Research Topics
Species | M ChernerSummaryAffiliation: University of California Country: USA Publications
Research Grants
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Detail Information
Publications
Impact of childhood trauma on functionality and quality of life in HIV-infected womenZyrhea C E Troeman
South African Research Chairs Initiative SARChI, PTSD Program, Department of Psychiatry, University of Stellenbosch, Cape Town, South Africa
Health Qual Life Outcomes 9:84. 2011..While there are many published studies on HIV and functional limitations, there are few in the context of early abuse and its impact on functionality and Quality of Life (QoL) in HIV...
Neurocognitive dysfunction predicts postmortem findings of HIV encephalitisM Cherner
Departments of Psychiatry, University of California at San Diego, CA 92103, USA
Neurology 59:1563-7. 2002..To investigate the value of antemortem cognitive functioning in predicting postmortem evidence of HIV encephalitis (HIVE)...- Equivalency of Spanish language versions of the trail making test part B including or excluding "CH"Mariana Cherner
Department of Psychiatry, University of California San Diego, La Jolla, California, USA
Clin Neuropsychol 22:662-5. 2008..The findings suggest that both versions are equivalent and can be administered to Spanish speakers based on their preference without sacrificing comparability... - Cytochrome P450-2D6 extensive metabolizers are more vulnerable to methamphetamine-associated neurocognitive impairment: preliminary findingsMariana Cherner
Department of Psychiatry, University of California San Diego, La Jolla, California 92093 0847, USA
J Int Neuropsychol Soc 16:890-901. 2010..This preliminary study is the first to suggest that efficient meth metabolism is associated with worse neurocognitive outcomes in humans, and implicates the products of oxidative metabolism of meth as a possible source of brain injury... - Neuropathologic confirmation of definitional criteria for human immunodeficiency virus-associated neurocognitive disordersMariana Cherner
Departments of Psychiatry, University of California San Diego, San Diego, California 92103, USA
J Neurovirol 13:23-8. 2007..The modifications to the AAN 1991 criteria proposed by the HNRC and others in the field have served as a point of departure for a recently revised consensus nomenclature... - Demographically corrected norms for the Brief Visuospatial Memory Test-revised and Hopkins Verbal Learning Test-revised in monolingual Spanish speakers from the U.S.-Mexico border regionM Cherner
Department of Psychiatry, University of California San Diego, HIV Neurobehavioral Research Center, San Diego, CA92103, USA
Arch Clin Neuropsychol 22:343-53. 2007..Because the age range of our sample was limited, the norms presented should not be applied to elderly populations... - Hepatitis C augments cognitive deficits associated with HIV infection and methamphetamineM Cherner
Department of Psychiatry, University of California San Diego, San Diego, CA 92103, USA
Neurology 64:1343-7. 2005..To examine the contribution of hepatitis C virus (HCV) infection to neurocognitive dysfunction in individuals with comorbid HIV infection or methamphetamine (METH) dependence... - Variable patterns of neuropsychological performance in HIV-1 infectionS Dawes
Department of Psychiatry, HIV Neurobehavioral Research Center, University of California San Diego, San Diego, CA 92093 0603, USA
J Clin Exp Neuropsychol 30:613-26. 2008..Thus, there does not appear to be a single, prototypical pattern of neuropsychological impairment associated with HIV infection for this battery of representative neuropsychological tests... - Negative mood and sexual behavior among non-monogamous men who have sex with men in the context of methamphetamine and HIVC A Bousman
University of California San Diego, HIV Neurobehavioral Research Center, Department of Psychiatry, La Jolla, California 92103, USA
J Affect Disord 119:84-91. 2009..This study examined the contextual influence of METH, HIV-infection and their combination on mood states and sexual behavior... - Dynamics of cognitive change in impaired HIV-positive patients initiating antiretroviral therapyL A Cysique
Department of Psychiatry, University of California at San Diego, CA, USA
Neurology 73:342-8. 2009.... - Low CSF leptin levels are associated with worse learning and memory performance in HIV-infected menJ S Huang
Department of Pediatrics, University of California, San Diego, USA
J Neuroimmune Pharmacol 2:352-8. 2007..We hypothesized that human CSF leptin levels positively correlate with NP performance... - Methamphetamine use parameters do not predict neuropsychological impairment in currently abstinent dependent adultsMariana Cherner
Department of Psychiatry, University of California San Diego School of Medicine, 9500 Gilman Drive, La Jolla, CA 92093 0847, USA
