Yu Chen

Summary

Affiliation: University of Chicago
Country: USA

Publications

  1. ncbi request reprint Arsenic exposure from drinking-water and carotid artery intima-medial thickness in healthy young adults in Bangladesh
    Yu Chen
    Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, 10032, USA
    J Health Popul Nutr 24:253-7. 2006
  2. ncbi request reprint New insight into site-specific recombination from Flp recombinase-DNA structures
    Yu Chen
    Department of Biochemistry and Molecular Biology, The University of Chicago, Chicago, Illinois 60637, USA
    Annu Rev Biophys Biomol Struct 32:135-59. 2003
  3. ncbi request reprint Structural plasticity of the Flp-Holliday junction complex
    Adam B Conway
    Department of Biochemistry and Molecular Biology, University of Chicago, 920 E 58th Street CLSC 221, Chicago, IL 60637, USA
    J Mol Biol 326:425-34. 2003
  4. ncbi request reprint The role of the conserved Trp330 in Flp-mediated recombination. Functional and structural analysis
    Yu Chen
    Department of Biochemistry and Molecular Biology, The University of Chicago, Illinois 60637, USA
    J Biol Chem 278:24800-7. 2003
  5. pmc Identification of a potential general acid/base in the reversible phosphoryl transfer reactions catalyzed by tyrosine recombinases: Flp H305
    Katrine L Whiteson
    Department of Biochemistry and Molecular Biology, The University of Chicago, Chicago, IL 60637, USA
    Chem Biol 14:121-9. 2007
  6. ncbi request reprint Arsenic metabolism, genetic susceptibility, and risk of premalignant skin lesions in Bangladesh
    Habibul Ahsan
    Departments of Epidemiology, Columbia University, USA
    Cancer Epidemiol Biomarkers Prev 16:1270-8. 2007
  7. doi request reprint Arsenic exposure from drinking water, and all-cause and chronic-disease mortalities in Bangladesh (HEALS): a prospective cohort study
    Maria Argos
    Department of Health Studies, University of Chicago, Chicago, IL 60637, USA
    Lancet 376:252-8. 2010
  8. ncbi request reprint TGFBR1*6A may contribute to hereditary colorectal cancer
    Yansong Bian
    Cancer Genetics Program, Division of Hematology Oncology, Department of Medicine, Robert H Lurie Comprehensive Cancer Center, Northwestern University Feinberg School of Medicine, 676 N St Clair St, Suite 880, Chicago, IL 60611, USA
    J Clin Oncol 23:3074-8. 2005
  9. ncbi request reprint Combined genetic assessment of transforming growth factor-beta signaling pathway variants may predict breast cancer risk
    Virginia G Kaklamani
    Cancer Genetics Program, Division of Hematology Oncology, Department of Medicine, Feinberg School of Medicine and Robert H Lurie Comprehensive Cancer Center, Northwestern University, 676 North St Clair Street, Chicago, IL 60611, USA
    Cancer Res 65:3454-61. 2005
  10. pmc No major association between TGFBR1*6A and prostate cancer
    Virginia Kaklamani
    Cancer Genetics Program, Division of Hematology Oncology, Department of Medicine, Robert H Lurie Comprehensive Cancer Center, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA
    BMC Genet 5:28. 2004

Collaborators

Detail Information

Publications63

  1. ncbi request reprint Arsenic exposure from drinking-water and carotid artery intima-medial thickness in healthy young adults in Bangladesh
    Yu Chen
    Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, 10032, USA
    J Health Popul Nutr 24:253-7. 2006
    ....
  2. ncbi request reprint New insight into site-specific recombination from Flp recombinase-DNA structures
    Yu Chen
    Department of Biochemistry and Molecular Biology, The University of Chicago, Chicago, Illinois 60637, USA
    Annu Rev Biophys Biomol Struct 32:135-59. 2003
    ..The emergence of new Flp structures and solution data provides insights not only into its unique mechanism of active site assembly and activity regulation but also into the specific contributions of certain protein residues to catalysis...
  3. ncbi request reprint Structural plasticity of the Flp-Holliday junction complex
    Adam B Conway
    Department of Biochemistry and Molecular Biology, University of Chicago, 920 E 58th Street CLSC 221, Chicago, IL 60637, USA
    J Mol Biol 326:425-34. 2003
    ..These results suggest a steric occlusion model for enforcement of half-of-the-sites activity...
