Research Topics
Species | Yuhchyau ChenSummaryAffiliation: University of Rochester Country: USA Publications
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Detail Information
Publications
Preclinical and pilot clinical studies of docetaxel chemoradiation for Stage III non-small-cell lung cancerYuhchyau Chen
Department of Radiation Oncology, University of Rochester Medical Center, Rochester, NY 14642, USA
Int J Radiat Oncol Biol Phys 80:1358-64. 2011....
Validating high-throughput micronucleus analysis of peripheral reticulocytes for radiation biodosimetry: benchmark against dicentric and CBMN assays in a mouse modelYuhchyau Chen
Department of Radiation Oncology, University of Rochester Medical Center, Rochester, NY 14642, USA
Health Phys 98:218-27. 2010..In mice, the dose range of detection is useful up to 1 Gy (C57Bl/6) and 2 Gy (C3H) but not reliable beyond these dose limits. The utilization of this automated analysis for human radiation biodosimetry is currently under investigation...
Radiation and third-generation chemotherapyYuhchyau Chen
Department of Radiation Oncology, University of Rochester Medical Center, 600 Elmwood Avenue, Box 647, Rochester, NY 14642, USA
Hematol Oncol Clin North Am 18:55-80. 2004..The challenge of targeting distant disease control for locally advanced NSCLC continues...- Adverse event reporting and developments in radiation biology after normal tissue injury: International Atomic Energy Agency consultationYuhchyau Chen
Department of Radiation Oncology, James P Wilmot Cancer Center, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642 8647, USA
Int J Radiat Oncol Biol Phys 64:1442-51. 2006.... - Toxicity profile and pharmacokinetic study of a phase I low-dose schedule-dependent radiosensitizing paclitaxel chemoradiation regimen for inoperable non-small-cell lung cancerYuhchyau Chen
Department of Radiation Oncology, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
Int J Radiat Oncol Biol Phys 71:407-13. 2008..We report the toxicity profile and pharmacokinetic data of a schedule-dependent chemoradiation regimen using pulsed low-dose paclitaxel for radiosensitization in a Phase I study for inoperable non-small-cell lung cancer... - Phase I/II clinical study of pulsed paclitaxel radiosensitization for thoracic malignancy: a therapeutic approach on the basis of preclinical research of human cancer cell linesYuhchyau Chen
Department of Radiation, James P Wilmot Cancer Center, University of Rochester, 601 Elmwood Avenue, Rochester, NY 14642, USA
Clin Cancer Res 9:969-75. 2003..The study was based on preclinical research of the effects of paclitaxel on apoptosis and the cell cycle in human cancer cell lines... - Predictive value of histologic tumor necrosis after radiationY Chen
Department of Radiation Oncology, Massachusetts General Hospital, Boston, Massachusetts, USA
Int J Cancer 96:334-40. 2001..Despite common practices in histologic examination of tumors posttherapy, clinical interpretations and implications of histologic tumor necrosis after radiotherapy should be considered with caution... - Reticulocyte and micronucleated reticulocyte responses to gamma irradiation: dose-response and time-course profiles measured by flow cytometryStephen D Dertinger
Litron Laboratories, Rochester, NY 14623, USA
Mutat Res 634:119-25. 2007.... - Central thoracic lesions treated with hypofractionated stereotactic body radiotherapyMichael T Milano
Department of Radiation Oncology, University of Rochester Medical Center, Rochester, NY 14642, USA
Radiother Oncol 91:301-6. 2009..To investigate the toxicity and outcome after moderately hypofractionated stereotactic body radiotherapy (SBRT) for central thoracic lesions... - Tumor response kinetics after schedule-dependent paclitaxel chemoradiation treatment for inoperable non-small cell lung cancer: a model for low-dose chemotherapy radiosensitizationHong Zhang
Departments of Radiation Oncology, James P Wilmot Cancer Center, University of Rochester Medical Center, Rochester, New York, USA
J Thorac Oncol 3:563-8. 2008..Given our unique results, we analyzed the tumor response kinetics and conducted a statistical modeling of tumor response to characterize this regimen... - Reticulocyte and micronucleated reticulocyte responses to gamma irradiation: effect of ageStephen D Dertinger
