Yuzhi Chen

Summary

Affiliation: University of Arkansas for Medical Sciences
Country: USA

Publications

  1. pmc Neddylation dysfunction in Alzheimer's disease
    Yuzhi Chen
    Department of Geriatrics and Department of Neurobiology and Developmental Sciences, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA
    J Cell Mol Med 16:2583-91. 2012
  2. pmc APP-BP1 inhibits Abeta42 levels by interacting with Presenilin-1
    Yuzhi Chen
    Department of Geriatrics, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA
    Mol Neurodegener 2:3. 2007
  3. pmc Unique aspects of transcriptional regulation in neurons--nuances in NFkappaB and Sp1-related factors
    Xianrong R Mao
    Department of Anesthesiology, Washington University School of Medicine, St Louis, MO 63110, USA
    J Neuroinflammation 6:16. 2009
  4. doi request reprint Abeta40 promotes neuronal cell fate in neural progenitor cells
    Y Chen
    Department of Geriatrics, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA
    Cell Death Differ 16:386-94. 2009
  5. ncbi request reprint APP induces neuronal apoptosis through APP-BP1-mediated downregulation of beta-catenin
    Y Z Chen
    Department of Geriatrics, College of Medicine, University of Arkansas for Medical Sciences, AR 72205, USA
    Apoptosis 9:415-22. 2004
  6. pmc Amyloid precursor protein modulates beta-catenin degradation
    Yuzhi Chen
    Department of Geriatrics, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA
    J Neuroinflammation 4:29. 2007
  7. pmc Cul4B regulates neural progenitor cell growth
    Helio C Liu
    Department of Geriatrics, University of Arkansas for Medical Sciences, Slot 807, Little Rock, AR 72205, USA
    BMC Neurosci 13:112. 2012
  8. pmc APP-BP1 mediates APP-induced apoptosis and DNA synthesis and is increased in Alzheimer's disease brain
    Yuzhi Chen
    MRC 223, McLean Hospital, 115 Mill St, Belmont, MA 02478, USA
    J Cell Biol 163:27-33. 2003
  9. ncbi request reprint DNA synthesis and neuronal apoptosis caused by familial Alzheimer disease mutants of the amyloid precursor protein are mediated by the p21 activated kinase PAK3
    Donna L McPhie
    Department of Psychiatry, Harvard Medical School and McLean Hospital, Belmont, Massachusetts 02478, USA
    J Neurosci 23:6914-27. 2003
  10. ncbi request reprint ASPP2 inhibits APP-BP1-mediated NEDD8 conjugation to cullin-1 and decreases APP-BP1-induced cell proliferation and neuronal apoptosis
    Yuzhi Chen
    Department of Psychiatry, Harvard Medical School, McLean Hospital, Belmont, Massachusetts, USA
    J Neurochem 85:801-9. 2003

