T L Chenevert

Summary

Affiliation: University of Michigan
Country: USA

Publications

  1. ncbi Monitoring early response of experimental brain tumors to therapy using diffusion magnetic resonance imaging
    T L Chenevert
    Departments of Radiology and Pathology, University of Michigan, Ann Arbor, Michigan 48109, USA
    Clin Cancer Res 3:1457-66. 1997
  2. ncbi Diffusion MRI: a new strategy for assessment of cancer therapeutic efficacy
    Thomas L Chenevert
    Department of Radiology, Center for Molecular Imaging, University of Michigan Medical School, 1500 East Medical Center Drive, Ann Arbor, MI 48109 0030, USA
    Mol Imaging 1:336-43. 2002
  3. ncbi Diffusion coefficient measurement using a temperature-controlled fluid for quality control in multicenter studies
    Thomas L Chenevert
    Department of Radiology, University of Michigan, Ann Arbor, Michigan, USA
    J Magn Reson Imaging 34:983-7. 2011
  4. ncbi Diffusion imaging: insight to cell status and cytoarchitecture
    Thomas L Chenevert
    Department of Radiology, University of Michigan Health Systems, 1500 East Medical Center Drive, Ann Arbor, MI 48109, USA
    Neuroimaging Clin N Am 16:619-32, viii-ix. 2006
  5. ncbi Diffusion imaging for therapy response assessment of brain tumor
    Thomas L Chenevert
    Department of Radiology, University of Michigan Medical Center, Ann Arbor, MI 48109, USA
    Neuroimaging Clin N Am 19:559-71. 2009
  6. ncbi Functional diffusion map as an early imaging biomarker for high-grade glioma: correlation with conventional radiologic response and overall survival
    Daniel A Hamstra
    University of Michigan, B2A209 UH 1500 East Medical Center Dr, Ann Arbor, MI 48109 0030, USA
    J Clin Oncol 26:3387-94. 2008
  7. ncbi The parametric response map is an imaging biomarker for early cancer treatment outcome
    Craig J Galban
    Departments of Radiology, University of Michigan, Center for Molecular Imaging, Ann Arbor, USA
    Nat Med 15:572-6. 2009
  8. ncbi Evaluation of treatment-associated inflammatory response on diffusion-weighted magnetic resonance imaging and 2-[18F]-fluoro-2-deoxy-D-glucose-positron emission tomography imaging biomarkers
    Craig J Galban
    Center for Molecular Imaging and Departments of Radiology, University of Michigan, School of Medicine, Ann Arbor, Michigan 48109 0220, USA
    Clin Cancer Res 16:1542-52. 2010
  9. ncbi The functional diffusion map: an imaging biomarker for the early prediction of cancer treatment outcome
    Bradford A Moffat
    Center for Molecular Imaging, Department of Radiology, University of Michigan School of Medicine, Ann Arbor, MI 48109-0648, USA
    Neoplasia 8:259-67. 2006
  10. ncbi Inhibition of vascular endothelial growth factor (VEGF)-A causes a paradoxical increase in tumor blood flow and up-regulation of VEGF-D
    Bradford A Moffat
    Department of Radiology, Center for Molecular Imaging, University of Michigan Medical School, Ann Arbor, Michigan 48109 0503, USA
    Clin Cancer Res 12:1525-32. 2006

Detail Information

Publications66

  1. ncbi Monitoring early response of experimental brain tumors to therapy using diffusion magnetic resonance imaging
    T L Chenevert
    Departments of Radiology and Pathology, University of Michigan, Ann Arbor, Michigan 48109, USA
    Clin Cancer Res 3:1457-66. 1997
    ..0 +/- 0.3 (n = 4). These results suggest that diffusion measurements are sensitive to therapy-induced changes in cellular structure and may provide an early noninvasive indicator of treatment efficacy...