  4. ncbi request reprint The role of the conserved Trp330 in Flp-mediated recombination. Functional and structural analysis
    Yu Chen
    Department of Biochemistry and Molecular Biology, The University of Chicago, Illinois 60637, USA
    J Biol Chem 278:24800-7. 2003
    ..Our studies of Trp330 provide the first detailed examination of this conserved residue in the lambda-integrase family, suggesting that the relative importance of active site residues may differ among Flp and related enzymes...
  5. pmc Identification of a potential general acid/base in the reversible phosphoryl transfer reactions catalyzed by tyrosine recombinases: Flp H305
    Katrine L Whiteson
    Department of Biochemistry and Molecular Biology, The University of Chicago, Chicago, IL 60637, USA
    Chem Biol 14:121-9. 2007
    ..These results provide experimental evidence that this conserved histidine functions as a general acid/base catalyst in tyrosine recombinases...
  6. ncbi request reprint Arsenic metabolism, genetic susceptibility, and risk of premalignant skin lesions in Bangladesh
    Habibul Ahsan
    Departments of Epidemiology, Columbia University, USA
    Cancer Epidemiol Biomarkers Prev 16:1270-8. 2007
    ....
  7. doi request reprint Arsenic exposure from drinking water, and all-cause and chronic-disease mortalities in Bangladesh (HEALS): a prospective cohort study
    Maria Argos
    Department of Health Studies, University of Chicago, Chicago, IL 60637, USA
    Lancet 376:252-8. 2010
    ..We therefore prospectively assessed whether chronic and recent changes in arsenic exposure are associated with all-cause and chronic-disease mortalities in a Bangladeshi population...
  8. ncbi request reprint TGFBR1*6A may contribute to hereditary colorectal cancer
    Yansong Bian
    Cancer Genetics Program, Division of Hematology Oncology, Department of Medicine, Robert H Lurie Comprehensive Cancer Center, Northwestern University Feinberg School of Medicine, 676 N St Clair St, Suite 880, Chicago, IL 60611, USA
    J Clin Oncol 23:3074-8. 2005
    ..To test this hypothesis, we determined whether TGFBR16A contributes to a proportion of mismatch repair (MMR) gene mutation-negative hereditary nonpolyposis colorectal cancer (HNPCC) patients...
  9. ncbi request reprint Combined genetic assessment of transforming growth factor-beta signaling pathway variants may predict breast cancer risk
    Virginia G Kaklamani
    Cancer Genetics Program, Division of Hematology Oncology, Department of Medicine, Feinberg School of Medicine and Robert H Lurie Comprehensive Cancer Center, Northwestern University, 676 North St Clair Street, Chicago, IL 60611, USA
    Cancer Res 65:3454-61. 2005
    ..25-3.87). This is the first study assessing the TGF-beta signaling pathway through two common and functionally relevant TGFBR1 and TGFB1 variants. This approach may predict breast cancer risk in a large subset of the population...
  10. pmc No major association between TGFBR1*6A and prostate cancer
    Virginia Kaklamani
    Cancer Genetics Program, Division of Hematology Oncology, Department of Medicine, Robert H Lurie Comprehensive Cancer Center, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA
    BMC Genet 5:28. 2004
    ..080) but the differences in TGFBR1*6A genotype distribution between cases and controls did not reach statistical significance (p = 0.67). Our data suggest that TGFBR1*6A does not contribute to the development of prostate cancer...
  11. pmc Association between arsenic exposure from drinking water and plasma levels of soluble cell adhesion molecules
    Yu Chen
    Departments of Environmental Medicine and Medicine, and New York University Cancer Institute, New York University School of Medicine, New York, New York 10016, USA
    Environ Health Perspect 115:1415-20. 2007
    ..Epidemiologic studies of cardiovascular disease risk factors and appropriate biomarkers in populations exposed to a wide range of arsenic levels are a public health research priority...
  12. ncbi request reprint Arsenic exposure from drinking water and risk of premalignant skin lesions in Bangladesh: baseline results from the Health Effects of Arsenic Longitudinal Study
    Habibul Ahsan
    Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY 10032, USA
    Am J Epidemiol 163:1138-48. 2006
    ..53, 5.44), and 5.39 (95% CI: 3.69, 7.86), respectively. The effect seemed to be influenced by gender, age, and body mass index. These findings provide information that should be considered in future research and policy decisions...
