Research Topics
Species | Yu ChenSummaryAffiliation: University of Chicago Country: USA Publications
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Publications
Arsenic exposure from drinking-water and carotid artery intima-medial thickness in healthy young adults in BangladeshYu Chen
Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, 10032, USA
J Health Popul Nutr 24:253-7. 2006....- New insight into site-specific recombination from Flp recombinase-DNA structuresYu Chen
Department of Biochemistry and Molecular Biology, The University of Chicago, Chicago, Illinois 60637, USA
Annu Rev Biophys Biomol Struct 32:135-59. 2003..The emergence of new Flp structures and solution data provides insights not only into its unique mechanism of active site assembly and activity regulation but also into the specific contributions of certain protein residues to catalysis... - Structural plasticity of the Flp-Holliday junction complexAdam B Conway
Department of Biochemistry and Molecular Biology, University of Chicago, 920 E 58th Street CLSC 221, Chicago, IL 60637, USA
J Mol Biol 326:425-34. 2003..These results suggest a steric occlusion model for enforcement of half-of-the-sites activity... - The role of the conserved Trp330 in Flp-mediated recombination. Functional and structural analysisYu Chen
Department of Biochemistry and Molecular Biology, The University of Chicago, Illinois 60637, USA
J Biol Chem 278:24800-7. 2003..Our studies of Trp330 provide the first detailed examination of this conserved residue in the lambda-integrase family, suggesting that the relative importance of active site residues may differ among Flp and related enzymes... 
Identification of a potential general acid/base in the reversible phosphoryl transfer reactions catalyzed by tyrosine recombinases: Flp H305Katrine L Whiteson
Department of Biochemistry and Molecular Biology, The University of Chicago, Chicago, IL 60637, USA
Chem Biol 14:121-9. 2007..These results provide experimental evidence that this conserved histidine functions as a general acid/base catalyst in tyrosine recombinases...- Arsenic metabolism, genetic susceptibility, and risk of premalignant skin lesions in BangladeshHabibul Ahsan
Departments of Epidemiology, Columbia University, USA
Cancer Epidemiol Biomarkers Prev 16:1270-8. 2007.... 
Arsenic exposure from drinking water, and all-cause and chronic-disease mortalities in Bangladesh (HEALS): a prospective cohort studyMaria Argos
Department of Health Studies, University of Chicago, Chicago, IL 60637, USA
Lancet 376:252-8. 2010..We therefore prospectively assessed whether chronic and recent changes in arsenic exposure are associated with all-cause and chronic-disease mortalities in a Bangladeshi population...- TGFBR1*6A may contribute to hereditary colorectal cancerYansong Bian
Cancer Genetics Program, Division of Hematology Oncology, Department of Medicine, Robert H Lurie Comprehensive Cancer Center, Northwestern University Feinberg School of Medicine, 676 N St Clair St, Suite 880, Chicago, IL 60611, USA
J Clin Oncol 23:3074-8. 2005..To test this hypothesis, we determined whether TGFBR16A contributes to a proportion of mismatch repair (MMR) gene mutation-negative hereditary nonpolyposis colorectal cancer (HNPCC) patients... - Combined genetic assessment of transforming growth factor-beta signaling pathway variants may predict breast cancer riskVirginia G Kaklamani
Cancer Genetics Program, Division of Hematology Oncology, Department of Medicine, Feinberg School of Medicine and Robert H Lurie Comprehensive Cancer Center, Northwestern University, 676 North St Clair Street, Chicago, IL 60611, USA
Cancer Res 65:3454-61. 2005..25-3.87). This is the first study assessing the TGF-beta signaling pathway through two common and functionally relevant TGFBR1 and TGFB1 variants. This approach may predict breast cancer risk in a large subset of the population... - No major association between TGFBR1*6A and prostate cancerVirginia Kaklamani
Cancer Genetics Program, Division of Hematology Oncology, Department of Medicine, Robert H Lurie Comprehensive Cancer Center, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA
BMC Genet 5:28. 2004..080) but the differences in TGFBR1*6A genotype distribution between cases and controls did not reach statistical significance (p = 0.67). Our data suggest that TGFBR1*6A does not contribute to the development of prostate cancer... - Association between arsenic exposure from drinking water and plasma levels of soluble cell adhesion moleculesYu Chen
