Thomas L Cherpes

Summary

Affiliation: University of Pittsburgh
Country: USA

Publications

  1. pmc Chlamydia trachomatis infection control programs: lessons learned and implications for vaccine development
    Jean M Chavez
    Department of Pediatrics, University of Pittsburgh School of Medicine, Rangos Research Center, Room 9123, 4401 Penn Avenue, Pittsburgh, PA 15224, USA
    Infect Dis Obstet Gynecol 2011:754060. 2011
  2. pmc Human female genital tract infection by the obligate intracellular bacterium Chlamydia trachomatis elicits robust Type 2 immunity
    Rodolfo D Vicetti Miguel
    Department of Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    PLoS ONE 8:e58565. 2013
  3. pmc Neonatal herpes simplex virus infection
    Thomas L Cherpes
    Department of Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    Clin Obstet Gynecol 55:938-44. 2012
  4. pmc PD-L1/B7-H1 regulates the survival but not the function of CD8+ T cells in herpes simplex virus type 1 latently infected trigeminal ganglia
    Sohyun Jeon
    Department of Ophthalmology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    J Immunol 190:6277-86. 2013
  5. pmc Transient detection of Chlamydial-specific Th1 memory cells in the peripheral circulation of women with history of Chlamydia trachomatis genital tract infection
    Rodolfo D Vicetti Miguel
    Department of Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, PA 15224, USA
    Am J Reprod Immunol 68:499-506. 2012
  6. pmc Endometrial leukocyte subpopulations associated with Chlamydia trachomatis, Neisseria gonorrhoeae, and Trichomonas vaginalis genital tract infection
    Seth D Reighard
    Department of Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, PA 15224, USA
    Am J Obstet Gynecol 205:324.e1-7. 2011
  7. pmc Reevaluating the CD8 T-cell response to herpes simplex virus type 1: involvement of CD8 T cells reactive to subdominant epitopes
    Brian S Sheridan
    Graduate Program in Immunology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    J Virol 83:2237-45. 2009
  8. pmc 17-beta estradiol promotion of herpes simplex virus type 1 reactivation is estrogen receptor dependent
    Rodolfo D Vicetti Miguel
    Graduate Program in Immunology, Department of Ophthalmology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA corrected
    J Virol 84:565-72. 2010
  9. pmc Use of transcriptional profiling to delineate the initial response of mice to intravaginal herpes simplex virus type 2 infection
    Thomas L Cherpes
    Department of Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15224, USA
    Viral Immunol 26:172-9. 2013
  10. pmc Early CD4(+) T cell help prevents partial CD8(+) T cell exhaustion and promotes maintenance of Herpes Simplex Virus 1 latency
    Gregory M Frank
    Graduate Program in Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    J Immunol 184:277-86. 2010

