- Mechanisms and models of immune tolerance breakdown in the ovaryMickie H Cheng
Division of Endocrinology, Department of Medicine, UCSF Diabetes Center, 513 Parnassus Ave, HSW 1102 Box 0540, San Francisco, CA 94143, USA
Semin Reprod Med 29:308-16. 2011..Work in translational models continues to provide insight into mechanisms of disease pathogenesis that will allow more accurate diagnosis and, ultimately, improved interventions for women with aPOI...
- Autoimmune oophoritis with multiple molecular targets mitigated by transgenic expression of materNoriyuki Otsuka
University of California San Francisco Diabetes Center, San Francisco, California 94143, USA
Endocrinology 152:2465-73. 2011..As a known autoantigen in the human APS1 (autoimmune polyglandular syndrome type 1), which is associated with POI, MATER may represent a relevant target for future diagnostic and therapeutic clinical interventions...
- Monogenic autoimmunityMickie H Cheng
Department of Medicine, Division of Endocrinology and Metabolism, University of California at San Francisco, San Francisco, California 94143, USA
Annu Rev Immunol 30:393-427. 2012..The continued study of rare variants in autoimmune disease will inform future investigations and treatments directed at rare and common autoimmune diseases alike...
- What's new in the Aire?Mickie H Cheng
Diabetes Center, University of California San Francisco, San Francisco, CA 94143, USA
Trends Immunol 28:321-7. 2007..Recent characterization of Aire-targeted antigens continues to bear this out. Here, we review the current progress surrounding the role of Aire in central tolerance from a molecular, genetic and developmental basis...