Departments of Environmental Medicine and Medicine, and New York University Cancer Institute, New York University School of Medicine, New York, New York 10016, USA
Environ Health Perspect 115:1415-20. 2007..Epidemiologic studies of cardiovascular disease risk factors and appropriate biomarkers in populations exposed to a wide range of arsenic levels are a public health research priority... - Arsenic exposure from drinking water and risk of premalignant skin lesions in Bangladesh: baseline results from the Health Effects of Arsenic Longitudinal StudyHabibul Ahsan
Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY 10032, USA
Am J Epidemiol 163:1138-48. 2006..53, 5.44), and 5.39 (95% CI: 3.69, 7.86), respectively. The effect seemed to be influenced by gender, age, and body mass index. These findings provide information that should be considered in future research and policy decisions... - Modification of risk of arsenic-induced skin lesions by sunlight exposure, smoking, and occupational exposures in BangladeshYu Chen
Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, New York 10032, USA
Epidemiology 17:459-67. 2006..Because most arsenic-induced skin cancers arise from these skin lesions, treatment and remediation plans should take into consideration these etiologic cofactors... - Reduction in urinary arsenic levels in response to arsenic mitigation efforts in Araihazar, BangladeshYu Chen
Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, New York, USA
Environ Health Perspect 115:917-23. 2007..There is a need to identify and evaluate an effective mitigation program for arsenic exposure from drinking water in Bangladesh... - Protective effects of B vitamins and antioxidants on the risk of arsenic-related skin lesions in BangladeshLydia B Zablotska
Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, New York, USA
Environ Health Perspect 116:1056-62. 2008..The mitigating effects of diet on arsenic-related premalignant skin lesions are largely unknown... - Arsenic exposure and anemia in Bangladesh: a population-based studyJulia E Heck
Department of Epidemiology, Mailman School of Public Health, College of Physicians and Surgeons, Columbia University, New York, NY, USA
J Occup Environ Med 50:80-7. 2008..The purpose of this study was to examine the association between arsenic exposure and anemia, based on blood hemoglobin concentration... - Blood arsenic as a biomarker of arsenic exposure: results from a prospective studyMarni Hall
Department of Environmental Health Sciences, Mailman School of Public Health, Columbia University Medical Center, 60 Haven Avenue B1, New York, NY 10032, USA
Toxicology 225:225-33. 2006..This prospective study confirms the increased risk of skin lesions in relation to As concentrations in blood, urine and water and also establishes that BAs is a useful biomarker of As exposure in this study population... - Structure and mechanism of the phosphotyrosyl phosphatase activatorYang Chao
Department of Molecular Biology, Lewis Thomas Laboratory, Princeton University, Princeton, New Jersey 08544, USA
Mol Cell 23:535-46. 2006..This function of PTPA strictly depends on the composite ATPase activity. These observations reveal significant insights into the function and mechanism of PTPA and have important ramifications for understanding PP2A function... - Structure of protein phosphatase 2A core enzyme bound to tumor-inducing toxinsYongna Xing
Department of Molecular Biology, Lewis Thomas Laboratory, Princeton University, NJ 08544, USA
Cell 127:341-53. 2006..These structures, together with biochemical analyses, reveal significant insights into PP2A function and serve as a framework for deciphering the diverse roles of PP2A in cellular physiology... - Folate and arsenic metabolism: a double-blind, placebo-controlled folic acid-supplementation trial in BangladeshMary V Gamble
Departments of Environmental Health Sciences, Columbia University, New York, NY, USA
Am J Clin Nutr 84:1093-101. 2006..Consequently, folate nutritional status may influence arsenic methylation and toxicity... - A prospective study of blood selenium levels and the risk of arsenic-related premalignant skin lesionsYu Chen
Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY, USA
