Thomas L Cherpes

Summary

Affiliation: University of Pittsburgh
Country: USA

Publications

  1. ncbi request reprint Cunnilingus and vaginal intercourse are risk factors for herpes simplex virus type 1 acquisition in women
    Thomas L Cherpes
    Department of Medicine, Division of Infectious Disease, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    Sex Transm Dis 32:84-9. 2005
  2. ncbi request reprint Hormonal contraceptive use modulates the local inflammatory response to bacterial vaginosis
    T L Cherpes
    Department of Obstetrics, Gynecology, and Reproductive Sciences, University of Pittsburgh, Pittsburgh, PA, USA
    Sex Transm Infect 84:57-61. 2008
  3. ncbi request reprint A delicate balance: risk factors for acquisition of bacterial vaginosis include sexual activity, absence of hydrogen peroxide-producing lactobacilli, black race, and positive herpes simplex virus type 2 serology
    Thomas L Cherpes
    Department of Obstetrics, Gynecology, and Reproductive Sciences, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Sex Transm Dis 35:78-83. 2008
  4. ncbi request reprint The associations between pelvic inflammatory disease, Trichomonas vaginalis infection, and positive herpes simplex virus type 2 serology
    Thomas L Cherpes
    Department of Obstetrics, Gynecology, and Reproductive Sciences, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Sex Transm Dis 33:747-52. 2006
  5. ncbi request reprint Genital tract shedding of herpes simplex virus type 2 in women: effects of hormonal contraception, bacterial vaginosis, and vaginal group B Streptococcus colonization
    Thomas L Cherpes
    Department of Medicine, Division of Infectious Disease, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Clin Infect Dis 40:1422-8. 2005
  6. ncbi request reprint Association between acquisition of herpes simplex virus type 2 in women and bacterial vaginosis
    Thomas L Cherpes
    Department of Medicine, Division of Infectious Disease, University of Pittsburgh, Pittsburgh, PA, USA
    Clin Infect Dis 37:319-25. 2003
  7. pmc PD-L1/B7-H1 regulates the survival but not the function of CD8+ T cells in herpes simplex virus type 1 latently infected trigeminal ganglia
    Sohyun Jeon
    Department of Ophthalmology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    J Immunol 190:6277-86. 2013
  8. pmc Transient detection of Chlamydial-specific Th1 memory cells in the peripheral circulation of women with history of Chlamydia trachomatis genital tract infection
    Rodolfo D Vicetti Miguel
    Department of Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, PA 15224, USA
    Am J Reprod Immunol 68:499-506. 2012
  9. ncbi request reprint Risk factors for infection with herpes simplex virus type 2: role of smoking, douching, uncircumcised males, and vaginal flora
    Thomas L Cherpes
    Department of Medicine, Division of Infectious Disease, Magee Womens Research Institute, 204 Craft Avenue, Pittsburgh, PA 15213, USA
    Sex Transm Dis 30:405-10. 2003
  10. pmc Reevaluating the CD8 T-cell response to herpes simplex virus type 1: involvement of CD8 T cells reactive to subdominant epitopes
    Brian S Sheridan
    Graduate Program in Immunology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    J Virol 83:2237-45. 2009

