K N Chengappa

Summary

Affiliation: University of Pittsburgh
Country: USA

Publications

  1. ncbi Clozapine: its impact on aggressive behavior among patients in a state psychiatric hospital
    K N R Chengappa
    Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, Pittsburgh, PA 15213 2593, USA
    Schizophr Res 53:1-6. 2002
  2. ncbi Risperidone use at a state hospital: a clinical audit 2 years after the first wave of risperidone prescriptions
    K N Chengappa
    Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, University of Pittsburgh, PA, USA
    J Clin Psychiatry 60:373-8. 1999
  3. ncbi Bupropion sustained release as a smoking cessation treatment in remitted depressed patients maintained on treatment with selective serotonin reuptake inhibitor antidepressants
    K N Chengappa
    Western Psychiatric Institute and Clinic, University of Pittsburgh, Mayview State Hospital, PA 15213, USA
    J Clin Psychiatry 62:503-8. 2001
  4. ncbi The evolving role of topiramate among other mood stabilizers in the management of bipolar disorder
    K N Chengappa
    Western Psychiatric Institute and Clinic University of Pittsburgh Health System, PA 15213 2593, USA
    Bipolar Disord 3:215-32. 2001
  5. ncbi Changes in body weight and body mass index among psychiatric patients receiving lithium, valproate, or topiramate: an open-label, nonrandomized chart review
    K N Roy Chengappa
    Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania 15213 2593, USA
    Clin Ther 24:1576-84. 2002
  6. ncbi Rates of response, euthymia and remission in two placebo-controlled olanzapine trials for bipolar mania
    K N Roy Chengappa
    Western Psychiatric Institute and Clinic, Mayview State Hospital, University of Pittsburgh Medical Center, PA 15213 2593, USA
    Bipolar Disord 5:1-5. 2003
  7. ncbi A post hoc analysis of the impact on hostility and agitation of quetiapine and haloperidol among patients with schizophrenia
    K N Roy Chengappa
    Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213 2593, USA
    Clin Ther 25:530-41. 2003
  8. ncbi Relationship of birth cohort and early age at onset of illness in a bipolar disorder case registry
    K N Roy Chengappa
    Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, 3811 O Hara Street, Pittsburgh, PA 15213 2593, USA
    Am J Psychiatry 160:1636-42. 2003
  9. ncbi Treatment of bipolar mania with atypical antipsychotics
    K N Roy Chengappa
    Western Psychiatric Institute and Clinic, University of Pittsburgh, 3811 O Hara Street, Pittsburgh, PA 15213 2593, USA
    Expert Rev Neurother 4:S17-25. 2004
  10. ncbi Long-term effects of topiramate on bipolar mood instability, weight change and glycemic control: a case-series
    K N Roy Chengappa
    Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, 3811 O Hara Street, Pittsburgh, PA 15213 2593, USA
    Eur Psychiatry 16:186-90. 2001