Collaborators

Detail Information

Publications19

  1. pmc Chlamydia trachomatis infection control programs: lessons learned and implications for vaccine development
    Jean M Chavez
    Department of Pediatrics, University of Pittsburgh School of Medicine, Rangos Research Center, Room 9123, 4401 Penn Avenue, Pittsburgh, PA 15224, USA
    Infect Dis Obstet Gynecol 2011:754060. 2011
    ..In this paper, we detail findings from C. trachomatis infection control programs that increase our understanding of chlamydial immunoepidemiology and discuss their implications for prophylactic vaccine design...
  2. pmc Human female genital tract infection by the obligate intracellular bacterium Chlamydia trachomatis elicits robust Type 2 immunity
    Rodolfo D Vicetti Miguel
    Department of Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    PLoS ONE 8:e58565. 2013
    ..trachomatis in the human female genital tract to control infection and minimize immunopathological damage to vital reproductive structures...
  3. pmc Neonatal herpes simplex virus infection
    Thomas L Cherpes
    Department of Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    Clin Obstet Gynecol 55:938-44. 2012
    ....
  4. pmc PD-L1/B7-H1 regulates the survival but not the function of CD8+ T cells in herpes simplex virus type 1 latently infected trigeminal ganglia
    Sohyun Jeon
    Department of Ophthalmology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    J Immunol 190:6277-86. 2013
    ..Unlike observations in some chronic infection models, B7-H1 blockade did not increase the function of exhausted gB-Tet(-) CD8 T cells in latently infected TG...
  5. pmc Transient detection of Chlamydial-specific Th1 memory cells in the peripheral circulation of women with history of Chlamydia trachomatis genital tract infection
    Rodolfo D Vicetti Miguel
    Department of Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, PA 15224, USA
    Am J Reprod Immunol 68:499-506. 2012
    ..Development of safe and effective Chlamydia trachomatis vaccines requires better understanding of the host immune responses elicited by natural infection...
  6. pmc Endometrial leukocyte subpopulations associated with Chlamydia trachomatis, Neisseria gonorrhoeae, and Trichomonas vaginalis genital tract infection
    Seth D Reighard
    Department of Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, PA 15224, USA
    Am J Obstet Gynecol 205:324.e1-7. 2011
    ..The objective of the study was to characterize endometrial inflammation associated with common genital tract pathogens...
  7. pmc Reevaluating the CD8 T-cell response to herpes simplex virus type 1: involvement of CD8 T cells reactive to subdominant epitopes
    Brian S Sheridan
    Graduate Program in Immunology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    J Virol 83:2237-45. 2009
    ..Identification of the viral proteins recognized by these cells will contribute to a better understanding of the dynamics of HSV-1 latency...
  8. pmc 17-beta estradiol promotion of herpes simplex virus type 1 reactivation is estrogen receptor dependent
    Rodolfo D Vicetti Miguel
    Graduate Program in Immunology, Department of Ophthalmology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA corrected
    J Virol 84:565-72. 2010
    ..Additional research is needed to confirm whether pregnancy or hormonal contraceptives containing 17-betaE also promote HSV reactivation from latency in an estrogen receptor-dependent manner...
  9. pmc Use of transcriptional profiling to delineate the initial response of mice to intravaginal herpes simplex virus type 2 infection
    Thomas L Cherpes
    Department of Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15224, USA
    Viral Immunol 26:172-9. 2013
    ....
  10. pmc Early CD4(+) T cell help prevents partial CD8(+) T cell exhaustion and promotes maintenance of Herpes Simplex Virus 1 latency
    Gregory M Frank
    Graduate Program in Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    J Immunol 184:277-86. 2010
    ..CD4(+) T cells are not needed to maintain CD8(+) T cell memory through 34 d after infection, nor do they have a direct involvement in the maintenance of HSV-1 latency...
  11. pmc Brefeldin A, but not monensin, enables flow cytometric detection of interleukin-4 within peripheral T cells responding to ex vivo stimulation with Chlamydia trachomatis
    Rodolfo D Vicetti Miguel
    Department of Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, PA 15224, USA
    J Immunol Methods 384:191-5. 2012
    ....
  12. pmc Dendritic cell activation and memory cell development are impaired among mice administered medroxyprogesterone acetate prior to mucosal herpes simplex virus type 1 infection
    Rodolfo D Vicetti Miguel
    Department of Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, PA 15224, USA
    J Immunol 189:3449-61. 2012
    ..Taken together, our results reveal that the administration of MPA prior to viral infection of mucosal tissue impairs DC activation, virus-specific T cell expansion, and development of virus-specific immunological memory...
  13. pmc Recalcitrance of bacterial vaginosis among herpes-simplex-virus-type-2-seropositive women
    Kevin A Stoner
    Departments of Obstetrics and Gynecology and Reproductive Sciences Pediatrics Medicine Pathology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    J Obstet Gynaecol Res 38:77-83. 2012
    ..Herein, we evaluated the effects of herpes simplex virus type 2 (HSV-2), a suspected BV risk factor, on vaginal flora composition...
  14. pmc Hypothesis: Chlamydia trachomatis infection of the female genital tract is controlled by Type 2 immunity
    Rodolfo D Vicetti Miguel
    Department of Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    Med Hypotheses 79:713-6. 2012
    ..trachomatis infection in the female genital tract will transform current research, now focused on developing vaccines that elicit strong, and therefore potentially tissue destructive, Chlamydia-specific T(H)1 immunity...
  15. pmc CTL induction of tumoricidal nitric oxide production by intratumoral macrophages is critical for tumor elimination
    Rodolfo D Vicetti Miguel
    Graduate Program in Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    J Immunol 185:6706-18. 2010
    ..In conclusion, the decreased capacity of Ms to produce NO within the ocular microenvironment limits CTL tumoricidal activity allowing ocular tumors to progress...
  16. pmc Limitations of the criteria used to diagnose histologic endometritis in epidemiologic pelvic inflammatory disease research
    Rodolfo D Vicetti Miguel
    University of Pittsburgh School of Medicine, Department of Pediatrics, PA 15224, USA
    Pathol Res Pract 207:680-5. 2011
    ....
  17. pmc Serologic detection of herpes simplex virus type 2 antibodies among pregnant women using a point-of-care test from Focus Diagnostics
    Bridget Leyland
    Magee Womens Research Institute, Pittsburgh, PA 15213, USA
    J Clin Virol 44:125-8. 2009
    ..Greater acceptance of these tests is hindered by uncertainty regarding their performance in real-world clinical settings...
  18. pmc Medroxyprogesterone acetate inhibits CD8+ T cell viral-specific effector function and induces herpes simplex virus type 1 reactivation
    Thomas L Cherpes
    Department of Obstetrics, Gynecology, and Reproductive Sciences, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    J Immunol 181:969-75. 2008
    ....