Genomes and Genes
P R Chess
Affiliation: University of Rochester
- Reactive oxidant and p42/44 MAP kinase signaling is necessary for mechanical strain-induced proliferation in pulmonary epithelial cellsPatricia R Chess
Department of Pediatrics, University of Rochester, New York, USA
J Appl Physiol 99:1226-32. 2005....
- Macroarray analysis reveals a strain-induced oxidant response in pulmonary epithelial cellsPatricia R Chess
Department of Pediatrics, University of Rochester, Rochester, New York, USA
Exp Lung Res 30:739-53. 2004..Strain-induced oxidative stress was verified with the oxidant-sensitive dye dichlorodihydrofluorescein diacetate...
- Pathogenesis of bronchopulmonary dysplasiaPatricia R Chess
Department of Pediatrics, University of Rochester, Rochester, NY 14642, USA
Semin Perinatol 30:171-8. 2006..The contribution of hyperoxia and hypoxia, mechanical forces, vascular maldevelopment, inflammation, fluid management, patent ductus arteriosus (PDA), nutrition, and genetics will be discussed...
- Mechanical strain-induced proliferation and signaling in pulmonary epithelial H441 cellsP R Chess
Department of Pediatrics, University of Rochester, Rochester, New York 14642, USA
Am J Physiol Lung Cell Mol Physiol 279:L43-51. 2000..We conclude that strain induces proliferation in pulmonary epithelial cells and that tyrosine kinase activity is necessary to signal the proliferative response to mechanical strain...
- Cyclic strain induces proliferation of cultured embryonic heart cellsC E Miller
Department of Pediatrics, University of Rochester School of Medicine and Dentistry, New York 14642, USA
In Vitro Cell Dev Biol Anim 36:633-9. 2000..The results of this study indicate that embryonic chick cardiocytes can be cultured in an active mechanical environment without significant detachment and damage and that increased proliferation may be a primary response to strain...
- Rescue use of DNase in critical lung atelectasis and mucus retention in premature neonatesN O El Hassan
Department of Pediatrics, Division of Neonatology, University of Rochester Medical Center, Rochester, NY 14642, USA
Pediatrics 108:468-70. 2001..The rescue use of DNase was effective in reestablishing airway patency. Thus, this drug could be a valuable tool in treating atelectasis and mucus-plugging in mechanically ventilated, premature neonates...
- Pressure-regulated volume control ventilation vs synchronized intermittent mandatory ventilation for very low-birth-weight infants: a randomized controlled trialCARL T D'ANGIO
Strong Children s Research Center, University of Rochester, Rochester, NY 14642, USA
Arch Pediatr Adolesc Med 159:868-75. 2005....
- TNF receptor signaling contributes to chemokine secretion, inflammation, and respiratory deficits during Pneumocystis pneumoniaTerry W Wright
Department of Pediatrics, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
J Immunol 172:2511-21. 2004....
- Survival in early- and late-term infants with congenital diaphragmatic hernia treated with extracorporeal membrane oxygenationTimothy P Stevens
Division of Neonatology, Department of Pediatrics, Strong Children s Research Center, Golisano Children s Hospital at Strong, Rochester, New York 14642, USA
Pediatrics 110:590-6. 2002..Changes in survival rates of term infants and the factors associated with these changes were assessed over the 25 years that ECMO has been available...
- Early dexamethasone-attempting to prevent chronic lung diseaseR A Sinkin
Departments of Pediatrics Neonatology and Biostatistics, Rochester, NY 14642, USA
Pediatrics 105:542-8. 2000..1) A multicenter, randomized, double-blind trial was undertaken to confirm these results...
- Inhibition of surfactant activity by Pneumocystis carinii organisms and components in vitroZhengdong Wang
Dept of Pediatrics, Box 850, Univ of Rochester School of Medicine, 601 Elmwood Ave, Rochester, NY 14642, USA
Am J Physiol Lung Cell Mol Physiol 288:L1124-31. 2005....
- Neonatal oxygen adversely affects lung function in adult mice without altering surfactant composition or activityMin Yee
Dept of Pediatrics, Univ of Rochester, Rochester, NY 14642, USA
Am J Physiol Lung Cell Mol Physiol 297:L641-9. 2009..Furthermore, the disruptive effects of oxygen on epithelial development and lung mechanics are not equivalently dose dependent...
- The effect of gentle ventilation on survival in congenital diaphragmatic herniaPatricia R Chess
Departments of Pediatrics and Biomedical Engineering, University of Rochester, Rochester, NY 14642
Pediatrics 113:917. 2004
- Growth arrest in G1 protects against oxygen-induced DNA damage and cell deathRaymond C Rancourt
Department of Environmental Medicine, The University of Rochester, Rochester, New York 14642, USA
J Cell Physiol 193:26-36. 2002..Our findings suggest that the protective effects of G1 is mediated not simply by a reduction in intracellular ROS, but rather through an enhanced ability to limit or rapidly recognize and repair damaged DNA...