  2. ncbi Diffusion MRI: a new strategy for assessment of cancer therapeutic efficacy
    Thomas L Chenevert
    Department of Radiology, Center for Molecular Imaging, University of Michigan Medical School, 1500 East Medical Center Drive, Ann Arbor, MI 48109 0030, USA
    Mol Imaging 1:336-43. 2002
    ....
  3. ncbi Diffusion coefficient measurement using a temperature-controlled fluid for quality control in multicenter studies
    Thomas L Chenevert
    Department of Radiology, University of Michigan, Ann Arbor, Michigan, USA
    J Magn Reson Imaging 34:983-7. 2011
    ..Validating imaging biomarkers through multicenter trials requires calibration and performance testing across sites...
  4. ncbi Diffusion imaging: insight to cell status and cytoarchitecture
    Thomas L Chenevert
    Department of Radiology, University of Michigan Health Systems, 1500 East Medical Center Drive, Ann Arbor, MI 48109, USA
    Neuroimaging Clin N Am 16:619-32, viii-ix. 2006
    ..Similarly, therapeutic intervention that alters these properties may be monitored for efficacy via diffusion MR imaging. This article outlines basic technical concepts and applications of diffusion imaging with an emphasis on oncology...
  5. ncbi Diffusion imaging for therapy response assessment of brain tumor
    Thomas L Chenevert
    Department of Radiology, University of Michigan Medical Center, Ann Arbor, MI 48109, USA
    Neuroimaging Clin N Am 19:559-71. 2009
    ..Diffusion tensor imaging and its derivative maps of diffusion anisotropy allow assessment of tumor compression or destruction of adjacent normal tissue anisotropy and may aid to assess tumor infiltration and aid presurgical planning...
  6. ncbi Functional diffusion map as an early imaging biomarker for high-grade glioma: correlation with conventional radiologic response and overall survival
    Daniel A Hamstra
    University of Michigan, B2A209 UH 1500 East Medical Center Dr, Ann Arbor, MI 48109 0030, USA
    J Clin Oncol 26:3387-94. 2008
    ..Diffusion magnetic resonance imaging (MRI) using a functional diffusion map (fDM) may provide an earlier measure to predict patient survival...
  7. ncbi The parametric response map is an imaging biomarker for early cancer treatment outcome
    Craig J Galban
    Departments of Radiology, University of Michigan, Center for Molecular Imaging, Ann Arbor, USA
    Nat Med 15:572-6. 2009
    ..Even when accounting for baseline rCBV, which is prognostic, PRM(rCBV) proved more predictive of overall survival...
  8. ncbi Evaluation of treatment-associated inflammatory response on diffusion-weighted magnetic resonance imaging and 2-[18F]-fluoro-2-deoxy-D-glucose-positron emission tomography imaging biomarkers
    Craig J Galban
    Center for Molecular Imaging and Departments of Radiology, University of Michigan, School of Medicine, Ann Arbor, Michigan 48109 0220, USA
    Clin Cancer Res 16:1542-52. 2010
    ....
  9. ncbi The functional diffusion map: an imaging biomarker for the early prediction of cancer treatment outcome
    Bradford A Moffat
    Center for Molecular Imaging, Department of Radiology, University of Michigan School of Medicine, Ann Arbor, MI 48109-0648, USA
    Neoplasia 8:259-67. 2006
    ..Therefore, The fDM imaging biomarker for early prediction of treatment efficacy can be used in the drug development process...
  10. ncbi Inhibition of vascular endothelial growth factor (VEGF)-A causes a paradoxical increase in tumor blood flow and up-regulation of VEGF-D
    Bradford A Moffat
    Department of Radiology, Center for Molecular Imaging, University of Michigan Medical School, Ann Arbor, Michigan 48109 0503, USA
    Clin Cancer Res 12:1525-32. 2006
    ..The aim of this study was to evaluate the effect of VEGF-A expression on tumor growth, perfusion, and chemotherapeutic efficacy in orthotopic 9L gliosarcomas...
