M Cherner

Summary

Affiliation: University of California
Country: USA

Publications

  1. pmc Impact of childhood trauma on functionality and quality of life in HIV-infected women
    Zyrhea C E Troeman
    South African Research Chairs Initiative SARChI, PTSD Program, Department of Psychiatry, University of Stellenbosch, Cape Town, South Africa
    Health Qual Life Outcomes 9:84. 2011
  2. ncbi request reprint Neurocognitive dysfunction predicts postmortem findings of HIV encephalitis
    M Cherner
    Departments of Psychiatry, University of California at San Diego, CA 92103, USA
    Neurology 59:1563-7. 2002
  3. pmc Equivalency of Spanish language versions of the trail making test part B including or excluding "CH"
    Mariana Cherner
    Department of Psychiatry, University of California San Diego, La Jolla, California, USA
    Clin Neuropsychol 22:662-5. 2008
  4. pmc Cytochrome P450-2D6 extensive metabolizers are more vulnerable to methamphetamine-associated neurocognitive impairment: preliminary findings
    Mariana Cherner
    Department of Psychiatry, University of California San Diego, La Jolla, California 92093 0847, USA
    J Int Neuropsychol Soc 16:890-901. 2010
  5. ncbi request reprint Neuropathologic confirmation of definitional criteria for human immunodeficiency virus-associated neurocognitive disorders
    Mariana Cherner
    Departments of Psychiatry, University of California San Diego, San Diego, California 92103, USA
    J Neurovirol 13:23-8. 2007
  6. pmc Demographically corrected norms for the Brief Visuospatial Memory Test-revised and Hopkins Verbal Learning Test-revised in monolingual Spanish speakers from the U.S.-Mexico border region
    M Cherner
    Department of Psychiatry, University of California San Diego, HIV Neurobehavioral Research Center, San Diego, CA92103, USA
    Arch Clin Neuropsychol 22:343-53. 2007
  7. ncbi request reprint Hepatitis C augments cognitive deficits associated with HIV infection and methamphetamine
    M Cherner
    Department of Psychiatry, University of California San Diego, San Diego, CA 92103, USA
    Neurology 64:1343-7. 2005
  8. pmc Variable patterns of neuropsychological performance in HIV-1 infection
    S Dawes
    Department of Psychiatry, HIV Neurobehavioral Research Center, University of California San Diego, San Diego, CA 92093 0603, USA
    J Clin Exp Neuropsychol 30:613-26. 2008
  9. pmc Negative mood and sexual behavior among non-monogamous men who have sex with men in the context of methamphetamine and HIV
    C A Bousman
    University of California San Diego, HIV Neurobehavioral Research Center, Department of Psychiatry, La Jolla, California 92103, USA
    J Affect Disord 119:84-91. 2009
  10. pmc Dynamics of cognitive change in impaired HIV-positive patients initiating antiretroviral therapy
    L A Cysique
    Department of Psychiatry, University of California at San Diego, CA, USA
    Neurology 73:342-8. 2009