Collaborators

Detail Information

Publications39

  1. ncbi Clozapine: its impact on aggressive behavior among patients in a state psychiatric hospital
    K N R Chengappa
    Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, Pittsburgh, PA 15213 2593, USA
    Schizophr Res 53:1-6. 2002
    ..Preliminary data suggests other second generation antipsychotic agents may have similar effects...
  2. ncbi Risperidone use at a state hospital: a clinical audit 2 years after the first wave of risperidone prescriptions
    K N Chengappa
    Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, University of Pittsburgh, PA, USA
    J Clin Psychiatry 60:373-8. 1999
    ..In the present retrospective naturalistic study, we evaluated key clinical outcomes among the first wave of risperidone-treated patients at a state psychiatric hospital...
  3. ncbi Bupropion sustained release as a smoking cessation treatment in remitted depressed patients maintained on treatment with selective serotonin reuptake inhibitor antidepressants
    K N Chengappa
    Western Psychiatric Institute and Clinic, University of Pittsburgh, Mayview State Hospital, PA 15213, USA
    J Clin Psychiatry 62:503-8. 2001
    ....
  4. ncbi The evolving role of topiramate among other mood stabilizers in the management of bipolar disorder
    K N Chengappa
    Western Psychiatric Institute and Clinic University of Pittsburgh Health System, PA 15213 2593, USA
    Bipolar Disord 3:215-32. 2001
    ..This article will focus on the use of topiramate for bipolar disorder...
  5. ncbi Changes in body weight and body mass index among psychiatric patients receiving lithium, valproate, or topiramate: an open-label, nonrandomized chart review
    K N Roy Chengappa
    Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania 15213 2593, USA
    Clin Ther 24:1576-84. 2002
    ..Among the newer anticonvulsant agents, topiramate is a candidate agent for bipolar disorder and is associated with weight loss when used as adjunctive treatment...
  6. ncbi Rates of response, euthymia and remission in two placebo-controlled olanzapine trials for bipolar mania
    K N Roy Chengappa
    Western Psychiatric Institute and Clinic, Mayview State Hospital, University of Pittsburgh Medical Center, PA 15213 2593, USA
    Bipolar Disord 5:1-5. 2003
    ....
  7. ncbi A post hoc analysis of the impact on hostility and agitation of quetiapine and haloperidol among patients with schizophrenia
    K N Roy Chengappa
    Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213 2593, USA
    Clin Ther 25:530-41. 2003
    ..Available data for other second-generation antipsychotic agents show that quetiapine may have better efficacy in improving agitation compared with haloperidol...
  8. ncbi Relationship of birth cohort and early age at onset of illness in a bipolar disorder case registry
    K N Roy Chengappa
    Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, 3811 O Hara Street, Pittsburgh, PA 15213 2593, USA
    Am J Psychiatry 160:1636-42. 2003
    ..Utilizing data from a previously characterized registry of subjects with bipolar illness, the authors examined age at onset of the first illness episode in cohorts of subjects born from 1900 through 1939 and from 1940 through 1959...
  9. ncbi Treatment of bipolar mania with atypical antipsychotics
    K N Roy Chengappa
    Western Psychiatric Institute and Clinic, University of Pittsburgh, 3811 O Hara Street, Pittsburgh, PA 15213 2593, USA
    Expert Rev Neurother 4:S17-25. 2004
    ..The ultimate choice of the atypical agent will depend on the patient's individual needs, but atypical antipsychotics are clinically effective options for achieving mood stabilization in the treatment of acute bipolar mania...
  10. ncbi Long-term effects of topiramate on bipolar mood instability, weight change and glycemic control: a case-series
    K N Roy Chengappa
    Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, 3811 O Hara Street, Pittsburgh, PA 15213 2593, USA
    Eur Psychiatry 16:186-90. 2001
    ..In addition to improved mood stability, these individuals lost between 16 to 20.5% of their pre-topiramate body weight and also achieved significant glycemic control...
  11. ncbi Lifetime prevalence of substance or alcohol abuse and dependence among subjects with bipolar I and II disorders in a voluntary registry
    K N Chengappa
    Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, School of Medicine, PA 15213 2593, USA
    Bipolar Disord 2:191-5. 2000
    ..To evaluate the prevalence of substance abuse dependence and/or alcohol abuse dependence among subjects with bipolar I versus bipolar II disorder in a voluntary registry...
  12. ncbi Response to placebo among bipolar I disorder patients experiencing their first manic episode
    K N Chengappa
    Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, Special Studies Center at Mayview State Hospital, PA 15213 2593, USA
    Bipolar Disord 2:332-5. 2000
    ..Olanzapine versus placebo in the treatment of acute mania. Am J Psychiatry 1999; 156: 702-709)...
  13. ncbi Anticholinergic differences among patients receiving standard clinical doses of olanzapine or clozapine
    K N Chengappa
    Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, Pennsylvania 15213 2593, USA
    J Clin Psychopharmacol 20:311-6. 2000
    ..However, none of the patients in either group expressed any desire to discontinue these medications as a result of the anticholinergic side effects...