  11. ncbi Therapeutic efficacy of DTI-015 using diffusion magnetic resonance imaging as an early surrogate marker
    Daniel E Hall
    University of Michigan, Center for Molecular Imaging and Department of Radiology, 1150 West Medical Center Drive, Ann Arbor, MI 48109-0648, USA
    Clin Cancer Res 10:7852-9. 2004
    ....
  12. ncbi Comparison of apparent diffusion coefficients and distributed diffusion coefficients in high-grade gliomas
    Thomas C Kwee
    Department of Radiology, University of Michigan Medical Center, Ann Arbor, Michigan 48109, USA
    J Magn Reson Imaging 31:531-7. 2010
    ..To compare apparent diffusion coefficients (ADCs) with distributed diffusion coefficients (DDCs) in high-grade gliomas...
  13. ncbi Prospective early response imaging biomarker for neoadjuvant breast cancer chemotherapy
    Kuei C Lee
    Department of Radiology, Center for Molecular Imaging, University of Michigan Medical School, Biomedical Sciences Research Building, 109 Zina Pitcher Place, Ann Arbor, MI 48109, USA
    Clin Cancer Res 13:443-50. 2007
    ..In this study, we evaluate the feasibility of using diffusion magnetic resonance imaging (MRI) as a reliable and quantitative measure for the early assessment of response in a breast cancer model...
  14. ncbi Diffusion imaging for evaluation of tumor therapies in preclinical animal models
    B A Moffat
    Center for Molecular Imaging, Department of Radiology, University of Michigan, Ann Arbor, 1150 W Medical Center Drive, MSRB III Rm 9303, Ann Arbor, MI, 48109 0503, USA
    MAGMA 17:249-59. 2004
    ....
  15. ncbi Magnetic resonance angiography with gadomer-17. An animal study original investigation
    Q Dong
    Department of Radiology, University of Michigan, Ann Arbor 48109 0030, USA
    Invest Radiol 33:699-708. 1998
    ....
  16. ncbi Motion correction in fMRI via registration of individual slices into an anatomical volume
    B Kim
    Department of Radiology, University of Michigan, Ann Arbor 48109 0553, USA
    Magn Reson Med 41:964-72. 1999
    ..The data presented in a standard anatomical coordinate system suggest the reliability of the mapping-each-slice-to-volume method to detect the activation signals consistent between the two subjects...
  17. ncbi Order information in working memory: fMRI evidence for parietal and prefrontal mechanisms
    C Marshuetz
    Department of Psychology, University of Michigan, Ann Arbor, 48109, USA
    J Cogn Neurosci 12:130-44. 2000
    ..Parietal activations overlapped those involved in number processing, leading to the suggestion that the underlying representation of order and numbers may share a common process, coding for magnitude...
  18. ncbi Registration methodology for histological sections and in vivo imaging of human prostate
    Hyunjin Park
    Department of Radiology, 109 Zina Pitcher Place, BSRB A520, University of Michigan, Ann Arbor, MI 48109, USA
    Acad Radiol 15:1027-39. 2008
    ..Our objective is to register in vivo imaging with histologic sections of the human prostate so that histologic truth can be correlated with in vivo imaging features...
  19. ncbi A methodology for registration of a histological slide and in vivo MRI volume based on optimizing mutual information
    Charles R Meyer
    University of Michigan, Ann Arbor, USA
    Mol Imaging 5:16-23. 2006
    ..Overall, this approach provides a robust method for coregistration of in vivo images with histological sections and will have broad applications in the field of functional and molecular imaging...
  20. ncbi Estimate of vascular permeability and cerebral blood volume using Gd-DTPA contrast enhancement and dynamic T2*-weighted MRI
    Yue Cao
    Department of Radiation Oncology, University of Michigan, Ann Arbor, Michigan 48109 0010, USA
    J Magn Reson Imaging 24:288-96. 2006
    ..To develop a numerical approach for estimation of vascular permeability from dynamic T2*-weighted imaging, a technique routinely used to measure cerebral blood volume (CBV) and flow in gliomas...
