Yuhchyau Chen

Summary

Affiliation: University of Rochester
Country: USA

Publications

  1. ncbi request reprint Radiation and third-generation chemotherapy
    Yuhchyau Chen
    Department of Radiation Oncology, University of Rochester Medical Center, 600 Elmwood Avenue, Box 647, Rochester, NY 14642, USA
    Hematol Oncol Clin North Am 18:55-80. 2004
  2. pmc Preclinical and pilot clinical studies of docetaxel chemoradiation for Stage III non-small-cell lung cancer
    Yuhchyau Chen
    Department of Radiation Oncology, University of Rochester Medical Center, Rochester, NY 14642, USA
    Int J Radiat Oncol Biol Phys 80:1358-64. 2011
  3. doi request reprint Validating high-throughput micronucleus analysis of peripheral reticulocytes for radiation biodosimetry: benchmark against dicentric and CBMN assays in a mouse model
    Yuhchyau Chen
    Department of Radiation Oncology, University of Rochester Medical Center, Rochester, NY 14642, USA
    Health Phys 98:218-27. 2010
  4. pmc Toxicity profile and pharmacokinetic study of a phase I low-dose schedule-dependent radiosensitizing paclitaxel chemoradiation regimen for inoperable non-small-cell lung cancer
    Yuhchyau Chen
    Department of Radiation Oncology, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
    Int J Radiat Oncol Biol Phys 71:407-13. 2008
  5. ncbi request reprint Adverse event reporting and developments in radiation biology after normal tissue injury: International Atomic Energy Agency consultation
    Yuhchyau Chen
    Department of Radiation Oncology, James P Wilmot Cancer Center, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642 8647, USA
    Int J Radiat Oncol Biol Phys 64:1442-51. 2006
  6. ncbi request reprint Predictive value of histologic tumor necrosis after radiation
    Y Chen
    Department of Radiation Oncology, Massachusetts General Hospital, Boston, Massachusetts, USA
    Int J Cancer 96:334-40. 2001
  7. ncbi request reprint Phase I/II clinical study of pulsed paclitaxel radiosensitization for thoracic malignancy: a therapeutic approach on the basis of preclinical research of human cancer cell lines
    Yuhchyau Chen
    Department of Radiation, James P Wilmot Cancer Center, University of Rochester, 601 Elmwood Avenue, Rochester, NY 14642, USA
    Clin Cancer Res 9:969-75. 2003
  8. doi request reprint Central thoracic lesions treated with hypofractionated stereotactic body radiotherapy
    Michael T Milano
    Department of Radiation Oncology, University of Rochester Medical Center, Rochester, NY 14642, USA
    Radiother Oncol 91:301-6. 2009
  9. pmc Reticulocyte and micronucleated reticulocyte responses to gamma irradiation: dose-response and time-course profiles measured by flow cytometry
    Stephen D Dertinger
    Litron Laboratories, Rochester, NY 14623, USA
    Mutat Res 634:119-25. 2007
  10. doi request reprint Tumor response kinetics after schedule-dependent paclitaxel chemoradiation treatment for inoperable non-small cell lung cancer: a model for low-dose chemotherapy radiosensitization
    Hong Zhang
    Departments of Radiation Oncology, James P Wilmot Cancer Center, University of Rochester Medical Center, Rochester, New York, USA
    J Thorac Oncol 3:563-8. 2008

Collaborators

Detail Information

Publications45

  1. ncbi request reprint Radiation and third-generation chemotherapy
    Yuhchyau Chen
    Department of Radiation Oncology, University of Rochester Medical Center, 600 Elmwood Avenue, Box 647, Rochester, NY 14642, USA
    Hematol Oncol Clin North Am 18:55-80. 2004
    ..The challenge of targeting distant disease control for locally advanced NSCLC continues...
  2. pmc Preclinical and pilot clinical studies of docetaxel chemoradiation for Stage III non-small-cell lung cancer
    Yuhchyau Chen
    Department of Radiation Oncology, University of Rochester Medical Center, Rochester, NY 14642, USA
    Int J Radiat Oncol Biol Phys 80:1358-64. 2011
    ....
  3. doi request reprint Validating high-throughput micronucleus analysis of peripheral reticulocytes for radiation biodosimetry: benchmark against dicentric and CBMN assays in a mouse model
    Yuhchyau Chen
    Department of Radiation Oncology, University of Rochester Medical Center, Rochester, NY 14642, USA
    Health Phys 98:218-27. 2010
    ..In mice, the dose range of detection is useful up to 1 Gy (C57Bl/6) and 2 Gy (C3H) but not reliable beyond these dose limits. The utilization of this automated analysis for human radiation biodosimetry is currently under investigation...