Cancer Epidemiol Biomarkers Prev 16:207-13. 2007..The findings support the hypothesis that dietary selenium intake may reduce the incidence of arsenic-related premalignant skin lesions among populations exposed to arsenic exposure from drinking water... - Structure and dynamics of CTX-M enzymes reveal insights into substrate accommodation by extended-spectrum beta-lactamasesJulien Delmas
Laboratoire de Bacteriologie, CHU Clermont Ferrand, Clermont Ferrand F 63003, France
J Mol Biol 375:192-201. 2008.... - Socioeconomic status and risk for arsenic-related skin lesions in BangladeshMaria Argos
Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY, USA
Am J Public Health 97:825-31. 2007..In this study, we explored the association between socioeconomic status and arsenic toxicity... - Consumption of folate-related nutrients and metabolism of arsenic in BangladeshJulia E Heck
Department of Epidemiology, Mailman School of Public Health and Institute for Social and Economic Research and Policy, Columbia University, New York, NY, USA
Am J Clin Nutr 85:1367-74. 2007..Previous studies suggest that persons with more complete methylation, characterized as greater proportions of DMA and lesser proportions of MMA and InAs in urine, have a lower risk of adverse arsenic-related health outcomes... - A CYP19 (aromatase) polymorphism is associated with increased premenopausal breast cancer riskKathryn E Talbott
Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY, 10032, USA
Breast Cancer Res Treat 111:481-7. 2008..The finding supports the potential role of variation in estrogen biosynthesis genes in premenopausal breast cancer risk... - Prevalence of arsenic exposure from drinking water and awareness of its health risks in a Bangladeshi population: results from a large population-based studyFaruque Parvez
Mailman School of Public Health, Columbia University, New York, New York 10032, USA
Environ Health Perspect 114:355-9. 2006..Increasing knowledge of the health consequences of As may be an important element in facilitating remediation... - The deacylation mechanism of AmpC beta-lactamase at ultrahigh resolutionYu Chen
Department of Pharmaceutical Chemistry, University of California San Francisco, QB3 Building Room 508D, 1700 4th Street, San Francisco, CA 94143 2550, USA
J Am Chem Soc 128:2970-6. 2006.... - DNA repair gene XPD and susceptibility to arsenic-induced hyperkeratosisHabibul Ahsan
Department of Epidemiology, Mailman School of Public Health, Columbia University, Room 18 129, 622 West 168th Street, New York, NY 10032, USA
Toxicol Lett 143:123-31. 2003..Future larger studies are needed to confirm this novel finding and investigate how combinations of different candidate genes and/or other host and environmental factors may influence the risk of arsenic induced skin and other cancers... - F-actin and myosin II binding domains in supervillinYu Chen
Department of Cell Biology, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
J Biol Chem 278:46094-106. 2003..Taken together, these results suggest that supervillin may mediate actin and myosin II filament organization at cholesterol-rich membrane domains... - NMR studies of protein-nucleic acid interactionsGabriele Varani
Department of Biochemistry, University of Washington, Seattle, WA, USA
Methods Mol Biol 278:289-312. 2004..g., residual dipolar couplings and new Web-based analysis tools) that have facilitated NMR studies of these complexes and expanded the type of biological problems to which NMR techniques of structural elucidation can now be applied... - Susceptibility to arsenic-induced hyperkeratosis and oxidative stress genes myeloperoxidase and catalaseHabibul Ahsan
Department of Epidemiology, Mailman School of Public Health, Columfbia University, Room 720G, 722 West 168th Street, New York, NY 10032, USA
Cancer Lett 201:57-65. 2003..Our findings, although based on small numbers, suggest that the oxidative stress genes MPO and CAT may influence the risk of arsenic-induced premalignant hyperkeratotic skin lesions... - Structure, function, and inhibition along the reaction coordinate of CTX-M beta-lactamasesYu Chen
Department of Pharmaceutical Chemistry, University of California, San Francisco, Genentech Hall, 600 16th Street, San Francisco, California 94143 2240, USA
