D B Chepeha

Summary

Affiliation: University of Michigan
Country: USA

Publications

  1. doi request reprint Rectangle tongue template for reconstruction of the hemiglossectomy defect
    Douglas B Chepeha
    Department of Otolaryngology Head and Neck Surgery, University of Michigan Health System, 1904 Taubman Center, 1500 E Medical Center Dr, Ann Arbor, MI 48109 0312, USA
    Arch Otolaryngol Head Neck Surg 134:993-8. 2008
  2. ncbi request reprint Osseocutaneous radial forearm free tissue transfer for repair of complex midfacial defects
    Douglas B Chepeha
    Department of Otolaryngology Head and Neck Surgery, University of Michigan Health System, Ann Arbor 48109 0312, USA
    Arch Otolaryngol Head Neck Surg 131:513-7. 2005
  3. ncbi request reprint Functional assessment using Constant's Shoulder Scale after modified radical and selective neck dissection
    Douglas B Chepeha
    Department of Otolaryngology Head and Neck Surgery, University of Michigan, 1500 E Medical Center Drive, Taubman Center 1904, Ann Arbor 48109 0312, USA
    Head Neck 24:432-6. 2002
  4. ncbi request reprint Selective neck dissection for the treatment of neck metastasis from squamous cell carcinoma of the head and neck
    Douglas B Chepeha
    Department of Otolaryngology, University of Michigan Health System, Ann Arbor 48109 0312, USA
    Laryngoscope 112:434-8. 2002
  5. doi request reprint Lateral oromandibular defect: when is it appropriate to use a bridging reconstruction plate combined with a soft tissue revascularized flap?
    Douglas B Chepeha
    Department Otolaryngology Head and Neck Surgery, University of Michigan, Ann Arbor, Michigan 48109 0312, USA
    Head Neck 30:709-17. 2008
  6. ncbi request reprint Leech therapy for patients with surgically unsalvageable venous obstruction after revascularized free tissue transfer
    Douglas B Chepeha
    Department of Otolaryngology, University of Michigan Health System, Ann Arbor 48109 0312, USA
    Arch Otolaryngol Head Neck Surg 128:960-5. 2002
  7. ncbi request reprint Pectoralis major myocutaneous flap vs revascularized free tissue transfer: complications, gastrostomy tube dependence, and hospitalization
    Douglas B Chepeha
    Department of Otolaryngology Head and Neck Surgery, University of Michigan, Ann Arbor 48109 0312, USA
    Arch Otolaryngol Head Neck Surg 130:181-6. 2004
  8. doi request reprint Oropharyngoplasty with template-based reconstruction of oropharynx defects
    Douglas B Chepeha
    Department of Otolaryngology Head and Neck Surgery, University of Michigan Health System, 1904 Taubman Center, Ann Arbor, MI 48109 0312, USA
    Arch Otolaryngol Head Neck Surg 135:887-94. 2009
  9. ncbi request reprint Radial forearm free tissue transfer reduces complications in salvage skull base surgery
    Douglas B Chepeha
    Department of Otolaryngology Head and Neck Surgery, University of Michigan Health System, Ann Arbor 48109 0312, USA
    Otolaryngol Head Neck Surg 131:958-63. 2004
  10. ncbi request reprint Restoration of the orbital aesthetic subunit in complex midface defects
    Douglas B Chepeha
    Department of Otolaryngology, University of Michigan Health System, 1904 Taubman Health Center, 1500 East Medical Center Drive, Ann Arbor, MI 48109, U S A
    Laryngoscope 114:1706-13. 2004

Detail Information

Publications71

  1. doi request reprint Rectangle tongue template for reconstruction of the hemiglossectomy defect
    Douglas B Chepeha
    Department of Otolaryngology Head and Neck Surgery, University of Michigan Health System, 1904 Taubman Center, 1500 E Medical Center Dr, Ann Arbor, MI 48109 0312, USA
    Arch Otolaryngol Head Neck Surg 134:993-8. 2008
    ..To determine if a rectangular template free tissue transfer is effective for the reconstruction of the hemiglossectomy defect...
  2. ncbi request reprint Osseocutaneous radial forearm free tissue transfer for repair of complex midfacial defects
    Douglas B Chepeha
    Department of Otolaryngology Head and Neck Surgery, University of Michigan Health System, Ann Arbor 48109 0312, USA
    Arch Otolaryngol Head Neck Surg 131:513-7. 2005
    ..To evaluate the resulting aesthetics, function, and donor site morbidity of the osseocutaneous radial forearm free flap (OCRFFF) used for midface reconstruction...