  4. pmc Toxicity profile and pharmacokinetic study of a phase I low-dose schedule-dependent radiosensitizing paclitaxel chemoradiation regimen for inoperable non-small-cell lung cancer
    Yuhchyau Chen
    Department of Radiation Oncology, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
    Int J Radiat Oncol Biol Phys 71:407-13. 2008
    ..We report the toxicity profile and pharmacokinetic data of a schedule-dependent chemoradiation regimen using pulsed low-dose paclitaxel for radiosensitization in a Phase I study for inoperable non-small-cell lung cancer...
  5. ncbi request reprint Adverse event reporting and developments in radiation biology after normal tissue injury: International Atomic Energy Agency consultation
    Yuhchyau Chen
    Department of Radiation Oncology, James P Wilmot Cancer Center, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642 8647, USA
    Int J Radiat Oncol Biol Phys 64:1442-51. 2006
    ....
  6. ncbi request reprint Predictive value of histologic tumor necrosis after radiation
    Y Chen
    Department of Radiation Oncology, Massachusetts General Hospital, Boston, Massachusetts, USA
    Int J Cancer 96:334-40. 2001
    ..Despite common practices in histologic examination of tumors posttherapy, clinical interpretations and implications of histologic tumor necrosis after radiotherapy should be considered with caution...
  7. ncbi request reprint Phase I/II clinical study of pulsed paclitaxel radiosensitization for thoracic malignancy: a therapeutic approach on the basis of preclinical research of human cancer cell lines
    Yuhchyau Chen
    Department of Radiation, James P Wilmot Cancer Center, University of Rochester, 601 Elmwood Avenue, Rochester, NY 14642, USA
    Clin Cancer Res 9:969-75. 2003
    ..The study was based on preclinical research of the effects of paclitaxel on apoptosis and the cell cycle in human cancer cell lines...
  8. doi request reprint Central thoracic lesions treated with hypofractionated stereotactic body radiotherapy
    Michael T Milano
    Department of Radiation Oncology, University of Rochester Medical Center, Rochester, NY 14642, USA
    Radiother Oncol 91:301-6. 2009
    ..To investigate the toxicity and outcome after moderately hypofractionated stereotactic body radiotherapy (SBRT) for central thoracic lesions...
  9. pmc Reticulocyte and micronucleated reticulocyte responses to gamma irradiation: dose-response and time-course profiles measured by flow cytometry
    Stephen D Dertinger
    Litron Laboratories, Rochester, NY 14623, USA
    Mutat Res 634:119-25. 2007
    ....
  10. doi request reprint Tumor response kinetics after schedule-dependent paclitaxel chemoradiation treatment for inoperable non-small cell lung cancer: a model for low-dose chemotherapy radiosensitization
    Hong Zhang
    Departments of Radiation Oncology, James P Wilmot Cancer Center, University of Rochester Medical Center, Rochester, New York, USA
    J Thorac Oncol 3:563-8. 2008
    ..Given our unique results, we analyzed the tumor response kinetics and conducted a statistical modeling of tumor response to characterize this regimen...
  11. ncbi request reprint Interleukin (IL)-1A and IL-6: applications to the predictive diagnostic testing of radiation pneumonitis
    Yuhchyau Chen
    Department of Radiation Oncology, James P Wilmot Cancer Center, University of Rochester Medical Center, Rochester, NY 14642, USA
    Int J Radiat Oncol Biol Phys 62:260-6. 2005
    ..To explore the application of interleukin (IL)-1alpha and IL-6 measurements in the predictive diagnostic testing for symptomatic radiation pneumonitis (RP)...
  12. pmc Reticulocyte and micronucleated reticulocyte responses to gamma irradiation: effect of age
    Stephen D Dertinger
    Litron Laboratories, Rochester, NY, USA
    Mutat Res 675:77-80. 2009
    ....
  13. ncbi request reprint Three-color labeling method for flow cytometric measurement of cytogenetic damage in rodent and human blood
    Stephen D Dertinger
    Litron Laboratories, Rochester, New York 14620, USA
    Environ Mol Mutagen 44:427-35. 2004
    ....
  14. pmc Response kinetics of radiation-induced micronucleated reticulocytes in human bone marrow culture
    Hongliang Sun
    Department of Radiation Oncology, University of Rochester Medical Center, 601 Elmwood Ave, Box 647, Rochester, NY 14642 8647, United States
    Mutat Res 718:38-43. 2011
    ....
