Zhijian Chen

Summary

Affiliation: University of Texas Southwestern Medical Center
Country: USA

Publications

  1. pmc Direct activation of protein kinases by unanchored polyubiquitin chains
    Zong Ping Xia
    Department of Molecular Biology, University of Texas, Southwestern Medical Center, Dallas, Texas 75390 9148, USA
    Nature 461:114-9. 2009
  2. pmc CC2D1A, a DM14 and C2 domain protein, activates NF-kappaB through the canonical pathway
    Meng Zhao
    Department of Molecular Biology, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390 9148, USA
    J Biol Chem 285:24372-80. 2010
  3. pmc Sequence specific detection of bacterial 23S ribosomal RNA by TLR13
    Xiao Dong Li
    Department of Molecular Biology
    elife 1:e00102. 2012
  4. pmc Getting to grips with hepatitis
    Zhijian J Chen
    is an eLife reviewing editor, and is in the Department of Molecular Biology and the Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, United States
    elife 1:e00301. 2012
  5. pmc Ubiquitination in signaling to and activation of IKK
    Zhijian J Chen
    Department of Molecular Biology, Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, TX 75390 9148, USA
    Immunol Rev 246:95-106. 2012
  6. doi request reprint Nonproteolytic functions of ubiquitin in cell signaling
    Zhijian J Chen
    Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, TX 75390 9148, USA
    Mol Cell 33:275-86. 2009
  7. pmc Ubiquitin signalling in the NF-kappaB pathway
    Zhijian J Chen
    Department of Molecular Biology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390 9148, USA
    Nat Cell Biol 7:758-65. 2005
  8. ncbi request reprint The TRAF6 ubiquitin ligase and TAK1 kinase mediate IKK activation by BCL10 and MALT1 in T lymphocytes
    Lijun Sun
    Department of Molecular Biology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA
    Mol Cell 14:289-301. 2004
  9. ncbi request reprint TRAF2: a double-edged sword?
    Zong Ping Xia
    Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390 9148, USA
    Sci STKE 2005:pe7. 2005
  10. ncbi request reprint TAB2 and TAB3 activate the NF-kappaB pathway through binding to polyubiquitin chains
    Atsuhiro Kanayama
    Department of Molecular Biology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA
    Mol Cell 15:535-48. 2004

Collaborators

  • Qinmiao Sun
  • Atsuhiro Kanayama
  • Xiao Dong Li
  • Xiang Chen
  • SERGE FUCHS
  • S Akira
  • Kenneth Tew
  • D A Dobbelaere
  • Neal Silverman
  • Jin Ye
  • Lijun Sun
  • Wenwen Zeng
  • Chee Kwee Ea
  • Zong Ping Xia
  • Brian Skaug
  • Anirban Adhikari
  • Ming Xu
  • Gabriel Pineda
  • Xiaomo Jiang
  • Li Deng
  • Meng Zhao
  • Vijay G Bhoj
  • Beatrice Coornaert
  • Hui Xiao
  • Hong Hsing Liu
  • Nicolai S C van Oers
  • Rashu B Seth
  • Brenda A Schulman
  • Rui Zhou
  • Jun Wan
  • Arunima Misra
  • Volker T Heussler
  • Brenda Fredericksen
  • Fajian Hou
  • Siqi Liu
  • Mathijs Baens
  • Rudi Beyaert
  • Peter Marynen
  • Mira Haegman
  • Yue Wei Qian
  • Tine Bekaert
  • Grace Cui
  • Mariam Ehsani
  • Raymond Gilmour
  • Karen Heyninck
  • Zhengfan Jiang
  • Xiliang Wang
  • Wen Qian
  • Youcun Qian
  • Kirk Staschke
  • Jens Staal
  • Min Xie
  • Michael D Schneider
  • Tom Maniatis
  • Yvonne Chung
  • Mei Hong
  • Dorothy S Liao
  • Kunihiro Matsumoto
  • Luguo Sun
  • Shinobu Suzuki
  • Zhenguo Wu
  • Jun ichiro Inoue
  • Yiu Loon Chui
  • Zheng Gang Liu
  • Dolly P Huang
  • Wen Chen Yeh
  • Jennifer Woo Mendoza
  • Nobutaka Suzuki
  • Natarajan Sivasubramanian
  • Jesus G Vallejo
  • Mark L Entman
  • Eric N Olson
  • Lloyd H Michael
  • Pascal Knuefermann
  • Douglas L Mann
  • Sandra B Haudek
  • Eileen Foy
  • Jill Pflugheber
  • Peter Küenzi
  • Michael Gale
  • Sven Rottenberg
  • Kim Orth
  • Giridhar R Akkaraju
  • Paula C Fernandez
  • Brian Shiels
  • Chunfu Wang
  • Susan McKellar
  • David Wallach
  • Rebekka Schwab