  3. ncbi request reprint Functional assessment using Constant's Shoulder Scale after modified radical and selective neck dissection
    Douglas B Chepeha
    Department of Otolaryngology Head and Neck Surgery, University of Michigan, 1500 E Medical Center Drive, Taubman Center 1904, Ann Arbor 48109 0312, USA
    Head Neck 24:432-6. 2002
    ..We used this instrument to assess which treatment and demographic variables contribute to shoulder dysfunction after neck dissection in head and neck cancer patients...
  4. ncbi request reprint Selective neck dissection for the treatment of neck metastasis from squamous cell carcinoma of the head and neck
    Douglas B Chepeha
    Department of Otolaryngology, University of Michigan Health System, Ann Arbor 48109 0312, USA
    Laryngoscope 112:434-8. 2002
    ....
  5. doi request reprint Lateral oromandibular defect: when is it appropriate to use a bridging reconstruction plate combined with a soft tissue revascularized flap?
    Douglas B Chepeha
    Department Otolaryngology Head and Neck Surgery, University of Michigan, Ann Arbor, Michigan 48109 0312, USA
    Head Neck 30:709-17. 2008
    ..A quasi-experimental retrospective study was undertaken to evaluate a new concept of free tissue volume restoration combined with bridging reconstruction plate (compartment approach) to reduce plate-related complication rates...
  6. ncbi request reprint Leech therapy for patients with surgically unsalvageable venous obstruction after revascularized free tissue transfer
    Douglas B Chepeha
    Department of Otolaryngology, University of Michigan Health System, Ann Arbor 48109 0312, USA
    Arch Otolaryngol Head Neck Surg 128:960-5. 2002
    ..To assess the efficacy and associated complications of a leech therapy protocol used for patients with a head and neck free tissue transfer in whom flap viability is threatened because of surgically unsalvageable venous obstruction...
  7. ncbi request reprint Pectoralis major myocutaneous flap vs revascularized free tissue transfer: complications, gastrostomy tube dependence, and hospitalization
    Douglas B Chepeha
    Department of Otolaryngology Head and Neck Surgery, University of Michigan, Ann Arbor 48109 0312, USA
    Arch Otolaryngol Head Neck Surg 130:181-6. 2004
    ..To evaluate the factors related to surgical complications, rate of gastrostomy tube (G-tube) dependence, and hospitalization in patients undergoing reconstruction with a pectoralis myocutaneous flap vs a soft-tissue revascularized flap...
  8. doi request reprint Oropharyngoplasty with template-based reconstruction of oropharynx defects
    Douglas B Chepeha
    Department of Otolaryngology Head and Neck Surgery, University of Michigan Health System, 1904 Taubman Center, Ann Arbor, MI 48109 0312, USA
    Arch Otolaryngol Head Neck Surg 135:887-94. 2009
    ....
  9. ncbi request reprint Radial forearm free tissue transfer reduces complications in salvage skull base surgery
    Douglas B Chepeha
    Department of Otolaryngology Head and Neck Surgery, University of Michigan Health System, Ann Arbor 48109 0312, USA
    Otolaryngol Head Neck Surg 131:958-63. 2004
    ..To determine whether the complication rate could be reduced, fasciocutaneous free tissue transfer was used to reinforce the dural closure in patients who had prior skull base surgery or radiation...
  10. ncbi request reprint Restoration of the orbital aesthetic subunit in complex midface defects
    Douglas B Chepeha
    Department of Otolaryngology, University of Michigan Health System, 1904 Taubman Health Center, 1500 East Medical Center Drive, Ann Arbor, MI 48109, U S A
    Laryngoscope 114:1706-13. 2004
    ..The study describes an approach using free tissue transfer for restoration of the native orbital aesthetic subunit...
  11. doi request reprint Advanced squamous cell carcinoma of the oropharynx: efficacy of positron emission tomography and computed tomography for determining primary tumor response during induction chemotherapy
    Douglas B Chepeha
    Department of Otolaryngology Head and Neck Surgery, University of Michigan, Ann Arbor, Michigan 48109 0312, USA
    Head Neck 31:452-60. 2009
    ....
  12. doi request reprint Thoracodorsal artery scapular tip autogenous transplant: vascularized bone with a long pedicle and flexible soft tissue
    Douglas B Chepeha
    Department of Otolaryngology Head and Neck Surgery, University of Michigan Health System, 1904 Taubman Center, 1500 E Medical Center Dr, Ann Arbor, MI 48109 0312, USA
    Arch Otolaryngol Head Neck Surg 136:958-64. 2010
    ....