  15. doi request reprint Split-course palliative radiotherapy for advanced non-small cell lung cancer
    Su K Metcalfe
    Department of Radiation Oncology, James P Wilmot Cancer Center, University of Rochester, Rochester, New York, USA
    J Thorac Oncol 5:185-90. 2010
    ..Albeit an important subject, there is a lack of consensus for an optimal palliative RT regimen. We report the outcomes of a split-course palliative chest RT, a frequently used schema at our institution...
  16. doi request reprint Second primary lung cancer after head and neck squamous cell cancer: population-based study of risk factors
    Michael T Milano
    Department of Radiation Oncology, University of Rochester Medical Center, Rochester, NY 14642, USA
    Head Neck 34:1782-8. 2012
    ..Patients with head and neck squamous cell cancer (HNSCC) are at risk of developing second primary lung cancer (SPLC)...
  17. pmc Gamma-radiation induces micronucleated reticulocytes in 3D bone marrow bioreactors in vitro
    Hongliang Sun
    Department of Radiation Oncology, University of Rochester Medical Center, Rochester, NY, United States
    Mutat Res 680:49-55. 2009
    ..5-2.0 Gy. The MN-RET response showed a downtrend beyond 2 Gy. Our data suggest that bone marrow culture in the 3D bioreactor may be a useful organ culture system for the investigation of radiation genotoxic effect in vitro...
  18. pmc Comparison of outcomes in patients with stage III versus limited stage IV non-small cell lung cancer
    Praveena Cheruvu
    Department of Radiation Oncology, University of Rochester Medical Center, Rochester, New York, USA
    Radiat Oncol 6:80. 2011
    ..We hypothesized that patients treated with SBRT for limited metastases have comparable outcomes with those treated with curative-intent radiation for Stage III NSCLC...
  19. ncbi request reprint Translational research in lung cancer
    Yuhchyau Chen
    Department of Radiation Oncology, University of Rochester Medical Center, Rochester, New York 14642, USA
    Semin Surg Oncol 21:205-19. 2003
    ..We believe that knowledge of lung cancer biology will continue to provide the foundation for future improvements in lung cancer treatment...
  20. ncbi request reprint The biological basis of a comprehensive grading system for the adverse effects of cancer treatment
    Jacqueline Williams
    Department of Radiation Oncology, University of Rochester Medical Center, Rochester, NY 14642, USA
    Semin Radiat Oncol 13:182-8. 2003
    ..It also provides insights into potential targets and strategies for modulating response, which may in turn lead to effective interventions for altering the therapeutic ratio...
  21. ncbi request reprint Combination of radiation and celebrex (celecoxib) reduce mammary and lung tumor growth
    Weimin Liu
    Department of Radiation Oncology, University of Rochester, Rochester, New York 14642, USA
    Am J Clin Oncol 26:S103-9. 2003
    ....
  22. pmc Eltrombopag, a thrombopoietin receptor agonist, enhances human umbilical cord blood hematopoietic stem/primitive progenitor cell expansion and promotes multi-lineage hematopoiesis
    Hongliang Sun
    Department of Radiation Oncology, University of Rochester Medical Center, 601 Elmwood Ave, Box 647, Rochester, NY 14642, USA
    Stem Cell Res 9:77-86. 2012
    ..Eltrombopag differed somewhat from rhTPO in the signal transduction pathways by favoring earlier HSC/HPC populations...
  23. doi request reprint Impact of radiotherapy on laryngeal cancer survival: a population-based study of 13,808 US patients
    Hong Zhang
    Department of Radiation Oncology, University of Rochester Medical Center, Rochester, New York 14642 8647, USA
    Cancer 118:1276-87. 2012
    ..However, the impact of radiation on overall survival (OS) in a large population-based study has not been evaluated to date...
  24. ncbi request reprint Micronucleated CD71-positive reticulocytes: a blood-based endpoint of cytogenetic damage in humans
    Stephen D Dertinger
    Litron Laboratories, 1351 Mount Hope Avenue, Rochester, NY 14620, USA
    Mutat Res 542:77-87. 2003
    ....
  25. doi request reprint Use of eltrombopag, a thrombopoietin receptor agonist, in post-transplantation thrombocytopenia
    Robin Reid
    Department of Internal Medicine, University of Rochester Medical Center, Rochester, New York, USA
    Am J Hematol 87:743-5. 2012
    ..The use of eltrombopag in these two cases was effective in elevating platelet counts to levels that eliminated the need for platelet transfusions...