  21. ncbi The extent and severity of vascular leakage as evidence of tumor aggressiveness in high-grade gliomas
    Yue Cao
    Departments of Radiation Oncology, University of Michigan, Ann Arbor, MI 48109 0010, USA
    Cancer Res 66:8912-7. 2006
    ..In contrast, survival depends chiefly on the volume of aggressive tumor at the time of presentation...
  22. ncbi Differentiation of recurrent brain tumor versus radiation injury using diffusion tensor imaging in patients with new contrast-enhancing lesions
    Pia C Sundgren
    Department of Radiology, University of Michigan Health Systems, Ann Arbor, MI 48109 0030, USA
    Magn Reson Imaging 24:1131-42. 2006
    ....
  23. ncbi Parametric response map as an imaging biomarker to distinguish progression from pseudoprogression in high-grade glioma
    Christina Tsien
    Department of Radiation Oncology, University of Michigan Medical Center, 1500 E Medical Center Dr, Ann Arbor, MI 48109, USA
    J Clin Oncol 28:2293-9. 2010
    ..To assess whether a new method of quantifying therapy-associated hemodynamic alterations may help to distinguish pseudoprogression from true progression in patients with high-grade glioma...
  24. ncbi Voxel-by-voxel functional diffusion mapping for early evaluation of breast cancer treatment
    Bing Ma
    Department of Radiology, University of Michigan Medical School, Ann Arbor, MI, 48109, USA
    Inf Process Med Imaging 21:276-87. 2009
    ..Comparison of the experimental results with pathology shows that ADC changes can be used to evaluate early response of breast cancer treatment...
  25. ncbi Manually adjusted versus vendor-preset definition of metabolite boundaries impact on proton metabolite ratios
    Myria Petrou
    Department of Radiology, University of Michigan Health System, 1500 E Medical Center Drive, Ann Arbor, MIMI 48109 0030, USA
    Acad Radiol 14:340-3. 2007
    ..The first two of these methods are commercially available...
  26. ncbi Neuroradiologic applications of dynamic MR angiography at 3 T
    Hemant Parmar
    Department of Radiology, University of Michigan Health System, 1500 East Medical Center Drive, Ann Arbor, MI 48109 5030, USA
    Magn Reson Imaging Clin N Am 17:63-75. 2009
    ....
  27. ncbi Technical principles of MR angiography methods
    Marko K Ivancevic
    Philips Healthcare, MR Clinical Science, 595 Miner Road, Cleveland, OH 44143, USA Department of Radiology, University of Michigan Health System, 1500 East Medical Center Drive, Ann Arbor, MI 48109 5030, USA
    Magn Reson Imaging Clin N Am 17:1-11. 2009
    ....
  28. ncbi Arterial vulnerable plaque characterization using ultrasound-induced thermal strain imaging (TSI)
    Kang Kim
    Department of Biomedical Engineering, University of Michigan, Ann Arbor 48109, USA
    IEEE Trans Biomed Eng 55:171-80. 2008
    ..Both longitudinal and transversal TSI agreed well with anatomy. These in vitro results demonstrate the potential of high-resolution US-induced TSI with a small temperature change (<1 degrees C) for plaque characterization...
  29. ncbi Radiation-induced changes in normal-appearing white matter in patients with cerebral tumors: a diffusion tensor imaging study
    Vijaya Nagesh
    Department of Radiation Oncology, University of Michigan Medical School, Ann Arbor, MI 48109 0100, USA
    Int J Radiat Oncol Biol Phys 70:1002-10. 2008
    ..To quantify the radiation-induced changes in normal-appearing white matter before, during, and after radiotherapy (RT) in cerebral tumor patients...