Detail Information

Publications37

  1. pmc Direct activation of protein kinases by unanchored polyubiquitin chains
    Zong Ping Xia
    Department of Molecular Biology, University of Texas, Southwestern Medical Center, Dallas, Texas 75390 9148, USA
    Nature 461:114-9. 2009
    ..These results indicate that unanchored polyubiquitin chains directly activate TAK1 and IKK, suggesting a new mechanism of protein kinase regulation...
  2. pmc CC2D1A, a DM14 and C2 domain protein, activates NF-kappaB through the canonical pathway
    Meng Zhao
    Department of Molecular Biology, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390 9148, USA
    J Biol Chem 285:24372-80. 2010
    ..In addition, the deubiquitination enzyme Cylindromatosis (CYLD) negatively regulates the activity of CC2D1A. These results suggest that CC2D1A activates NF-kappaB through the canonical IKK pathway...
  3. pmc Sequence specific detection of bacterial 23S ribosomal RNA by TLR13
    Xiao Dong Li
    Department of Molecular Biology
    elife 1:e00102. 2012
    ..Knockout of TLR13 in mice abolished the induction of interleukin-1β and other cytokines by the 23S rRNA sequence. Thus, TLR13 detects bacterial RNA with exquisite sequence specificity.DOI:http://dx.doi.org/10.7554/eLife.00102.001...
  4. pmc Getting to grips with hepatitis
    Zhijian J Chen
    is an eLife reviewing editor, and is in the Department of Molecular Biology and the Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, United States
    elife 1:e00301. 2012
    ..The receptor that allows hepatitis B and hepatitis D viruses to enter human liver cells has been identified as a protein that transports bile acids in the liver...
  5. pmc Ubiquitination in signaling to and activation of IKK
    Zhijian J Chen
    Department of Molecular Biology, Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, TX 75390 9148, USA
    Immunol Rev 246:95-106. 2012
    ....
  6. doi request reprint Nonproteolytic functions of ubiquitin in cell signaling
    Zhijian J Chen
    Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, TX 75390 9148, USA
    Mol Cell 33:275-86. 2009
    ..Recent advances in understanding ubiquitination in protein kinase activation and DNA repair are discussed to illustrate the nonproteolytic functions of ubiquitin in cell signaling...
  7. pmc Ubiquitin signalling in the NF-kappaB pathway
    Zhijian J Chen
    Department of Molecular Biology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390 9148, USA
    Nat Cell Biol 7:758-65. 2005
    ..Recent studies have revealed several enzymes involved in the ubiquitination and deubiquitination of signalling proteins that mediate IKK activation through a degradation-independent mechanism...
  8. ncbi request reprint The TRAF6 ubiquitin ligase and TAK1 kinase mediate IKK activation by BCL10 and MALT1 in T lymphocytes
    Lijun Sun
    Department of Molecular Biology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA
    Mol Cell 14:289-301. 2004
    ..These results reveal an oligomerization --> ubiquitination --> phosphorylation cascade that culminates in NF-kappaB activation in T lymphocytes...
  9. ncbi request reprint TRAF2: a double-edged sword?
    Zong Ping Xia
    Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390 9148, USA
    Sci STKE 2005:pe7. 2005
    ..Thus, ubiquitin chains are dynamic switches that can influence signaling outputs in dramatically different ways...
  10. ncbi request reprint TAB2 and TAB3 activate the NF-kappaB pathway through binding to polyubiquitin chains
    Atsuhiro Kanayama
    Department of Molecular Biology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA
    Mol Cell 15:535-48. 2004
    ..These results indicate that polyubiquitin binding domains represent a new class of signaling domains that regulate protein kinase activity through a nonproteolytic mechanism...
  11. pmc TIFA activates IkappaB kinase (IKK) by promoting oligomerization and ubiquitination of TRAF6
    Chee Kwee Ea
    Department of Molecular Biology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390 9148, USA
    Proc Natl Acad Sci U S A 101:15318-23. 2004
    ..Importantly, TIFA induces the oligomerization and polyubiquitination of TRAF6, which leads to the activation of TAK1 and IKK through a proteasome-independent mechanism...
  12. doi request reprint Ubiquitylation in innate and adaptive immunity
    Vijay G Bhoj
    Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    Nature 458:430-7. 2009
    ..Recent work has shown that several ubiquitin ligases help to prevent the immune system from attacking self tissues. The dysfunction of several ubiquitin ligases has been linked to autoimmune diseases...