  26. doi request reprint Definitive radiotherapy for stage I nonsmall cell lung cancer: a population-based study of survival
    Michael T Milano
    Department of Radiation Oncology, University of Rochester Medical Center, Rochester, New York 14642, USA
    Cancer 118:5572-9. 2012
    ....
  27. pmc Sublethal radiation injury uncovers a functional transition during erythroid maturation
    Scott A Peslak
    Center for Pediatric Biomedical Research, Department of Pediatrics, University of Rochester Medical Center, Rochester, NY 14642, USA
    Exp Hematol 39:434-45. 2011
    ..To better understand this phenomenon, we investigated the kinetics and apoptotic response of the erythron to sublethal radiation injury...
  28. pmc Molecular markers of radiation-related normal tissue toxicity
    Paul Okunieff
    Department of Radiation Oncology, James P Wilmot Cancer Center, University of Rochester School of Medicine and Dentistry, 601 Elmwood Avenue, Box 647, Rochester, NY 14642, USA
    Cancer Metastasis Rev 27:363-74. 2008
    ..Genomics and proteomics are still in nascent stages and are actively being studied and developed...
  29. doi request reprint Palifermin reduces severe mucositis in definitive chemoradiotherapy of locally advanced head and neck cancer: a randomized, placebo-controlled study
    Quynh Thu Le
    Department of Radiation Oncology, Stanford University, Stanford, CA 94305, USA
    J Clin Oncol 29:2808-14. 2011
    ..This randomized, placebo-controlled, double-blind study evaluated the efficacy and safety of palifermin to reduce OM associated with definitive chemoradiotherapy for locally advanced HNC...
  30. ncbi request reprint Circulating IL-6 as a predictor of radiation pneumonitis
    Y Chen
    Department of Radiation Oncology, James P Wilmot Cancer Center, University of Rochester, 601 Elmwood Ave, Box 647, Rochester, NY 14642, USA
    Int J Radiat Oncol Biol Phys 49:641-8. 2001
    ..We report results from a clinical research protocol investigating circulating pro-inflammatory cytokines (interleukin-6 [IL-6] and tumor necrosis factor alpha [TNFalpha]) in relation to radiation pulmonary injury...
  31. doi request reprint Stereotactic body radiotherapy for treatment of adrenal metastases
    Sheema Chawla
    Department of Radiation Oncology, University of Rochester Medical Center, Rochester, NY 14642, USA
    Int J Radiat Oncol Biol Phys 75:71-5. 2009
    ..To investigate the dosimetry and outcomes of patients undergoing stereotactic body radiotherapy (SBRT) for metastases to the adrenal glands...
  32. ncbi request reprint Radiation pneumonitis and early circulatory cytokine markers
    Yuhchyau Chen
    Department of Radiation Oncology, James P Wilmot Cancer Center, University of Rochester, Rochester, NY 14642, USA
    Semin Radiat Oncol 12:26-33. 2002
    ..Analysis of a panel of circulating cytokines with different putative functions in radiation pulmonary injury identified IL-1alpha and IL-6 as early circulating cytokine markers for radiation pneumonitis...
  33. pmc Loss of androgen receptor promotes adipogenesis but suppresses osteogenesis in bone marrow stromal cells
    Chiung Kuei Huang
    George Whipple Lab for Cancer Research, Departments of Pathology, Radiation Oncology, Urology, and The Wilmot Cancer Center University of Rochester Medical Center, Rochester, NY 14642, USA
    Stem Cell Res 11:938-50. 2013
    ..These results suggested that AR-mediated changes in IGFBP3 might modulate the IGF-Akt axis to regulate adipogenesis in BMSCs. ..
  34. pmc Acupressure bands are effective in reducing radiation therapy-related nausea
    Joseph A Roscoe
    University of Rochester James P Wilmot Cancer Center, Rochester, NY 14642, USA
    J Pain Symptom Manage 38:381-9. 2009
    ..An attempt to boost the efficacy of the acupressure bands by providing positive information was not successful...
  35. ncbi request reprint ERK MAP kinase links cytokine signals to activation of latent HIV-1 infection by stimulating a cooperative interaction of AP-1 and NF-kappaB
    X Yang
    Department of Cancer Immunology and AIDS, Dana Farber Cancer Institute, Boston, Massachusetts 02115, USA
    J Biol Chem 274:27981-8. 1999
    ..These results define a mechanism for signal-dependent activation of HIV-1 replication in latently infected cells and suggest potential therapeutic strategies for unmasking latent reservoirs of HIV-1...