  30. ncbi Dynamic imaging of emerging resistance during cancer therapy
    Kuei C Lee
    Department of Biological Chemistry, University of Michigan Medical School, Ann Arbor, MI 48109, USA
    Cancer Res 66:4687-92. 2006
    ..Overall, this study highlights the ability of diffusion MRI to provide sensitive dynamic assessment of therapy-induced response, allowing early opportunities for optimization of therapeutic protocols...
  31. ncbi Sodium and proton diffusion MRI as biomarkers for early therapeutic response in subcutaneous tumors
    Victor D Schepkin
    Department of Radiology, Center for Molecular Imaging, University of Michigan Medical School, Ann Arbor, MI 48109 0503, USA
    Magn Reson Imaging 24:273-8. 2006
    ..The results of this study support the continued clinical testing of diffusion MRI for evaluation of early tumor treatment response and demonstrate the complementary insights of sodium MRI for oncology applications...
  32. ncbi Evaluation of (E)-2'-deoxy-2'-(fluoromethylene)cytidine on the 9L rat brain tumor model using MRI
    Brian D Ross
    Department of Radiology, Center for Molecular Imaging, University of Michigan, Ann Arbor, MI 48109, USA
    NMR Biomed 16:67-76. 2003
    ....
  33. ncbi Sodium magnetic resonance imaging of chemotherapeutic response in a rat glioma
    Victor D Schepkin
    Department of Radiology, Center for Molecular Imaging, University of Michigan Medical School, Kresge II Research Building, R3028, 200 Zina Pitcher Place, Ann Arbor, MI 48109, USA
    Magn Reson Med 53:85-92. 2005
    ..This study demonstrates the possibility of Na MRI to function as a biomarker for monitoring early tumor treatment and validates the use of monitoring changes in diffusion MRI values for assessing tumor cellularity...
  34. ncbi Improving cerebral cortical magnetic resonance imaging using a readily available surface coil
    Diana M Gomez-Hassan
    Department of Radiology, University of Michigan Hospitals, 1500 East Medical Center Drive, Ann Arbor 48109, USA
    J Neuroimaging 14:231-4. 2004
    ..Delineating the cortical surface using a shoulder coil can help to detect subtle areas of cortical thickening, blurring of the gray-white matter junction, or focally abnormal gyral and sulcal patterns...
  35. ncbi Use of magnetic resonance imaging to assess blood-brain/blood-glioma barrier opening during conformal radiotherapy
    Yue Cao
    Department of Radiation Oncology, University of Michigan, 1500 E Medical Center Dr, Rm B2C438, Box 0010, Ann Arbor, MI 48109 0010, USA
    J Clin Oncol 23:4127-36. 2005
    ..The objective of this study was to assess BBB/BTB status using magnetic resonance imaging (MRI) during a course of radiotherapy of high-grade gliomas...
  36. ncbi Diffusion-weighted magnetic resonance imaging
    Suresh K Mukherji
    Department of Radiology, University of Michigan Health System, Ann Arbor 48109, USA
    J Neuroophthalmol 22:118-22. 2002
    ....
  37. ncbi Predicting outcome of patients with high-grade gliomas after radiotherapy using quantitative analysis of T1-weighted magnetic resonance imaging
    Christina Tsien
    Department of Radiation Oncology, University of Michigan, Ann Arbor, MI 48109, USA
    Int J Radiat Oncol Biol Phys 67:1476-83. 2007
    ....
  38. ncbi Survival prediction in high-grade gliomas by MRI perfusion before and during early stage of RT [corrected]
    Yue Cao
    Department of Radiation Oncology, University of Michigan, Ann Arbor, MI 48109 0010, USA
    Int J Radiat Oncol Biol Phys 64:876-85. 2006
    ..To determine whether cerebral blood volume (CBV) and cerebral blood flow can predict the response of high-grade gliomas to radiotherapy (RT) by taking into account spatial heterogeneity and temporal changes in perfusion...
