Genhong Cheng

Summary

Affiliation: University of California
Country: USA

Publications

  1. Li C, Wang Z, Cao Y, Wang L, Ji J, Chen Z, et al. Screening for Novel Small-Molecule Inhibitors Targeting the Assembly of Influenza Virus Polymerase Complex by a Bimolecular Luminescence Complementation-Based Reporter System. J Virol. 2017;91: pubmed publisher
    ..Thus, we developed an innovative method to investigate PPIs of multisubunit complexes effectively and to identify new molecules inhibiting influenza virus polymerase assembly. ..
  2. Li C, Deng Y, Zu S, Quanquin N, Shang J, Tian M, et al. Zika virus shedding in the stool and infection through the anorectal mucosa in mice. Emerg Microbes Infect. 2018;7:169 pubmed publisher
    ..Overall, our results identify the anorectal mucosa as a potential site of ZIKV infection in mice, reveal the associated pathogenesis of i.a. infection, and highlight the complexity of ZIKV transmission through anal intercourse. ..
  3. Zhu X, Li C, Afridi S, Zu S, Xu J, Quanquin N, et al. E90 subunit vaccine protects mice from Zika virus infection and microcephaly. Acta Neuropathol Commun. 2018;6:77 pubmed publisher
    ..It also supports the further development of the E90 subunit vaccine towards clinical trials. ..
  4. Parvatiyar K, Pindado J, Dev A, Aliyari S, Zaver S, Gerami H, et al. A TRAF3-NIK module differentially regulates DNA vs RNA pathways in innate immune signaling. Nat Commun. 2018;9:2770 pubmed publisher
    ..Thus a previously undescribed pathway for NIK exists in activating IFN in the DNA pathway. ..
  5. Wu L, Su Y, Yu H, Qian X, Zhang X, Wang Q, et al. Rapid Determination of Saponins in the Honey-Fried Processing of Rhizoma Cimicifugae by Near Infrared Diffuse Reflectance Spectroscopy. Molecules. 2018;23: pubmed publisher
    ..This method is convenient and efficient, and the experimentally established model has good prediction ability, and can be used for the rapid determination of Shengmaxinside I content in the honey-fried processing of Rhizoma Cimicifugae. ..
  6. Ci X, Lv H, Wang L, Wang X, Peng L, Qin F, et al. The antioxidative potential of farrerol occurs via the activation of Nrf2 mediated HO-1 signaling in RAW 264.7 cells. Chem Biol Interact. 2015;239:192-9 pubmed publisher
    ..These results support the central role of HO-1 in the cytoprotective effect of farrerol. ..
  7. Wang L, Valderramos S, Wu A, Ouyang S, Li C, Brasil P, et al. From Mosquitos to Humans: Genetic Evolution of Zika Virus. Cell Host Microbe. 2016;19:561-5 pubmed publisher
    ..Sequence analysis of all 41 known ZIKV RNA open reading frames to date indicates that ZIKV has undergone significant changes in both protein and nucleotide sequences during the past half century. ..
  8. Boxx G, Cheng G. The Roles of Type I Interferon in Bacterial Infection. Cell Host Microbe. 2016;19:760-9 pubmed publisher
    ..In this review, we summarize the effect of type I IFNs on specific bacterial infections and highlight the effector mechanisms regulated by type I IFNs in an attempt to elucidate new avenues to understanding their role. ..
  9. Ma F, Li B, Yu Y, Iyer S, Sun M, Cheng G. Positive feedback regulation of type I interferon by the interferon-stimulated gene STING. EMBO Rep. 2015;16:202-12 pubmed publisher
    ..Thus, our study demonstrates that STING is an interferon-stimulated gene (ISG) and its induction is crucial for the IFN-I positive feedback loop. ..

More Information

Publications14

  1. Ma F, Li B, Liu S, Iyer S, Yu Y, Wu A, et al. Positive feedback regulation of type I IFN production by the IFN-inducible DNA sensor cGAS. J Immunol. 2015;194:1545-54 pubmed publisher
    ..Thus, our study not only provides a novel mechanism of modulating cGAS expression, but also adds another layer of regulation in DNA-triggered IFN-I production by induction of cGAS. ..
  2. Wang L, Liu S, Chen H, Xu J, Chapon M, Zhang T, et al. Generation of a Live Attenuated Influenza Vaccine that Elicits Broad Protection in Mice and Ferrets. Cell Host Microbe. 2017;21:334-343 pubmed publisher
    ..These studies present an LAIV development strategy to rapidly generate and screen entire libraries of viral clones. ..
  3. Li C, Deng Y, Wang S, Ma F, Aliyari R, Huang X, et al. 25-Hydroxycholesterol Protects Host against Zika Virus Infection and Its Associated Microcephaly in a Mouse Model. Immunity. 2017;46:446-456 pubmed publisher
    ..Our findings highlight the protective role of CH25H during ZIKV infection and the potential use of 25HC as a natural antiviral agent to combat ZIKV infection and prevent ZIKV-associated outcomes, such as microcephaly. ..
  4. Li C, Zhu X, Ji X, Quanquin N, Deng Y, Tian M, et al. Chloroquine, a FDA-approved Drug, Prevents Zika Virus Infection and its Associated Congenital Microcephaly in Mice. EBioMedicine. 2017;24:189-194 pubmed publisher
    ..Selecting drugs that were previously FDA-approved, such as CQ, also improves the likelihood that they may more quickly reach stages of clinical testing and use by the public. ..
  5. Yuan Y, Yang M, Wang K, Sun J, Song L, Diao X, et al. Excessive activation of the TLR9/TGF-?1/PDGF-B pathway in the peripheral blood of patients with systemic lupus erythematosus. Arthritis Res Ther. 2017;19:70 pubmed publisher
    ..Further studies are necessary to identify TLR9, TGF-?1, and PDGF-B as new therapeutic targets to prevent the development of glomerulonephritis and LN. ..