  13. pmc Essential role of TAK1 in thymocyte development and activation
    Hong Hsing Liu
    Department of Molecular Biology and Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, TX 75390 9148, USA
    Proc Natl Acad Sci U S A 103:11677-82. 2006
    ..Our results provide the genetic evidence that TAK1 is required for the activation of NF-kappaB in thymocytes and suggest that TAK1 plays a central role in both innate and adaptive immunity...
  14. ncbi request reprint Ubiquitin-dependent activation of NF-kappaB: K63-linked ubiquitin chains: a link to cancer?
    Zhijian J Chen
    Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, Texas, USA
    Cancer Biol Ther 3:286-8. 2004
    ..Recent discoveries of the novel roles of lysine 63-linked polyubiquitin chains in the activation of NF-kappaB transcription factor shed new light on both the mechanistic aspects of this signal transduction pathway and its role in cancer...
  15. ncbi request reprint The novel functions of ubiquitination in signaling
    Lijun Sun
    University of Texas Southwestern Medical Center, Department of Molecular Biology, 5323 Harry Hines Boulevard, Dallas, TX 75390 9148, USA
    Curr Opin Cell Biol 16:119-26. 2004
    ..Thus, polyubiquitination and monoubiquitination have emerged as important signaling mechanisms that control diverse physiological and pathological processes...
  16. ncbi request reprint Identification and characterization of MAVS, a mitochondrial antiviral signaling protein that activates NF-kappaB and IRF 3
    Rashu B Seth
    Howard Hughes Medical Institute, Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    Cell 122:669-82. 2005
    ..The transmembrane domain targets MAVS to the mitochondria, implicating a new role of mitochondria in innate immunity...
  17. ncbi request reprint Protein ubiquitination: CHIPping away the symmetry
    Brenda A Schulman
    Howard Hughes Medical Institute, St Jude Children s Research Hospital, 332 North Lauderdale Street, Memphis, Tennessee 38105, USA
    Mol Cell 20:653-5. 2005
    ....
  18. pmc Reconstitution of the RIG-I pathway reveals a signaling role of unanchored polyubiquitin chains in innate immunity
    Wenwen Zeng
    Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390 9148, USA
    Cell 141:315-30. 2010
    ..Our results delineate the mechanism of RIG-I activation, identify CARD domains as a ubiquitin sensor, and demonstrate that unanchored K63-polyubiquitin chains are signaling molecules in antiviral innate immunity...
  19. ncbi request reprint SUMO, Ubiquitin, UBL Proteins: Implications For Human Diseases - Fifth International Conference
    Brian Skaug
    University of Texas Southwestern Medical Center, Department of Molecular Biology, Dallas, TX 75390 9148, USA
    IDrugs 13:224-7. 2010
    ..Investigational drugs discussed include MLN-4924 (Millennium Pharmaceuticals Inc)...
  20. ncbi request reprint Cell biology. Kinasing and clipping down the NF-kappa B trail
    Nicolai S C van Oers
    Department of Microbiology and the Center for Immunology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Science 308:65-6. 2005
  21. pmc A ubiquitin replacement strategy in human cells reveals distinct mechanisms of IKK activation by TNFalpha and IL-1beta
    Ming Xu
    Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390 9148, USA
    Mol Cell 36:302-14. 2009
    ..The ubiquitin replacement methodology described here provides a means to investigate the function of polyubiquitin topology in various cellular processes...
  22. doi request reprint The role of ubiquitin in NF-kappaB regulatory pathways
    Brian Skaug
    Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390 9148, USA
    Annu Rev Biochem 78:769-96. 2009
    ....
  23. pmc Key role of Ubc5 and lysine-63 polyubiquitination in viral activation of IRF3
    Wenwen Zeng
    Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390 9148, USA
    Mol Cell 36:315-25. 2009
    ..Furthermore, we show that replacement of endogenous ubiquitin with its K63R mutant abolishes viral activation of IRF3, demonstrating that K63 polyubiquitination plays a key role in IRF3 activation...
  24. doi request reprint Diversity of polyubiquitin chains
    Anirban Adhikari
    Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390 9148, USA
    Dev Cell 16:485-6. 2009
    ..They find that linkages through all lysines of ubiquitin, except lysine-63, can target proteasomal degradation in vivo, and that lysine-11 polyubiquitination is important for endoplasmic reticulum-associated degradation (ERAD)...
  25. ncbi request reprint Activation of the interferon-beta promoter during hepatitis C virus RNA replication