  13. ncbi request reprint Prospective evaluation of eyelid function with gold weight implant and lower eyelid shortening for facial paralysis
    D B Chepeha
    University of Michigan, Department of Otolaryngology, 1904 Taubman Center, 1500 E Medical Center Dr, Ann Arbor, MI 48109 0312, USA
    Arch Otolaryngol Head Neck Surg 127:299-303. 2001
    ..To assess which signs and symptoms were relieved by gold weight implantation and which signs and symptoms persisted...
  14. ncbi request reprint Conformal re-irradiation of recurrent and new primary head-and-neck cancer
    L A Dawson
    Department of Radiation Oncology, University of Michigan, Ann Arbor, USA
    Int J Radiat Oncol Biol Phys 50:377-85. 2001
    ..To review the outcome of head-and-neck cancer patients re-irradiated using conformal radiation...
  15. pmc Intensity-modulated chemoradiotherapy aiming to reduce dysphagia in patients with oropharyngeal cancer: clinical and functional results
    Felix Y Feng
    Department of Radiation Oncology, University of Michigan, 1500 E Medical Center Drive, Ann Arbor, MI 48109, USA
    J Clin Oncol 28:2732-8. 2010
    ..To assess clinical and functional results of chemoradiotherapy for oropharyngeal cancer (OPC), utilizing intensity-modulated radiotherapy (IMRT) to spare the important swallowing structures to reduce post-therapy dysphagia...
  16. ncbi request reprint Radiation concurrent with gemcitabine for locally advanced head and neck cancer: a phase I trial and intracellular drug incorporation study
    A Eisbruch
    Departments of Radiation Oncology, University of Michigan Medical Center, Ann Arbor, MI, USA
    J Clin Oncol 19:792-9. 2001
    ..Tumor incorporation of gemcitabine triphosphate (dFdCTP) was measured to assess whether adequate concentrations were achieved at each dose level...
  17. ncbi request reprint Sentinel node localization in oral cavity and oropharynx squamous cell cancer
    R J Taylor
    Department of Otolaryngology-Head and Neck Surgery, University of Michigan, Ann Arbor, MI, USA
    Arch Otolaryngol Head Neck Surg 127:970-4. 2001
    ..The sentinel node technique has the potential to decrease the number of neck dissections performed in clinically negative necks, thus reducing the associated morbidity for patients in this group...
  18. ncbi request reprint Free tissue reconstruction of the hypopharynx after organ preservation therapy: analysis of wound complications
    T N Teknos
    Department of Otolaryngology Head and Neck Surgery, Division of Head and Neck Surgery, University of Michigan, Ann Arbor, Michigan 48109 0312, USA
    Laryngoscope 111:1192-6. 2001
    ..The purpose of this study is to determine the incidence of wound complications in these patients when microvascular free tissue transfers are used for reconstruction of the hypopharynx...
  19. ncbi request reprint Predictive factors of local-regional recurrences following parotid sparing intensity modulated or 3D conformal radiotherapy for head and neck cancer
    Mary Feng
    Department of Radiation Oncology, University of Michigan, Ann Arbor, MI, USA
    Radiother Oncol 77:32-8. 2005
    ..Predictive factors for local-regional (LR) failures after parotid-sparing, Intensity modulated (IMRT) or 3D conformal radiotherapy for head and neck (HN) cancers were assessed...
  20. ncbi request reprint Prevention of wound complications following salvage laryngectomy using free vascularized tissue
    Kevin Fung
    Department of Otolaryngology Head and Neck Surgery, University of Michigan, Ann Arbor, MI, USA
    Head Neck 29:425-30. 2007
    ..The purpose of this study was to outline our technique and determine the effectiveness of this new approach...
  21. ncbi request reprint Acceleration of hyperfractionated chemoradiation regimen for advanced head and neck cancer
    Aaron M Allen
    Department of Radiation Oncology, University of Michigan, Ann Arbor, Michigan, USA
    Head Neck 29:137-42. 2007
    ..Our aim was to evaluate the acceleration of a hyperfractionated, concurrent chemoradiation regimen (HxCRT) for advanced head and neck squamous cell carcinoma (HNSCC)...
  22. ncbi request reprint Intensity-modulated radiotherapy of head and neck cancer aiming to reduce dysphagia: early dose-effect relationships for the swallowing structures
    Felix Y Feng
    Department of Radiation Oncology, University of Michigan, Ann Arbor, MI 48109 0010, USA
    Int J Radiat Oncol Biol Phys 68:1289-98. 2007
    ....