J Am Chem Soc 127:5423-34. 2005..The structure of its complex with CTX-M enzyme and the structural view of the reaction coordinate described here provide templates for inhibitor design and intervention to combat this family of antibiotic resistance enzymes... - Health Effects of Arsenic Longitudinal Study (HEALS): description of a multidisciplinary epidemiologic investigationHabibul Ahsan
Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY 10032, USA
J Expo Sci Environ Epidemiol 16:191-205. 2006..HEALS is a valuable resource for examining novel research questions on the health effects of As exposure... - A randomized, double-blind placebo-controlled trial evaluating the effects of vitamin E and selenium on arsenic-induced skin lesions in BangladeshWendy J Verret
Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, New York 10032, USA
J Occup Environ Med 47:1026-35. 2005..CONCLUSIONS: Supplementation with vitamin E and selenium, either alone or in combination, slightly improved skin lesion status, although the improvement was not statistically significant... - Enhance immune response to DNA vaccine based on a novel multicomponent supramolecular assemblyXianfeng Zhou
College of Life Science, Key Laboratory for Supramolecular Structure and Materials of Ministry of Education, Jilin University, Changchun 130012, and Sichuan Tumor Hospital and Institute, Chengdu, PR China
Biomaterials 28:4684-92. 2007..Consequently, formulation of DNA vaccines into multicomponent vectors is a powerful means of increasing vaccine potency... - Cardiomyocytes overexpressing TNF-alpha attract migration of embryonic stem cells via activation of p38 and c-Jun amino-terminal kinaseYu Chen
Stem Cells Research Laboratory, The Charles A. Dana Research Institute and Harvard-Thorndike Laboratory, Cardiovascular Division, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
FASEB J 17:2231-9. 2003..Our data demonstrate that excessive TNF-alpha stimulates TNF-RII and enhances migration of ESCs in vitro. Activation of p38 and JNK is required for TNF-alpha-enhanced ESC migration... - Facile access to polysubstituted indoles via a cascade Cu-catalyzed arylation-condensation processYu Chen
Department of Chemistry, Fudan University, Shanghai, China
J Org Chem 72:9329-34. 2007..Polysubstituted indoles can be prepared from substituted 2-halotrifluoroacetanilides with high regioselectivity... - Polycyclic aromatic hydrocarbon-DNA adducts among rickshaw drivers in Dhaka City, BangladeshM Hafizur Rahman
Department of Biochemistry, Bangabandhu Sheikh Mujib Medical University (BSMMU, Dhaka, Bangladesh
Int Arch Occup Environ Health 76:533-8. 2003..In conclusion, the results suggest that urban residents who are occupationally exposed to traffic pollution in Dhaka are at potentially higher risk of health effects from exposure to carcinogenic PAH compounds... - A model for C74 addition by CCA-adding enzymes: C74 addition, like C75 and A76 addition, does not involve tRNA translocationHyundae D Cho
Department of Biochemistry, School of Medicine, University of Washington, Seattle, Washington 98195-7350, USA
J Biol Chem 281:9801-11. 2006..Thus a single flexible beta-turn would orchestrate consecutive addition of all three nucleotides without significant movement of the tRNA on the enzyme surface... - Structure of stem-loop IV of Tetrahymena telomerase RNAYu Chen
Department of Chemistry, University of Washington, Seattle, 98185-1700, USA
EMBO J 25:3156-66. 2006..We propose that the bending induced by the GA bulge and the flexibility of the template-proximal region allow positioning of the prestructured apical loop during the catalytic cycle... - Estrogen-biosynthesis gene CYP17 and its interactions with reproductive, hormonal and lifestyle factors in breast cancer risk: results from the Long Island Breast Cancer Study ProjectYu Chen
Department of Environmental Medicine and New York University Cancer Institute, New York University School of Medicine, New York, NY 10016, USA
Carcinogenesis 29:766-71. 2008..In conclusion, the findings suggest that the CYP17 variant C allele may increase breast cancer risk in conjunction with long-term HRT use and high BMI in postmenopausal women... - Nonmalignant respiratory effects of chronic arsenic exposure from drinking water among never-smokers in BangladeshFaruque Parvez
Department of Environmental Health Sciences, Mailman School of Public Health, Columbia University, New York, NY, USA