Litron Laboratories, Rochester, NY, USA
Mutat Res 675:77-80. 2009.... - Three-color labeling method for flow cytometric measurement of cytogenetic damage in rodent and human bloodStephen D Dertinger
Litron Laboratories, Rochester, New York 14620, USA
Environ Mol Mutagen 44:427-35. 2004.... - Interleukin (IL)-1A and IL-6: applications to the predictive diagnostic testing of radiation pneumonitisYuhchyau Chen
Department of Radiation Oncology, James P. Wilmot Cancer Center, University of Rochester Medical Center, Rochester, NY 14642, USA
Int J Radiat Oncol Biol Phys 62:260-6. 2005..Interleukin-6 measurements offer stronger positive predictive value than IL-1alpha. This application might be further explored in a larger sample of patients... - Response kinetics of radiation-induced micronucleated reticulocytes in human bone marrow cultureHongliang Sun
Department of Radiation Oncology, University of Rochester Medical Center, 601 Elmwood Ave, Box 647, Rochester, NY 14642 8647, United States
Mutat Res 718:38-43. 2011.... - Split-course palliative radiotherapy for advanced non-small cell lung cancerSu K Metcalfe
Department of Radiation Oncology, James P Wilmot Cancer Center, University of Rochester, Rochester, New York, USA
J Thorac Oncol 5:185-90. 2010..Albeit an important subject, there is a lack of consensus for an optimal palliative RT regimen. We report the outcomes of a split-course palliative chest RT, a frequently used schema at our institution... - Gamma-radiation induces micronucleated reticulocytes in 3D bone marrow bioreactors in vitroHongliang Sun
Department of Radiation Oncology, University of Rochester Medical Center, Rochester, NY, United States
Mutat Res 680:49-55. 2009..5-2.0 Gy. The MN-RET response showed a downtrend beyond 2 Gy. Our data suggest that bone marrow culture in the 3D bioreactor may be a useful organ culture system for the investigation of radiation genotoxic effect in vitro... - Comparison of outcomes in patients with stage III versus limited stage IV non-small cell lung cancerPraveena Cheruvu
Department of Radiation Oncology, University of Rochester Medical Center, Rochester, New York, USA
Radiat Oncol 6:80. 2011..We hypothesized that patients treated with SBRT for limited metastases have comparable outcomes with those treated with curative-intent radiation for Stage III NSCLC... - Translational research in lung cancerYuhchyau Chen
Department of Radiation Oncology, University of Rochester Medical Center, Rochester, New York 14642, USA
Semin Surg Oncol 21:205-19. 2003..We believe that knowledge of lung cancer biology will continue to provide the foundation for future improvements in lung cancer treatment... - The biological basis of a comprehensive grading system for the adverse effects of cancer treatmentJacqueline Williams
Department of Radiation Oncology, University of Rochester Medical Center, Rochester, NY 14642, USA
Semin Radiat Oncol 13:182-8. 2003..It also provides insights into potential targets and strategies for modulating response, which may in turn lead to effective interventions for altering the therapeutic ratio... - Combination of radiation and celebrex (celecoxib) reduce mammary and lung tumor growthWeimin Liu
Department of Radiation Oncology, University of Rochester, Rochester, New York 14642, USA
Am J Clin Oncol 26:S103-9. 2003.... - Eltrombopag, a thrombopoietin receptor agonist, enhances human umbilical cord blood hematopoietic stem/primitive progenitor cell expansion and promotes multi-lineage hematopoiesisHongliang Sun
Department of Radiation Oncology, University of Rochester Medical Center, 601 Elmwood Ave, Box 647, Rochester, NY 14642, USA
Stem Cell Res 9:77-86. 2012..Eltrombopag differed somewhat from rhTPO in the signal transduction pathways by favoring earlier HSC/HPC populations... - Impact of radiotherapy on laryngeal cancer survival: a population-based study of 13,808 US patientsHong Zhang
Department of Radiation Oncology, University of Rochester Medical Center, Rochester, New York 14642 8647, USA