  23. ncbi request reprint Voice and swallowing outcomes of an organ-preservation trial for advanced laryngeal cancer
    Kevin Fung
    Head and Neck Oncology Program, Department of Otolaryngology Head and Neck Surgery, University of Michigan, Ann Arbor, MI, USA
    Int J Radiat Oncol Biol Phys 63:1395-9. 2005
    ....
  24. pmc Evaluating and reporting dysphagia in trials of chemoirradiation for head-and-neck cancer
    Iris Gluck
    Department of Radiation Oncology, University of Michigan, Ann Arbor, MI 48109, USA
    Int J Radiat Oncol Biol Phys 77:727-33. 2010
    ....
  25. ncbi request reprint Conformal and intensity modulated irradiation of head and neck cancer: the potential for improved target irradiation, salivary gland function, and quality of life
    A Eisbruch
    Department of Radiation Oncology, University of Michigan, Ann Arbor, USA
    Acta Otorhinolaryngol Belg 53:271-5. 1999
    ..The pattern of recurrence suggests that careful escalation of the dose to targets judged to be at highest risk may improve tumor control...
  26. pmc The pattern of failure after reirradiation of recurrent squamous cell head and neck cancer: implications for defining the targets
    Aron Popovtzer
    Department of Radiation Oncology, University of Michigan, Ann Arbor, MI, USA
    Int J Radiat Oncol Biol Phys 74:1342-7. 2009
    ..Limiting the re-RT targets to the recurrent gross tumor volume (rGTV) would reduce the volumes of reirradiated tissues; however, its effect on tumor recurrence pattern is unknown...
  27. ncbi request reprint Metabolic abnormalities associated with weight loss during chemoirradiation of head-and-neck cancer
    Alexander Lin
    Department of Radiation Oncology, University of Michigan, Ann Arbor, MI 48109 0010, USA
    Int J Radiat Oncol Biol Phys 63:1413-8. 2005
    ..Weight loss caused by acute mucositis and dysphagia is common during concurrent chemoirradiation (chemo-RT) of head-and-neck (HN) cancer. The metabolic consequences of weight loss during chemo-RT were investigated...
  28. pmc Chemotherapy alone for organ preservation in advanced laryngeal cancer
    Vasu Divi
    Department of Otolaryngology Head and Neck Surgery, Comprehensive Cancer Center, University of Michigan Medical School, Ann Arbor, MI, USA
    Head Neck 32:1040-7. 2010
    ....
  29. pmc EGFR, p16, HPV Titer, Bcl-xL and p53, sex, and smoking as indicators of response to therapy and survival in oropharyngeal cancer
    Bhavna Kumar
    Department of Otolaryngology Head and Neck Surgery, University of Michigan Comprehensive Cancer Center Head and Neck Cancer Program, Ann Arbor, MI 48109, USA
    J Clin Oncol 26:3128-37. 2008
    ..To prospectively identify markers of response to therapy and outcome in an organ-sparing trial for advanced oropharyngeal cancer...
  30. pmc Skin cancer of the head and neck with perineural invasion: defining the clinical target volumes based on the pattern of failure
    Iris Gluck
    Department of Radiation Oncology, University of Michigan, Ann Arbor MI, USA
    Int J Radiat Oncol Biol Phys 74:38-46. 2009
    ....
  31. ncbi request reprint Prognostic factors in oral cavity and oropharyngeal squamous cell carcinoma
    Benjamin Marcus
    Department of Otolaryngology Head and Neck Surgery, University of Michigan Medical Center, Ann Arbor, Michigan 48103, USA
    Cancer 101:2779-87. 2004
    ..The authors hypothesized that tumor-associated macrophages contribute to HNSCC aggressiveness, and the objective of the current study was to prove this hypothesis using mRNA expression analysis and a large cohort of clinical specimens...
  32. ncbi request reprint Immune reactivity does not predict chemotherapy response, organ preservation, or survival in advanced laryngeal cancer
    Gregory T Wolf
    Department of Otolaryngology Head and Neck Surgery, University of Michigan, Ann Arbor, Michigan 48109 0312, USA
    Laryngoscope 112:1351-6. 2002
    ..To determine whether pretreatment lymphocyte subpopulations correlate with tumor response to induction chemotherapy as part of an organ preservation treatment approach in patients with advanced laryngeal cancer...
  33. ncbi request reprint Primary versus secondary tracheoesophageal puncture in salvage total laryngectomy following chemoradiation
    Kevin S Emerick
    Department of Otolaryngology Head and Neck Surgery, University of Michigan, Ann Arbor, MI, USA
    Otolaryngol Head Neck Surg 140:386-90. 2009
    ..To compare the rate of postoperative wound-healing complications and voice fluency in primary vs secondary tracheoesophageal puncture (TEP) following chemoradiation...