  14. ncbi Clozapine reduces severe self-mutilation and aggression in psychotic patients with borderline personality disorder
    K N Chengappa
    Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, PA 15213 2593, USA
    J Clin Psychiatry 60:477-84. 1999
    ..This article describes the impact of clozapine on severe self-mutilation among patients with the dual diagnoses of borderline personality disorder and persistent psychoses...
  15. ncbi Inositol as an add-on treatment for bipolar depression
    K N Chengappa
    Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, PA, USA
    Bipolar Disord 2:47-55. 2000
    ..Inositol crosses the blood-brain barrier in pharmacological doses, and has shown efficacy in a small double-blind study of unipolar depression. This pilot study evaluated its potential efficacy and safety in bipolar depression...
  16. ncbi Impact of risperidone on seclusion and restraint at a state psychiatric hospital
    K N Chengappa
    University of Pittsburgh, Western Psychiatric Institute and Clinic, Special Studies Center Mayview State Hospital, 3811 O Hara Street, Pittsburgh, PA 15213 2593, USA
    Can J Psychiatry 45:827-32. 2000
    ..To evaluate the impact of risperidone on seclusion and restraint in patients at a state psychiatric facility, shortly after risperidone's release...
  17. ncbi Topiramate as add-on treatment for patients with bipolar mania
    K N Chengappa
    Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, PA 15215 2593, USA
    Bipolar Disord 1:42-53. 1999
    ..Topiramate (Topamax), a new antiepileptic agent, is a candidate drug for bipolar disorder. We evaluated topiramate as adjunctive treatment for bipolar patients...
  18. ncbi Illness characteristics and their association with prescription patterns for bipolar I disorder
    J Levine
    Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, PA 15213-2593, USA
    Bipolar Disord 3:41-9. 2001
    ..CONCLUSIONS: Our results suggest that subjects with bipolar I disorder have high rate of suicidal attempts and may have serious functional impairments...
  19. ncbi Psychotropic drug prescription patterns among patients with bipolar I disorder
    J Levine
    Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, PA, USA
    Bipolar Disord 2:120-30. 2000
    ..We evaluated prescription patterns and the influence of demographic variables on these patterns in a voluntary registry of subjects with bipolar disorder...
  20. ncbi Citalopram as adjunctive therapy in bipolar depression
    D J Kupfer
    Department of Psychiatry, University of Pittsburgh School of Medicine, Western Psychiatric Institute and Clinic, PA 15213, USA
    J Clin Psychiatry 62:985-90. 2001
    ..The treatment of bipolar depression remains a major clinical challenge. The effectiveness and safety of adjunctive citalopram were evaluated in DSM-IV-diagnosed bipolar depressed patients in a 5-site study...
  21. ncbi Differentiating primary pathophysiologic from secondary adaptational processes
    J Levine
    Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    Depress Anxiety 14:105-11. 2001
    ..Also, the first example relates to a biological perturbation associated with a primary pathophysiological mechanism, while the second represents a biological alteration associated with secondary adaptational processes...
  22. ncbi Anxiety disorders and major depression, together or apart
    J Levine
    Stanley Center for the Innovative Treatment of Bipolar Disorder, Western Psychiatric Institute and Clinic, Pittsburgh, Pennsylvania, USA
    Depress Anxiety 14:94-104. 2001
    ....
  23. ncbi Clozapine impact on clinical outcomes and aggression in severely ill adolescents with childhood-onset schizophrenia
    L Chalasani
    Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, Mayview State Hospital, Pittsburgh, Pennsylvania, USA
    Can J Psychiatry 46:965-8. 2001
    ..This may be particularly important for improved morale of patients, their families, and treating staff. It may also be helpful in discharge to a less restrictive environment...
  24. ncbi Recovery and functional outcomes following olanzapine treatment for bipolar I mania
    K N Roy Chengappa
    Western Psychiatric Institute and Clinic, University of Pittsburgh, School of Medicine, Pittsburgh, PA 15213 2593, USA
    Bipolar Disord 7:68-76. 2005
    ..Typical experimental categorizations of treatment responses in bipolar disorder (BPD) patients may have limited relationship to clinical recovery or functional status, and there is inadequate research on such clinically important outcomes...
  25. ncbi Weight gain and metabolic issues of medicines used for bipolar disorder
    Andrea Fagiolini
    Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, Pittsburgh, PA 15213 2593, USA
    Curr Psychiatry Rep 9:521-8. 2007
    ....
  26. ncbi Effects of topiramate on smoking in patients with schizoaffective disorder, bipolar type
    Andrea H Weinberger
    J Clin Psychopharmacol 28:247-8. 2008
  27. ncbi Bipolar disorder and the metabolic syndrome: causal factors, psychiatric outcomes and economic burden
    Andrea Fagiolini
    Department of Psychiatry, University of Pittsburgh School of Medicine, Western Psychiatric Institute and Clinic, Pittsburgh, Pennsylvania, USA
    CNS Drugs 22:655-69. 2008
    ..Prevention of weight gain and metabolic disturbances or early intervention when these are present in bipolar disorder could result in significant health and economic benefits...