  13. ncbi request reprint Modification of risk of arsenic-induced skin lesions by sunlight exposure, smoking, and occupational exposures in Bangladesh
    Yu Chen
    Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, New York 10032, USA
    Epidemiology 17:459-67. 2006
    ..The risk of skin lesions associated with arsenic exposure from drinking water in Bangladesh is considerably greater in men than in women...
  14. pmc Reduction in urinary arsenic levels in response to arsenic mitigation efforts in Araihazar, Bangladesh
    Yu Chen
    Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, New York, USA
    Environ Health Perspect 115:917-23. 2007
    ..There is a need to identify and evaluate an effective mitigation program for arsenic exposure from drinking water in Bangladesh...
  15. pmc Protective effects of B vitamins and antioxidants on the risk of arsenic-related skin lesions in Bangladesh
    Lydia B Zablotska
    Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, New York, USA
    Environ Health Perspect 116:1056-62. 2008
    ..The mitigating effects of diet on arsenic-related premalignant skin lesions are largely unknown...
  16. doi request reprint Arsenic exposure and anemia in Bangladesh: a population-based study
    Julia E Heck
    Department of Epidemiology, Mailman School of Public Health, College of Physicians and Surgeons, Columbia University, New York, NY, USA
    J Occup Environ Med 50:80-7. 2008
    ..The purpose of this study was to examine the association between arsenic exposure and anemia, based on blood hemoglobin concentration...
  17. ncbi request reprint Blood arsenic as a biomarker of arsenic exposure: results from a prospective study
    Marni Hall
    Department of Environmental Health Sciences, Mailman School of Public Health, Columbia University Medical Center, 60 Haven Avenue B1, New York, NY 10032, USA
    Toxicology 225:225-33. 2006
    ..This prospective study confirms the increased risk of skin lesions in relation to As concentrations in blood, urine and water and also establishes that BAs is a useful biomarker of As exposure in this study population...
  18. ncbi request reprint Structure and mechanism of the phosphotyrosyl phosphatase activator
    Yang Chao
    Department of Molecular Biology, Lewis Thomas Laboratory, Princeton University, Princeton, New Jersey 08544, USA
    Mol Cell 23:535-46. 2006
    ..This function of PTPA strictly depends on the composite ATPase activity. These observations reveal significant insights into the function and mechanism of PTPA and have important ramifications for understanding PP2A function...
  19. ncbi request reprint Structure of protein phosphatase 2A core enzyme bound to tumor-inducing toxins
    Yongna Xing
    Department of Molecular Biology, Lewis Thomas Laboratory, Princeton University, NJ 08544, USA
    Cell 127:341-53. 2006
    ..These structures, together with biochemical analyses, reveal significant insights into PP2A function and serve as a framework for deciphering the diverse roles of PP2A in cellular physiology...
  20. pmc Folate and arsenic metabolism: a double-blind, placebo-controlled folic acid-supplementation trial in Bangladesh
    Mary V Gamble
    Departments of Environmental Health Sciences, Columbia University, New York, NY, USA
    Am J Clin Nutr 84:1093-101. 2006
    ..Consequently, folate nutritional status may influence arsenic methylation and toxicity...
  21. pmc A prospective study of blood selenium levels and the risk of arsenic-related premalignant skin lesions
    Yu Chen
    Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY, USA
    Cancer Epidemiol Biomarkers Prev 16:207-13. 2007
    ..The findings support the hypothesis that dietary selenium intake may reduce the incidence of arsenic-related premalignant skin lesions among populations exposed to arsenic exposure from drinking water...
  22. ncbi request reprint Structure and dynamics of CTX-M enzymes reveal insights into substrate accommodation by extended-spectrum beta-lactamases
    Julien Delmas
    Laboratoire de Bacteriologie, CHU Clermont Ferrand, Clermont Ferrand F 63003, France
    J Mol Biol 375:192-201. 2008
    ....
  23. pmc Socioeconomic status and risk for arsenic-related skin lesions in Bangladesh
    Maria Argos
    Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY, USA
    Am J Public Health 97:825-31. 2007
    ..In this study, we explored the association between socioeconomic status and arsenic toxicity...