Research Grants

Detail Information

Publications14

  1. pmc Neddylation dysfunction in Alzheimer's disease
    Yuzhi Chen
    Department of Geriatrics and Department of Neurobiology and Developmental Sciences, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA
    J Cell Mol Med 16:2583-91. 2012
    ..Here we review the functions of neddylation and summarize evidence suggesting that dysfunction of neddylation is involved in Alzheimer's disease...
  2. pmc APP-BP1 inhibits Abeta42 levels by interacting with Presenilin-1
    Yuzhi Chen
    Department of Geriatrics, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA
    Mol Neurodegener 2:3. 2007
    ..Increased Abeta42/Abeta40 ratios trigger amyloid plaque formations in Alzheimer's disease (AD). APP binds to APP-BP1, but the biological consequence is not well understood...
  3. pmc Unique aspects of transcriptional regulation in neurons--nuances in NFkappaB and Sp1-related factors
    Xianrong R Mao
    Department of Anesthesiology, Washington University School of Medicine, St Louis, MO 63110, USA
    J Neuroinflammation 6:16. 2009
    ..These findings and their implications for neuronal differentiation--as well as potential dedifferentiation during degenerative processes--are discussed here...
  4. doi request reprint Abeta40 promotes neuronal cell fate in neural progenitor cells
    Y Chen
    Department of Geriatrics, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA
    Cell Death Differ 16:386-94. 2009
    ..Collectively, this report provides strong evidence that Abeta40 is a neurogenic factor and suggests that the debilitated function of Abeta40 in neurogenesis may account for the shortage of neurons in Alzheimer's disease...
  5. ncbi request reprint APP induces neuronal apoptosis through APP-BP1-mediated downregulation of beta-catenin
    Y Z Chen
    Department of Geriatrics, College of Medicine, University of Arkansas for Medical Sciences, AR 72205, USA
    Apoptosis 9:415-22. 2004
    ..Evidence in the literature is summarized to show that dysfunction of APP in downregulating beta-catenin may underlie the mechanism of neuronal death in AD and Down syndrome...
  6. pmc Amyloid precursor protein modulates beta-catenin degradation
    Yuzhi Chen
    Department of Geriatrics, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA
    J Neuroinflammation 4:29. 2007
    ..Elucidating the function of APP should help understand AD pathogenesis and provide insights into therapeutic designs against this devastating neurodegenerative disease...
  7. pmc Cul4B regulates neural progenitor cell growth
    Helio C Liu
    Department of Geriatrics, University of Arkansas for Medical Sciences, Slot 807, Little Rock, AR 72205, USA
    BMC Neurosci 13:112. 2012
    ..Genetic mutations of cullin-4b (cul4b) cause a prevalent type of X-linked intellectual disability (XLID) in males, but the physiological function of Cul4B in neuronal cells remains unclear...
  8. pmc APP-BP1 mediates APP-induced apoptosis and DNA synthesis and is increased in Alzheimer's disease brain
    Yuzhi Chen
    MRC 223, McLean Hospital, 115 Mill St, Belmont, MA 02478, USA
    J Cell Biol 163:27-33. 2003
    ..This translocation of APP-BP1 to lipid rafts is accompanied by a change in the subcellular localization of the ubiquitin-like protein NEDD8, which is activated by APP-BP1...
  9. ncbi request reprint DNA synthesis and neuronal apoptosis caused by familial Alzheimer disease mutants of the amyloid precursor protein are mediated by the p21 activated kinase PAK3
    Donna L McPhie
    Department of Psychiatry, Harvard Medical School and McLean Hospital, Belmont, Massachusetts 02478, USA
    J Neurosci 23:6914-27. 2003
    ..These data suggest that a normal signaling pathway mediated by the interaction of APP, PAK3, and Go is constitutively activated in neurons by FAD mutations in APP and that this activation causes cell cycle entry and consequent apoptosis...
  10. ncbi request reprint ASPP2 inhibits APP-BP1-mediated NEDD8 conjugation to cullin-1 and decreases APP-BP1-induced cell proliferation and neuronal apoptosis
    Yuzhi Chen
    Department of Psychiatry, Harvard Medical School, McLean Hospital, Belmont, Massachusetts, USA
    J Neurochem 85:801-9. 2003
    ....
  11. pmc Optimal decoding of correlated neural population responses in the primate visual cortex
    Yuzhi Chen
    Department of Psychology and Center for Perceptual Systems, 1 University Station, A8000, University of Texas at Austin, Austin, Texas 78712, USA
    Nat Neurosci 9:1412-20. 2006
    ..Overall, our results suggest an unexpected role for inhibitory mechanisms in efficient decoding of neural population responses...
  12. ncbi request reprint Rab5 mediates an amyloid precursor protein signaling pathway that leads to apoptosis
    Daphna Laifenfeld
    Department of Psychiatry, Harvard Medical School, McLean Hospital, Belmont, Massachusetts 02478, USA
    J Neurosci 27:7141-53. 2007
    ....
  13. ncbi request reprint A coarse-to-fine disparity energy model with both phase-shift and position-shift receptive field mechanisms
    Yuzhi Chen
    Center for Neurobiology and Behavior and Department of Physiology and Cellular Biophysics, Columbia University, New York, NY 10032, U S A
    Neural Comput 16:1545-77. 2004
    ..We have tested the algorithm on both synthetic and natural stereo images and found that it often performs better than a simple scale-averaging procedure...
  14. pmc An intact NEDD8 pathway is required for Cullin-dependent ubiquitylation in mammalian cells
    Michael Ohh
    Department of Adult Oncology, Dana Farber Cancer Institute and Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    EMBO Rep 3:177-82. 2002
    ..Thus, neddylation regulates the activity of two specific subclasses of mammalian ubiquitin ligases...

Research Grants1

  1. Amyloid Precursor Protein and Ubiquitination
    Yuzhi Chen; Fiscal Year: 2010
    ..PUBLIC HEALTH RELEVANCE: This project has the potential for discovering molecular mechanisms invaluable for developing rational disease intervention strategies and or biomarkers. ..