  28. ncbi The impact of olanzapine on tardive dyskinetic symptoms in a state hospital population
    Jaspreet S Brar
    School of Medicine, Western Psychiatric Institute and Clinic and University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    Ann Clin Psychiatry 20:139-44. 2008
    ..However, the data with regard to the effect of switching from first- to second-generation antipsychotic agents on pre-existing dyskinetic symptoms during routine clinical care is sparse...
  29. ncbi Leukopenia in clozapine treated patients may be induced by other drugs: a case series
    Mary Jo Imbarlina
    Special Studies Center at Mayview State Hospital, Pittsburgh, PA 15213, USA
    Eur Psychiatry 19:506-9. 2004
    ..When adding potentially leukopenic drugs, clinicians should look for possible alternatives especially as clozapine is often a drug used as the last resort in treatment refractory schizophrenia...
  30. ncbi Dosage and administration issues of antipsychotic agents (and adjunctive medicines) in the acute stabilization of psychoses
    K N Roy Chengappa
    Department of Psychiatry, University of Pittsburgh School of Medicine, Western Psychiatric Institute and Clinic, Pittsburgh, PA 15213 2593, USA
    CNS Spectr 9:6-10. 2004
    ..The speed of titration to an effective target dose for these newer agents are addressed as well...
  31. ncbi The prevalence of the metabolic syndrome in patients with schizoaffective disorder--bipolar subtype
    Ranita Basu
    Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, Pittsburgh, PA 15213-2593, USA
    Bipolar Disord 6:314-8. 2004
    ....
  32. ncbi The off-label use of clozapine in adolescents with bipolar disorder, intermittent explosive disorder, or posttraumatic stress disorder
    Ravi Kant
    Head Injury Clinic, Pittsburgh, Pennsylvania, USA
    J Child Adolesc Psychopharmacol 14:57-63. 2004
    ..Clozapine is also associated with serious side effects in subsets of individuals. Therefore, a very careful evaluation of the risk-to-benefit ratio in each individual subject being considered for clozapine is highly recommended...
  33. ncbi Relapse prevention in bipolar I disorder: 18-month comparison of olanzapine plus mood stabiliser v. mood stabiliser alone
    Mauricio Tohen
    Lilly Research Laboratories, Indianapolis, Indiana 46285, USA
    Br J Psychiatry 184:337-45. 2004
    ..Aims To evaluate whether olanzapine plus either lithium or valproate reduces the rate of relapse, compared with lithium or valproate alone...
  34. ncbi A random-assignment, double-blind, clinical trial of once- vs twice-daily administration of quetiapine fumarate in patients with schizophrenia or schizoaffective disorder: a pilot study
    K N Roy Chengappa
    Mayview State Hospital, 1601 Mayview Road, Bridgeville, PA 15017-1599, USA
    Can J Psychiatry 48:187-94. 2003
    ..A minority may experience worsening of symptoms or orthostatic hypotension during the switch. This strategy of administering quetiapine entirely at bedtime may promote improved adherence to treatment...
  35. ncbi The effect of age on the pharmacological management of ambulatory patients treated with depot neuroleptic medications for schizophrenia and related psychotic disorders
    David C Mamo
    Centre for Addiction and Mental Health, Toronto, Canada
    Int J Geriatr Psychiatry 17:1012-7. 2002
    ..CONCLUSION: The results of this study highlight the need for prospective assessments of depot neuroleptic dose requirements in older patients suffering from primary psychotic disorders...
  36. ncbi The use of concomitant medications in psychiatric inpatients treated with either olanzapine or other antipsychotic agents: a naturalistic study at a state psychiatric hospital
    Haranath Parepally
    Western Psychiatric Institute and Clinic, Pittsburgh, PA 15213, USA
    Prog Neuropsychopharmacol Biol Psychiatry 26:437-40. 2002
    ..e. use of blood and organ system monitoring with mood stabilizers). At the end of treatment, olanzapine-treated subjects had statistically significantly lesser concomitant medicine usage compared to control subjects...
  37. ncbi Efficacy of olanzapine in combination with valproate or lithium in the treatment of mania in patients partially nonresponsive to valproate or lithium monotherapy
    Mauricio Tohen
    Lilly Research Laboratories, Eli Lilly and Co, Indianapolis, IN 46285, USA
    Arch Gen Psychiatry 59:62-9. 2002
    ..CONCLUSION: Compared with the use of valproate or lithium alone, the addition of olanzapine provided superior efficacy in the treatment of manic and mixed bipolar episodes...
  38. ncbi Reporting outcomes in clinical trials for bipolar disorder: a commentary and suggestions for change
    Anabel Martinez-Aran
    Bipolar Disorders Program, IDIBAPS, CIBER SAM, Clinical Institute of Neuroscience, Hospital Clinic, University of Barcelona, Barcelona, Spain
    Bipolar Disord 10:566-79. 2008
    ..Using efficacy studies as illustrations, the authors review and recommend changes in the reporting of traditional clinical outcomes both in the acute and maintenance phases of bipolar disorder...
  39. ncbi Diagnostic guidelines for bipolar disorder: a summary of the International Society for Bipolar Disorders Diagnostic Guidelines Task Force Report
    S Nassir Ghaemi
    Bipolar Disorder Research Program, Department of Psychiatry, Emory University, Atlanta, GA 30322, USA
    Bipolar Disord 10:117-28. 2008
    ....