    Brenda Fredericksen
    Departments of Microbiology, University of Texas Southwestern Medical Center, Dallas 75390 9048, USA
    Viral Immunol 15:29-40. 2002
    ..Stable HCV RNA replication in the face of the host antiviral response suggests that HCV may encode one or more proteins capable of overcoming specific antiviral processes, thereby supporting persistent infection...
  26. ncbi request reprint Activation of IKK by TNFalpha requires site-specific ubiquitination of RIP1 and polyubiquitin binding by NEMO
    Chee Kwee Ea
    Howard Hughes Medical Institute, Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    Mol Cell 22:245-57. 2006
    ..These results reveal the biochemical mechanism underlying the essential signaling function of NEMO and provide direct evidence that signal-induced site-specific ubiquitination of RIP1 is required for IKK activation...
  27. ncbi request reprint The specific and essential role of MAVS in antiviral innate immune responses
    Qinmiao Sun
    Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    Immunity 24:633-42. 2006
    ..These results provide the in vivo evidence that the cytosolic viral signaling pathway through MAVS is specifically required for innate immune responses against viral infection...
  28. ncbi request reprint Ubiquitination and TRAF signaling
    Gabriel Pineda
    Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9148, USA
    Adv Exp Med Biol 597:80-92. 2007
  29. doi request reprint MITAgating viral infection
    Wenwen Zeng
    Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Immunity 29:513-5. 2008
    ..2008), report the identification of a membrane protein, termed MITA or STING, that activates the transcription factor IRF3 to induce type-I interferons to mitigate viral infection...
  30. pmc Pellino 3b negatively regulates interleukin-1-induced TAK1-dependent NF kappaB activation
    Hui Xiao
    Department of Immunology, Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    J Biol Chem 283:14654-64. 2008
    ..Taken together, our results suggest that Pellino 3b acts as a negative regulator for IL-1 signaling by regulating IRAK degradation through its ubiquitin protein ligase activity...
  31. pmc Elucidation of the c-Jun N-terminal kinase pathway mediated by Estein-Barr virus-encoded latent membrane protein 1
    Jun Wan
    Department of Biochemistry, Hong Kong University of Science and Technology, Hong Kong, People s Republic of China
    Mol Cell Biol 24:192-9. 2004
    ..Moreover, we have further elucidated the LMP1-mediated JNK pathway by demonstrating that LMP1 selectively utilizes TNF receptor-associated factor 6, TAK1/TAB1, and c-Jun N-terminal kinase kinases 1 and 2 to activate JNK...
  32. ncbi request reprint Glutathione and ABC transporters as determinants of sensitivity to oxidative and nitrosative stress
    Kenneth D Tew
    Department of Pharmacology, Fox Chase Cancer Center, Philadelphia, PA, USA
    J Nutr 134:3205S-3206S. 2004
  33. doi request reprint T cell antigen receptor stimulation induces MALT1 paracaspase-mediated cleavage of the NF-kappaB inhibitor A20
    Beatrice Coornaert
    Department of Molecular Biology, Ghent University, B 9052 Ghent, Belgium
    Nat Immunol 9:263-71. 2008
    ..Our studies identify A20 as a substrate of MALT1 and emphasize the importance of MALT1 proteolytic activity in the 'fine tuning' of T cell antigen receptor signaling...
  34. ncbi request reprint The role of ubiquitination in Drosophila innate immunity
    Rui Zhou
    Department of Molecular and Cellular Biology, Harvard University, Cambridge, Massachusetts 02138, USA
    J Biol Chem 280:34048-55. 2005
    ..These studies reveal an evolutionarily conserved role of ubiquitination in IKK activation, and provide new insights into the hierarchy of signaling components in the Drosophila antibacterial immunity pathway...
  35. ncbi request reprint Nuclear factor-kappaB protects the adult cardiac myocyte against ischemia-induced apoptosis in a murine model of acute myocardial infarction
    Arunima Misra
    Winters Center for Heart Failure Research, Medical Care Service Line, Houston Veterans Administration Medical Center, Houston, Tex 77030, USA
    Circulation 108:3075-8. 2003
    ....
  36. ncbi request reprint Hijacking of host cell IKK signalosomes by the transforming parasite Theileria
    Volker T Heussler
    Division of Molecular Pathology, Institute of Animal Pathology, University of Bern, CH 3012 Bern, Switzerland
    Science 298:1033-6. 2002
    ..Our findings provide insights into IKK activation and how pathogens subvert host-cell signaling pathways...

