Igor Chesnokov

Summary

Affiliation: University of Alabama at Birmingham
Country: USA

Publications

  1. pmc Functional analysis of an Orc6 mutant in Drosophila
    Maxim Balasov
    Department of Biochemistry and Molecular Genetics, University of Alabama at Birmingham School of Medicine, Birmingham, AL 35294, USA
    Proc Natl Acad Sci U S A 106:10672-7. 2009
  2. pmc A cytokinetic function of Drosophila ORC6 protein resides in a domain distinct from its replication activity
    Igor N Chesnokov
    Department of Biochemistry and Molecular Genetics, University of Alabama at Birmingham School of Medicine, Birmingham, AL 35294, USA
    Proc Natl Acad Sci U S A 100:9150-5. 2003
  3. pmc Drosophila Orc6 facilitates GTPase activity and filament formation of the septin complex
    Richard P H Huijbregts
    Department of Biochemistry and Molecular Genetics, University of Alabama at Birmingham, School of Medicine, Birmingham, AL 35294, USA
    Mol Biol Cell 20:270-81. 2009
  4. ncbi request reprint Study of DNA replication in Drosophila using cell free in vitro system
    Anton Svitin
    Department of Biochemistry and Molecular Genetics, University of Alabama at Birmingham, School of Medicine, Birmingham, AL, USA
    Cell Cycle 9:815-9. 2010
  5. pmc Role of the Orc6 protein in origin recognition complex-dependent DNA binding and replication in Drosophila melanogaster
    Maxim Balasov
    Department of Biochemistry and Molecular Genetics, University of Alabama at Birmingham, School of Medicine, 720 20th Street South, Birmingham, AL 35294, USA
    Mol Cell Biol 27:3143-53. 2007
  6. ncbi request reprint Multiple functions of the origin recognition complex
    Igor N Chesnokov
    Department of Biochemistry and Molecular Genetics, University of Alabama at Birmingham, School of Medicine, Birmingham, Alabama, USA
    Int Rev Cytol 256:69-109. 2007

Research Grants

Collaborators

  • Richard P H Huijbregts
  • Maxim Balasov
  • Anton Svitin
  • Monica W Stinnett
  • Matthew B Renfrow

Detail Information

Publications6

  1. pmc Functional analysis of an Orc6 mutant in Drosophila
    Maxim Balasov
    Department of Biochemistry and Molecular Genetics, University of Alabama at Birmingham School of Medicine, Birmingham, AL 35294, USA
    Proc Natl Acad Sci U S A 106:10672-7. 2009
    ..In a cross-species complementation experiment, the expression of human Orc6 in Drosophila Orc6 mutant cells rescued DNA replication, suggesting that this function of the protein is conserved among metazoans...
  2. pmc A cytokinetic function of Drosophila ORC6 protein resides in a domain distinct from its replication activity
    Igor N Chesnokov
    Department of Biochemistry and Molecular Genetics, University of Alabama at Birmingham School of Medicine, Birmingham, AL 35294, USA
    Proc Natl Acad Sci U S A 100:9150-5. 2003
    ..This mutant protein does not localize to the membrane or cleavage furrows. These results suggest that Orc6 has evolved a domain critical mainly for cytokinesis...
  3. pmc Drosophila Orc6 facilitates GTPase activity and filament formation of the septin complex
    Richard P H Huijbregts
    Department of Biochemistry and Molecular Genetics, University of Alabama at Birmingham, School of Medicine, Birmingham, AL 35294, USA
    Mol Biol Cell 20:270-81. 2009
    ..These results suggest an active role for Orc6 in septin complex function. Orc6 might be a part of a control mechanism directing the cytokinesis machinery during the final steps of mitosis...
  4. ncbi request reprint Study of DNA replication in Drosophila using cell free in vitro system
    Anton Svitin
    Department of Biochemistry and Molecular Genetics, University of Alabama at Birmingham, School of Medicine, Birmingham, AL, USA
    Cell Cycle 9:815-9. 2010
    ..Our studies indicate that a Drosophila cell free system proves to be an extremely useful tool for a functional dissection of the processes and factors involved in DNA replication in metazoans...
  5. pmc Role of the Orc6 protein in origin recognition complex-dependent DNA binding and replication in Drosophila melanogaster
    Maxim Balasov
    Department of Biochemistry and Molecular Genetics, University of Alabama at Birmingham, School of Medicine, 720 20th Street South, Birmingham, AL 35294, USA
    Mol Cell Biol 27:3143-53. 2007
    ..Our studies provide a molecular analysis for the functional requirement of Orc6 in replicative functions of ORC in Drosophila and suggest that Orc6 may contribute to the sequence preferences of ORC in targeting to the origins...
  6. ncbi request reprint Multiple functions of the origin recognition complex
    Igor N Chesnokov
    Department of Biochemistry and Molecular Genetics, University of Alabama at Birmingham, School of Medicine, Birmingham, Alabama, USA
    Int Rev Cytol 256:69-109. 2007
    ..In this review, we discuss the participation of ORC proteins in various cell functions, in addition to the canonical role of ORC in initiating DNA replication...

Research Grants6

  1. The Role of origin Recognition Complex in the Cell Cycle
    Igor Chesnokov; Fiscal Year: 2009
    ..Such control might lead to rationally designed therapies for cancer and may provide the means for regenerating cells lost due to aging, disease or injury. ..
  2. The Role of origin Recognition Complex in the Cell Cycle
    Igor Chesnokov; Fiscal Year: 2009
    ..Such control might lead to rationally designed therapies for cancer and may provide the means for regenerating cells lost due to aging, disease or injury. ..