Collaborators

Detail Information

Publications42

  1. pmc Impact of childhood trauma on functionality and quality of life in HIV-infected women
    Zyrhea C E Troeman
    South African Research Chairs Initiative SARChI, PTSD Program, Department of Psychiatry, University of Stellenbosch, Cape Town, South Africa
    Health Qual Life Outcomes 9:84. 2011
    ..While there are many published studies on HIV and functional limitations, there are few in the context of early abuse and its impact on functionality and Quality of Life (QoL) in HIV...
  2. ncbi request reprint Neurocognitive dysfunction predicts postmortem findings of HIV encephalitis
    M Cherner
    Departments of Psychiatry, University of California at San Diego, CA 92103, USA
    Neurology 59:1563-7. 2002
    ..To investigate the value of antemortem cognitive functioning in predicting postmortem evidence of HIV encephalitis (HIVE)...
  3. pmc Equivalency of Spanish language versions of the trail making test part B including or excluding "CH"
    Mariana Cherner
    Department of Psychiatry, University of California San Diego, La Jolla, California, USA
    Clin Neuropsychol 22:662-5. 2008
    ..The findings suggest that both versions are equivalent and can be administered to Spanish speakers based on their preference without sacrificing comparability...
  4. pmc Cytochrome P450-2D6 extensive metabolizers are more vulnerable to methamphetamine-associated neurocognitive impairment: preliminary findings
    Mariana Cherner
    Department of Psychiatry, University of California San Diego, La Jolla, California 92093 0847, USA
    J Int Neuropsychol Soc 16:890-901. 2010
    ..This preliminary study is the first to suggest that efficient meth metabolism is associated with worse neurocognitive outcomes in humans, and implicates the products of oxidative metabolism of meth as a possible source of brain injury...
  5. ncbi request reprint Neuropathologic confirmation of definitional criteria for human immunodeficiency virus-associated neurocognitive disorders
    Mariana Cherner
    Departments of Psychiatry, University of California San Diego, San Diego, California 92103, USA
    J Neurovirol 13:23-8. 2007
    ..The modifications to the AAN 1991 criteria proposed by the HNRC and others in the field have served as a point of departure for a recently revised consensus nomenclature...
  6. pmc Demographically corrected norms for the Brief Visuospatial Memory Test-revised and Hopkins Verbal Learning Test-revised in monolingual Spanish speakers from the U.S.-Mexico border region
    M Cherner
    Department of Psychiatry, University of California San Diego, HIV Neurobehavioral Research Center, San Diego, CA92103, USA
    Arch Clin Neuropsychol 22:343-53. 2007
    ..Because the age range of our sample was limited, the norms presented should not be applied to elderly populations...
  7. ncbi request reprint Hepatitis C augments cognitive deficits associated with HIV infection and methamphetamine
    M Cherner
    Department of Psychiatry, University of California San Diego, San Diego, CA 92103, USA
    Neurology 64:1343-7. 2005
    ..To examine the contribution of hepatitis C virus (HCV) infection to neurocognitive dysfunction in individuals with comorbid HIV infection or methamphetamine (METH) dependence...
  8. pmc Variable patterns of neuropsychological performance in HIV-1 infection
    S Dawes
    Department of Psychiatry, HIV Neurobehavioral Research Center, University of California San Diego, San Diego, CA 92093 0603, USA
    J Clin Exp Neuropsychol 30:613-26. 2008
    ..Thus, there does not appear to be a single, prototypical pattern of neuropsychological impairment associated with HIV infection for this battery of representative neuropsychological tests...
  9. pmc Negative mood and sexual behavior among non-monogamous men who have sex with men in the context of methamphetamine and HIV
    C A Bousman
    University of California San Diego, HIV Neurobehavioral Research Center, Department of Psychiatry, La Jolla, California 92103, USA
    J Affect Disord 119:84-91. 2009
    ..This study examined the contextual influence of METH, HIV-infection and their combination on mood states and sexual behavior...
  10. pmc Dynamics of cognitive change in impaired HIV-positive patients initiating antiretroviral therapy
    L A Cysique
    Department of Psychiatry, University of California at San Diego, CA, USA
    Neurology 73:342-8. 2009
    ....
  11. ncbi request reprint Low CSF leptin levels are associated with worse learning and memory performance in HIV-infected men
    J S Huang
    Department of Pediatrics, University of California, San Diego, USA
    J Neuroimmune Pharmacol 2:352-8. 2007
    ..We hypothesized that human CSF leptin levels positively correlate with NP performance...
  12. pmc Methamphetamine use parameters do not predict neuropsychological impairment in currently abstinent dependent adults