Research Grants17

  1. Mechanisms of Ubiquitin-Mediated Activation of IKK
    Zhijian Chen; Fiscal Year: 2007
    ..Moreover, our research should help establish a new paradigm of signal transduction in which ubiquitin plays an important regulatory role. ..
  2. Mechanisms of NF-kappaB Activation in T Lymphocytes
    Zhijian Chen; Fiscal Year: 2006
    ..Such knowledge is crucial to understanding and treating various human diseases, including MALT lymphoma and other immune disorders. ..
  3. Ubiquitin-Mediated Activation of the IkB Kinase Complex
    Zhijian Chen; Fiscal Year: 2004
    ..Given the importance of NF-kappaB in human diseases, information gained from the proposed studies will be of direct relevance to biomedicine, including discovery of novel therapeutic targets. ..
  4. Ubiquitin-Mediated Activation of the IkB Kinase Complex
    Zhijian Chen; Fiscal Year: 2002
    ..Given the importance of NF-kappaB in human diseases, information gained from the proposed studies will be of direct relevance to biomedicine, including discovery of novel therapeutic targets. ..
  5. MECHANISMS OF SIGNAL INDUCED UBIQUITINATION OF IKBA
    Zhijian Chen; Fiscal Year: 2001
    ..abstract_text> ..
  6. MECHANISMS OF SIGNAL INDUCED UBIQUITINATION OF IKBA
    Zhijian Chen; Fiscal Year: 2000
    ..abstract_text> ..
  7. Mechanisms of NF-kappaB Activation in T Lymphocytes
    Zhijian Chen; Fiscal Year: 2007
    ..Such knowledge is crucial to understanding and treating various human diseases, including MALT lymphoma and other immune disorders. ..
  8. Mechanisms of Ubiquitin-Mediated Activation of IKK
    Zhijian Chen; Fiscal Year: 2006
    ..Moreover, our research should help establish a new paradigm of signal transduction in which ubiquitin plays an important regulatory role. ..
  9. MECHANISMS OF SIGNAL INDUCED UBIQUITINATION OF IKBA
    Zhijian Chen; Fiscal Year: 1999
    ..abstract_text> ..
  10. Mechanisms of NF-kappaB Activation in T Lymphocytes
    Zhijian Chen; Fiscal Year: 2005
    ..Such knowledge is crucial to understanding and treating various human diseases, including MALT lymphoma and other immune disorders. ..
  11. Mechanisms of NF-kappaB Activation in T Lymphocytes
    Zhijian Chen; Fiscal Year: 2004
    ..Such knowledge is crucial to understanding and treating various human diseases, including MALT lymphoma and other immune disorders. ..
  12. Ubiquitin-Mediated Activation of the IkB Kinase Complex
    Zhijian Chen; Fiscal Year: 2003
    ..Given the importance of NF-kappaB in human diseases, information gained from the proposed studies will be of direct relevance to biomedicine, including discovery of novel therapeutic targets. ..
  13. MECHANISMS OF SIGNAL INDUCED UBIQUITINATION OF IKBA
    Zhijian Chen; Fiscal Year: 2002
    ..abstract_text> ..
  14. Ubiquitin-Mediated Activation of the IkB Kinase Complex
    Zhijian Chen; Fiscal Year: 2001
    ..Given the importance of NF-kappaB in human diseases, information gained from the proposed studies will be of direct relevance to biomedicine, including discovery of novel therapeutic targets. ..
  15. Mechanisms of Ubiquitin-Mediated Activation of IKK
    Zhijian Chen; Fiscal Year: 2005
    ..Moreover, our research should help establish a new paradigm of signal transduction in which ubiquitin plays an important regulatory role. ..