Cancer 118:1276-87. 2012..However, the impact of radiation on overall survival (OS) in a large population-based study has not been evaluated to date... - Micronucleated CD71-positive reticulocytes: a blood-based endpoint of cytogenetic damage in humansStephen D Dertinger
Litron Laboratories, 1351 Mount Hope Avenue, Rochester, NY 14620, USA
Mutat Res 542:77-87. 2003.... - Use of eltrombopag, a thrombopoietin receptor agonist, in post-transplantation thrombocytopeniaRobin Reid
Department of Internal Medicine, University of Rochester Medical Center, Rochester, New York, USA
Am J Hematol 87:743-5. 2012..The use of eltrombopag in these two cases was effective in elevating platelet counts to levels that eliminated the need for platelet transfusions... - Definitive radiotherapy for stage I nonsmall cell lung cancer: a population-based study of survivalMichael T Milano
Department of Radiation Oncology, University of Rochester Medical Center, Rochester, New York 14642, USA
Cancer 118:5572-9. 2012.... - Palifermin reduces severe mucositis in definitive chemoradiotherapy of locally advanced head and neck cancer: a randomized, placebo-controlled studyQuynh Thu Le
Department of Radiation Oncology, Stanford University, Stanford, CA 94305, USA
J Clin Oncol 29:2808-14. 2011..This randomized, placebo-controlled, double-blind study evaluated the efficacy and safety of palifermin to reduce OM associated with definitive chemoradiotherapy for locally advanced HNC... - Sublethal radiation injury uncovers a functional transition during erythroid maturationScott A Peslak
Center for Pediatric Biomedical Research, Department of Pediatrics, University of Rochester Medical Center, Rochester, NY 14642, USA
Exp Hematol 39:434-45. 2011..To better understand this phenomenon, we investigated the kinetics and apoptotic response of the erythron to sublethal radiation injury... - Molecular markers of radiation-related normal tissue toxicityPaul Okunieff
Department of Radiation Oncology, James P Wilmot Cancer Center, University of Rochester School of Medicine and Dentistry, 601 Elmwood Avenue, Box 647, Rochester, NY 14642, USA
Cancer Metastasis Rev 27:363-74. 2008..Genomics and proteomics are still in nascent stages and are actively being studied and developed... - Circulating IL-6 as a predictor of radiation pneumonitisY Chen
Department of Radiation Oncology, James P Wilmot Cancer Center, University of Rochester, 601 Elmwood Ave, Box 647, Rochester, NY 14642, USA
Int J Radiat Oncol Biol Phys 49:641-8. 2001..We report results from a clinical research protocol investigating circulating pro-inflammatory cytokines (interleukin-6 [IL-6] and tumor necrosis factor alpha [TNFalpha]) in relation to radiation pulmonary injury... - Second primary lung cancer after head and neck squamous cell cancer: Population-based study of risk factorsMichael T Milano
Department of Radiation Oncology, University of Rochester Medical Center, Rochester, NY 14642
Head Neck 34:1782-8. 2012..Patients with head and neck squamous cell cancer (HNSCC) are at risk of developing second primary lung cancer (SPLC)... - Radiation pneumonitis and early circulatory cytokine markersYuhchyau Chen
Department of Radiation Oncology, James P Wilmot Cancer Center, University of Rochester, Rochester, NY 14642, USA
Semin Radiat Oncol 12:26-33. 2002..Analysis of a panel of circulating cytokines with different putative functions in radiation pulmonary injury identified IL-1alpha and IL-6 as early circulating cytokine markers for radiation pneumonitis... - Stereotactic body radiotherapy for treatment of adrenal metastasesSheema Chawla
Department of Radiation Oncology, University of Rochester Medical Center, Rochester, NY 14642, USA
Int J Radiat Oncol Biol Phys 75:71-5. 2009..To investigate the dosimetry and outcomes of patients undergoing stereotactic body radiotherapy (SBRT) for metastases to the adrenal glands... - Acupressure bands are effective in reducing radiation therapy-related nauseaJoseph A Roscoe
University of Rochester James P Wilmot Cancer Center, Rochester, NY 14642, USA