  34. pmc Early prediction of outcome in advanced head-and-neck cancer based on tumor blood volume alterations during therapy: a prospective study
    Yue Cao
    Department of Radiation Oncology, University of Michigan, Ann Arbor, MI, USA
    Int J Radiat Oncol Biol Phys 72:1287-90. 2008
    ..To assess whether alterations in tumor blood volume (BV) and blood flow (BF) during the early course of chemo-radiotherapy (chemo-RT) for head-and-neck cancer (HNC) predict treatment outcome...
  35. pmc The effect of neck dissection on quality of life after chemoradiation
    Amy Anne Donatelli-Lassig
    Department of Otolaryngology Head and Neck Surgery, University of Michigan Medical School, Ann Arbor, MI, USA
    Otolaryngol Head Neck Surg 139:511-8. 2008
    ..To determine differences in quality of life (QOL) between patients with head and neck cancer who receive chemoradiation versus chemoradiation and neck dissection...
  36. doi request reprint Usefulness of percutaneously injected ethylene-vinyl alcohol copolymer in conjunction with standard endovascular embolization techniques for preoperative devascularization of hypervascular head and neck tumors: technique, initial experience, and correlati
    J J Gemmete
    Division of Interventional Neuroradiology, Department of Radiology, University of Michigan Health System, Ann Arbor, Michigan 48109 0030, USA
    AJNR Am J Neuroradiol 31:961-6. 2010
    ..We describe the technical aspects of the procedure and its efficacy in reducing intraoperative blood loss...
  37. ncbi request reprint Pain, quality of life, and spinal accessory nerve status after neck dissection
    J E Terrell
    Health Services Research and Development Center of Excellence, Ann Arbor Veterans Affairs Medical Center, University of Michigan 48109 0312, USA
    Laryngoscope 110:620-6. 2000
    ....
  38. pmc Response to therapy and outcomes in oropharyngeal cancer are associated with biomarkers including human papillomavirus, epidermal growth factor receptor, gender, and smoking
    Bhavna Kumar
    Department of Otolaryngology Head and Neck Surgery, University of Michigan, Ann Arbor, MI, USA
    Int J Radiat Oncol Biol Phys 69:S109-11. 2007
    ..Smoking cessation and strategies to target EGFR may be useful adjuncts for therapy to improve outcome in the cases with the poorest biomarker profile...
  39. pmc Tobacco use in human papillomavirus-positive advanced oropharynx cancer patients related to increased risk of distant metastases and tumor recurrence
    Jessica H Maxwell
    Departments of Otolaryngology Head and Neck Surgery, University of Michigan Medical School, Ann Arbor, Michigan, USA
    Clin Cancer Res 16:1226-35. 2010
    ....
  40. pmc Can IMRT or brachytherapy reduce dysphagia associated with chemoradiotherapy of head and neck cancer? The Michigan and Rotterdam experiences
    Avraham Eisbruch
    Department of Radiation Oncology, University of Michigan, Ann Arbor, MI 48109 0010, USA
    Int J Radiat Oncol Biol Phys 69:S40-2. 2007
    ..The initial clinical results of intensity-modulated radiotherapy (IMRT), or brachytherapy, planned specifically to reduce dysphagia are presented...
  41. pmc Correlation of cellular immunity with human papillomavirus 16 status and outcome in patients with advanced oropharyngeal cancer
    Derrick Wansom
    Department of Otolaryngology Head and Neck Surgery, University of Michigan Health System, 1904 H Taubman, PO Box 5312, Ann Arbor, MI 48109, USA
    Arch Otolaryngol Head Neck Surg 136:1267-73. 2010
    ..to determine whether the favorable outcome associated with human papillomavirus (HPV) 16-positive oropharyngeal cancer is related to a patient's adaptive immunity...
  42. pmc Chemoselection as a strategy for organ preservation in patients with T4 laryngeal squamous cell carcinoma with cartilage invasion
    Francis P Worden
    Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, USA
    Laryngoscope 119:1510-7. 2009
    ..Patients were treated with chemoradiation after a >50% primary tumor response to one cycle of neoadjuvant chemotherapy (IC). We analyzed outcomes for T4 patients with cartilage invasion from both studies...