Environ Health Perspect 116:190-5. 2008..The association with nonmalignant respiratory illnesses has not been well established because the assessments of respiratory symptoms may be influenced by recall bias or interviewer bias because participants had visible skin lesions... - MMPs, TIMP-2, and TGF-beta1 in the cancerization of oral lichen planusYu Chen
Department of Oral Pathology, West China College of Stomatology, Sichuan University, Chengdu, China
Head Neck 30:1237-45. 2008..Matrix metalloproteinases (MMPs) and transforming growth factor-beta1 (TGF-beta1) are important in many physiological and pathological processes... - Proteomic analysis identifies MMP-9, DJ-1 and A1BG as overexpressed proteins in pancreatic juice from pancreatic ductal adenocarcinoma patientsMei Tian
Key Laboratory of Ministry of Health for Biotech Drug, Key Laboratory for Modern Medicine and Technology of Shandong Province, Shandong Medicinal Biotechnology Center, Shandong Academy of Medical Sciences, Jinan 250062, PR China
BMC Cancer 8:241. 2008..Pancreatic juice is an ideal specimen for PDAC biomarkers discovery, because it is an exceptionally rich source of proteins released from pancreatic cancer cells... - A study on the relationship between genetic and environmental factors of type 2 diabetes mellitus in humansYu Chen
Department of Nutriology, Tourism and Chinese Cuisine of Yangzhou University, Yangzhou 225001, China
Zhonghua Yu Fang Yi Xue Za Zhi 36:191-4. 2002..To study the relationship between the inheritable factor and environmental factors of type 2 diabetes mellitus in humans... - Structure of a protein phosphatase 2A holoenzyme: insights into B55-mediated Tau dephosphorylationYanhui Xu
Department of Molecular Biology, Lewis Thomas Laboratory, Princeton University, Princeton, NJ 08544, USA
Mol Cell 31:873-85. 2008..The beta propeller latches onto the ridge of the PP2A scaffold subunit with the help of a protruding beta hairpin arm. Structure-guided mutagenesis studies revealed the underpinnings of PP2A-mediated dephosphorylation of Tau... - [Transitional CK19 positive cells-a new possible marker of hepatic precancerous lesion]Yu Chen
Beijing You'an Hospital, Beijing 100050, China
Zhonghua Gan Zang Bing Za Zhi 12:38-9. 2004..CONCLUSION: Transitional CK19 positive cells could be regarded as a new possible pathological marker of hepatic precancerous lesion... - A family-based genetic association study of variants in estrogen-metabolism genes COMT and CYP1B1 and breast cancer riskHabibul Ahsan
Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY 10032, USA
Breast Cancer Res Treat 85:121-31. 2004.... - Synthesis of multiarm star poly(glycerol)-block-poly(2-hydroxyethyl methacrylate)Yu Chen
Department of Chemistry, Tianjin University, 300072, Tianjin, People s Republic of China
Biomacromolecules 7:919-26. 2006..After this induction period, a linear dependence of ln ([M](0)/[M](t)()) on time was observed. Due to the star architecture, the viscosity of the obtained multiarm star PHEMA is much lower than that of linear PHEMA... - RANTES gene single nucleotide polymorphisms and expression in patients with chronic hepatitis B virus infectionZhong Ping Duan
Beijing You An Hospital, Capital University of Medical Science, Beijing 100054, China
Chin Med J (Engl) 118:909-14. 2005..The present study was to ascertain the possible correlations between chronic hepatitis B virus (HBV) infection and the RANTES gene polymorphisms and their expression... - Atomic resolution structures of CTX-M beta-lactamases: extended spectrum activities from increased mobility and decreased stabilityYu Chen
Department of Pharmaceutical Chemistry, University of California, San Francisco, Genentech Hall, 600 16th Street, San Francisco, CA 94143 2240, USA
J Mol Biol 348:349-62. 2005..The unusually high resolution of these structures that makes such analyses possible also makes them good templates for inhibitor discovery... - Genome-scale gene function prediction using multiple sources of high-throughput data in yeast Saccharomyces cerevisiaeTrupti Joshi
Digital Biology Laboratory, Computer Science Department, University of Missouri-Columbia, Columbia, Missouri 65211, USA
OMICS 8:322-33. 2004..We have developed a Web server for the predictions. We have applied our method to yeast Saccharomyces cerevisiae and predicted functions for 1548 out of 2472 unannotated proteins... - Validity of a food-frequency questionnaire for a large prospective cohort study in BangladeshYu Chen
Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, USA
Br J Nutr 92:851-9. 2004..To our knowledge, the present study is the first to document the validity of a FFQ with the use of 7 d FD in a Bangladeshi population... - Nutritional influence on risk of high blood pressure in Bangladesh: a population-based cross-sectional studyYu Chen
Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY, USA
Am J Clin Nutr 84:1224-32. 2006..The nutritional determinants of hypertension in Bangladesh and other low-income countries are largely unknown... - Polymorphisms of type I interferon receptor 1 promoter and their effects on chronic hepatitis B virus infectionJie Zhou
Department of Microbiology, The University of Hong Kong, Hong Kong
J Hepatol 46:198-205. 2007..We aimed to study polymorphisms of type I interferon receptor 1 (IFNAR1) promoter and their potential effects on chronic HBV infection... - Cdk5 regulates EphA4-mediated dendritic spine retraction through an ephexin1-dependent mechanismWing Yu Fu
Department of Biochemistry, Biotechnology Research Institute and Molecular Neuroscience Center, Hong Kong University of Science and Technology, Clear Water Bay, Hong Kong, China
Nat Neurosci 10:67-76. 2007..These findings suggest that ephrin-A1 promotes EphA4-dependent spine retraction through the activation of Cdk5 and ephexin1, which in turn modulates actin cytoskeletal dynamics... - Arsenic exposure from drinking water, dietary intakes of B vitamins and folate, and risk of high blood pressure in Bangladesh: a population-based, cross-sectional studyYu Chen
Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY, USA
Am J Epidemiol 165:541-52. 2007..Future research is needed to evaluate the effect of low-level arsenic exposure on specific cardiovascular outcomes... - A new hydrogen-bonding potential for the design of protein-RNA interactions predicts specific contacts and discriminates decoysYu Chen
Department of Chemistry, University of Washington, Box 351700, Seattle, WA 98195-1700, USA
Nucleic Acids Res 32:5147-62. 2004..By incorporating the new hydrogen-bonding potential into a physical model of protein-RNA interfaces with full atom representation, we were able to recover native amino acids at protein-RNA interfaces... - S-nitrosothiols react preferentially with zinc thiolate clusters of metallothionein III through transnitrosationYu Chen
Center for Biochemical and Biophysical Sciences and Medicine, Harvard Medical School, One Kendall Square, Building 600, Cambridge, Massachusetts 02139, USA
Biochemistry 41:8360-7. 2002..This could bear importantly on the physiological action of MT-III, whose biological activity as a neuronal growth inhibitory factor is unique, and for brain diseases that have been related to oxidative or nitrosative stress... - Stereochemical and skeletal diversity employing pipecolate ester scaffoldsYu Chen
Department of Chemistry and Center for Chemical Methodology and Library Development CMLD BU, Metcalf Center for Science and Engineering, 590 Commonwealth Avenue, Boston University, Boston, Massachusetts 02215, USA
Org Lett 9:1529-32. 2007..The sequence of functional group interconversions generates diversity through topological and stereochemical variation... - Cancer burden from arsenic in drinking water in BangladeshYu Chen
Department of Epidemiology, Mailman School of Public Health, Columbia University, 722 W. 168th Street, New York, NY 10032, USA
Am J Public Health 94:741-4. 2004..Results indicated at least a doubling of lifetime mortality risk from liver, bladder, and lung cancers (229.6 vs 103.5 per 100 000 population) in Bangladesh owing to arsenic in drinking water... - Inverse associations of Helicobacter pylori with asthma and allergyYu Chen
Department of Environmental Medicine, New York University School of Medicine, New York, USA
Arch Intern Med 167:821-7. 2007..Acquisition of Helicobacter pylori, which predominantly occurs before age 10 years, may reduce risks of asthma and allergy... - Elaboration of 2-(trifluoromethyl)indoles via a cascade coupling/condensation/deacylation processYu Chen
Department of Chemistry, Fudan University, Shanghai 200433, China
Org Lett 10:625-8. 2008..This reaction is suggested to occur via a novel coupling/condensation/deacylation mechanism, and many functional groups are tolerated under these conditions...