  24. ncbi request reprint Consumption of folate-related nutrients and metabolism of arsenic in Bangladesh
    Julia E Heck
    Department of Epidemiology, Mailman School of Public Health and Institute for Social and Economic Research and Policy, Columbia University, New York, NY, USA
    Am J Clin Nutr 85:1367-74. 2007
    ..Previous studies suggest that persons with more complete methylation, characterized as greater proportions of DMA and lesser proportions of MMA and InAs in urine, have a lower risk of adverse arsenic-related health outcomes...
  25. ncbi request reprint A CYP19 (aromatase) polymorphism is associated with increased premenopausal breast cancer risk
    Kathryn E Talbott
    Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY, 10032, USA
    Breast Cancer Res Treat 111:481-7. 2008
    ..The finding supports the potential role of variation in estrogen biosynthesis genes in premenopausal breast cancer risk...
  26. pmc Prevalence of arsenic exposure from drinking water and awareness of its health risks in a Bangladeshi population: results from a large population-based study
    Faruque Parvez
    Mailman School of Public Health, Columbia University, New York, New York 10032, USA
    Environ Health Perspect 114:355-9. 2006
    ..Increasing knowledge of the health consequences of As may be an important element in facilitating remediation...
  27. pmc The deacylation mechanism of AmpC beta-lactamase at ultrahigh resolution
    Yu Chen
    Department of Pharmaceutical Chemistry, University of California San Francisco, QB3 Building Room 508D, 1700 4th Street, San Francisco, CA 94143 2550, USA
    J Am Chem Soc 128:2970-6. 2006
    ....
  28. ncbi request reprint DNA repair gene XPD and susceptibility to arsenic-induced hyperkeratosis
    Habibul Ahsan
    Department of Epidemiology, Mailman School of Public Health, Columbia University, Room 18 129, 622 West 168th Street, New York, NY 10032, USA
    Toxicol Lett 143:123-31. 2003
    ..Future larger studies are needed to confirm this novel finding and investigate how combinations of different candidate genes and/or other host and environmental factors may influence the risk of arsenic induced skin and other cancers...
  29. ncbi request reprint F-actin and myosin II binding domains in supervillin
    Yu Chen
    Department of Cell Biology, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
    J Biol Chem 278:46094-106. 2003
    ..Taken together, these results suggest that supervillin may mediate actin and myosin II filament organization at cholesterol-rich membrane domains...
  30. ncbi request reprint NMR studies of protein-nucleic acid interactions
    Gabriele Varani
    Department of Biochemistry, University of Washington, Seattle, WA, USA
    Methods Mol Biol 278:289-312. 2004
    ..g., residual dipolar couplings and new Web-based analysis tools) that have facilitated NMR studies of these complexes and expanded the type of biological problems to which NMR techniques of structural elucidation can now be applied...
  31. ncbi request reprint Susceptibility to arsenic-induced hyperkeratosis and oxidative stress genes myeloperoxidase and catalase
    Habibul Ahsan
    Department of Epidemiology, Mailman School of Public Health, Columfbia University, Room 720G, 722 West 168th Street, New York, NY 10032, USA
    Cancer Lett 201:57-65. 2003
    ..Our findings, although based on small numbers, suggest that the oxidative stress genes MPO and CAT may influence the risk of arsenic-induced premalignant hyperkeratotic skin lesions...
  32. pmc Structure, function, and inhibition along the reaction coordinate of CTX-M beta-lactamases
    Yu Chen
    Department of Pharmaceutical Chemistry, University of California, San Francisco, Genentech Hall, 600 16th Street, San Francisco, California 94143 2240, USA
    J Am Chem Soc 127:5423-34. 2005
    ..The structure of its complex with CTX-M enzyme and the structural view of the reaction coordinate described here provide templates for inhibitor design and intervention to combat this family of antibiotic resistance enzymes...
  33. ncbi request reprint Health Effects of Arsenic Longitudinal Study (HEALS): description of a multidisciplinary epidemiologic investigation
    Habibul Ahsan
    Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY 10032, USA
    J Expo Sci Environ Epidemiol 16:191-205. 2006
    ..HEALS is a valuable resource for examining novel research questions on the health effects of As exposure...
  34. ncbi request reprint A randomized, double-blind placebo-controlled trial evaluating the effects of vitamin E and selenium on arsenic-induced skin lesions in Bangladesh
    Wendy J Verret
    Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, New York 10032, USA
    J Occup Environ Med 47:1026-35. 2005
    ..We sought to determine whether supplementation of vitamin E (alpha-tocopherol), selenium (L-selenomethionine), or their combination improves arsenical skin lesions...