  43. pmc Chemoselection as a strategy for organ preservation in advanced oropharynx cancer: response and survival positively associated with HPV16 copy number
    Francis P Worden
    Department of Internal Medicine, Division of Hematology Oncology, University of Michigan, Ann Arbor, MI, USA
    J Clin Oncol 26:3138-46. 2008
    ..To test induction chemotherapy (IC) followed by concurrent chemoradiotherapy (CRT) or surgery/radiotherapy (RT) for advanced oropharyngeal cancer and to assess the effect of human papilloma virus (HPV) on response and outcome...
  44. ncbi request reprint Recurrences near base of skull after IMRT for head-and-neck cancer: implications for target delineation in high neck and for parotid gland sparing
    Avraham Eisbruch
    Department of Radiation Oncology, University of Michigan, Ann Arbor, MI 48109 0010, USA
    Int J Radiat Oncol Biol Phys 59:28-42. 2004
    ..Locoregional (LR) failures near the base of the skull, and their relationships to the targets in the high neck, were examined in a series of patients who underwent intensity-modulated radiotherapy (IMRT) for head-and-neck cancer...
  45. ncbi request reprint Molecular profiling and the identification of genes associated with metastatic oral cavity/pharynx squamous cell carcinoma
    Cecelia E Schmalbach
    Department of Otolaryngology Head and Neck Surgery, University of Michigan Medical School, Ann Arbor 48109 0656, USA
    Arch Otolaryngol Head Neck Surg 130:295-302. 2004
    ..To investigate differences in gene expression profiles between oral cavity/oropharynx squamous cell carcinoma (OC/OP SCC) primary tumors that have metastasized to cervical lymph nodes and nonmetastatic OC/OP SCC tumors...
  46. ncbi request reprint Clinical predictors of quality of life in patients with head and neck cancer
    Jeffrey E Terrell
    Department of Otolaryngology, University of Michigan, Ann Arbor 48109 0312, USA
    Arch Otolaryngol Head Neck Surg 130:401-8. 2004
    ..To identify clinical predictors of quality of life (QoL) in a head and neck cancer patient population...
  47. ncbi request reprint Disability in patients with head and neck cancer
    Joseph C Taylor
    Department of Otolaryngology, University of Michigan, Ann Arbor 48109 0312, USA
    Arch Otolaryngol Head Neck Surg 130:764-9. 2004
    ..These patients often become unemployed as a result of their disease process, which adds financial burden to their already stressful lives. Yet the specific factors associated with unemployment have not been systematically studied...
  48. ncbi request reprint Reconstruction of complex parotidectomy defects using the lateral arm free tissue transfer
    Theodoros N Teknos
    Department of Otolaryngology, University of Michigan Health System, Ann Arbor, MI 48109 0312, USA
    Otolaryngol Head Neck Surg 129:183-91. 2003
    ..The posterior cutaneous nerve of the forearm (PCNF) was used as a facial nerve cable graft in 14 patients. Facial disability outcomes were measured using the Facial Clinimetric Evaluation scale...
  49. ncbi request reprint Bcl-2 protects endothelial cells against gamma-radiation via a Raf-MEK-ERK-survivin signaling pathway that is independent of cytochrome c release
    Pawan Kumar
    Department of Biologic and Materials Sciences, University of Michigan School of Dentistry, 1011 North University Avenue, Ann Arbor, MI 48109, USA
    Cancer Res 67:1193-202. 2007
    ....
  50. ncbi request reprint Elevated serum vascular endothelial growth factor and decreased survival in advanced laryngeal carcinoma
    Theodoros N Teknos
    Department of Otolaryngology Head and Neck Surgery, University of Michigan Health System, 1500 E Medical Center Dr, Ann Arbor, Michigan 48109 0312, USA
    Head Neck 24:1004-11. 2002
    ..Comparisons with a cohort of normal healthy controls were also performed to determine the potential usefulness of s-VEGF as a screening tool...
  51. ncbi request reprint Salivary gland sparing and improved target irradiation by conformal and intensity modulated irradiation of head and neck cancer
    Avraham Eisbruch
    Department of Radiation Oncology, University of Michigan, 1500 Medical Center Drive, Ann Arbor, Michigan 48109, USA
    World J Surg 27:832-7. 2003
    ..The pattern of recurrence suggests that careful escalation of the dose to areas judged to be at highest risk may improve tumor control...
  52. ncbi request reprint Tumor angiogenesis as a predictive marker for organ preservation in patients with advanced laryngeal carcinoma
    Theodoros N Teknos
    University of Michigan Health System, Department of Otolaryngology Head and Neck Surgery, Ann Arbor 48109 0312, USA
    Laryngoscope 112:844-51. 2002
    ..The purpose of this study was to retrospectively investigate tumor angiogenesis as a predictive marker for response to neoadjuvant chemotherapy, organ preservation, and survival in patients with advanced laryngeal carcinoma...