    Mariana Cherner
    Department of Psychiatry, University of California San Diego School of Medicine, 9500 Gilman Drive, La Jolla, CA 92093 0847, USA
    Drug Alcohol Depend 106:154-63. 2010
    ..The apparent lack of correspondence between substance use parameters and cognitive impairment suggests the need for further study of individual differences in vulnerability to the neurotoxic effects of methamphetamine...
  13. ncbi request reprint Cognitive deficits and degeneration of interneurons in HIV+ methamphetamine users
    G Chana
    Department of Neurosciences, University of California San Diego, La Jolla, CA 92093 0624, USA
    Neurology 67:1486-9. 2006
    ..Compared with other markers, loss of calbindin and parvalbumin interneurons in the frontal cortex was the most significant correlate to memory deficits, suggesting a role in neurobehavioral alterations of HIV+ METH users...
  14. pmc Cliniconeuropathologic correlates of human immunodeficiency virus in the era of antiretroviral therapy
    I Everall
    HIV Neurobehavioral Research Center HNRC, University of California, San Diego, La Jolla, California 92093 0603, USA
    J Neurovirol 15:360-70. 2009
    ..Noninfectious pathologies and minimal changes correlated with HIV-associated neurocognitive disorder, suggesting a shift in pathogenesis from florid HIV replication to other, diverse mechanisms...
  15. ncbi request reprint Significance testing of a cluster of multivariate binary variables: comparison of the tripartite T index to three common similarity measures
    R Deutsch
    Department of Family and Preventive Medicine, University of California San Diego, CA 92103 8203, USA
    Stat Methods Med Res 15:285-99. 2006
    ..Some shortcomings with the Tulloss algorithm were found and limit the usefulness of the tripartite T index in medical applications...
  16. pmc Prospective memory deficits are associated with unemployment in persons living with HIV infection
    Steven Paul Woods
    Department of Psychiatry, University of California, San Diego, USA
    Rehabil Psychol 56:77-84. 2011
    ..To determine whether deficits in prospective memory (i.e., "remembering to remember") confer an increased risk of unemployment in individuals living with chronic HIV infection...
  17. pmc Select resistance-associated mutations in blood are associated with lower CSF viral loads and better neuropsychological performance
    George K Hightower
    University of California, San Diego, La Jolla, CA 92037, USA
    Virology 394:243-8. 2009
    ..Our study evaluated whether antiretroviral resistance was associated with viral loads in the cerebrospinal fluid (CSF) and better neuropsychological (NP) performance...
  18. pmc The semantic relatedness of cue-intention pairings influences event-based prospective memory failures in older adults with HIV infection
    Steven Paul Woods
    HIV Neurobehavioral Research Center, Department of Psychiatry, University of California, San Diego, CA 92103, USA
    J Clin Exp Neuropsychol 32:398-407. 2010
    ....
  19. pmc HIV-associated neurocognitive disorders before and during the era of combination antiretroviral therapy: differences in rates, nature, and predictors
    Robert K Heaton
    University of California, San Diego, CA, USA
    J Neurovirol 17:3-16. 2011
    ..Clinical trials targeting HAND prevention should specifically examine timing of ART initiation...
  20. pmc Spontaneous strategy use protects against visual working memory deficits in older adults infected with HIV
    Steven Paul Woods
    Department of Psychiatry, University of California San Diego, La Jolla, USA
    Arch Clin Neuropsychol 25:724-33. 2010
    ....
  21. ncbi request reprint Interrater reliability of clinical ratings and neurocognitive diagnoses in HIV
    Steven Paul Woods
    University of California, San Diego, CA 92103, USA
    J Clin Exp Neuropsychol 26:759-78. 2004
    ..Not surprisingly, most diagnostic disagreements concerned the etiology of impairments in persons with medical and neuropsychiatric risk factors in addition to HIV...
  22. pmc Preliminary evidence of ethnic divergence in associations of putative genetic variants for methamphetamine dependence
    Chad A Bousman
    Department of Psychiatry, University of California San Diego, La Jolla, CA 92103, USA
    Psychiatry Res 178:295-8. 2010
    ..Results provide preliminary support for further exploration and validation of candidate single nucleotide polymorphisms (SNPs) for methamphetamine (METH) dependence reported among Asian populations across other ethnic/ancestral groups...
  23. pmc Longer term improvement in neurocognitive functioning and affective distress among methamphetamine users who achieve stable abstinence
    Jennifer E Iudicello
    Department of Psychiatry, HIV Neurobehavioral Research Center, University of California, San Diego, School of Medicine, La Jolla, CA 92103, USA