  39. ncbi Hepatic arterial phase MR imaging with automated bolus-detection three-dimensional fast gradient-recalled-echo sequence: comparison with test-bolus method
    Hero K Hussain
    Department of Radiology, University of Michigan Health System, 1500 E Medical Center Dr, UH B2B311 MRI, Ann Arbor, MI 48109 0030, USA
    Radiology 226:558-66. 2003
    ..There was good correlation and agreement between delay times estimated with both timing methods. Optimal hepatic arterial phase MR images can be obtained routinely with automated detection of a contrast material bolus...
  40. ncbi Metabolic alterations: a biomarker for radiation-induced normal brain injury-an MR spectroscopy study
    P C Sundgren
    Department of Radiology, University of Michigan University Health Systems, Ann Arbor, Michigan 48109, USA
    J Magn Reson Imaging 29:291-7. 2009
    ..To assess if interval changes in metabolic status in normal cerebral tissue after radiation therapy (RT) can be detected by 2D CSI (chemical shift imaging) proton spectroscopy...
  41. ncbi Continuous arterial spin labeling using a train of adiabatic inversion pulses
    Bradford A Moffat
    Department of Radiology, University of Michigan, Ann Arbor, Michigan, USA
    J Magn Reson Imaging 21:290-6. 2005
    ....
  42. ncbi Intravoxel water diffusion heterogeneity imaging of human high-grade gliomas
    Thomas C Kwee
    Department of Radiology, University of Michigan Medical Center, Ann Arbor, MI 48109, USA
    NMR Biomed 23:179-87. 2010
    ..The observed negative correlation between tumor alpha and tumor DDC requires further investigation...
  43. ncbi Functional diffusion map: a noninvasive MRI biomarker for early stratification of clinical brain tumor response
    Bradford A Moffat
    Department of Radiology, University of Michigan School of Medicine, Ann Arbor, MI 48109, USA
    Proc Natl Acad Sci U S A 102:5524-9. 2005
    ..Overall, fDM analysis provided an early biomarker for predicting treatment response in brain tumor patients...
  44. ncbi Evaluation of the functional diffusion map as an early biomarker of time-to-progression and overall survival in high-grade glioma
    Daniel A Hamstra
    Department of Radiation Oncology, University of Michigan Medical School, Ann Arbor, MI 48109-0648, USA
    Proc Natl Acad Sci U S A 102:16759-64. 2005
    ..Further evaluation of this technique is warranted to determine whether it may be useful in the individualization of treatment or evaluation of the response in clinical protocols...
  45. ncbi Decreased motor cortex γ-aminobutyric acid in amyotrophic lateral sclerosis
    B R Foerster
    Department of Radiology, University of Michigan, Ann Arbor, USA
    Neurology 78:1596-600. 2012
    ....
  46. ncbi Utility of the k-means clustering algorithm in differentiating apparent diffusion coefficient values of benign and malignant neck pathologies
    A Srinivasan
    Department of Radiology, University of Michigan Health System, Ann Arbor, 48109, USA
    AJNR Am J Neuroradiol 31:736-40. 2010
    ....
  47. ncbi Multiphase-multistep gadolinium-enhanced MR angiography of the abdominal aorta and runoff vessels
    S O Schoenberg
    Department of Radiology, University of Michigan, Ann Arbor, Michigan, USA
    Invest Radiol 36:283-91. 2001
    ..CONCLUSIONS: Multiphase-multistep 3D-Gd-MRA reduces the limitations of standard 3D-Gd-MRA techniques with respect to anatomic coverage, spatial resolution, and nonuniform arterial vessel enhancement...
  48. ncbi Evaluating changes in tumor volume using magnetic resonance imaging during the course of radiotherapy treatment of high-grade gliomas: Implications for conformal dose-escalation studies
    Christina Tsien
    Department of Radiation Oncology, University of Michigan, Ann Arbor, MI 48109, USA
    Int J Radiat Oncol Biol Phys 62:328-32. 2005
    ..To determine whether changes in tumor volume occur during the course of conformal 3D radiotherapy of high-grade gliomas by use of magnetic resonance imaging (MRI) during treatment and whether these changes had an impact on tumor coverage...