- Expression of vascular endothelial growth factor and Flk-1 in developing and glucocorticoid-treated mouse lungA J Bhatt
Strong Children s Research Center Division of Neonatology, Children s Hospital at Strong, University of Rochester School of Medicine, New York, USA
Pediatr Res 47:606-13. 2000..The relatively high levels of VEGF and Flk-1 mRNA in adult lung imply a role for pulmonary VEGF in endothelial cell maintenance or capillary permeability...
- CD40 is a functional activation antigen and B7-independent T cell costimulatory molecule on normal human lung fibroblastsG D Sempowski
University of Rochester Cancer Center, and Department of Microbiology, NY 14642, USA
J Immunol 158:4670-7. 1997..Data reported herein support the hypothesis that cognate interactions between tissue fibroblasts and infiltrating T lymphocytes, via the CD40/CD40L pathway, augment inflammation and may promote fibrogenesis by activating both cell types...
- Growth factors in lung developmentVasanth H Kumar
Department of Pediatrics Neonatology, State University of New York, The Women and Children s Hospital of Buffalo, Buffalo, New York, USA
Adv Clin Chem 40:261-316. 2005....
- Surfactant dysfunction in SP-A-/- and iNOS-/- mice with mycoplasma infectionJudy M Hickman-Davis
Department of Pediatrics, University of Rochester School of Medicine, Rochester, NY 14642, USA
Am J Respir Cell Mol Biol 36:103-13. 2007..In addition, SP-A deficiency modifies surfactant aggregate content and lowers the inhibition resistance of LA surfactant in vitro compared with congenic normal mice...
- Peripheral cell wall lipids of Mycobacterium tuberculosis are inhibitory to surfactant functionZhengdong Wang
Department of Pediatrics, University of Rochester School of Medicine, Box 850, 601 Elmwood Avenue, Rochester, NY 14642, USA
Tuberculosis (Edinb) 88:178-86. 2008....
- Surfactant for pediatric acute lung injuryDouglas F Willson
Pediatric ICU and Division of Pediatric Critical Care, University of Virginia Children s Medical Center, UVA Health Sciences System, Box 800386, Charlottesville, VA 22908 0386, USA
Pediatr Clin North Am 55:545-75, ix. 2008..Particular advantages from surfactant therapy in direct pulmonary forms of these syndromes are described. Also discussed are additional factors affecting the efficacy of exogenous surfactants in ALI/ARDS...
- Surfactant alterations in acute inflammatory lung injury from aspiration of acid and gastric particulatesBruce A Davidson
Departments of Anesthesiology, University at Buffalo State University of New York, Buffalo, NY 14214, USA
Am J Physiol Lung Cell Mol Physiol 288:L699-708. 2005..005). These results indicate that surfactant abnormalities are functionally important in gastric aspiration lung injury and contribute significantly to the increased severity of injury found in CASP compared with ACID or SNAP alone...
- Statistical prediction of the type of gastric aspiration lung injury based on early cytokine/chemokine profilesAlan D Hutson
Department of Biostatistics, State University of New York at Buffalo, Buffalo, New York 14214, USA
Anesthesiology 104:73-9. 2006..The authors hypothesized that inflammatory mediator profiles could be used to help diagnose different types of gastric aspiration...
- Discrimination of resident and infiltrated alveolar macrophages by flow cytometry in influenza A virus-infected miceBruce A Davidson
Department of Anesthesiology, University at Buffalo SUNY School of Medicine, Biomedical Research Building, Room 247, 3435 Main Street, Buffalo, NY 14214, USA
Exp Lung Res 31:323-39. 2005..The discrimination of subpopulations of resident and newly recruited macrophages in BAL should facilitate future mechanistic studies on pulmonary infection and inflammatory lung injury...
- Surfactant dysfunction and lung injury due to the E. coli virulence factor hemolysin in a rat pneumonia modelThomas A Russo
Department of Medicine, The Witebsky Center for Microbial Pathogenesis, NY, USA
Am J Physiol Lung Cell Mol Physiol 292:L632-43. 2007..Together, these data demonstrate that Hly is an important direct mediator of surfactant dysfunction and lung injury in gram-negative pneumonia...
- SIGNALING OF MECHANICAL STRAIN IN LUNG EPITHELIAL CELLSPatricia Chess; Fiscal Year: 2003..The project is designed to optimize the principle investigator's research development, while yielding information regarding pulmonary epithelial responses to mechanical strain. ..