J Pain Symptom Manage 38:381-9. 2009..An attempt to boost the efficacy of the acupressure bands by providing positive information was not successful... - ERK MAP kinase links cytokine signals to activation of latent HIV-1 infection by stimulating a cooperative interaction of AP-1 and NF-kappaBX Yang
Department of Cancer Immunology and AIDS, Dana Farber Cancer Institute, Boston, Massachusetts 02115, USA
J Biol Chem 274:27981-8. 1999..These results define a mechanism for signal-dependent activation of HIV-1 replication in latently infected cells and suggest potential therapeutic strategies for unmasking latent reservoirs of HIV-1... - Schedule-dependent pulsed paclitaxel radiosensitization for thoracic malignancyY Chen
Department of Radiation Oncology, James P. Wilmot Cancer Center, University of Rochester, Rochester, New York, USA
Am J Clin Oncol 24:432-7. 2001..It is concluded that pulsed low-dose paclitaxel and radiation is a very effective and well-tolerated regimen for thoracic malignancy... - Relationship between dopamine-stimulated phospholipid methylation and the single-carbon folate pathwayR Zhao
Department of Pharmaceutical Sciences, Northeastern University, Boston, Massachusetts 02115, USA
J Neurochem 78:788-96. 2001..Together, these findings indicate a close functional relationship between single-carbon folate metabolism and DA-stimulated PLM, consistent with a role for 5-methylTHF as the methyl donor for the D4R-mediated process... - Quercetin inhibits the expression and function of the androgen receptor in LNCaP prostate cancer cellsN Xing
Department of Urology and Biochemistry and Molecular Biology, Mayo Graduate School, Mayo Foundation, Rochester, MN 55905, USA
Carcinogenesis 22:409-14. 2001..Our result suggests that quercetin can attenuate the function of AR by repressing its expression and has the potential to become a chemopreventive and/or chemotherapeutic agent for prostate cancer... - Hypoxia and acidosis independently up-regulate vascular endothelial growth factor transcription in brain tumors in vivoD Fukumura
Edwin L Steele Laboratory, Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
Cancer Res 61:6020-4. 2001..These results suggest that VEGF transcription in brain tumors is regulated by both tissue pO(2) and pH via distinct pathways... - Evaluation of inelastic hadronic processes for 250 MeV proton interactions in tissue and iron using GEANT4Y Chen
Department of Radiation Oncology, The University of Oklahoma Health Sciences Center, 825 N E 10th Street, Oklahoma City, OK 73104, USA
Radiat Prot Dosimetry 136:11-6. 2009..The findings suggest that the models play critical roles in terms of secondary particle generation. Further benchmarks are necessary to select the best model predicting a realistic scenario... - Calnexin and other factors that alter translocation affect the rapid binding of ubiquitin to apoB in the Sec61 complexY Chen
Molecular Medicine Unit, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA
J Biol Chem 273:11887-94. 1998..Thus, ubiquitin can be attached to unassembled apolipoprotein B in the Sec61 complex, and this process is affected by factors including calnexin that alter the translocation of apolipoprotein B... - Independent dosimetric calculation with inclusion of head scatter and MLC transmission for IMRTY Yang
Department of Radiation Oncology, Stanford University School of Medicine, Stanford, California 94305-5304, USA
Med Phys 30:2937-47. 2003..These results indicate that the approach is robust and valuable for routine clinical IMRT plan validation... - Past, present, and future of oxygen in cancer researchPaul Okunieff
Adv Exp Med Biol 566:213-22. 2005..ISOTT scientists are responsible for much of the elucidation of the specific effects of O2, ADP/ATP ratios, hypoglycemia, and acidosis on tumor responses to radiation and hyperthermia. Many questions still remain... - Automated human blood micronucleated reticulocyte measurements for rapid assessment of chromosomal damageStephen D Dertinger
Litron Laboratories, 200 Canal View Boulevard, Rochester, NY, United States
Mutat Res 626:111-9. 2007..Taken together, these data support the hypothesis that the MNCD71+ endpoint represents a valuable biomarker of cytogenetic damage that does not require cell culture or microscopy-based scoring...