  49. ncbi Validation of an adapted MRI pulse sequence for quantification of fatty infiltration in muscle
    Lisa Case Doro
    Department of Orthopaedic Surgery, University of Michigan, Ann Arbor, MI 48109, USA
    Magn Reson Imaging 27:823-7. 2009
    ..Therefore, the objective of this project was to adapt and validate a novel magnetic resonance imaging pulse sequence for quantifying the extent of fatty infiltration for the supraspinatus muscle...
  50. ncbi Morphologic and functional magnetic resonance imaging of renal artery stenosis: a multireader tricenter study
    Stefan O Schoenberg
    Department of Radiology, University of Michigan, Ann Arbor, Michigan, USA
    J Am Soc Nephrol 13:158-69. 2002
    ..It can be considered a safe and noninvasive alternative for diagnostic DSA in cases that do not require assessment of intrarenal vessels...
  51. ncbi Clinical applications of diffusion tensor imaging
    Qian Dong
    Department of Radiology, University of Michigan, Ann Arbor, Michigan 48109-0030, USA
    J Magn Reson Imaging 19:6-18. 2004
    ..This review describes the clinical utility of diffusion tensor imaging, including the basic principles of the technique, acquisition, data analysis, and the major clinical applications...
  52. ncbi A novel polyacrylamide magnetic nanoparticle contrast agent for molecular imaging using MRI
    Bradford A Moffat
    University of Michigan, Ann Arbor, USA
    Mol Imaging 2:324-32. 2003
    ..The flexible formulation of these nanoparticles suggests that future modifications could be accomplished allowing for their use as a targeted molecular imaging contrast agent and/or therapeutic platform for multiple indications...
  53. ncbi Effects on breast MRI of artifacts caused by metallic tissue marker clips
    Charles C Genson
    Department of Radiology, University of Michigan Health System, B1 D520 UH, 1500 E Medical Center Dr, Ann Arbor, MI 48109 0030, USA
    AJR Am J Roentgenol 188:372-6. 2007
    ..The purpose of our study was to investigate MR artifacts related to tissue marker clips used in breast imaging procedures...
  54. ncbi A feasibility study evaluating the functional diffusion map as a predictive imaging biomarker for detection of treatment response in a patient with metastatic prostate cancer to the bone
    Kuei C Lee
    Department of Radiology, University of Michigan School of Medicine, Ann Arbor, MI 48109, USA
    Neoplasia 9:1003-11. 2007
    ..Thus, the fDM imaging biomarker may provide a quantifiable therapeutic endpoint to assess response in patients with metastatic bone cancer...
  55. ncbi Quantitative characterization of hemodynamic properties and vasculature dysfunction of high-grade gliomas
    Vijaya Nagesh
    Department of Radiation Oncology, University of Michigan, Ann Arbor, MI 48109 0010, USA
    NMR Biomed 20:566-77. 2007
    ..Progressive abnormalities in vasculature and hemodynamic characteristics of the vascular bed were delineated, with significant disorder in the tumor but mild abnormality in peritumoral tissue...
  56. ncbi Magnetic resonance imaging in cancer research
    B D Ross
    Department of Radiology, University of Michigan Medical School, 1150 West Medical Center Drive, Medical Sciences Research Building III, Room 9303, Ann Arbor 48109 0648, USA
    Eur J Cancer 38:2147-56. 2002
    ..These examples provide an overview of areas in which imaging of animal tumour models can contribute towards improving the evaluation of experimental therapeutic agents...
  57. ncbi Diffusion tensor imaging in patients with acute onset of neuropsychiatric systemic lupus erythematosus: a prospective study of apparent diffusion coefficient, fractional anisotropy values, and eigenvalues in different regions of the brain
    M Hughes
    Department of Radiology, School of Public Health, University of Michigan Health Systems, Ann Arbor, Michigan 48109, USA
    Acta Radiol 48:213-22. 2007
    ..To investigate whether apparent diffusion coefficient (ADC), fractional anisotropy (FA), and eigenvalues in neuropsychiatric systemic lupus erythematosus (NPSLE) patients differ from those of healthy controls...