Research Grants

Collaborators

Detail Information

Publications29

  1. ncbi request reprint Cunnilingus and vaginal intercourse are risk factors for herpes simplex virus type 1 acquisition in women
    Thomas L Cherpes
    Department of Medicine, Division of Infectious Disease, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    Sex Transm Dis 32:84-9. 2005
    ..Our objective was to identify demographic and behavioral variables in women associated with the prevalence and acquisition of HSV-1...
  2. ncbi request reprint Hormonal contraceptive use modulates the local inflammatory response to bacterial vaginosis
    T L Cherpes
    Department of Obstetrics, Gynecology, and Reproductive Sciences, University of Pittsburgh, Pittsburgh, PA, USA
    Sex Transm Infect 84:57-61. 2008
    ....
  3. ncbi request reprint A delicate balance: risk factors for acquisition of bacterial vaginosis include sexual activity, absence of hydrogen peroxide-producing lactobacilli, black race, and positive herpes simplex virus type 2 serology
    Thomas L Cherpes
    Department of Obstetrics, Gynecology, and Reproductive Sciences, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Sex Transm Dis 35:78-83. 2008
    ..The etiology of bacterial vaginosis (BV) is poorly understood, but better definition of the risk factors associated with its acquisition should improve our understanding of this complex disease entity...
  4. ncbi request reprint The associations between pelvic inflammatory disease, Trichomonas vaginalis infection, and positive herpes simplex virus type 2 serology
    Thomas L Cherpes
    Department of Obstetrics, Gynecology, and Reproductive Sciences, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Sex Transm Dis 33:747-52. 2006
    ....
  5. ncbi request reprint Genital tract shedding of herpes simplex virus type 2 in women: effects of hormonal contraception, bacterial vaginosis, and vaginal group B Streptococcus colonization
    Thomas L Cherpes
    Department of Medicine, Division of Infectious Disease, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Clin Infect Dis 40:1422-8. 2005
    ..We investigated the effects of vaginal coinfections and hormonal contraceptive use on genital tract shedding of HSV-2 in women...
  6. ncbi request reprint Association between acquisition of herpes simplex virus type 2 in women and bacterial vaginosis
    Thomas L Cherpes
    Department of Medicine, Division of Infectious Disease, University of Pittsburgh, Pittsburgh, PA, USA
    Clin Infect Dis 37:319-25. 2003
    ..In this study, the population attributable risk of BV for HSV-2 seroconversion was 21%. Additional studies are needed to determine whether screening and treatment of BV could reduce susceptibility to the acquisition of HSV-2 in women...
  7. pmc PD-L1/B7-H1 regulates the survival but not the function of CD8+ T cells in herpes simplex virus type 1 latently infected trigeminal ganglia
    Sohyun Jeon
    Department of Ophthalmology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    J Immunol 190:6277-86. 2013
    ..Unlike observations in some chronic infection models, B7-H1 blockade did not increase the function of exhausted gB-Tet(-) CD8 T cells in latently infected TG...
  8. pmc Transient detection of Chlamydial-specific Th1 memory cells in the peripheral circulation of women with history of Chlamydia trachomatis genital tract infection
    Rodolfo D Vicetti Miguel
    Department of Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, PA 15224, USA
    Am J Reprod Immunol 68:499-506. 2012
    ..Development of safe and effective Chlamydia trachomatis vaccines requires better understanding of the host immune responses elicited by natural infection...
  9. ncbi request reprint Risk factors for infection with herpes simplex virus type 2: role of smoking, douching, uncircumcised males, and vaginal flora
    Thomas L Cherpes
    Department of Medicine, Division of Infectious Disease, Magee Womens Research Institute, 204 Craft Avenue, Pittsburgh, PA 15213, USA
    Sex Transm Dis 30:405-10. 2003
    ..Herpes simplex virus type 2 (HSV-2), the primary cause of genital herpes, is one of the most prevalent sexually transmitted diseases worldwide. Epidemiologic serosurveys suggest that infections occur more frequently in women than in men...
  10. pmc Reevaluating the CD8 T-cell response to herpes simplex virus type 1: involvement of CD8 T cells reactive to subdominant epitopes
    Brian S Sheridan
    Graduate Program in Immunology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    J Virol 83:2237-45. 2009
    ..Identification of the viral proteins recognized by these cells will contribute to a better understanding of the dynamics of HSV-1 latency...
  11. pmc Human female genital tract infection by the obligate intracellular bacterium Chlamydia trachomatis elicits robust Type 2 immunity
    Rodolfo D Vicetti Miguel
    Department of Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    PLoS ONE 8:e58565. 2013
    ..trachomatis in the human female genital tract to control infection and minimize immunopathological damage to vital reproductive structures...
  12. pmc Recalcitrance of bacterial vaginosis among herpes-simplex-virus-type-2-seropositive women
    Kevin A Stoner
    Departments of Obstetrics and Gynecology and Reproductive Sciences Pediatrics Medicine Pathology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    J Obstet Gynaecol Res 38:77-83. 2012
    ..Herein, we evaluated the effects of herpes simplex virus type 2 (HSV-2), a suspected BV risk factor, on vaginal flora composition...
  13. pmc Medroxyprogesterone acetate inhibits CD8+ T cell viral-specific effector function and induces herpes simplex virus type 1 reactivation
    Thomas L Cherpes
    Department of Obstetrics, Gynecology, and Reproductive Sciences, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    J Immunol 181:969-75. 2008
    ....
  14. pmc Plasma versus serum for detection of herpes simplex virus type 2-specific immunoglobulin G antibodies with a glycoprotein G2-based enzyme immunoassay
    Thomas L Cherpes
    Department of Medicine, Division of Infectious Disease, Magee Womens Research Institute, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    J Clin Microbiol 41:2758-9. 2003
    ..and found 98.9% agreement between the two specimen types. Plasma appears to be an acceptable matrix for use with this assay...
  15. pmc Use of transcriptional profiling to delineate the initial response of mice to intravaginal herpes simplex virus type 2 infection