Drug Alcohol Depend 106:154-63. 2010..The apparent lack of correspondence between substance use parameters and cognitive impairment suggests the need for further study of individual differences in vulnerability to the neurotoxic effects of methamphetamine... - Cognitive deficits and degeneration of interneurons in HIV+ methamphetamine usersG Chana
Department of Neurosciences, University of California San Diego, La Jolla, CA 92093-0624, USA
Neurology 67:1486-9. 2006..Compared with other markers, loss of calbindin and parvalbumin interneurons in the frontal cortex was the most significant correlate to memory deficits, suggesting a role in neurobehavioral alterations of HIV+ METH users... - Cliniconeuropathologic correlates of human immunodeficiency virus in the era of antiretroviral therapyI Everall
HIV Neurobehavioral Research Center HNRC, University of California, San Diego, La Jolla, California 92093 0603, USA
J Neurovirol 15:360-70. 2009..Noninfectious pathologies and minimal changes correlated with HIV-associated neurocognitive disorder, suggesting a shift in pathogenesis from florid HIV replication to other, diverse mechanisms... - Significance testing of a cluster of multivariate binary variables: comparison of the tripartite T index to three common similarity measuresR Deutsch
Department of Family and Preventive Medicine, University of California San Diego, CA 92103 8203, USA
Stat Methods Med Res 15:285-99. 2006..Some shortcomings with the Tulloss algorithm were found and limit the usefulness of the tripartite T index in medical applications... - Prospective memory deficits are associated with unemployment in persons living with HIV infectionSteven Paul Woods
Department of Psychiatry, University of California, San Diego, USA
Rehabil Psychol 56:77-84. 2011..To determine whether deficits in prospective memory (i.e., "remembering to remember") confer an increased risk of unemployment in individuals living with chronic HIV infection... - Select resistance-associated mutations in blood are associated with lower CSF viral loads and better neuropsychological performanceGeorge K Hightower
University of California, San Diego, La Jolla, CA 92037, USA
Virology 394:243-8. 2009..Our study evaluated whether antiretroviral resistance was associated with viral loads in the cerebrospinal fluid (CSF) and better neuropsychological (NP) performance... - The semantic relatedness of cue-intention pairings influences event-based prospective memory failures in older adults with HIV infectionSteven Paul Woods
HIV Neurobehavioral Research Center, Department of Psychiatry, University of California, San Diego, CA 92103, USA
J Clin Exp Neuropsychol 32:398-407. 2010.... - HIV-associated neurocognitive disorders before and during the era of combination antiretroviral therapy: differences in rates, nature, and predictorsRobert K Heaton
University of California, San Diego, CA, USA
J Neurovirol 17:3-16. 2011..Clinical trials targeting HAND prevention should specifically examine timing of ART initiation... - Spontaneous strategy use protects against visual working memory deficits in older adults infected with HIVSteven Paul Woods
Department of Psychiatry, University of California San Diego, La Jolla, USA
Arch Clin Neuropsychol 25:724-33. 2010.... - Interrater reliability of clinical ratings and neurocognitive diagnoses in HIVSteven Paul Woods
University of California, San Diego, CA 92103, USA
J Clin Exp Neuropsychol 26:759-78. 2004..Not surprisingly, most diagnostic disagreements concerned the etiology of impairments in persons with medical and neuropsychiatric risk factors in addition to HIV... - Preliminary evidence of ethnic divergence in associations of putative genetic variants for methamphetamine dependenceChad A Bousman
Department of Psychiatry, University of California San Diego, La Jolla, CA 92103, USA
Psychiatry Res 178:295-8. 2010..Results provide preliminary support for further exploration and validation of candidate single nucleotide polymorphisms (SNPs) for methamphetamine (METH) dependence reported among Asian populations across other ethnic/ancestral groups... - Longer term improvement in neurocognitive functioning and affective distress among methamphetamine users who achieve stable abstinenceJennifer E Iudicello
Department of Psychiatry, HIV Neurobehavioral Research Center, University of California, San Diego, School of Medicine, La Jolla, CA 92103, USA
J Clin Exp Neuropsychol 32:704-18. 2010..These results suggest partial recovery of neuropsychological functioning and improvement in affective distress upon sustained abstinence from MA that may extend beyond a year or more... - Pleocytosis is associated with disruption of HIV compartmentalization between blood and cerebral spinal fluid viral populationsDavey M Smith
