Affiliation: University of Colorado Denver
Woolaver R, Wang X, Dollin Y, Xie P, Wang J, Chen Z. TRAF2 Deficiency in B Cells Impairs CD40-Induced Isotype Switching That Can Be Rescued by Restoring NF-κB1 Activation. J Immunol. 2018;201:3421-3430 pubmed publisher
..Our studies provide significant biological bases for optimizing treatment of B cell-associated immune disorders by targeting CD40 signaling. ..
Chen Z, Wang J. Signaling control of antibody isotype switching. Adv Immunol. 2019;141:105-164 pubmed publisher
..These receptors may share common signaling pathways or may use distinct signaling elements to regulate CSR. Here, we discuss how signals emanating from different receptors positively or negatively regulate AID expression and CSR. ..
Chen Z, Gowan K, Leach S, Viboolsittiseri S, Mishra A, Kadoishi T, et al
. Unexpected effects of different genetic backgrounds on identification of genomic rearrangements via whole-genome next generation sequencing. BMC Genomics. 2016;17:823 pubmed
..Thus, our studies have critical impact on the manner of data analysis for cancer genomics. ..