    Thomas L Cherpes
    Department of Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15224, USA
    Viral Immunol 26:172-9. 2013
    ....
  16. pmc Dendritic cell activation and memory cell development are impaired among mice administered medroxyprogesterone acetate prior to mucosal herpes simplex virus type 1 infection
    Rodolfo D Vicetti Miguel
    Department of Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, PA 15224, USA
    J Immunol 189:3449-61. 2012
    ..Taken together, our results reveal that the administration of MPA prior to viral infection of mucosal tissue impairs DC activation, virus-specific T cell expansion, and development of virus-specific immunological memory...
  17. pmc 17-beta estradiol promotion of herpes simplex virus type 1 reactivation is estrogen receptor dependent
    Rodolfo D Vicetti Miguel
    Graduate Program in Immunology, Department of Ophthalmology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA corrected
    J Virol 84:565-72. 2010
    ..Additional research is needed to confirm whether pregnancy or hormonal contraceptives containing 17-betaE also promote HSV reactivation from latency in an estrogen receptor-dependent manner...
  18. pmc Early CD4(+) T cell help prevents partial CD8(+) T cell exhaustion and promotes maintenance of Herpes Simplex Virus 1 latency
    Gregory M Frank
    Graduate Program in Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    J Immunol 184:277-86. 2010
    ..CD4(+) T cells are not needed to maintain CD8(+) T cell memory through 34 d after infection, nor do they have a direct involvement in the maintenance of HSV-1 latency...
  19. pmc Brefeldin A, but not monensin, enables flow cytometric detection of interleukin-4 within peripheral T cells responding to ex vivo stimulation with Chlamydia trachomatis
    Rodolfo D Vicetti Miguel
    Department of Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, PA 15224, USA
    J Immunol Methods 384:191-5. 2012
    ....
  20. pmc Serologic detection of herpes simplex virus type 2 antibodies among pregnant women using a point-of-care test from Focus Diagnostics
    Bridget Leyland
    Magee Womens Research Institute, Pittsburgh, PA 15213, USA
    J Clin Virol 44:125-8. 2009
    ..Greater acceptance of these tests is hindered by uncertainty regarding their performance in real-world clinical settings...
  21. pmc Longitudinal reliability of focus glycoprotein G-based type-specific enzyme immunoassays for detection of herpes simplex virus types 1 and 2 in women
    Thomas L Cherpes
    Department of Medicine, Division of Infectious Disease, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    J Clin Microbiol 41:671-4. 2003
    ..Overall, the seroreversion rates were low; the use of glycoprotein G-based serologic tests for the measurement of HSV-1 and HSV-2 antibodies in incidence studies therefore appears warranted...
  22. pmc Hypothesis: Chlamydia trachomatis infection of the female genital tract is controlled by Type 2 immunity
    Rodolfo D Vicetti Miguel
    Department of Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    Med Hypotheses 79:713-6. 2012
    ..trachomatis infection in the female genital tract will transform current research, now focused on developing vaccines that elicit strong, and therefore potentially tissue destructive, Chlamydia-specific T(H)1 immunity...
  23. pmc Chlamydia trachomatis infection control programs: lessons learned and implications for vaccine development
    Jean M Chavez
    Department of Pediatrics, University of Pittsburgh School of Medicine, Rangos Research Center, Room 9123, 4401 Penn Avenue, Pittsburgh, PA 15224, USA
    Infect Dis Obstet Gynecol 2011:754060. 2011
    ..In this paper, we detail findings from C. trachomatis infection control programs that increase our understanding of chlamydial immunoepidemiology and discuss their implications for prophylactic vaccine design...
  24. pmc Neonatal herpes simplex virus infection
    Thomas L Cherpes
    Department of Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    Clin Obstet Gynecol 55:938-44. 2012
    ....
  25. ncbi request reprint A triple entente: virus, neurons, and CD8+ T cells maintain HSV-1 latency
    Sherrie Divito
    Graduate Program in Immunology, University of Pittsburgh, Pittsburgh, PA 15123, USA
    Immunol Res 36:119-26. 2006
    ..Exciting new evidence supports the view that CD8+ effector T cells employ both lytic granule-dependent and interferon gamma-dependent effector mechanisms in maintaining HSV-1 latency...
  26. pmc CTL induction of tumoricidal nitric oxide production by intratumoral macrophages is critical for tumor elimination
    Rodolfo D Vicetti Miguel
    Graduate Program in Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    J Immunol 185:6706-18. 2010
    ..In conclusion, the decreased capacity of Ms to produce NO within the ocular microenvironment limits CTL tumoricidal activity allowing ocular tumors to progress...
  27. pmc Comparative genomic analyses of 17 clinical isolates of Gardnerella vaginalis provide evidence of multiple genetically isolated clades consistent with subspeciation into genovars
    Azad Ahmed
    Center for Genomic Sciences, Allegheny Singer Research Institute, Pittsburgh, Pennsylvania, USA
    J Bacteriol 194:3922-37. 2012
    ..Consequently, it may be appropriate to treat these four groups as separate species...
  28. pmc Endometrial leukocyte subpopulations associated with Chlamydia trachomatis, Neisseria gonorrhoeae, and Trichomonas vaginalis genital tract infection
    Seth D Reighard
    Department of Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, PA 15224, USA
    Am J Obstet Gynecol 205:324.e1-7. 2011
    ..The objective of the study was to characterize endometrial inflammation associated with common genital tract pathogens...
  29. pmc Haemophilus influenzae septic abortion
    Thomas L Cherpes
    Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    Infect Dis Obstet Gynecol 10:161-4. 2002
    ..Furthermore, nontypeable species with a special affinity for the genital tract are the most frequent isolates encountered, and an ascending vaginal or cervical infection is often the suspected route of transmission...

Research Grants2

  1. HSV-2 shedding: role of hormonal contraception and BV
    THOMAS CHERPES; Fiscal Year: 2007
    ..The effects of exogenous sex steroids on the capacity of HSV-specific T lymphocytes to inhibit HSV reactivation in sensory neurons and subsequent shedding on epithelial surfaces in a murine model. ..