  53. ncbi request reprint Spinal epidural abscess after cervical pharyngoesophageal dilation
    Dale C Ekbom
    Department of Otolaryngology, University of Michigan Medical Center, 1500 E Medical Center Drive, Ann Arbor, MI 48109, USA
    Head Neck 27:543-8. 2005
    ..Esophageal perforation is an uncommon but known complication of esophageal dilation. Abscess after esophageal tear is rare, especially in the spinal epidural space. This is one case report of such an abscess...
  54. ncbi request reprint Crosstalk between tumor and endothelial cells promotes tumor angiogenesis by MAPK activation of Notch signaling
    Qinghua Zeng
    Laboratory of Molecular Signaling and Apoptosis, Department of Biologic and Materials Sciences, University of Michigan, Ann Arbor, MI 48109, USA
    Cancer Cell 8:13-23. 2005
    ..Our results elucidate a novel mechanism by which the direct interplay between tumor cells and ECs promotes angiogenesis through MAPK and Notch signaling pathways...
  55. ncbi request reprint Raynaud's phenomenon in radial forearm free-tissue transfer
    Theodoros N Teknos
    Department of Otolaryngology Head and Neck Surgery, University of Michigan, Ann Arbor, USA
    Ear Nose Throat J 81:467-9. 2002
    ..A salvage procedure was unsuccessful. In this article, we discuss the perioperative course, proposed pathophysiology, and treatment strategies aimed at optimizing hand and flap outcomes in patients with Raynaud's phenomenon...
  56. ncbi request reprint Objective assessment of swallowing dysfunction and aspiration after radiation concurrent with chemotherapy for head-and-neck cancer
    Avraham Eisbruch
    Department of Radiation Oncology, University of Michigan Hospital, Ann Arbor, MI 48109 0010, USA
    Int J Radiat Oncol Biol Phys 53:23-8. 2002
    ..To objectively assess swallowing function after an intensive chemoradiation regimen for locally advanced head-and-neck cancer and to assess the clinical implications of swallowing dysfunction...
  57. ncbi request reprint Preoperative MR angiography in free fibula flap transfer for head and neck cancer: clinical application and influence on surgical decision making
    Aine M Kelly
    Department of Radiology, University of Michigan, University of Michigan Hospitals, B1 132 H Taubman Center, 1500 East Medical Center Drive, Ann Arbor, MI 48109 0030, USA
    AJR Am J Roentgenol 188:268-74. 2007
    ..We review the fibular free flap surgical procedure to illustrate the usefulness of preoperative lower limb MR angiography and to show how calf vascular anatomy on MR angiography affects patient surgical management...
  58. ncbi request reprint Selective cricothyroid muscle reinnervation by muscle-nerve-muscle neurotization
    H K El-Kashlan
    Department of Otolaryngology, University of Michigan, 1500 E Medical Center Dr, Ann Arbor, MI 48109 0312, USA
    Arch Otolaryngol Head Neck Surg 127:1211-5. 2001
    ..To determine if selective reinnervation of the cricothyroid muscle could be achieved with muscle-nerve-muscle neurotization...
  59. doi request reprint Microvascular reconstruction of the orbital complex
    Jeffrey S Moyer
    University of Michigan Medical Center, 1500 East Medical Center Drive, TC1904, Ann Arbor, MI 48109, USA
    Facial Plast Surg Clin North Am 17:225-37. 2009
    ..This article summarizes the approach to orbitomaxillary reconstruction and discusses the use of free tissue transfer in the rehabilitation of this complex region...
  60. ncbi request reprint Development and validation of the neck dissection impairment index: a quality of life measure
    Rodney J Taylor
    Department of Otolaryngology Head and Neck Surgery, University of Michigan, Ann Arbor, MI 48109, USA
    Arch Otolaryngol Head Neck Surg 128:44-9. 2002
    ..To validate a health-related quality-of-life (QOL) instrument for patients following neck dissection and to identify the factors that affect QOL following neck dissection...
  61. pmc HPV-positive/p16-positive/EBV-negative nasopharyngeal carcinoma in white North Americans
    Jessica H Maxwell
    University of Michigan Medical School, The University of Michigan Health System and Comprehensive Cancer Center, Ann Arbor, MI, USA
    Head Neck 32:562-7. 2010
    ..The HPV, p16, and EBV status was examined in current University of Michigan patients with NPC...