    J Clin Exp Neuropsychol 32:704-18. 2010
    ..These results suggest partial recovery of neuropsychological functioning and improvement in affective distress upon sustained abstinence from MA that may extend beyond a year or more...
  24. pmc Pleocytosis is associated with disruption of HIV compartmentalization between blood and cerebral spinal fluid viral populations
    Davey M Smith
    University of California San Diego, La Jolla, 92093, USA
    Virology 385:204-8. 2009
    ....
  25. ncbi request reprint Cortical and subcortical neurodegeneration is associated with HIV neurocognitive impairment
    David J Moore
    HIV Neurobehavioral Research Center and University of California, San Diego, California 92161, USA
    AIDS 20:879-87. 2006
    ..To determine the association of markers of regional neurodegeneration (ND) at autopsy to degree of neurocognitive impairment in persons with HIV...
  26. ncbi request reprint Deficient strategic control of verbal encoding and retrieval in individuals with methamphetamine dependence
    Steven Paul Woods
    HIV Neurobehavioral Research Center, University of California, San Diego, San Diego, CA 92103, USA
    Neuropsychology 19:35-43. 2005
    ..e., executive) control of verbal encoding and retrieval, which is consistent with the sequelae of MA-related prefronto-striatal circuit neurotoxicity...
  27. ncbi request reprint Neurocognitive performance of methamphetamine users discordant for history of marijuana exposure
    Raul Gonzalez
    HIV Neurobehavioral Research Center, University of California, San Diego, 150 W Washington Street, 2nd Floor, San Diego, CA 92103, USA
    Drug Alcohol Depend 76:181-90. 2004
    ..Further investigations are needed to determine if the emerging literature, suggesting that certain cannabinoids might have neuroprotective actions, is generalizable to community-dwelling substance abusers...
  28. ncbi request reprint Increased human immunodeficiency virus loads in active methamphetamine users are explained by reduced effectiveness of antiretroviral therapy
    Ronald J Ellis
    Department of Neurosciences, University of California San Diego, San Diego, California, USA
    J Infect Dis 188:1820-6. 2003
    ..In contrast, abstinent former METH abusers (METH(+)Tox-) receiving HAART effectively suppressed viral replication. These data suggest that abstinence programs are a key component of effective treatment of HIV in METH-abusing populations...
  29. pmc Prospective memory in HIV infection: is "remembering to remember" a unique predictor of self-reported medication management?
    Steven Paul Woods
    Department of Psychiatry, HIV Neurobehavioral Research Center, University of California, San Diego, School of Medicine, La Jolla, CA 92093, USA
    Arch Clin Neuropsychol 23:257-70. 2008
    ..The potential benefits of individualized remediation strategies that are informed by conceptual models of ProM and specifically target medication adherence warrant further exploration...
  30. pmc Psychometric characteristics of the memory for intentions screening test
    Steven Paul Woods
    Department of Psychiatry, University of California, San Diego, CA, USA
    Clin Neuropsychol 22:864-78. 2008
    ..Recommendations are provided regarding future research to enhance the clinical usefulness of the MIST...
  31. pmc Neurobehavioral effects of human immunodeficiency virus infection among former plasma donors in rural China
    Robert K Heaton
    HIV Neurobehavioral Research Center HNRC, Department of Psychiatry, University of California at San Diego, San Diego, California 92093 0603, USA
    J Neurovirol 14:536-49. 2008
    ..These findings indicate that HAND is likely to be an important feature of HIV infection in developing countries, underscoring the need for international efforts to develop CNS-relevant treatments...
  32. ncbi request reprint Computerized reaction time battery versus a traditional neuropsychological battery: detecting HIV-related impairments
    Raul Gonzalez
    HIV Neurobehavioral Research Center HNRC, University of California, San Diego, 150 West Washington Street, 2nd Floor, San Diego, CA 92103, USA
    J Int Neuropsychol Soc 9:64-71. 2003
    ..44). Data from this study suggest that traditional NP batteries and computerized reaction time tests do not measure the same thing, and are not interchangeable in examining HIV-related NP impairments...
  33. ncbi request reprint The effects of hepatitis C, HIV, and methamphetamine dependence on neuropsychological performance: biological correlates of disease
    Scott L Letendre
    Department of Medicine, University of California San Diego, CA 92103, USA
    AIDS 19:S72-8. 2005
    ..To determine the effects of hepatitis C virus (HCV) infection on neuropsychological (NP) performance...
  34. pmc COMT Val158Met Polymorphism, Executive Dysfunction, and Sexual Risk Behavior in the Context of HIV Infection and Methamphetamine Dependence