  36. pmc Increased chemosensitivity via targeting testicular nuclear receptor 4 (TR4)-Oct4-interleukin 1 receptor antagonist (IL1Ra) axis in prostate cancer CD133+ stem/progenitor cells to battle prostate cancer
    Dong Rong Yang
    George Whipple Laboratory for Cancer Research, Department of Pathology, University of Rochester Medical Center, Rochester, New York 14642, USA
    J Biol Chem 288:16476-83. 2013
    ....
  37. ncbi request reprint Schedule-dependent pulsed paclitaxel radiosensitization for thoracic malignancy
    Y Chen
    Department of Radiation Oncology, James P. Wilmot Cancer Center, University of Rochester, Rochester, New York, USA
    Am J Clin Oncol 24:432-7. 2001
    ..It is concluded that pulsed low-dose paclitaxel and radiation is a very effective and well-tolerated regimen for thoracic malignancy...
  38. ncbi request reprint Calnexin and other factors that alter translocation affect the rapid binding of ubiquitin to apoB in the Sec61 complex
    Y Chen
    Molecular Medicine Unit, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA
    J Biol Chem 273:11887-94. 1998
    ..Thus, ubiquitin can be attached to unassembled apolipoprotein B in the Sec61 complex, and this process is affected by factors including calnexin that alter the translocation of apolipoprotein B...
  39. ncbi request reprint Relationship between dopamine-stimulated phospholipid methylation and the single-carbon folate pathway
    R Zhao
    Department of Pharmaceutical Sciences, Northeastern University, Boston, Massachusetts 02115, USA
    J Neurochem 78:788-96. 2001
    ..Together, these findings indicate a close functional relationship between single-carbon folate metabolism and DA-stimulated PLM, consistent with a role for 5-methylTHF as the methyl donor for the D4R-mediated process...
  40. ncbi request reprint Quercetin inhibits the expression and function of the androgen receptor in LNCaP prostate cancer cells
    N Xing
    Department of Urology and Biochemistry and Molecular Biology, Mayo Graduate School, Mayo Foundation, Rochester, MN 55905, USA
    Carcinogenesis 22:409-14. 2001
    ..Our result suggests that quercetin can attenuate the function of AR by repressing its expression and has the potential to become a chemopreventive and/or chemotherapeutic agent for prostate cancer...
  41. ncbi request reprint Hypoxia and acidosis independently up-regulate vascular endothelial growth factor transcription in brain tumors in vivo
    D Fukumura
    Edwin L Steele Laboratory, Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
    Cancer Res 61:6020-4. 2001
    ..These results suggest that VEGF transcription in brain tumors is regulated by both tissue pO(2) and pH via distinct pathways...
  42. doi request reprint Evaluation of inelastic hadronic processes for 250 MeV proton interactions in tissue and iron using GEANT4
    Y Chen
    Department of Radiation Oncology, The University of Oklahoma Health Sciences Center, 825 N E 10th Street, Oklahoma City, OK 73104, USA
    Radiat Prot Dosimetry 136:11-6. 2009
    ..The findings suggest that the models play critical roles in terms of secondary particle generation. Further benchmarks are necessary to select the best model predicting a realistic scenario...
  43. ncbi request reprint Independent dosimetric calculation with inclusion of head scatter and MLC transmission for IMRT
    Y Yang
    Department of Radiation Oncology, Stanford University School of Medicine, Stanford, California 94305 5304, USA
    Med Phys 30:2937-47. 2003
    ..These results indicate that the approach is robust and valuable for routine clinical IMRT plan validation...
  44. ncbi request reprint Past, present, and future of oxygen in cancer research
    Paul Okunieff
    Adv Exp Med Biol 566:213-22. 2005
    ..ISOTT scientists are responsible for much of the elucidation of the specific effects of O2, ADP/ATP ratios, hypoglycemia, and acidosis on tumor responses to radiation and hyperthermia. Many questions still remain...
  45. pmc Automated human blood micronucleated reticulocyte measurements for rapid assessment of chromosomal damage
    Stephen D Dertinger
    Litron Laboratories, 200 Canal View Boulevard, Rochester, NY, United States
    Mutat Res 626:111-9. 2007
    ..Taken together, these data support the hypothesis that the MNCD71+ endpoint represents a valuable biomarker of cytogenetic damage that does not require cell culture or microscopy-based scoring...