  35. ncbi request reprint Enhance immune response to DNA vaccine based on a novel multicomponent supramolecular assembly
    Xianfeng Zhou
    College of Life Science, Key Laboratory for Supramolecular Structure and Materials of Ministry of Education, Jilin University, Changchun 130012, and Sichuan Tumor Hospital and Institute, Chengdu, PR China
    Biomaterials 28:4684-92. 2007
    ..Consequently, formulation of DNA vaccines into multicomponent vectors is a powerful means of increasing vaccine potency...
  36. ncbi request reprint Cardiomyocytes overexpressing TNF-alpha attract migration of embryonic stem cells via activation of p38 and c-Jun amino-terminal kinase
    Yu Chen
    Stem Cells Research Laboratory, The Charles A Dana Research Institute and Harvard Thorndike Laboratory, Cardiovascular Division, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    FASEB J 17:2231-9. 2003
    ..Our data demonstrate that excessive TNF-alpha stimulates TNF-RII and enhances migration of ESCs in vitro. Activation of p38 and JNK is required for TNF-alpha-enhanced ESC migration...
  37. ncbi request reprint Facile access to polysubstituted indoles via a cascade Cu-catalyzed arylation-condensation process
    Yu Chen
    Department of Chemistry, Fudan University, Shanghai, China
    J Org Chem 72:9329-34. 2007
    ..Polysubstituted indoles can be prepared from substituted 2-halotrifluoroacetanilides with high regioselectivity...
  38. ncbi request reprint Polycyclic aromatic hydrocarbon-DNA adducts among rickshaw drivers in Dhaka City, Bangladesh
    M Hafizur Rahman
    Department of Biochemistry, Bangabandhu Sheikh Mujib Medical University BSMMU, Dhaka, Bangladesh
    Int Arch Occup Environ Health 76:533-8. 2003
    ..In conclusion, the results suggest that urban residents who are occupationally exposed to traffic pollution in Dhaka are at potentially higher risk of health effects from exposure to carcinogenic PAH compounds...
  39. ncbi request reprint A model for C74 addition by CCA-adding enzymes: C74 addition, like C75 and A76 addition, does not involve tRNA translocation
    Hyundae D Cho
    Department of Biochemistry, School of Medicine, University of Washington, Seattle, Washington 98195 7350, USA
    J Biol Chem 281:9801-11. 2006
    ..Thus a single flexible beta-turn would orchestrate consecutive addition of all three nucleotides without significant movement of the tRNA on the enzyme surface...
  40. pmc Structure of stem-loop IV of Tetrahymena telomerase RNA
    Yu Chen
    Department of Chemistry, University of Washington, Seattle, 98185 1700, USA
    EMBO J 25:3156-66. 2006
    ..We propose that the bending induced by the GA bulge and the flexibility of the template-proximal region allow positioning of the prestructured apical loop during the catalytic cycle...
  41. doi request reprint Estrogen-biosynthesis gene CYP17 and its interactions with reproductive, hormonal and lifestyle factors in breast cancer risk: results from the Long Island Breast Cancer Study Project
    Yu Chen
    Department of Environmental Medicine and New York University Cancer Institute, New York University School of Medicine, New York, NY 10016, USA
    Carcinogenesis 29:766-71. 2008
    ..In conclusion, the findings suggest that the CYP17 variant C allele may increase breast cancer risk in conjunction with long-term HRT use and high BMI in postmenopausal women...
  42. pmc Nonmalignant respiratory effects of chronic arsenic exposure from drinking water among never-smokers in Bangladesh
    Faruque Parvez
    Department of Environmental Health Sciences, Mailman School of Public Health, Columbia University, New York, NY, USA
    Environ Health Perspect 116:190-5. 2008
    ..The association with nonmalignant respiratory illnesses has not been well established because the assessments of respiratory symptoms may be influenced by recall bias or interviewer bias because participants had visible skin lesions...
  43. doi request reprint MMPs, TIMP-2, and TGF-beta1 in the cancerization of oral lichen planus
    Yu Chen
    Department of Oral Pathology, West China College of Stomatology, Sichuan University, Chengdu, China
    Head Neck 30:1237-45. 2008
    ..Matrix metalloproteinases (MMPs) and transforming growth factor-beta1 (TGF-beta1) are important in many physiological and pathological processes...