    C A Bousman
    Department of Psychiatry, University of California San Diego, La Jolla, CA 92103, USA
    Interdiscip Perspect Infect Dis 2010:678648. 2010
    ....
  35. pmc The functional impact of HIV-associated neuropsychological impairment in Spanish-speaking adults: a pilot study
    Monica Rivera Mindt
    Department of Psychiatry, University of California, San Diego, CA 92103, USA
    J Clin Exp Neuropsychol 25:122-32. 2003
    ..These results, though preliminary, suggest that Spanish language functional assessments are potentially valid tools for detecting everyday functioning deficits associated with NP impairments in HIV-infected Spanish-speakers...
  36. doi request reprint Increased frequency of alpha-synuclein in the substantia nigra in human immunodeficiency virus infection
    Negar Khanlou
    Department of Pathology and Laboratory Medicine, Division of Neuropathology, David Geffen School of Medicine, Ronald Reagan UCLA Medical Center, Los Angeles, California, USA
    J Neurovirol 15:131-8. 2009
    ..The increased prevalence of alpha-synuclein and beta-amyloid in the brains of older HIV-infected individuals may predict an increased risk of developing neurodegenerative disease...
  37. ncbi request reprint Pathogenesis of hepatitis C virus coinfection in the brains of patients infected with HIV
    Scott Letendre
    Department of Medicine, University of California, San Diego, La Jolla, CA 92093 0624, USA
    J Infect Dis 196:361-70. 2007
    ..The results support the hypothesis that HCV traffics into the HIV-infected brain, where it might lead to a productive coinfection associated with cognitive impairment...
  38. doi request reprint Co-factors in HIV neurobehavioural disturbances: substance abuse, hepatitis C and aging
    Raul Gonzalez
    Department of Psychiatry, University of Illinois, Chicago, IL, USA
    Int Rev Psychiatry 20:49-60. 2008
    ..As aging confers additional metabolic, neurologic, and neuropsychiatric vulnerability, it is important to understand how this constellation of changes affects neurocognitive functioning in the context of HIV...
  39. pmc Differential expression of immunophilins FKBP51 and FKBP52 in the frontal cortex of HIV-infected patients with major depressive disorder
    Erick T Tatro
    Department of Psychiatry 0603, University of California at San Diego, La Jolla, San Diego, CA 92093 0603, USA
    J Neuroimmune Pharmacol 4:218-26. 2009
    ..Instead, an increase in FKBP51 at both the transcript (FKBP5) and protein level correlated with MDD. Increased FKBP4 expression of correlated to HIV(+)MDD but not to HIV without MDD...
  40. pmc Increased accumulation of intraneuronal amyloid beta in HIV-infected patients
    Cristian L Achim
    Department of Psychiatry, University of California, San Diego, CA 92093 0624, USA
    J Neuroimmune Pharmacol 4:190-9. 2009
    ..These findings suggest that long-term survival with HIV might interfere with clearance of proteins such as Abeta and worsen neuronal damage and cognitive impairment in this population...
  41. pmc Implications of hepatitis C virus infection for behavioral symptoms and activities of daily living
    Carolina Posada
    San Diego State University University of California, San Diego Joint Doctoral Program in Clinical Psychology, San Diego, CA, USA
    J Clin Exp Neuropsychol 32:637-44. 2010
    ..These results show that a subset of HCV-infected individuals report clinically elevated behavioral symptoms. Clinical implications for the assessment and management of elevated behavioral symptoms in HCV are discussed...
  42. ncbi request reprint The 50 and 100-item short forms of the Paced Auditory Serial Addition Task (PASAT): demographically corrected norms and comparisons with the full PASAT in normal and clinical samples
    Michael C Diehr
    College of Business Administration, California State University San Marcos, San Marcos, CA, USA
    J Clin Exp Neuropsychol 25:571-85. 2003
    ..0 vs. 5.9 on a 10-point scale, p < .05). We conclude that in many cases the PASAT-50 and PASAT-100 provide equivalent diagnostic accuracy with a significant reduction in administration time and patient discomfort...

Research Grants8

  1. Neurocognitive Consequences of MDMA Use in HIV
    Mariana Cherner; Fiscal Year: 2003
    ..It is anticipated that this pilot project will lead to a larger-scale, prospective investigation of the combined neurocognitive effects of HIV and MDMA. ..
  2. Functional & Cognitive Impact of HIV in Spanish Speakers
    Mariana Cherner; Fiscal Year: 2007
    ..abstract_text> ..
  3. COMT Genotype and Risky Decision Making in HIV and Methamphetamine Dependence
    Mariana Cherner; Fiscal Year: 2010
    ..Findings will add to the understanding of individual differences in response to risk-reduction interventions and have the potential to inform the tailoring of future interventions. ..