA
    Pediatr Clin North Am 55:545-75, ix. 2008
    ..Particular advantages from surfactant therapy in direct pulmonary forms of these syndromes are described. Also discussed are additional factors affecting the efficacy of exogenous surfactants in ALI/ARDS...
  21. ncbi Surfactant alterations in acute inflammatory lung injury from aspiration of acid and gastric particulates
    Bruce A Davidson
    Departments of Anesthesiology, University at Buffalo-State University of New York, Buffalo, NY 14214, USA
    Am J Physiol Lung Cell Mol Physiol 288:L699-708. 2005
    ..005). These results indicate that surfactant abnormalities are functionally important in gastric aspiration lung injury and contribute significantly to the increased severity of injury found in CASP compared with ACID or SNAP alone...
  22. ncbi Statistical prediction of the type of gastric aspiration lung injury based on early cytokine/chemokine profiles
    Alan D Hutson
    Department of Biostatistics, State University of New York at Buffalo, Buffalo, New York 14214, USA
    Anesthesiology 104:73-9. 2006
    ....
  23. ncbi Discrimination of resident and infiltrated alveolar macrophages by flow cytometry in influenza A virus-infected mice
    Bruce A Davidson
    Department of Anesthesiology, University at Buffalo SUNY School of Medicine, Biomedical Research Building, Room 247, 3435 Main Street, Buffalo, NY 14214, USA
    Exp Lung Res 31:323-39. 2005
    ..The discrimination of subpopulations of resident and newly recruited macrophages in BAL should facilitate future mechanistic studies on pulmonary infection and inflammatory lung injury...
  24. ncbi Surfactant dysfunction and lung injury due to the E. coli virulence factor hemolysin in a rat pneumonia model
    Thomas A Russo
    Department of Medicine, The Witebsky Center for Microbial Pathogenesis, NY, USA
    Am J Physiol Lung Cell Mol Physiol 292:L632-43. 2007
    ..Together, these data demonstrate that Hly is an important direct mediator of surfactant dysfunction and lung injury in gram-negative pneumonia...

Research Grants1

  1. SIGNALING OF MECHANICAL STRAIN IN LUNG EPITHELIAL CELLS
    Patricia Chess; Fiscal Year: 2003
    ..The project is designed to optimize the principle investigator's research development, while yielding information regarding pulmonary epithelial responses to mechanical strain. ..