  44. pmc Proteomic analysis identifies MMP-9, DJ-1 and A1BG as overexpressed proteins in pancreatic juice from pancreatic ductal adenocarcinoma patients
    Mei Tian
    Key Laboratory of Ministry of Health for Biotech Drug, Key Laboratory for Modern Medicine and Technology of Shandong Province, Shandong Medicinal Biotechnology Center, Shandong Academy of Medical Sciences, Jinan 250062, PR China
    BMC Cancer 8:241. 2008
    ..Pancreatic juice is an ideal specimen for PDAC biomarkers discovery, because it is an exceptionally rich source of proteins released from pancreatic cancer cells...
  45. ncbi request reprint A study on the relationship between genetic and environmental factors of type 2 diabetes mellitus in humans
    Yu Chen
    Department of Nutriology, Tourism and Chinese Cuisine of Yangzhou University, Yangzhou 225001, China
    Zhonghua Yu Fang Yi Xue Za Zhi 36:191-4. 2002
    ..To study the relationship between the inheritable factor and environmental factors of type 2 diabetes mellitus in humans...
  46. pmc Structure of a protein phosphatase 2A holoenzyme: insights into B55-mediated Tau dephosphorylation
    Yanhui Xu
    Department of Molecular Biology, Lewis Thomas Laboratory, Princeton University, Princeton, NJ 08544, USA
    Mol Cell 31:873-85. 2008
    ..The beta propeller latches onto the ridge of the PP2A scaffold subunit with the help of a protruding beta hairpin arm. Structure-guided mutagenesis studies revealed the underpinnings of PP2A-mediated dephosphorylation of Tau...
  47. ncbi request reprint [Transitional CK19 positive cells-a new possible marker of hepatic precancerous lesion]
    Yu Chen
    Beijing You An Hospital, Beijing 100050, China
    Zhonghua Gan Zang Bing Za Zhi 12:38-9. 2004
    ..To investigate the relationship between Transitional CK19 positive cells and hepatic precancerous lesion in chronic hepatitis B patients...
  48. ncbi request reprint A family-based genetic association study of variants in estrogen-metabolism genes COMT and CYP1B1 and breast cancer risk
    Habibul Ahsan
    Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY 10032, USA
    Breast Cancer Res Treat 85:121-31. 2004
    ....
  49. ncbi request reprint Synthesis of multiarm star poly(glycerol)-block-poly(2-hydroxyethyl methacrylate)
    Yu Chen
    Department of Chemistry, Tianjin University, 300072, Tianjin, People s Republic of China
    Biomacromolecules 7:919-26. 2006
    ..After this induction period, a linear dependence of ln ([M](0)/[M](t)()) on time was observed. Due to the star architecture, the viscosity of the obtained multiarm star PHEMA is much lower than that of linear PHEMA...
  50. ncbi request reprint RANTES gene single nucleotide polymorphisms and expression in patients with chronic hepatitis B virus infection
    Zhong Ping Duan
    Beijing You An Hospital, Capital University of Medical Science, Beijing 100054, China
    Chin Med J (Engl) 118:909-14. 2005
    ..The present study was to ascertain the possible correlations between chronic hepatitis B virus (HBV) infection and the RANTES gene polymorphisms and their expression...
  51. ncbi request reprint Atomic resolution structures of CTX-M beta-lactamases: extended spectrum activities from increased mobility and decreased stability
    Yu Chen
    Department of Pharmaceutical Chemistry, University of California, San Francisco, Genentech Hall, 600 16th Street, San Francisco, CA 94143 2240, USA
    J Mol Biol 348:349-62. 2005
    ..The unusually high resolution of these structures that makes such analyses possible also makes them good templates for inhibitor discovery...
  52. ncbi request reprint Genome-scale gene function prediction using multiple sources of high-throughput data in yeast Saccharomyces cerevisiae
    Trupti Joshi
    Digital Biology Laboratory, Computer Science Department, University of Missouri Columbia, Columbia, Missouri 65211, USA
    OMICS 8:322-33. 2004
    ..We have developed a Web server for the predictions. We have applied our method to yeast Saccharomyces cerevisiae and predicted functions for 1548 out of 2472 unannotated proteins...
  53. ncbi request reprint Validity of a food-frequency questionnaire for a large prospective cohort study in Bangladesh
    Yu Chen
    Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, USA
    Br J Nutr 92:851-9. 2004
    ..To our knowledge, the present study is the first to document the validity of a FFQ with the use of 7 d FD in a Bangladeshi population...