University of California San Diego, La Jolla, 92093, USA
Virology 385:204-8. 2009.... - Cortical and subcortical neurodegeneration is associated with HIV neurocognitive impairmentDavid J Moore
HIV Neurobehavioral Research Center and University of California, San Diego, California 92161, USA
AIDS 20:879-87. 2006..To determine the association of markers of regional neurodegeneration (ND) at autopsy to degree of neurocognitive impairment in persons with HIV... - Deficient strategic control of verbal encoding and retrieval in individuals with methamphetamine dependenceSteven Paul Woods
HIV Neurobehavioral Research Center, University of California, San Diego, San Diego, CA 92103, USA
Neuropsychology 19:35-43. 2005..e., executive) control of verbal encoding and retrieval, which is consistent with the sequelae of MA-related prefronto-striatal circuit neurotoxicity... - Neurocognitive performance of methamphetamine users discordant for history of marijuana exposureRaul Gonzalez
HIV Neurobehavioral Research Center, University of California, San Diego, 150 W. Washington Street, 2nd Floor, San Diego, CA 92103, USA
Drug Alcohol Depend 76:181-90. 2004..Further investigations are needed to determine if the emerging literature, suggesting that certain cannabinoids might have neuroprotective actions, is generalizable to community-dwelling substance abusers... - Increased human immunodeficiency virus loads in active methamphetamine users are explained by reduced effectiveness of antiretroviral therapyRonald J Ellis
Department of Neurosciences, University of California San Diego, San Diego, California, USA
J Infect Dis 188:1820-6. 2003..In contrast, abstinent former METH abusers (METH(+)Tox-) receiving HAART effectively suppressed viral replication. These data suggest that abstinence programs are a key component of effective treatment of HIV in METH-abusing populations... - Prospective memory in HIV infection: is "remembering to remember" a unique predictor of self-reported medication management?Steven Paul Woods
Department of Psychiatry, HIV Neurobehavioral Research Center, University of California, San Diego, School of Medicine, La Jolla, CA 92093, USA
Arch Clin Neuropsychol 23:257-70. 2008..The potential benefits of individualized remediation strategies that are informed by conceptual models of ProM and specifically target medication adherence warrant further exploration... - Psychometric characteristics of the memory for intentions screening testSteven Paul Woods
Department of Psychiatry, University of California, San Diego, CA, USA
Clin Neuropsychol 22:864-78. 2008..Recommendations are provided regarding future research to enhance the clinical usefulness of the MIST... - Neurobehavioral effects of human immunodeficiency virus infection among former plasma donors in rural ChinaRobert K Heaton
HIV Neurobehavioral Research Center HNRC, Department of Psychiatry, University of California at San Diego, San Diego, California 92093 0603, USA
J Neurovirol 14:536-49. 2008..These findings indicate that HAND is likely to be an important feature of HIV infection in developing countries, underscoring the need for international efforts to develop CNS-relevant treatments... - Computerized reaction time battery versus a traditional neuropsychological battery: detecting HIV-related impairmentsRaul Gonzalez
HIV Neurobehavioral Research Center HNRC, University of California, San Diego, 150 West Washington Street, 2nd Floor, San Diego, CA 92103, USA
J Int Neuropsychol Soc 9:64-71. 2003..44). Data from this study suggest that traditional NP batteries and computerized reaction time tests do not measure the same thing, and are not interchangeable in examining HIV-related NP impairments... - The effects of hepatitis C, HIV, and methamphetamine dependence on neuropsychological performance: biological correlates of diseaseScott L Letendre
Department of Medicine, University of California San Diego, CA 92103, USA
AIDS 19:S72-8. 2005..To determine the effects of hepatitis C virus (HCV) infection on neuropsychological (NP) performance... - COMT Val158Met Polymorphism, Executive Dysfunction, and Sexual Risk Behavior in the Context of HIV Infection and Methamphetamine DependenceC A Bousman
Department of Psychiatry, University of California San Diego, La Jolla, CA 92103, USA
Interdiscip Perspect Infect Dis 2010:678648. 2010.... - The functional impact of HIV-associated neuropsychological impairment in Spanish-speaking adults: a pilot studyMonica Rivera Mindt
Department of Psychiatry, University of California, San Diego, CA 92103, USA
J Clin Exp Neuropsychol 25:122-32. 2003..These results, though preliminary, suggest that Spanish language functional assessments are potentially valid tools for detecting everyday functioning deficits associated with NP impairments in HIV-infected Spanish-speakers... 