  62. pmc Targeting apoptosis to overcome cisplatin resistance: a translational study in head and neck cancer
    Joshua A Bauer
    Department of Pharmacology, University of Michigan, Ann Arbor, MI, USA
    Int J Radiat Oncol Biol Phys 69:S106-8. 2007
    ..Cisplatin resistance remains a barrier to organ-sparing and survival of patients with advanced head and neck squamous cell carcinoma (HNSCC). Targeted therapies to overcome cisplatin-resistant HNSCC are being developed...
  63. ncbi request reprint Use of cross-sectional imaging in predicting facial nerve sacrifice during surgery for parotid neoplasms
    Vasu Divi
    Department of Otolaryngology Head and Neck Surgery, Division of Neuroradiology, University of Michigan Medical Center, Ann Arbor, MI 48105, USA
    ORL J Otorhinolaryngol Relat Spec 66:262-6. 2004
    ..We hypothesize that along with the knowledge of the tumor type we would be able to accurately predict the likelihood of facial nerve sacrifice using cross-sectional imaging...
  64. ncbi request reprint Improved outcomes in patients with head and neck cancer using a standardized care protocol for postoperative alcohol withdrawal
    Christopher D Lansford
    Department of Otolaryngology Head and Neck Surgery, University of Michigan Health System, Ann Arbor, MI 48109, USA
    Arch Otolaryngol Head Neck Surg 134:865-72. 2008
    ..To show clinical benefit in the main outcome measures by the use of a standardized protocol for identification, characterization, and treatment of alcohol withdrawal syndrome (AWS) in postoperative patients with head and neck cancer...
  65. ncbi request reprint Contemporary skull base reconstruction
    Jeffrey S Moyer
    Department of Otolaryngology Head and Neck Surgery, University of Michigan Medical Center, Ann Arbor, Michigan 48109 0312, USA
    Curr Opin Otolaryngol Head Neck Surg 12:294-9. 2004
    ..The use of regional flaps in the 1970s and 1980s allowed skull base surgeons to perform more extensive surgeries, but complication rates were still quite high...
  66. ncbi request reprint Correlation between initial and early follow-up CT perfusion parameters with endoscopic tumor response in patients with advanced squamous cell carcinomas of the oropharynx treated with organ-preservation therapy
    D Gandhi
    Department of Radiology, University of Michigan Health System, Ann Arbor, MI 48109, USA
    AJNR Am J Neuroradiol 27:101-6. 2006
    ..The purpose of our study was to determine whether CT perfusion (CTP) parameters correlate with response to induction chemotherapy as assessed by endoscopy under general anesthesia...
  67. ncbi request reprint Generation of vaccine-primed lymphocytes for the treatment of head and neck cancer
    Alfred E Chang
    Division of Surgical Oncology, 3302 Cancer Center, 1500 E Medical Center Drive, Ann Arbor, Michigan 48109, USA
    Head Neck 25:198-209. 2003
    ..This study was performed to assess the ability of autologous tumor vaccines to induce T-cell reactivity to squamous cell cancers (SCC)...
  68. ncbi request reprint Tissue engineering: the current status of this futuristic modality in head neck reconstruction
    Brian Nussenbaum
    Department of Otolaryngology, Washington University School of Medicine, St Louis, Missouri, USA
    Curr Opin Otolaryngol Head Neck Surg 12:311-5. 2004
    ..To provide a general overview of selected exciting advances outside the field of general otolaryngology but of general interest to the reconstructive community...
  69. ncbi request reprint Thyroarytenoid muscle maintains normal contractile force in chronic vocal fold immobility
    M M Johns
    Department of Otolaryngology--Head and Neck Surgery, University of Michigan, Ann Arbor, Michigan 48109-0312, USA
    Laryngoscope 111:2152-6. 2001
    ..This finding supports the pursuit of reinnervation procedures in the treatment of chronic vocal fold immobility...
  70. ncbi request reprint Management of chyle fistula utilizing thoracoscopic ligation of the thoracic duct
    Chad B Gunnlaugsson
    Department of Otolaryngology, University of Michigan, Ann Arbor, MI 48109 0312, USA
    ORL J Otorhinolaryngol Relat Spec 66:148-54. 2004
    ..To document the treatment of refractory chyle leaks using thoracoscopic thoracic duct ligation and provide systematic guidelines to manage chyle leaks...
  71. ncbi request reprint Current status of transport-disc-distraction osteogenesis for mandibular reconstruction
    Assuntina G Sacco
    Department of Otolaryngology, University of Michigan, Ann Arbor, MI 48109 0312, USA
    Lancet Oncol 8:323-30. 2007
    ....