  54. ncbi request reprint Nutritional influence on risk of high blood pressure in Bangladesh: a population-based cross-sectional study
    Yu Chen
    Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY, USA
    Am J Clin Nutr 84:1224-32. 2006
    ..The nutritional determinants of hypertension in Bangladesh and other low-income countries are largely unknown...
  55. ncbi request reprint Polymorphisms of type I interferon receptor 1 promoter and their effects on chronic hepatitis B virus infection
    Jie Zhou
    Department of Microbiology, The University of Hong Kong, Hong Kong
    J Hepatol 46:198-205. 2007
    ..We aimed to study polymorphisms of type I interferon receptor 1 (IFNAR1) promoter and their potential effects on chronic HBV infection...
  56. ncbi request reprint Cdk5 regulates EphA4-mediated dendritic spine retraction through an ephexin1-dependent mechanism
    Wing Yu Fu
    Department of Biochemistry, Biotechnology Research Institute and Molecular Neuroscience Center, Hong Kong University of Science and Technology, Clear Water Bay, Hong Kong, China
    Nat Neurosci 10:67-76. 2007
    ..These findings suggest that ephrin-A1 promotes EphA4-dependent spine retraction through the activation of Cdk5 and ephexin1, which in turn modulates actin cytoskeletal dynamics...
  57. ncbi request reprint Arsenic exposure from drinking water, dietary intakes of B vitamins and folate, and risk of high blood pressure in Bangladesh: a population-based, cross-sectional study
    Yu Chen
    Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY, USA
    Am J Epidemiol 165:541-52. 2007
    ..Future research is needed to evaluate the effect of low-level arsenic exposure on specific cardiovascular outcomes...
  58. pmc A new hydrogen-bonding potential for the design of protein-RNA interactions predicts specific contacts and discriminates decoys
    Yu Chen
    Department of Chemistry, University of Washington, Box 351700, Seattle, WA 98195 1700, USA
    Nucleic Acids Res 32:5147-62. 2004
    ..By incorporating the new hydrogen-bonding potential into a physical model of protein-RNA interfaces with full atom representation, we were able to recover native amino acids at protein-RNA interfaces...
  59. ncbi request reprint S-nitrosothiols react preferentially with zinc thiolate clusters of metallothionein III through transnitrosation
    Yu Chen
    Center for Biochemical and Biophysical Sciences and Medicine, Harvard Medical School, One Kendall Square, Building 600, Cambridge, Massachusetts 02139, USA
    Biochemistry 41:8360-7. 2002
    ..This could bear importantly on the physiological action of MT-III, whose biological activity as a neuronal growth inhibitory factor is unique, and for brain diseases that have been related to oxidative or nitrosative stress...
  60. ncbi request reprint Stereochemical and skeletal diversity employing pipecolate ester scaffolds
    Yu Chen
    Department of Chemistry and Center for Chemical Methodology and Library Development CMLD BU, Metcalf Center for Science and Engineering, 590 Commonwealth Avenue, Boston University, Boston, Massachusetts 02215, USA
    Org Lett 9:1529-32. 2007
    ..The sequence of functional group interconversions generates diversity through topological and stereochemical variation...
  61. pmc Cancer burden from arsenic in drinking water in Bangladesh
    Yu Chen
    Department of Epidemiology, Mailman School of Public Health, Columbia University, 722 W 168th Street, New York, NY 10032, USA
    Am J Public Health 94:741-4. 2004
    ..Results indicated at least a doubling of lifetime mortality risk from liver, bladder, and lung cancers (229.6 vs 103.5 per 100 000 population) in Bangladesh owing to arsenic in drinking water...
  62. ncbi request reprint Inverse associations of Helicobacter pylori with asthma and allergy
    Yu Chen
    Department of Environmental Medicine, New York University School of Medicine, New York, USA
    Arch Intern Med 167:821-7. 2007
    ..Acquisition of Helicobacter pylori, which predominantly occurs before age 10 years, may reduce risks of asthma and allergy...
  63. doi request reprint Elaboration of 2-(trifluoromethyl)indoles via a cascade coupling/condensation/deacylation process
    Yu Chen
    Department of Chemistry, Fudan University, Shanghai 200433, China
    Org Lett 10:625-8. 2008
    ..This reaction is suggested to occur via a novel coupling/condensation/deacylation mechanism, and many functional groups are tolerated under these conditions...