Increased frequency of alpha-synuclein in the substantia nigra in human immunodeficiency virus infectionNegar Khanlou
Department of Pathology and Laboratory Medicine, Division of Neuropathology, David Geffen School of Medicine, Ronald Reagan UCLA Medical Center, Los Angeles, California, USA
J Neurovirol 15:131-8. 2009..The increased prevalence of alpha-synuclein and beta-amyloid in the brains of older HIV-infected individuals may predict an increased risk of developing neurodegenerative disease...- Pathogenesis of hepatitis C virus coinfection in the brains of patients infected with HIVScott Letendre
Department of Medicine, University of California, San Diego, La Jolla, CA 92093 0624, USA
J Infect Dis 196:361-70. 2007..The results support the hypothesis that HCV traffics into the HIV-infected brain, where it might lead to a productive coinfection associated with cognitive impairment... - Co-factors in HIV neurobehavioural disturbances: substance abuse, hepatitis C and agingRaul Gonzalez
Department of Psychiatry, University of Illinois, Chicago, IL, USA
Int Rev Psychiatry 20:49-60. 2008..As aging confers additional metabolic, neurologic, and neuropsychiatric vulnerability, it is important to understand how this constellation of changes affects neurocognitive functioning in the context of HIV... - Differential expression of immunophilins FKBP51 and FKBP52 in the frontal cortex of HIV-infected patients with major depressive disorderErick T Tatro
Department of Psychiatry 0603, University of California at San Diego, La Jolla, San Diego, CA 92093 0603, USA
J Neuroimmune Pharmacol 4:218-26. 2009..Instead, an increase in FKBP51 at both the transcript (FKBP5) and protein level correlated with MDD. Increased FKBP4 expression of correlated to HIV(+)MDD but not to HIV without MDD... - Increased accumulation of intraneuronal amyloid beta in HIV-infected patientsCristian L Achim
Department of Psychiatry, University of California, San Diego, CA 92093 0624, USA
J Neuroimmune Pharmacol 4:190-9. 2009..These findings suggest that long-term survival with HIV might interfere with clearance of proteins such as Abeta and worsen neuronal damage and cognitive impairment in this population... - Implications of hepatitis C virus infection for behavioral symptoms and activities of daily livingCarolina Posada
San Diego State University University of California, San Diego Joint Doctoral Program in Clinical Psychology, San Diego, CA, USA
J Clin Exp Neuropsychol 32:637-44. 2010..These results show that a subset of HCV-infected individuals report clinically elevated behavioral symptoms. Clinical implications for the assessment and management of elevated behavioral symptoms in HCV are discussed... - The 50 and 100-item short forms of the Paced Auditory Serial Addition Task (PASAT): demographically corrected norms and comparisons with the full PASAT in normal and clinical samplesMichael C Diehr
College of Business Administration, California State University San Marcos, San Marcos, CA, USA
J Clin Exp Neuropsychol 25:571-85. 2003..0 vs. 5.9 on a 10-point scale, p < .05). We conclude that in many cases the PASAT-50 and PASAT-100 provide equivalent diagnostic accuracy with a significant reduction in administration time and patient discomfort...
Research Grants
- Neurocognitive Consequences of MDMA Use in HIVMariana Cherner; Fiscal Year: 2003..It is anticipated that this pilot project will lead to a larger-scale, prospective investigation of the combined neurocognitive effects of HIV and MDMA. ..
- Functional & Cognitive Impact of HIV in Spanish SpeakersMariana Cherner; Fiscal Year: 2007..abstract_text> ..
- COMT Genotype and Risky Decision Making in HIV and Methamphetamine DependenceMariana Cherner; Fiscal Year: 2010..Findings will add to the understanding of individual differences in response to risk-reduction interventions and have the potential to inform the tailoring of future interventions. ..