  58. ncbi An imaging biomarker of early treatment response in prostate cancer that has metastasized to the bone
    Kuei C Lee
    Department of Radiology, and Center for Molecular Imaging, University of Michigan Medical School, 109 Zina Pitcher Place, Ann Arbor, MI 48109, USA
    Cancer Res 67:3524-8. 2007
    ..Validation of fDM results was accomplished by histologic analysis of excised tissue. Results from this study show the capability of fDM as a biomarker for detection of bone cancer treatment efficacy, thus warranting clinical evaluation...
  59. ncbi Evaluation of cancer therapy using diffusion magnetic resonance imaging
    Brian D Ross
    University of Michigan Medical School, Ann Arbor, Michigan 48109-0648, USA
    Mol Cancer Ther 2:581-7. 2003
    ..This article provides an overview of the use of diffusion magnetic resonance imaging as a surrogate marker for quantitating treatment responsiveness in both preclinical and clinical studies...
  60. ncbi Hepatic fat fraction: MR imaging for quantitative measurement and display--early experience
    Hero K Hussain
    Department of Radiology/MRI, University of Michigan Health System, 1500 E Medical Center Dr, MRI UHB2A209, Ann Arbor, MI 48109-0030, USA
    Radiology 237:1048-55. 2005
    ..3% +/- 2.8 [standard deviation] and 28.6% +/- 2.4, vs quantitative histopathologic analysis, 11.2% and 28.5%, respectively). Supplemental material: radiology.rsnajnls.org/cgi/content/full/2373041639/DC1..
  61. ncbi Zero and first-order phase shift correction for field map estimation with dual-echo GRE using bipolar gradients
    Desmond T B Yeo
    Department of Radiology, University of Michigan Medical School, Ann Arbor, MI 48109, USA
    Magn Reson Imaging 25:1263-71. 2007
    ..The zero-order phase correction term may change with time and is estimated empirically for different scans...
  62. ncbi Possible biliary disease: diagnostic performance of high-spatial-resolution isotropic 3D T2-weighted MRCP
    Kiran R Nandalur
    Department of Radiology MRI, University of Michigan Health System, 1500 E Medical Center Dr, MRI UHB2A209, Ann Arbor, MI 48109 0030, USA
    Radiology 249:883-90. 2008
    ....
  63. ncbi Noninvasive real-time imaging of apoptosis
    Bharathi Laxman
    Center for Molecular Imaging, University of Michigan Medical School, 1150 West Medical Center Drive, Medical Sciences Research Building III, Room 9303, Ann Arbor, MI 48109-0648, USA
    Proc Natl Acad Sci U S A 99:16551-5. 2002
    ....
  64. ncbi Molecular imaging of gene expression and efficacy following adenoviral-mediated brain tumor gene therapy
    Alnawaz Rehemtulla
    University of Michigan School of Medicine, USA
    Mol Imaging 1:43-55. 2002
    ....
  65. ncbi Proton and sodium MRI assessment of emerging tumor chemotherapeutic resistance
    Victor D Schepkin
    National High Magnetic Field Laboratory, Florida State University, Tallahassee, FL 32310, USA
    NMR Biomed 19:1035-42. 2006
    ..Overall, these experiments demonstrate the sensitivity and applicability of sodium and diffusion MRI as tools for dynamic assessment of tumor response to therapy...
  66. ncbi The use of 19F spectroscopy and diffusion-weighted MRI to evaluate differences in gene-dependent enzyme prodrug therapies
    Daniel A Hamstra
    Department of Radiation Oncology, The University of Michigan Medical Center, Ann Arbor 48109 0582, USA
    Mol Ther 10:916-28. 2004
    ....